Species

KNApSAcK Entry

Organism name Commiphora spp.
Genus Commiphora
Family Burseraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Commiphora
Linked NCBI taxonomy ID 43868
Linked level genus

Family

Family in NCBI taxonomy Burseraceae
ID 4014

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002725 External link 512 Cinnamaldehyde
CHEMBL293492
C012843
98 / 49 / 42 151 / 23 No. 2320 No. 6

Human Protein / Gene in interactions

98 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002725 1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00002725 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002725 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002725 2 / 2
P08246 Neutrophil elastase S1A C00002725 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00002725 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002725 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002725 0 / 0
P29466 Caspase-1 C14 C00002725 0 / 0
P17252 Protein kinase C alpha type Alpha C00002725 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00002725 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002725 2 / 2
P02545 Prelamin-A/C Unclassified protein C00002725 11 / 10
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002725 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00002725 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00002725 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002725 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00002725 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00002725 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002725 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002725 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002725 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00002725 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002725 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002725 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002725 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002725 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002725 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00002725 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002725 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002725 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002725 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002725 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002725 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002725 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002725 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002725 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002725 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002725 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002725 0 / 0
O75496 Geminin Unclassified protein C00002725 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002725 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002725 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00002725 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002725 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002725 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002725 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002725 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002725 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002725 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002725 0 / 0
P10145 Interleukin-8 Secreted protein C00002725 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00002725 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002725 0 / 0
P08311 Cathepsin G S1A C00002725 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002725 1 / 0
P03956 Interstitial collagenase M10A C00002725 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002725 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002725 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002725 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002725 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002725 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002725 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002725 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002725 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00002725 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002725 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002725 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002725 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002725 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002725 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002725 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002725 0 / 0
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00002725 1 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00002725 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002725 0 / 0
P03372 Estrogen receptor NR3A1 C00002725 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00002725 1 / 0
P22303 Acetylcholinesterase Hydrolase C00002725 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002725 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002725 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002725 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002725 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00002725 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002725 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002725 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002725 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002725 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002725 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002725 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002725 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002725 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002725 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002725 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002725 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00002725 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002725 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002725 1 / 0

