Species

KNApSAcK Entry

Organism name Morus insignis
Genus Morus
Family Moraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Morus insignis
Linked NCBI taxonomy ID 1031565
Linked level species

Family

Family in NCBI taxonomy Moraceae
ID 3487

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00019244 External link 512 Moracin M 3'-O-beta-glucopyranoside
C083338
No. 2 No. 15
C00005373 External link 512 Hirsutrin
/ Isoquercetin
/ Isoquercetrin
/ (-)-Isoquercetrin
/ Quercetin 3-glucoside
/ Quercetin 3-O-beta-D-glucoside
/ Quercetin-3-O-beta-D-glucopyranoside
/ Quercetin 3-O-beta-D-glucopyranoside
/ (-)-Quercetin-3-O-beta-D-glucopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
38 / 43 / 34 No. 2 No. 15
C00005138 External link 512 Astragalin
/ Kaempferol 3-glucoside
/ Kaempferol 3-O-beta-D-glucoside
/ Kaempferol 3-O-beta-D-glucopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C001579
10 / 6 / 7 0 / 1 No. 2 No. 15
C00003558 External link 512 Ursolic acid
CHEMBL297810
CHEMBL56048
CHEMBL300594
CHEMBL169
CHEMBL176234
CHEMBL491715
CHEMBL1316667
CHEMBL1555307
CHEMBL1593360
CHEMBL1979720
C005466
47 / 26 / 33 15 / 12 No. 13 No. 51
C00037514 External link 512 Morusignin A
No. 15 No. 15
C00037515 External link 512 Morusignin B
No. 15 No. 15
C00013459 External link 512 Morusignin L
No. 18 No. 15
C00030356 External link 512 Garcinone B
CHEMBL560332
No. 18 No. 15
C00036164 External link 512 Morusignin C
No. 24 No. 15
C00032369 External link 512 Toxyloxanthone B
CHEMBL482997
No. 24 No. 15
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00019309 External link 512 Moracin M
/ Veraphenol
/ 6,3',5'-Trihydroxy-2-phenylbenzofuran
CHEMBL512578
10 / 5 / 7 No. 71 No. 15
C00008105 External link 512 Mulberrofuran U
C083337
No. 81 No. 20
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520

Human Protein / Gene in interactions

94 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00003558 C00003672 C00005373 C00019308 0 / 0
P14679 Tyrosinase Oxidoreductase C00003672 C00005138 C00005373 4 / 2
P49841 Glycogen synthase kinase-3 beta Gsk C00003558 C00003672 C00019308 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003558 C00003672 C00019308 0 / 0
P15121 Aldose reductase Enzyme C00003558 C00005138 C00005373 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003558 C00003672 C00019308 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00003558 C00005138 C00005373 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003558 C00005373 C00019309 0 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003558 C00003672 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003558 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003558 C00003672 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003558 C00003672 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005138 C00005373 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00003558 C00005373 0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00003558 C00019309 2 / 2
P00734 Prothrombin S1A C00003672 C00019308 4 / 2
Q9Y253 DNA polymerase eta Enzyme C00005138 C00005373 1 / 1
P02545 Prelamin-A/C Unclassified protein C00003558 C00005373 11 / 10
Q01196 Runt-related transcription factor 1 Unclassified protein C00003558 C00005373 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00003558 C00005373 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003558 C00003672 1 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00003558 C00019309 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005138 C00005373 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003558 C00003672 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003558 0 / 0
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00003558 0 / 0
Q08499 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE_4D C00019309 1 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005373 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005373 1 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00003558 3 / 1
P41145 Kappa-type opioid receptor Opioid receptor C00005373 0 / 0
Q07343 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE_4B C00019309 0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00003558 1 / 1
P17405 Sphingomyelin phosphodiesterase Enzyme C00019309 2 / 2
Q9UQL6 Histone deacetylase 5 Hydrolase C00003558 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00005373 1 / 1
P39748 Flap endonuclease 1 Enzyme C00005373 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00003558 0 / 0
O75496 Geminin Unclassified protein C00005373 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00005373 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005373 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
Q04206 Transcription factor p65 Transcription Factor C00003558 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003558 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00005373 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005373 3 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00003558 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003558 0 / 0
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00003558 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005138 0 / 0
P06280 Alpha-galactosidase A Enzyme C00005373 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00003558 0 / 0
O15379 Histone deacetylase 3 Hydrolase C00003558 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00003558 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00005373 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005373 0 / 1
Q13547 Histone deacetylase 1 Hydrolase C00003558 0 / 0
O76083 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE_9A C00019309 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005373 2 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005138 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00019309 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00005373 0 / 0
P56524 Histone deacetylase 4 Hydrolase C00003558 1 / 1
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003558 0 / 0
P30305 M-phase inducer phosphatase 2 Ser_Thr_Tyr C00003558 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005373 1 / 1
P04062 Glucosylceramidase Enzyme C00005373 6 / 4
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00003558 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00005373 4 / 3
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005373 1 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003558 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00003558 0 / 1
Q9UBN7 Histone deacetylase 6 Hydrolase C00003558 0 / 0
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00003558 0 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005373 1 / 1
Q99700 Ataxin-2 Unclassified protein C00005138 1 / 1
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00003558 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005373 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005373 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00003558 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005373 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003558 1 / 0
O00255 Menin Unclassified protein C00003558 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003558 1 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005373 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00005373 4 / 1
Q9NPH5 NADPH oxidase 4 Enzyme C00005373 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005138 0 / 3
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00019309 0 / 0
Q9HCT0 Fibroblast growth factor 22 Unclassified protein C00019309 0 / 0

15 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00003558
578 BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 BCL2-antagonist/killer 1 C00003558
581 BAX, BCL2L4 BCL2-associated X protein C00003558
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00003558
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003558
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00003558
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00003558
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003558
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00003558
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00003558
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00003558
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00003558
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00003558
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00003558
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00003558

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (73)

OMIM preferred title UniProt
#614613 Acrodysostosis 2, with or without hormone resistance; acrdys2 Q08499
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614490 Blood group, junior system; jr Q9UNQ0
#600430 Brachydactyly-mental retardation syndrome; bdmr P56524
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (60)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
P16473 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00408 Type I diabetes mellitus P17706 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00561 Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome P56524 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

16 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003876 Dermatitis, Atopic C00005138
D001284 Atrophy C00003558
D006528 Carcinoma, Hepatocellular C00003558
D002471 Cell Transformation, Neoplastic C00003558
D003921 Diabetes Mellitus, Experimental C00003558
D006943 Hyperglycemia C00003558
D006949 Hyperlipidemias C00003558
D006965 Hyperplasia C00003558
D007249 Inflammation C00003558
D008103 Liver Cirrhosis C00003558
D017202 Myocardial Ischemia C00003558
D009369 Neoplasms C00003558
D012878 Skin Neoplasms C00003558
D002493 Central Nervous System Diseases C00019308
D003072 Cognition Disorders C00019308
D013118 Spinal Cord Diseases C00019308