Species

KNApSAcK Entry

Organism name Thapsia garganica
Genus Thapsia
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Thapsia garganica
Linked NCBI taxonomy ID 79022
Linked level species

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00035137 External link 512 Neohelmanthicin D
/ (-)-Neohelmanthicin D
No. 1913
C00035136 External link 512 Neohelmanthicin C
No. 1913
C00035135 External link 512 Neohelmanthicin B
No. 1913
C00035134 External link 512 Neohelmanthicin A
/ (-)-Neohelmanthicin A
No. 1913
C00020716 External link 512 Thapsivillosin K
No. 2100 No. 38
C00020715 External link 512 Thapsigargicin
CHEMBL328508
CHEMBL1537509
C046319
16 / 11 / 9 No. 2100 No. 38
C00003375 External link 512 Thapsigargin
CHEMBL96926
CHEMBL192566
CHEMBL1355952
D019284
45 / 52 / 75 157 / 0 No. 2100 No. 38

Human Protein / Gene in interactions

50 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00003375 C00020715 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003375 C00020715 4 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00003375 C00020715 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00003375 C00020715 1 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003375 C00020715 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00003375 C00020715 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00003375 C00020715 0 / 0
P06280 Alpha-galactosidase A Enzyme C00003375 C00020715 1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003375 C00020715 1 / 2
P51151 Ras-related protein Rab-9A Unclassified protein C00003375 C00020715 0 / 0
O14983 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Calcium C00003375 C00020715 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00003375 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003375 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00003375 3 / 2
P10253 Lysosomal alpha-glucosidase Hydrolase C00003375 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003375 0 / 1
P54132 Bloom syndrome protein Enzyme C00003375 1 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00003375 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003375 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00020715 0 / 0
P42858 Huntingtin Unclassified protein C00020715 1 / 1
O75496 Geminin Unclassified protein C00003375 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003375 1 / 0
Q9Y253 DNA polymerase eta Enzyme C00003375 1 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00003375 2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00003375 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00003375 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003375 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00003375 0 / 0
Q99700 Ataxin-2 Unclassified protein C00003375 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003375 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00003375 2 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00020715 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00003375 5 / 2
P17861 X-box-binding protein 1 Unclassified protein C00020715 1 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003375 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00003375 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003375 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003375 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00003375 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00003375 4 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00003375 7 / 37
P42345 Serine/threonine-protein kinase mTOR Enzyme C00003375 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00003375 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003375 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00003375 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00020715 0 / 0
P40225 Thrombopoietin Unclassified protein C00003375 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003375 0 / 0
O00255 Menin Unclassified protein C00003375 2 / 5

