KEGG   ENZYME: 2.7.11.24Help
Entry
EC 2.7.11.24                Enzyme                                 

Name
mitogen-activated protein kinase;
c-Jun N-terminal kinase;
Dp38;
ERK;
ERK1;
ERK2;
extracellular signal-regulated kinase;
JNK;
JNK3alpha1;
LeMPK3;
MAP kinase;
MAP-2 kinase;
MAPK;
MBP kinase I;
MBP kinase II;
microtubule-associated protein 2 kinase;
microtubule-associated protein kinase;
myelin basic protein kinase;
p38delta;
p38-2;
p42 mitogen-activated protein kinase;
p42mapk;
PMK-1;
PMK-2;
PMK-3;
pp42;
pp44mapk;
p44mpk;
SAPK;
STK26;
stress-activated protein kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
Orthology
K04371  
mitogen-activated protein kinase 1/3
K04440  
c-Jun N-terminal kinase
K04441  
p38 MAP kinase
K04464  
mitogen-activated protein kinase 7
K04468  
nemo like kinase
K06855  
mitogen-activated protein kinase 4/6
K08293  
mitogen-activated protein kinase
K14512  
mitogen-activated protein kinase 6
Genes
HSA: 
1432(MAPK14) 225689(MAPK15) 51701(NLK) 5594(MAPK1) 5595(MAPK3) 5596(MAPK4) 5597(MAPK6) 5598(MAPK7) 5599(MAPK8) 5600(MAPK11) 5601(MAPK9) 5602(MAPK10) 5603(MAPK13) 6300(MAPK12)
PTR: 
450161(MAPK14) 450445(MAPK8) 453439(MAPK6) 454037(MAPK3) 454499(MAPK7) 458680(MAPK1) 461358(MAPK10) 462336(MAPK9) 462644(MAPK13) 468536(MAPK4) 739132(NLK) 746712(MAPK15) 747077(MAPK12)
PPS: 
100967254(MAPK7) 100972270(MAPK15) 100979222(NLK) 100979542(MAPK3) 100980937(MAPK11) 100981268(MAPK12) 100982480(MAPK8) 100982544(MAPK13) 100983649(MAPK14) 100984173(MAPK10) 100988980(MAPK6) 100989422(MAPK4) 100990080(MAPK9) 100995567(MAPK1)
GGO: 
101124033(MAPK8) 101129084(MAPK15) 101134492(MAPK12) 101134843(MAPK11) 101135988(MAPK3) 101137450(MAPK7) 101138810(NLK) 101140164 101143697(MAPK6) 101148438(MAPK13) 101151665(MAPK4) 101152026(MAPK9) 101152640(MAPK14)
PON: 
100169740(MAPK1) 100173242(MAPK6) 100174482(MAPK10) 100431824(MAPK3) 100437263(MAPK12) 100437341(NLK) 100437424(MAPK8) 100438440 100440111(MAPK15) 100449269(MAPK14) 100449853(MAPK13) 100451029(MAPK7) 100459133(MAPK9)
MCC: 
677693(NLK) 694444(MAPK6) 694998(MAPK6) 698569(MAPK1) 699736(MAPK10) 700969(MAPK4) 702837(MAPK7) 708938(MAPK3) 711115(MAPK8) 715745(MAPK12) 715794(MAPK11) 718976 719085
MCF: 
MMU: 
18099(Nlk) 19094(Mapk11) 225724(Mapk4) 23939(Mapk7) 26413(Mapk1) 26414(Mapk10) 26415(Mapk13) 26416(Mapk14) 26417(Mapk3) 26419(Mapk8) 26420(Mapk9) 29857(Mapk12) 332110(Mapk15) 50772(Mapk6)
RNO: 
100912585 114509(Mapk7) 116554(Mapk8) 116590(Mapk1) 25272(Mapk10) 286997(Mapk15) 29513(Mapk13) 497961(Nlk) 50658(Mapk9) 50689(Mapk3) 54268(Mapk4) 58840(Mapk6) 60352(Mapk12) 689314(Mapk11) 81649(Mapk14)
CGE: 
HGL: 
