KEGG   ENZYME: 2.7.11.24Help
Entry
EC 2.7.11.24                Enzyme                                 

Name
mitogen-activated protein kinase;
c-Jun N-terminal kinase;
Dp38;
ERK;
ERK1;
ERK2;
extracellular signal-regulated kinase;
JNK;
JNK3alpha1;
LeMPK3;
MAP kinase;
MAP-2 kinase;
MAPK;
MBP kinase I;
MBP kinase II;
microtubule-associated protein 2 kinase;
microtubule-associated protein kinase;
myelin basic protein kinase;
p38delta;
p38-2;
p42 mitogen-activated protein kinase;
p42mapk;
PMK-1;
PMK-2;
PMK-3;
pp42;
pp44mapk;
p44mpk;
SAPK;
STK26;
stress-activated protein kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
History
EC 2.7.11.24 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04371  
mitogen-activated protein kinase 1/3
K04440  
c-Jun N-terminal kinase
K04441  
p38 MAP kinase
K04464  
mitogen-activated protein kinase 7
K04468  
nemo like kinase
K06855  
mitogen-activated protein kinase 4/6
K08293  
sporulation-specific mitogen-activated protein kinase SMK1 
K14512  
mitogen-activated protein kinase 6
K19603  
mitogen-activated protein kinase 15
K20535  
mitogen-activated protein kinase 1/2
K20536  
mitogen-activated protein kinase 3
K20537  
mitogen-activated protein kinase 7/14
K20538  
mitogen-activated protein kinase 8
Genes
HSA: 
1432(MAPK14) 225689(MAPK15) 51701(NLK) 5594(MAPK1) 5595(MAPK3) 5596(MAPK4) 5597(MAPK6) 5598(MAPK7) 5599(MAPK8) 5600(MAPK11) 5601(MAPK9) 5602(MAPK10) 5603(MAPK13) 6300(MAPK12)
PTR: 
450161(MAPK14) 450445(MAPK8) 453439(MAPK6) 454037(MAPK3) 454499(MAPK7) 458680(MAPK1) 461358(MAPK10) 462336(MAPK9) 462644(MAPK13) 468536(MAPK4) 739132(NLK) 746712(MAPK15) 747077(MAPK12)
PPS: 
100967254(MAPK7) 100972270(MAPK15) 100979222(NLK) 100979542(MAPK3) 100980937(MAPK11) 100981268(MAPK12) 100982480(MAPK8) 100982544(MAPK13) 100983649(MAPK14) 100984173(MAPK10) 100988980(MAPK6) 100989422(MAPK4) 100990080(MAPK9) 100995567(MAPK1)
GGO: 
101124033(MAPK8) 101127956 101129084(MAPK15) 101134492(MAPK12) 101134843(MAPK11) 101135988(MAPK3) 101137450(MAPK7) 101138810(NLK) 101140164 101143697(MAPK6) 101148438(MAPK13) 101151665(MAPK4) 101152026(MAPK9) 101152640(MAPK14)
PON: 
100169740(MAPK1) 100173242(MAPK6) 100174482(MAPK10) 100431824(MAPK3) 100437263(MAPK12) 100437341(NLK) 100437424(MAPK8) 100438440 100440111(MAPK15) 100449269(MAPK14) 100449853(MAPK13) 100451029(MAPK7) 100459133(MAPK9)
NLE: 
100580599(MAPK12) 100581677(MAPK9) 100589036(MAPK11) 100593682(MAPK6) 100593981(NLK) 100595369(MAPK13) 100597336(MAPK4) 100598787(MAPK7) 100600225(MAPK14) 100602081(MAPK10) 100605285(MAPK8) 100606092(MAPK15)
MCC: 
100428659(MAPK15) 677693(NLK) 694998(MAPK6) 698569(MAPK1) 699736(MAPK10) 700969(MAPK4) 702837(MAPK7) 708938(MAPK3) 711115(MAPK8) 715745(MAPK12) 715782(MAPK9) 715794(MAPK11) 718976(MAPK14) 719085(MAPK13)