151 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
8714 ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 C00002725
145447 ABHD12B, BEM46L3, C14orf29, c14_5314 abhydrolase domain containing 12B C00002725
8745 ADAM23, MDC-3, MDC3 ADAM metallopeptidase domain 23 C00002725
132 ADK, AK adenosine kinase (EC:2.7.1.20) C00002725
133 ADM, AM adrenomedullin C00002725
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00002725
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00002725
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00002725
57679 ALS2, ALS2CR6, ALSJ, IAHSP, PLSJ amyotrophic lateral sclerosis 2 (juvenile) C00002725
57636 ARHGAP23 Rho GTPase activating protein 23 C00002725
23250 ATP11A, ATPIH, ATPIS ATPase, class VI, type 11A (EC:3.6.3.1) C00002725
581 BAX, BCL2L4 BCL2-associated X protein C00002725
55973 BCAP29, BAP29 B-cell receptor-associated protein 29 C00002725
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002725
637 BID, FP497 BH3 interacting domain death agonist C00002725
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00002725
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00002725
834 CASP1, ICE, IL1BC, P45 caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36) C00002725
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002725
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00002725
91057 CCDC34, NY-REN-41, RAMA3 coiled-coil domain containing 34 C00002725
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00002725
29126 CD274, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1 CD274 molecule C00002725
942 CD86, B7-2, B7.2, B70, CD28LG2, LAB72 CD86 molecule C00002725
994 CDC25B cell division cycle 25B (EC:3.1.3.48) C00002725
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002725
1066 CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) C00002725
1196 CLK2, hCLK2 CDC-like kinase 2 (EC:2.7.12.1) C00002725
4848 CNOT2, CDC36, NOT2, NOT2H CCR4-NOT transcription complex, subunit 2 C00002725
1294 COL7A1, EBD1, EBDCT, EBR1 collagen, type VII, alpha 1 C00002725
1385 CREB1, CREB cAMP responsive element binding protein 1 C00002725
1390 CREM, CREM-2, ICER, hCREM-2 cAMP responsive element modulator C00002725
51232 CRIM1, CRIM-1, S52 cysteine rich transmembrane BMP regulator 1 (chordin-like) C00002725
1399 CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like C00002725
1490 CTGF, CCN2, HCS24, IGFBP8, NOV2 connective tissue growth factor C00002725
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00002725
1581 CYP7A1, CP7A, CYP7, CYPVII cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) C00002725
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00002725
54541 DDIT4, Dig2, REDD-1, REDD1 DNA-damage-inducible transcript 4 C00002725
56616 DIABLO, DFNA64, SMAC diablo, IAP-binding mitochondrial protein C00002725
2039 DMTN, DMT, EPB49 dematin actin binding protein C00002725
1789 DNMT3B, ICF, ICF1, M.HsaIIIB DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37) C00002725
1848 DUSP6, HH19, MKP3, PYST1 dual specificity phosphatase 6 (EC:3.1.3.16 3.1.3.48) C00002725
83658 DYNLRB1, BITH, BLP, DNCL2A, DNLC2A, ROBLD1 dynein, light chain, roadblock-type 1 C00002725
55840 EAF2, BM040, TRAITS, U19 ELL associated factor 2 C00002725
1958 EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 early growth response 1 C00002725
2034 EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 endothelial PAS domain protein 1 C00002725
2150 F2RL1, GPR11, PAR2 coagulation factor II (thrombin) receptor-like 1 C00002725
2213 FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2 Fc fragment of IgG, low affinity IIb, receptor (CD32) C00002725
9103 FCGR2C, CD32, CD32C, CDW32, FCG2, FCRIIC, IGFR2 Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) C00002725
2263 FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25 fibroblast growth factor receptor 2 (EC:2.7.10.1) C00002725
2330 FMO5 flavin containing monooxygenase 5 (EC:1.14.13.8) C00002725
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00002725
2495 FTH1, FHC, FTH, FTHL6, PIG15, PLIF ferritin, heavy polypeptide 1 (EC:1.16.3.1) C00002725
2535 FZD2, Fz2, fz-2, fzE2, hFz2 frizzled family receptor 2 C00002725
2539 G6PD, G6PD1 glucose-6-phosphate dehydrogenase (EC:1.1.1.49) C00002725
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00002725
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00002725
2745 GLRX, GRX, GRX1 glutaredoxin (thioltransferase) (EC:1.8.4.1) C00002725
2844 GPR21 G protein-coupled receptor 21 C00002725
2877 GPX2, GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2 glutathione peroxidase 2 (gastrointestinal) (EC:1.11.1.9) C00002725
2936 GSR glutathione reductase (EC:1.8.1.7) C00002725
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00002725
3077 HFE, HFE1, HH, HLA-H, MVCD7, TFQTL2 hemochromatosis C00002725
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00002725
3251 HPRT1, HGPRT, HPRT hypoxanthine phosphoribosyltransferase 1 (EC:2.4.2.8) C00002725
3304 HSPA1B, HSP70-1B, HSP70-2 heat shock 70kDa protein 1B C00002725
10553 HTATIP2, CC3, SDR44U1, TIP30 HIV-1 Tat interactive protein 2, 30kDa (EC:1.1.1.-) C00002725
27429 HTRA2, OMI, PARK13, PRSS25 HtrA serine peptidase 2 (EC:3.4.21.108) C00002725
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00002725
3429 IFI27, FAM14D, ISG12, ISG12A, P27 interferon, alpha-inducible protein 27 C00002725
10964 IFI44L, C1orf29 interferon-induced protein 44-like C00002725
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00002725
3575 IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA interleukin 7 receptor C00002725
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002725
3638 INSIG1, CL-6, CL6 insulin induced gene 1 C00002725
22801 ITGA11, HsT18964 integrin, alpha 11 C00002725
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00002725
3727 JUND, AP-1 jun D proto-oncogene C00002725
9817 KEAP1, INrf2, KLHL19 kelch-like ECH-associated protein 1 C00002725
10186 LHFP lipoma HMGIC fusion partner (EC:3.6.5.4) C00002725
29995 LMCD1 LIM and cysteine-rich domains 1 C00002725
29967 LRP12, ST7 low density lipoprotein receptor-related protein 12 C00002725
4049 LTA, LT, TNFB, TNFSF1 lymphotoxin alpha C00002725
79917 MAGIX, JM10, PDZX MAGI family member, X-linked C00002725
5605 MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) C00002725