157 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
133 ADM, AM adrenomedullin C00003375
150 ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 adrenoceptor alpha 2A C00003375
79026 AHNAK, AHNAKRS AHNAK nucleoprotein C00003375
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00003375
240 ALOX5, 5-LO, 5-LOX, 5LPG, LOG5 arachidonate 5-lipoxygenase (EC:1.13.11.34) C00003375
467 ATF3 activating transcription factor 3 C00003375
468 ATF4, CREB-2, CREB2, TAXREB67, TXREB activating transcription factor 4 C00003375
22926 ATF6, ATF6A activating transcription factor 6 C00003375
488 ATP2A2, ATP2B, DAR, DD, SERCA2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (EC:3.6.3.8) C00003375
489 ATP2A3, SERCA3 ATPase, Ca++ transporting, ubiquitous (EC:3.6.3.8) C00003375
245972 ATP6V0D2, ATP6D2, VMA6 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14) C00003375
581 BAX, BCL2L4 BCL2-associated X protein C00003375
10282 BET1, HBET1 Bet1 golgi vesicular membrane trafficking protein C00003375
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00003375
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00003375
672 BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53 breast cancer 1, early onset C00003375
675 BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2 breast cancer 2, early onset C00003375
773 CACNA1A, APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit C00003375
796 CALCA, CALC1, CGRP, CGRP-I, CGRP1, CT, KC calcitonin-related polypeptide alpha C00003375
811 CALR, CRT, RO, SSA, cC1qR calreticulin C00003375
813 CALU calumenin C00003375
821 CANX, CNX, IP90, P90 calnexin C00003375
100506742 CASP12, CASP-12, CASP12P1 caspase 12 (gene/pseudogene) C00003375
835 CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) C00003375
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003375
837 CASP4, ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX caspase 4, apoptosis-related cysteine peptidase (EC:3.4.22.57) C00003375
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00003375
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00003375
117155 CATSPER2 cation channel, sperm associated 2 C00003375
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00003375
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00003375
901 CCNG2 cyclin G2 C00003375
991 CDC20, CDC20A, bA276H19.3, p55CDC cell division cycle 20 C00003375
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00003375
1063 CENPF, CENF, PRO1779, hcp-1 centromere protein F, 350/400kDa C00003375
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00003375
1081 CGA, CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA glycoprotein hormones, alpha polypeptide C00003375
79094 CHAC1 ChaC, cation transport regulator homolog 1 (E. coli) C00003375
10036 CHAF1A, CAF-1, CAF1, CAF1B, CAF1P150, P150 chromatin assembly factor 1, subunit A (p150) C00003375
1152 CKB, B-CK, CKBB creatine kinase, brain (EC:2.7.3.2) C00003375
6320 CLEC11A, CLECSF3, LSLCL, P47, SCGF C-type lectin domain family 11, member A C00003375
1293 COL6A3 collagen, type VI, alpha 3 C00003375
51138 COPS4, CSN4 COP9 signalosome subunit 4 C00003375
8904 CPNE1, COPN1, CPN1 copine I C00003375
90993 CREB3L1, OASIS cAMP responsive element binding protein 3-like 1 C00003375
1429 CRYZ crystallin, zeta (quinone reductase) (EC:1.6.5.5) C00003375
1489 CTF1, CT-1, CT1 cardiotrophin 1 C00003375
2920 CXCL2, CINC-2a, GRO2, GROb, MGSA-b, MIP-2a, MIP2, MIP2A, SCYB2 chemokine (C-X-C motif) ligand 2 C00003375
4051 CYP4F3, CPF3, CYP4F, LTB4H cytochrome P450, family 4, subfamily F, polypeptide 3 (EC:1.14.13.30) C00003375
1611 DAP death-associated protein C00003375
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00003375
56616 DIABLO, DFNA64, SMAC diablo, IAP-binding mitochondrial protein C00003375
51726 DNAJB11, ABBP-2, ABBP2, DJ9, Dj-9, EDJ, ERdj3, ERj3, ERj3p, PRO1080, UNQ537, hDj-9 DnaJ (Hsp40) homolog, subfamily B, member 11 C00003375
4189 DNAJB9, ERdj4, MDG-1, MDG1, MST049, MSTP049 DnaJ (Hsp40) homolog, subfamily B, member 9 C00003375
54431 DNAJC10, ERdj5, JPDI, MTHr, PDIA19 DnaJ (Hsp40) homolog, subfamily C, member 10 C00003375
5611 DNAJC3, ERdj6, HP58, P58, P58IPK, PRKRI DnaJ (Hsp40) homolog, subfamily C, member 3 C00003375
10570 DPYSL4, CRMP3, DRP-4, ULIP4 dihydropyrimidinase-like 4 C00003375
1950 EGF, HOMG4, URG epidermal growth factor C00003375