MCF: 
101865361(NLK) 101867305(MAPK12) 101867352(MAPK13) 101925732(MAPK6) 101926770(MAPK14) 102114808(MAPK4) 102118497(MAPK9) 102121272(MAPK10) 102126339(MAPK8) 102129135(MAPK15) 102133212(MAPK7) 102134421(MAPK11)
RRO: 
104660707(MAPK7) 104660767(MAPK12) 104660769(MAPK11) 104660910(MAPK6) 104668007(MAPK10) 104669360(NLK) 104672911(MAPK4) 104676194(MAPK9) 104678447(MAPK8) 104679800(MAPK15) 104681150(MAPK3) 104682867(MAPK14) 104682868(MAPK13)
CJC: 
100387686(MAPK9) 100390109(MAPK10) 100392721(MAPK8) 100396611(MAPK11) 100396967(MAPK12) 100400023(MAPK7) 100404377(MAPK14) 100405093(MAPK13) 100407752(MAPK15) 100407964(MAPK4) 100414864(NLK) 100415140(MAPK6)
MMU: 
18099(Nlk) 19094(Mapk11) 225724(Mapk4) 23939(Mapk7) 26413(Mapk1) 26414(Mapk10) 26415(Mapk13) 26416(Mapk14) 26417(Mapk3) 26419(Mapk8) 26420(Mapk9) 29857(Mapk12) 332110(Mapk15) 50772(Mapk6)
RNO: 
100912585 114509(Mapk7) 116554(Mapk8) 116590(Mapk1) 25272(Mapk10) 286997(Mapk15) 29513(Mapk13) 497961(Nlk) 50658(Mapk9) 50689(Mapk3) 54268(Mapk4) 58840(Mapk6) 60352(Mapk12) 689314(Mapk11) 81649(Mapk14)
CGE: 
100689104(Mapk14) 100754042(Mapk12) 100754361(Mapk10) 100758520(Mapk7) 100758872(Mapk15) 100759172(Mapk11) 100759514(Mapk1) 100763519(Mapk13) 100764603(Mapk6) 100764964(Mapk9) 100768473(Nlk) 100771734(Mapk8) 100771894(Mapk4)
NGI: 
103724495(Nlk) 103728439(Mapk7) 103731405(Mapk6) 103735023(Mapk8) 103735280(Mapk15) 103735473(Mapk12) 103735474(Mapk11) 103739659(Mapk13) 103739660(Mapk14) 103748163(Mapk4) 103748972(Mapk10) 103749366(Mapk9)
HGL: 
101698286(Mapk9) 101700449(Mapk6) 101700581(Mapk4) 101701893(Nlk) 101705370(Mapk11) 101706002(Mapk12) 101712538(Mapk15) 101712980(Mapk10) 101715259(Mapk8) 101715692(Mapk13) 101726391(Mapk7) 106007524(Mapk14)
OCU: 
100337999(MAPK10) 100338535(MAPK7) 100338634(MAPK15) 100341695(MAPK14) 100342664(MAPK9) 100343055(MAPK4) 100344161(MAPK13) 100346929(MAPK8) 100347345(MAPK1) 100348930(NLK) 100350614(MAPK12) 100356648(MAPK6) 103346035(MAPK11)
TUP: 
102468920(NLK) 102472233(MAPK8) 102475335(MAPK7) 102475730(MAPK10) 102475742(MAPK4) 102481241(MAPK13) 102487603(MAPK11) 102494380(MAPK15) 102495693(MAPK14) 102496009(MAPK6) 102497095(MAPK9) 102501733(MAPK12)
CFA: 
100855877(MAPK3) 403856(MAPK14) 474652(MAPK9) 477575(MAPK1) 477746(MAPK8) 478311(MAPK6) 478464(MAPK10) 482080(MAPK15) 489532(MAPK7) 491160(NLK) 491690(MAPK4) 607019(MAPK11) 607023(MAPK12) 612821(MAPK13)
AML: 
100465223(MAPK13) 100465476(MAPK14) 100465770(MAPK6) 100467560(MAPK4) 100469296(NLK) 100470035(MAPK1) 100470193(MAPK7) 100472388(MAPK3) 100477600(MAPK9) 100477951(MAPK10) 100480235(MAPK12) 100480483(MAPK11) 100482196(MAPK8) 100482855(MAPK15)