101698286(Mapk9) 101700449(Mapk6) 101700581(Mapk4) 101701893(Nlk) 101702687(Mapk3) 101705370(Mapk11) 101706002(Mapk12) 101706099(Mapk1) 101712538(Mapk15) 101712980(Mapk10) 101715259(Mapk8) 101715692(Mapk14) 101726391(Mapk7)
TUP: 
102468920 102472233(MAPK8) 102475335(MAPK7) 102475730(MAPK10) 102475742(MAPK4) 102481241(MAPK13) 102483057(MAPK3) 102487603(MAPK11) 102494380(MAPK15) 102495693(MAPK14) 102496009(MAPK6) 102496453(MAPK1) 102497095(MAPK9) 102501733(MAPK12)
CFA: 
100855877(MAPK3) 403856(MAPK14) 474652(MAPK9) 477575(MAPK1) 477746(MAPK8) 478311(MAPK6) 478464(MAPK10) 479790(MAPK3) 482080(MAPK15) 489532(MAPK7) 491160(NLK) 491690(MAPK4) 607019(MAPK11) 607023(MAPK12) 612821(MAPK13)
AML: 
FCA: 
101080751(NLK) 101081149(MAPK12) 101081396(MAPK11) 101084765(MAPK9) 101087614(MAPK1) 101087958(MAPK3) 101091310(MAPK8) 101091508(MAPK15) 101092057(MAPK4) 101093275(MAPK6) 101097357(MAPK7) 101101135(MAPK14) 101101463(MAPK10)
BTA: 
327672(MAPK1) 507204(NLK) 512125(MAPK15) 512943(MAPK12) 529183(MAPK4) 531391(MAPK3) 534125(MAPK9) 534492(MAPK14) 535327(MAPK13) 537631(MAPK10) 537703(MAPK7) 538094(MAPK6) 539941(MAPK8) 618906(MAPK11)
BOM: 
102266282(MAPK4) 102266960(MAPK9) 102271030(MAPK13) 102271320(MAPK14) 102272368(MAPK3) 102272421(MAPK10) 102274050(NLK) 102274306(MAPK6) 102277976(MAPK8) 102278560(MAPK7) 102285026(MAPK15) 102285848(MAPK12)
PHD: 
102321680(MAPK13) 102322031(MAPK14) 102323252(MAPK9) 102324617(NLK) 102326136 102329495(MAPK4) 102331873(MAPK12) 102334117(MAPK8) 102335953(MAPK7) 102338495(MAPK6) 102342433(MAPK3) 102344390(MAPK10)
CHX: 
100860996(MAPK13) 100861087(MAPK8) 102169187(MAPK6) 102170408(MAPK9) 102180534(MAPK7) 102182774(MAPK10) 102183251 102184020(MAPK4) 102186040(MAPK1) 102188824(MAPK3) 102189174(MAPK14) 102190163(NLK)
SSC: 
100153927(MAPK1) 100156630(MAPK14) 100511657(NLK) 100521736(MAPK10) 100523414(MAPK4) 100620270 102164433 396609(MAPK9) 396610(MAPK8) 396833(MAPK6) 445013(MAPK3) 574062(MAPK12)
CFR: 
102503577(MAPK8) 102509244 102509448(MAPK10) 102511078(MAPK14) 102511298(MAPK13) 102515487(MAPK6) 102516847(MAPK12) 102517586(MAPK1) 102518561(MAPK9) 102518663(MAPK4) 102519162(NLK) 102519781(MAPK11) 102521659(MAPK3) 102522626(MAPK15) 102524416
ECB: 
100051798(MAPK8) 100052608(MAPK10) 100053916(MAPK4) 100055006(MAPK6) 100056239(MAPK12) 100056278(MAPK11) 100057701(MAPK1) 100057961(MAPK9) 100058876(NLK) 100063532(MAPK14) 100066173(MAPK3) 100073174(MAPK7) 100146864(MAPK15)
MYB: 
102245641(MAPK1) 102245831(MAPK7) 102246292(MAPK8) 102246580(NLK) 102248097 102249806(MAPK6) 102254628(MAPK12) 102255250(MAPK3) 102259698(MAPK4) 102259984(MAPK9) 102263026(MAPK10)
MDO: 
SHR: 
100913231(MAPK1) 100917749(MAPK7) 100919388(MAPK15) 100919999(MAPK4) 100924267(MAPK9) 100925013(MAPK14) 100925447(MAPK13) 100928480(MAPK10) 100928564(NLK) 100928729(MAPK12) 100930815(MAPK8) 100931440(MAPK6) 100934330(MAPK3)
