Species

KNApSAcK Entry

Organism name Euphorbia spp.
Genus Euphorbia
Family Euphorbiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Euphorbiaceae
Linked NCBI taxonomy ID 3977
Linked level family

Family

Family in NCBI taxonomy Euphorbiaceae
ID 3977

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005141 External link 512 Kaempferol 3-glucuronide
/ Kaempferol-3-O-beta-D-glucuronide
No. 2 No. 15
C00005376 External link 512 Miquelianin
/ Quercetin 3-O-beta-D-glucuronide
CHEMBL520546
CHEMBL1506682
23 / 30 / 21 No. 2 No. 15
C00008698 External link 512 Taxifolin 3-galactoside
CHEMBL2332678
CHEMBL2332679
No. 12 No. 14
C00006039 External link 512 Myricetin 3-(6''-galloylgalactoside)
No. 98
C00003745 External link 512 Euphol
/ alpha-Euphol
/ (+)-alpha-Euphol
CHEMBL225111
CHEMBL465181
CHEMBL1397369
C062557
10 / 17 / 17 No. 218 No. 51
C00002931 External link 512 Mallotusinic acid
No. 226 No. 81
C00002926 External link 512 Geraniin
CHEMBL506069
C024603
1 / 4 / 2 0 / 1 No. 226 No. 81
C00003439 External link 512 Ingenol
CHEMBL346507
CHEMBL2165402
C008125
1 / 0 / 0 No. 3700 No. 41

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein C00003745 C00005376 11 / 10
P10636 Microtubule-associated protein tau Unclassified protein C00003745 C00005376 4 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00003745 C00005376 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00005376 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005376 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003745 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005376 0 / 0
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 C00003745 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005376 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00003745 2 / 3
P10253 Lysosomal alpha-glucosidase Hydrolase C00005376 1 / 1
P39748 Flap endonuclease 1 Enzyme C00005376 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00005376 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00005376 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00005376 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005376 3 / 1
P17252 Protein kinase C alpha type Alpha C00003439 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003745 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005376 0 / 1
P12821 Angiotensin-converting enzyme M2 C00002926 4 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme C00003745 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003745 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005376 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005376 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005376 0 / 0
P06746 DNA polymerase beta Enzyme C00005376 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003745 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005376 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005376 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005376 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005376 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00005376 2 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#267430 Renal tubular dysgenesis; rtd P12821
#275210 Restrictive dermopathy, lethal P02545
#601367 Stroke, ischemic P12821
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (27)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00213 Hypophosphatasia P05186 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D012878 Skin Neoplasms C00002926