PCIDB

Carum carvi

Species

KNApSAcK Entry

Organism name Carum carvi
Genus Carum
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Carum carvi
Linked NCBI taxonomy ID 48032
Linked level species

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005138 External link 512 Astragalin
/ Kaempferol 3-glucoside
/ Kaempferol 3-O-beta-D-glucoside
/ Kaempferol 3-O-beta-D-glucopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C001579
10 / 6 / 7 0 / 1 No. 2 No. 15
C00005137 External link 512 Trifolin
/ Kaempferol 3-O-beta-D-galactopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C066407
10 / 6 / 7 1 / 1 No. 2 No. 15
C00005373 External link 512 Hirsutrin
/ Isoquercetin
/ Isoquercetrin
/ (-)-Isoquercetrin
/ Quercetin 3-glucoside
/ Quercetin 3-O-beta-D-glucoside
/ Quercetin-3-O-beta-D-glucopyranoside
/ Quercetin 3-O-beta-D-glucopyranoside
/ (-)-Quercetin-3-O-beta-D-glucopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
38 / 43 / 34 No. 2 No. 15
C00010891 External link 512 (S)-(+)-Carvone
CHEMBL15676
CHEMBL501949
8 / 9 / 9 No. 1740 No. 35
C00003039 External link 512 Cuminaldehyde
/ Cuminyl aldehyde
/ 4-Isopropyl benzaldehyde
CHEMBL161577
C007165
2 / 4 / 2 No. 3751 No. 35

Human Protein / Gene in interactions

51 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P14679 Tyrosinase Oxidoreductase C00003039 C00005137 C00005138 C00005373 4 / 2
Q9UNA4 DNA polymerase iota Enzyme C00005137 C00005138 C00005373 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005137 C00005138 C00005373 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005137 C00005138 C00005373 0 / 0
P15121 Aldose reductase Enzyme C00005137 C00005138 C00005373 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005137 C00005138 C00005373 1 / 1
Q99700 Ataxin-2 Unclassified protein C00005137 C00005138 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005137 C00005138 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005137 C00005138 0 / 3
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005137 C00005138 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00005373 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005373 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00010891 3 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005373 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005373 1 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005373 1 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00005373 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00010891 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00005373 1 / 1
P39748 Flap endonuclease 1 Enzyme C00005373 0 / 0
O75496 Geminin Unclassified protein C00005373 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00005373 0 / 0
P04062 Glucosylceramidase Enzyme C00005373 6 / 4
O00519 Fatty-acid amide hydrolase 1 Enzyme C00003039 0 / 0
P06746 DNA polymerase beta Enzyme C00005373 0 / 0
P02545 Prelamin-A/C Unclassified protein C00005373 11 / 10
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005373 3 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00005373 0 / 3
P06280 Alpha-galactosidase A Enzyme C00005373 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00005373 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005373 0 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005373 2 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00010891 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00010891 2 / 0
P35372 Mu-type opioid receptor Opioid receptor C00005373 0 / 0
Q9NPH5 NADPH oxidase 4 Enzyme C00005373 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005373 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00005373 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00010891 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005373 1 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005373 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00005373 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005373 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005373 0 / 0
O00255 Menin Unclassified protein C00010891 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00010891 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00005373 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005373 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005373 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00005373 4 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00010891 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5320 PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) C00005137

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (53)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614490 Blood group, junior system; jr Q9UNQ0
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (45)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00125 Fabry disease P06280 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003876 Dermatitis, Atopic C00005138
D004487 Edema C00005137