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002725
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00002725
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002725
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00002725
8550 MAPKAPK5, MAPKAP-K5, MK-5, MK5, PRAK mitogen-activated protein kinase-activated protein kinase 5 (EC:2.7.11.1) C00002725
57787 MARK4, MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D MAP/microtubule affinity-regulating kinase 4 (EC:2.7.11.1) C00002725
4170 MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT myeloid cell leukemia sequence 1 (BCL2-related) C00002725
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00002725
4599 MX1, IFI-78K, IFI78, MX, MxA myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) C00002725
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00002725
100132406 NBPF10, AB6, AG1, NBPF9 neuroblastoma breakpoint family, member 10 C00002725
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00002725
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00002725
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00002725
22981 NINL, NLP, dJ691N24.1 ninein-like C00002725
4854 NOTCH3, CADASIL, CASIL, IMF2 notch 3 C00002725
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00002725
56666 PANX2, PX2, hPANX2 pannexin 2 C00002725
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00002725
5140 PDE3B, HcGIP1, cGIPDE1 phosphodiesterase 3B, cGMP-inhibited (EC:3.1.4.17) C00002725
7262 PHLDA2, BRW1C, BWR1C, HLDA2, IPL, TSSC3 pleckstrin homology-like domain, family A, member 2 C00002725
8544 PIR pirin (iron-binding nuclear protein) (EC:1.13.11.24) C00002725
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00002725
5447 POR, CPR, CYPOR, P450R P450 (cytochrome) oxidoreductase (EC:1.6.2.4) C00002725
8496 PPFIBP1, L2, SGT2, hSGT2, hSgt2p PTPRF interacting protein, binding protein 1 (liprin beta 1) C00002725
5514 PPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99 protein phosphatase 1, regulatory subunit 10 C00002725
11107 PRDM5, BCS2, PFM2 PR domain containing 5 C00002725
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002725
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002725
146760 RTN4RL1, NGRH2, NgR3 reticulon 4 receptor-like 1 C00002725
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00002725
6444 SGCD, 35DAG, CMD1L, DAGD, SG-delta, SGCDP, SGD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) C00002725
6563 SLC14A1, HUT11, HsT1341, JK, RACH1, RACH2, UT-B1, UT1, UTE solute carrier family 14 (urea transporter), member 1 C00002725
6506 SLC1A2, EAAT2, GLT-1 solute carrier family 1 (glial high affinity glutamate transporter), member 2 C00002725
115111 SLC26A7, SUT2 solute carrier family 26 (anion exchanger), member 7 C00002725
114134 SLC2A13, HMIT solute carrier family 2 (facilitated glucose transporter), member 13 C00002725
11046 SLC35D2, HFRC1, SQV7L, UGTrel8, hfrc solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 C00002725
23657 SLC7A11, CCBR1, xCT solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 C00002725
6546 SLC8A1, NCX1 solute carrier family 8 (sodium/calcium exchanger), member 1 C00002725
4087 SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 SMAD family member 2 C00002725
28966 SNX24, PRO1284 sorting nexin 24 C00002725
9295 SRSF11, NET2, SFRS11, dJ677H15.2, p54 serine/arginine-rich splicing factor 11 C00002725
140809 SRXN1, C20orf139, Npn3, SRX, SRX1 sulfiredoxin 1 (EC:1.8.98.2) C00002725
27067 STAU2, 39K2, 39K3 staufen double-stranded RNA binding protein 2 C00002725
8428 STK24, MST3, MST3B, STE20, STK3 serine/threonine kinase 24 (EC:2.7.11.1) C00002725
51684 SUFU, PRO1280, SUFUH, SUFUXL suppressor of fused homolog (Drosophila) C00002725
6915 TBXA2R, BDPLT13, TXA2-R thromboxane A2 receptor C00002725
7041 TGFB1I1, ARA55, HIC-5, HIC5, TSC-5 transforming growth factor beta 1 induced transcript 1 C00002725
55258 THNSL2, SOFAT, THS2, TSH2 threonine synthase-like 2 (S. cerevisiae) (EC:4.2.3.-) C00002725
7099 TLR4, ARMD10, CD284, TLR-4, TOLL toll-like receptor 4 C00002725
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002725
27242 TNFRSF21, BM-018, CD358, DR6 tumor necrosis factor receptor superfamily, member 21 C00002725
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002725
10626 TRIM16, EBBP tripartite motif containing 16 C00002725
8989 TRPA1, ANKTM1, FEPS transient receptor potential cation channel, subfamily A, member 1 C00002725
7273 TTN, CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD titin (EC:2.7.11.1) C00002725
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00002725
7321 UBE2D1, E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A ubiquitin-conjugating enzyme E2D 1 (EC:6.3.2.19) C00002725
7360 UGP2, UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379 UDP-glucose pyrophosphorylase 2 (EC:2.7.7.9) C00002725
7374 UNG, DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2 uracil-DNA glycosylase (EC:3.2.2.27) C00002725
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00002725
340481 ZDHHC21, 9130404H11Rik, DHHC-21, DHHC21, DNZ1, HSPC097 zinc finger, DHHC-type containing 21 (EC:2.3.1.225) C00002725
79973 ZNF442 zinc finger protein 442 C00002725
440515 ZNF506 zinc finger protein 506 C00002725
51193 ZNF639, 6230400O18Rik, ANC-2H01, ANC_2H01, ZASC1 zinc finger protein 639 C00002725

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (49)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (42)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

23 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006528 Carcinoma, Hepatocellular C00002725
D002471 Cell Transformation, Neoplastic C00002725
D003110 Colonic Neoplasms C00002725
D003371 Cough C00002725
D003384 Coxsackievirus Infections C00002725
D017449 Dermatitis, Allergic Contact C00002725
D003921 Diabetes Mellitus, Experimental C00002725
D003924 Diabetes Mellitus, Type 2 C00002725
D004487 Edema C00002725
D004890 Erythema C00002725
D006470 Hemorrhage C00002725
D006930 Hyperalgesia C00002725
D006943 Hyperglycemia C00002725
D006984 Hypertrophy C00002725
D008545 Melanoma C00002725
D010146 Pain C00002725
D011655 Pulmonary Embolism C00002725
D012478 Salmonella Food Poisoning C00002725
D012481 Salmonella Infections, Animal C00002725
D012678 Sensation Disorders C00002725
D013927 Thrombosis C00002725
D014581 Urticaria C00002725
D014735 Vibrio Infections C00002725