1958 EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 early growth response 1 C00003375
83939 EIF2A, EIF-2A, MST089, MSTP004, MSTP089 eukaryotic translation initiation factor 2A, 65kDa C00003375
9451 EIF2AK3, PEK, PERK, WRS eukaryotic translation initiation factor 2-alpha kinase 3 (EC:2.7.11.1) C00003375
1965 EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa C00003375
8668 EIF3I, EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36 eukaryotic translation initiation factor 3, subunit I C00003375
1984 EIF5A, EIF-5A, EIF5A1, eIF5AI eukaryotic translation initiation factor 5A C00003375
63916 ELMO2, CED-12, CED12, ELMO-2 engulfment and cell motility 2 C00003375
2077 ERF, CRS4, PE-2, PE2 Ets2 repressor factor C00003375
2081 ERN1, IRE1, IRE1P, IRE1a, hIRE1p endoplasmic reticulum to nucleus signaling 1 (EC:2.7.11.1) C00003375
2258 FGF13, FGF-13, FGF2, FHF-2, FHF2 fibroblast growth factor 13 C00003375
23768 FLRT2 fibronectin leucine rich transmembrane protein 2 C00003375
2324 FLT4, FLT41, LMPH1A, PCL, VEGFR3 fms-related tyrosine kinase 4 (EC:2.7.10.1) C00003375
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00003375
2354 FOSB, AP-1, G0S3, GOS3, GOSB FBJ murine osteosarcoma viral oncogene homolog B C00003375
1647 GADD45A, DDIT1, GADD45 growth arrest and DNA-damage-inducible, alpha C00003375
2669 GEM, KIR GTP binding protein overexpressed in skeletal muscle C00003375
9527 GOSR1, GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28 golgi SNAP receptor complex member 1 C00003375
2936 GSR glutathione reductase (EC:1.8.1.7) C00003375
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00003375
3068 HDGF, HMG1L2 hepatoma-derived growth factor C00003375
3099 HK2, HKII, HXK2 hexokinase 2 (EC:2.7.1.1) C00003375
7184 HSP90B1, ECGP, GP96, GRP94, TRA1 heat shock protein 90kDa beta (Grp94), member 1 C00003375
3309 HSPA5, BIP, GRP78, MIF2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) C00003375
3313 HSPA9, CSA, GRP-75, GRP75, HSPA9B, MOT, MOT2, MTHSP75, PBP74 heat shock 70kDa protein 9 (mortalin) C00003375
3336 HSPE1, CPN10, EPF, GROES, HSP10 heat shock 10kDa protein 1 C00003375
3350 HTR1A, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled C00003375
50615 IL21R, CD360, NILR interleukin 21 receptor C00003375
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00003375
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00003375
3624 INHBA, EDF, FRP inhibin, beta A C00003375
83729 INHBE inhibin, beta E C00003375
3783 KCNN4, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 C00003375
115207 KCTD12, C13orf2, PFET1, PFETIN potassium channel tetramerization domain containing 12 C00003375
56992 KIF15, HKLP2, KNSL7, NY-BR-62 kinesin family member 15 C00003375
9585 KIF20B, CT90, KRMP1, MPHOSPH1, MPP-1, MPP1 kinesin family member 20B C00003375
11004 KIF2C, KNSL6, MCAK kinesin family member 2C C00003375
3853 KRT6A, CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D keratin 6A C00003375
3856 KRT8, CARD2, CK-8, CK8, CYK8, K2C8, K8, KO keratin 8 C00003375
3934 LCN2, 24p3, MSFI, NGAL lipocalin 2 C00003375
3998 LMAN1, ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58 lectin, mannose-binding, 1 C00003375
4069 LYZ, LZM lysozyme (EC:3.2.1.17) C00003375
23499 MACF1, ABP620, ACF7, MACF, OFC4 microtubule-actin crosslinking factor 1 C00003375
5607 MAP2K5, HsT17454, MAPKK5, MEK5, PRKMK5 mitogen-activated protein kinase kinase 5 (EC:2.7.12.2) C00003375
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00003375
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00003375
4149 MAX, bHLHd4 MYC associated factor X C00003375
4170 MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT myeloid cell leukemia sequence 1 (BCL2-related) C00003375
4176 MCM7, CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146 minichromosome maintenance complex component 7 (EC:3.6.4.12) C00003375
55669 MFN1, hfzo1, hfzo2 mitofusin 1 C00003375
84311 MRPL45, L45mt, MRP-L45 mitochondrial ribosomal protein L45 C00003375
92399 MRRF, MRFF, MTRRF, RRF mitochondrial ribosome recycling factor C00003375
4489 MT1A, MT1, MT1S, MTC metallothionein 1A C00003375
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00003375
4666 NACA, NACA1 nascent polypeptide-associated complex alpha subunit (EC:5.3.99.3) C00003375
4772 NFATC1, NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 C00003375