OAA: 
GGA: 
100858386 373953(MAPK1) 395983(MAPK9) 415419(MAPK6) 417669(NLK) 417739(MAPK11) 421183(MAPK14) 422592(MAPK10) 423778(MAPK8) 426292(MAPK15) 769763(MAPK12) 771145(MAPK13)
MGP: 
TGU: 
100217568(NLK) 100218485 100218726(MAPK6) 100220802(MAPK1) 100220867(MAPK8) 100223519(MAPK10) 100225101(MAPK11) 100225285(MAPK9) 100227852 100227993(MAPK12) 100229840(MAPK4)
FAB: 
101806540 101806829(MAPK6) 101807358(MAPK12) 101809052(MAPK10) 101811957(MAPK15) 101814783(MAPK11) 101815088(MAPK1) 101817298(NLK) 101817339(MAPK8) 101817434(MAPK13) 101817836(MAPK4) 101819306(MAPK9) 101819980(MAPK14)
PHI: 
102099139(MAPK6) 102099159(MAPK10) 102102818(MAPK1) 102104312(MAPK15) 102106744(MAPK9) 102108455(NLK) 102109820(MAPK11) 102110009(MAPK12) 102110807(MAPK13) 102111004(MAPK14) 102111242 102114247(MAPK4) 102114724(MAPK8)
APLA: 
101789910(MAPK4) 101791119(MAPK15) 101792057(MAPK11) 101793591(MAPK12) 101793594(MAPK8) 101797936(MAPK6) 101799011(MAPK9) 101799776(MAPK10) 101800319(MAPK1) 101802116(MAPK13) 101804891(NLK) 101805023(MAPK14)
FPG: 
101912679 101914611(MAPK1) 101915038(MAPK15) 101915315(NLK) 101917138(MAPK10) 101918008(MAPK4) 101919216(MAPK6) 101920170(MAPK12) 101920353(MAPK11) 101921076(MAPK9) 101921635(MAPK14) 101922433(MAPK13) 101924129(MAPK8)
FCH: 
102047380(MAPK8) 102048221(MAPK1) 102051874(MAPK12) 102052038(MAPK11) 102053335(MAPK6) 102053931(NLK) 102054176(MAPK10) 102054359(MAPK13) 102055655(MAPK15) 102055660(MAPK9) 102057908(MAPK4) 102059377(MAPK14)
CLV: 
102084319 102084879(MAPK1) 102085027(MAPK9) 102085840(MAPK10) 102086843(NLK) 102087983(MAPK8) 102089738(MAPK14) 102089969 102090037(MAPK13) 102090861(MAPK12) 102094655(MAPK4)
ASN: 
102374196(MAPK12) 102374345(MAPK4) 102374542(MAPK10) 102375835(MAPK11) 102375954(MAPK13) 102376040(MAPK9) 102376154(MAPK8) 102376541(MAPK14) 102376659(NLK) 102376690(MAPK1) 102381114(MAPK6) 102386241
PSS: 
102445212(NLK) 102445557(MAPK6) 102448785(MAPK14) 102450501 102452788(MAPK4) 102453224(MAPK9) 102453948(MAPK1) 102455939(MAPK13) 102459702(MAPK8) 102460734(MAPK10) 102460982 102462429(MAPK11) 102462672(MAPK12) 102463278(MAPK7)
ACS: 
XLA: 
100329215(p38-beta) 379876(mapk8) 379992(mapk14) 397785(mapk1-b) 398295(nlk.2) 398592(mapk12) 398985(mapk1-a) 414522(nlk) 446599(mapk7) 494669(mapk11) 734485(mapk15) 735153
XTR: 
100101766(mapk11) 100144638(nlk) 100144684(nlk.2) 100144715(mapk13) 100145045(mapk12) 100145558(mapk15) 100170194(mapk8) 100494114(mapk6) 100498202 448296(mapk14) 549834(mapk12) 549881(mapk1) 779515(mapk10) 779785(mapk7)
DRE: 