UMR: 
103656711(MAPK15) 103658546(MAPK7) 103664250(MAPK4) 103665451(MAPK14) 103665538(MAPK13) 103667237(NLK) 103667893(MAPK8) 103674004(MAPK11) 103674115(MAPK12) 103676754(MAPK6) 103676947(MAPK10) 103679990(MAPK9)
FCA: 
101080751(NLK) 101081396(MAPK11) 101084765(MAPK9) 101087614(MAPK1) 101087958(MAPK3) 101091310(MAPK8) 101091508(MAPK15) 101091536(MAPK13) 101092057(MAPK4) 101093275(MAPK6) 101097357(MAPK7) 101101135(MAPK14) 101101463(MAPK10) 105260786(MAPK12)
PTG: 
102950636(NLK) 102950880(MAPK8) 102957425(MAPK15) 102959159(MAPK10) 102960306(MAPK12) 102960590(MAPK11) 102963096(MAPK9) 102964803(MAPK7) 102965196(MAPK6) 102966349(MAPK4) 102968191(MAPK13) 102968482(MAPK14)
BTA: 
327672(MAPK1) 507204(NLK) 512125(MAPK15) 512943(MAPK12) 529183(MAPK4) 531391(MAPK3) 534125(MAPK9) 534492(MAPK14) 535327(MAPK13) 537631(MAPK10) 537703(MAPK7) 538094(MAPK6) 539941(MAPK8) 618906(MAPK11)
BOM: 
102266282(MAPK4) 102266960(MAPK9) 102271030(MAPK13) 102271320(MAPK14) 102272421(MAPK10) 102274050(NLK) 102274306(MAPK6) 102277976(MAPK8) 102278560(MAPK7) 102285026(MAPK15) 102285848(MAPK12) 106701244(MAPK11)
PHD: 
102321680(MAPK13) 102322031(MAPK14) 102323252(MAPK9) 102324617(NLK) 102326136 102329495(MAPK4) 102331873(MAPK12) 102334117(MAPK8) 102335953(MAPK7) 102338495(MAPK6) 102344390(MAPK10)
CHX: 
100860996(MAPK13) 100861087(MAPK8) 102169187(MAPK6) 102170408(MAPK9) 102180534(MAPK7) 102180926(MAPK12) 102182774(MAPK10) 102183251(MAPK15) 102184020(MAPK4) 102184510(MAPK11) 102189174(MAPK14) 102190163(NLK)
OAS: 
100194428(MAPK13) 100217411(MAPK14) 101103076(NLK) 101103324(MAPK6) 101110073(MAPK7) 101112234(MAPK15) 101112939(MAPK4) 101115956(MAPK12) 101116201(MAPK8) 101116223(MAPK11) 101120665(MAPK10) 101120826(MAPK9)
SSC: 
100153927(MAPK1) 100156630(MAPK14) 100511657(NLK) 100521736(MAPK10) 100523414(MAPK4) 100620270(NLK) 102164433(MAPK7) 396609(MAPK9) 396610(MAPK8) 396833(MAPK6) 445013(MAPK3) 574062(MAPK12)
CFR: 
102503577(MAPK8) 102509244 102509448(MAPK10) 102511078(MAPK14) 102511298(MAPK13) 102515487(MAPK6) 102516847(MAPK12) 102517586(MAPK1) 102518561(MAPK9) 102518663(MAPK4) 102519162(NLK) 102519781(MAPK11) 102522626(MAPK15) 102524416 106729653
BACU: 
102997603(MAPK8) 102999619(MAPK1) 102999798 102999884(MAPK7) 102999887(MAPK6) 103002378(MAPK13) 103002389(NLK) 103005755(MAPK15) 103007019(MAPK9) 103008537(MAPK14) 103008728(MAPK10) 103009561(MAPK11) 103009947(MAPK12) 103019117(MAPK4)
LVE: 
103070260(MAPK1) 103075265(NLK) 103077215(MAPK15) 103077530(MAPK12) 103078049(MAPK14) 103078710(MAPK13) 103078792(MAPK10) 103080813(MAPK7) 103083209(MAPK11) 103083820(MAPK6) 103084630(MAPK8) 103085294(MAPK4) 103087676(MAPK9)