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00003375
4929 NR4A2, HZF-3, NOT, NURR1, RNR1, TINUR nuclear receptor subfamily 4, group A, member 2 C00003375
26471 NUPR1, COM1, P8 nuclear protein, transcriptional regulator, 1 C00003375
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00003375
5106 PCK2, PEPCK, PEPCK-M, PEPCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32) C00003375
11235 PDCD10, CCM3, TFAR15 programmed cell death 10 C00003375
10015 PDCD6IP, AIP1, ALIX, DRIP4, HP95 programmed cell death 6 interacting protein C00003375
2923 PDIA3, ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC protein disulfide isomerase family A, member 3 (EC:5.3.4.1) C00003375
5187 PER1, PER, RIGUI, hPER period circadian clock 1 C00003375
5347 PLK1, PLK, STPK13 polo-like kinase 1 (EC:2.7.11.21) C00003375
10733 PLK4, SAK, STK18 polo-like kinase 4 (EC:2.7.11.21) C00003375
8985 PLOD3, LH3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) C00003375
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00003375
23645 PPP1R15A, GADD34 protein phosphatase 1, regulatory subunit 15A C00003375
5530 PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) C00003375
25824 PRDX5, ACR1, AOEB166, B166, PLP, PMP20, PRDX6, PRXV, prx-V peroxiredoxin 5 (EC:1.11.1.15) C00003375
5579 PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2 protein kinase C, beta (EC:2.7.11.13) C00003375
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00003375
5806 PTX3, TNFAIP5, TSG-14 pentraxin 3, long C00003375
5955 RCN2, E6BP, ERC-55, ERC55, TCBP49 reticulocalbin 2, EF-hand calcium binding domain C00003375
6284 S100A13 S100 calcium binding protein A13 C00003375
51435 SCARA3, APC7, CSR, CSR1, MSLR1, MSRL1 scavenger receptor class A, member 3 C00003375
23256 SCFD1, C14orf163, RA410, SLY1, SLY1P, STXBP1L2 sec1 family domain containing 1 C00003375
6326 SCN2A, BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, HBSCII, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2 sodium channel, voltage-gated, type II, alpha subunit C00003375
5265 SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 C00003375
5055 SERPINB2, HsT1201, PAI, PAI-2, PAI2, PLANH2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 C00003375
6418 SET, 2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA SET nuclear oncogene C00003375
119559 SFXN4, BCRM1 sideroflexin 4 C00003375
6786 STIM1, D11S4896E, GOK, IMD10, TAM stromal interaction molecule 1 C00003375
202374 STK32A, YANK1 serine/threonine kinase 32A (EC:2.7.11.1) C00003375
10492 SYNCRIP, GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q synaptotagmin binding, cytoplasmic RNA interacting protein C00003375
7052 TGM2, G-ALPHA-h, GNAH, TG2, TGC transglutaminase 2 (EC:2.3.2.13) C00003375
10469 TIMM44, TIM44 translocase of inner mitochondrial membrane 44 homolog (yeast) C00003375
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00003375
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00003375
7222 TRPC3, TRP3 transient receptor potential cation channel, subfamily C, member 3 C00003375
7272 TTK, CT96, ESK, MPH1, MPS1, MPS1L1, PYT TTK protein kinase (EC:2.7.12.1) C00003375
203068 TUBB, M40, OK/SW-cl.56, TUBB1, TUBB5 tubulin, beta class I C00003375
10190 TXNDC9, APACD, PHLP3 thioredoxin domain containing 9 C00003375
11065 UBE2C, UBCH10, dJ447F3.2 ubiquitin-conjugating enzyme E2C (EC:6.3.2.19) C00003375
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00003375
7494 XBP1, TREB5, XBP-1, XBP2 X-box binding protein 1 C00003375
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00003375
7531 YWHAE, 14-3-3E, KCIP-1, MDCR, MDS tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide C00003375

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (54)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#601003 Brody myopathy O14983
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#612371 Major affective disorder 7; mafd7 P17861
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257220 Niemann-pick disease, type c1; npc1 O15118
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (76)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01129 Brody myopathy O14983 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00125 Fabry disease P06280 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00059 Huntington's disease (HD) P42858 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)