100002318(mapk13) 100149273(mapk9) 266756(mapk14b) 30681(mapk12a) 360144(mapk1) 399480(mapk3) 405892(nlk1) 406782(mapk4) 415185(mapk11) 541323(mapk7) 553780(mapk15) 557810(mapk12b) 562552(fc89f08) 562720(mapk8a) 563460(nlk2) 565830(mapk6) 569698(mapk10) 65236(mapk8b) 65237(mapk14a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
100184138 778596(erk1/2) 778597(erk5) 778660(jnk) 778685(nemo-like) 778927(p38) 778965(erk3/4)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408917(erk7) 409286(bsk) 409523(rl) 410956(nmo) 411915(p38b)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_B0218.3(pmk-1) CELE_B0478.1(jnk-1) CELE_C05D10.2(C05D10.2) CELE_F42G8.3(pmk-2) CELE_F42G8.4(pmk-3) CELE_F43C1.2(mpk-1) CELE_W06F12.1(lit-1)
CBR: 
CBG01554(Cbr-pmk-2) CBG01555(Cbr-pmk-1) CBG05733(Cbr-jnk-1) CBG18286(Cbr-lit-1) CBG21144 CBG21247(Cbr-mpk-1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G01560(MPK11) AT1G07880(ATMPK13) AT1G10210(MPK1) AT1G59580(MPK2) AT2G18170(MPK7) AT2G43790(MPK6) AT2G46070(MPK12) AT3G45640(MPK3) AT3G59790(MPK10) AT4G01370(MPK4) AT4G11330(MPK5) AT4G36450(MPK14)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0002s03340g(POPTRDRAFT_643073) POPTR_0002s16400g(POPTRDRAFT_816604) POPTR_0005s12140g POPTR_0005s25270g(POPTRDRAFT_801509) POPTR_0007s00930g(POPTRDRAFT_718188) POPTR_0009s07050g(POPTRDRAFT_833180) POPTR_791419 POPTR_813465
VVI: 
SLY: 
100736474(MAPK6) 100736510(MAPK8) 100736512(MPK9) 100736513(MAPK4) 100736536(MAPK7) 543792(mpka1;1) 543879(MPK2) 543880(MPK3)
SOT: 
OSA: 
DOSA: 
Os02t0148100-01(Os02g0148100) Os03t0285800-01(Os03g0285800) Os06t0154500-01(Os06g0154500) Os06t0699400-01(Os06g0699400) Os08t0157000-00(Os08g0157000) Os10t0533600-01(Os10g0533600)
BDI: 
100834779(MPK6) 100837420(MPK3) 100839224(MPK11) 100839537(MPK14) 100841616(MPK7-1) 100846323
SBI: 
SORBI_01g030680(SORBIDRAFT_01g030680) SORBI_04g003480(SORBIDRAFT_04g003480) SORBI_07g003810(SORBIDRAFT_07g003810) SORBI_10g003810(SORBIDRAFT_10g003810) SORBI_10g028780(SORBIDRAFT_10g028780)
ZMA: 
100283121(pco133201) 100286386(MPK7) 100381337 542144(simk1) 542594(gpm355)
SITA: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
CCP: 
SCE: 
YBL016W(FUS3) YGR040W(KSS1) YHR030C(SLT2) YKL161C(KDX1) YLR113W(HOG1) YPR054W(SMK1)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A02120(NCAS0A02120) NCAS_0A06680(NCAS0A06680) NCAS_0A11020(NCAS0A11020) NCAS_0B05560(NCAS0B05560) NCAS_0C03380(NCAS0C03380)
NDI: 
NDAI_0A05280(NDAI0A05280) NDAI_0B02900(NDAI0B02900) NDAI_0D01620(NDAI0D01620) NDAI_0D04050(NDAI0D04050) NDAI_0G02700(NDAI0G02700)
TPF: 
TPHA_0A01630(TPHA0A01630) TPHA_0B02440(TPHA0B02440) TPHA_0C02880(TPHA0C02880) TPHA_0J00630(TPHA0J00630) TPHA_0M01500(TPHA0M01500)
TBL: 
TBLA_0A06670(TBLA0A06670) TBLA_0A08430(TBLA0A08430) TBLA_0A08810(TBLA0A08810) TBLA_0A10420(TBLA0A10420) TBLA_0H01330(TBLA0H01330)
TDL: 
TDEL_0B04490(TDEL0B04490) TDEL_0C04800(TDEL0C04800) TDEL_0D02650(TDEL0D02650) TDEL_0E03520(TDEL0E03520) TDEL_0F04290(TDEL0F04290)
KAF: 
KAFR_0B02980(KAFR0B02980) KAFR_0C02840(KAFR0C02840) KAFR_0E01810(KAFR0E01810) KAFR_0F03900(KAFR0F03900) KAFR_0H01040(KAFR0H01040)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.10404(ERK1) CaO19.2886(ERK1) CaO19.460(CEK2) CaO19.7208(CSK1) CaO19.7523(MKC1) CaO19.8091(CEK2) CaO19.8514(HOG1) CaO19.895(HOG1)
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_1044194 AOR_1_332184(AO090009000199) AOR_1_692154(AO090003000402)
ANG: 
ANI_1_1286014(An01g09520) ANI_1_1432074(An08g10670) ANI_1_492064(An07g03980) ANI_1_826074(An08g05850)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_08980(erkB)
EHI: 
EHI_073650(67.t00005) EHI_194420(46.t00053)
EDI: 
ACAN: 
PFA: 
PF11_0147(map-2) PF14_0294(PfMAP1)
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_IV005520(23.m06268)
BEQ: 
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:2842341]
  Authors
Ray LB, Sturgill TW.
  Title
Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.
  Journal
J. Biol. Chem. 263 (1988) 12721-7.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:1657919]
  Authors
Rossomando AJ, Sanghera JS, Marsden LA, Weber MJ, Pelech SL, Sturgill TW.
  Title
Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations.
  Journal
J. Biol. Chem. 266 (1991) 20270-5.
  Organism
Mus musculus [GN:mmu], Xenopus laevis [GN:xla]
Reference
3  [PMID:1321146]
  Authors
Seger R, Ahn NG, Posada J, Munar ES, Jensen AM, Cooper JA, Cobb MH, Krebs EG.
  Title
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
  Journal
J. Biol. Chem. 267 (1992) 14373-81.
  Organism
Xenopus laevis [GN:xla]
Reference
4  [PMID:9235954]
  Authors
Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS.
  Title
p38-2, a novel mitogen-activated protein kinase with distinct properties.
  Journal
J. Biol. Chem. 272 (1997) 19509-17.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:5600]
Reference
5  [PMID:10715136]
  Authors
Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P.
  Title
Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.
  Journal
Biochemistry. 39 (2000) 3141-8.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:5602]
Reference
6  [PMID:15187187]
  Authors
Roux PP, Blenis J.
  Title
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.
  Journal
Microbiol. Mol. Biol. Rev. 68 (2004) 320-44.
  Organism
Saccharomyces cerevisiae [GN:sce], mammalian
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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