ECB: 
100051798(MAPK8) 100052608(MAPK10) 100053916(MAPK4) 100055006(MAPK6) 100056239(MAPK12) 100056278(MAPK11) 100057701(MAPK1) 100057961(MAPK9) 100058876(NLK) 100063532(MAPK14) 100066173(MAPK3) 100073174(MAPK7) 100146864(MAPK15)
MYB: 
102245831(MAPK7) 102246292(MAPK8) 102246580(NLK) 102248097(MAPK14) 102249806(MAPK6) 102254628(MAPK12) 102254920(MAPK11) 102255250(MAPK3) 102259698(MAPK4) 102259984(MAPK9) 102263026(MAPK10) 106723559(MAPK13)
MYD: 
102751471(MAPK6) 102755728(MAPK14) 102756012(MAPK13) 102760175(NLK) 102761596(MAPK4) 102764416(MAPK8) 102769984(MAPK7) 102770021(MAPK12) 102770309(MAPK11) 102772062(MAPK9) 102772884(MAPK10) 102774243(MAPK15) 102775351(MAPK10)
PALE: 
102877720(MAPK13) 102881922(MAPK6) 102883986(MAPK15) 102885064(MAPK10) 102888602(MAPK11) 102888845(MAPK12) 102890689(MAPK9) 102890853(NLK) 102892777(MAPK8) 102895102(MAPK4) 102895900(MAPK14) 102897014(MAPK7)
MDO: 
100010279(MAPK12) 100010891(MAPK11) 100012916(MAPK3) 100015101(MAPK4) 100016316(MAPK7) 100016623(MAPK15) 100019356(NLK) 100026324(MAPK14) 100026361(MAPK6) 100028089(MAPK9) 100028096(MAPK1) 100028821(MAPK13) 100618895(MAPK10)
SHR: 
100913231(MAPK1) 100917749(MAPK7) 100919388(MAPK15) 100919999(MAPK4) 100924267(MAPK9) 100925013(MAPK14) 100925447(MAPK13) 100928480(MAPK10) 100928564(NLK) 100928729(MAPK12) 100928990(MAPK11) 100930815(MAPK8) 100931440(MAPK6) 100934330(MAPK3)
OAA: 
GGA: 
100858386 373953(MAPK1) 395983(MAPK9) 415419(MAPK6) 417669(NLK) 417739(MAPK11) 421183(MAPK14) 422592(MAPK10) 423778(MAPK8) 426292(MAPK15) 769763(MAPK12) 771145(MAPK13)
MGP: 
100540259(MAPK12) 100540416(MAPK11) 100541011(MAPK9) 100542628(MAPK10) 100543845(MAPK1) 100546825(NLK) 100546830(MAPK14) 100546983(MAPK13) 100547553(MAPK15) 100547737(MAPK8) 100548558(MAPK6) 104916721
CJO: 
107306769 107307520(MAPK7) 107308531 107308592(MAPK11) 107310653(MAPK15) 107313439(MAPK10) 107315851(MAPK8) 107318686(MAPK6) 107320159(MAPK9) 107322736(NLK) 107324607(MAPK13) 107324616(MAPK14)
APLA: 
101789910(MAPK4) 101791119(MAPK15) 101792057(MAPK11) 101793591(MAPK12) 101793594(MAPK8) 101797936(MAPK6) 101799011(MAPK9) 101799776(MAPK10) 101802116(MAPK13) 101804891(NLK) 101805023(MAPK14)
TGU: 
100217568(NLK) 100218416 100218485 100218726(MAPK6) 100220802(MAPK1) 100220867(MAPK8) 100223519(MAPK10) 100225101(MAPK11) 100225285(MAPK9) 100227852(MAPK14) 100227993(MAPK12) 100229840(MAPK4) 105759043(MAPK15)
GFR: 
102033058(NLK) 102035183(MAPK4) 102036009(MAPK8) 102038706(MAPK15) 102038787(MAPK11) 102040487(MAPK6) 102042160(MAPK13) 102043222(MAPK9) 102043521(MAPK12) 102043776(MAPK10) 102044158(MAPK14)
FAB: 
101806540 101806829(MAPK6) 101807358(MAPK12) 101809052(MAPK10) 101811957(MAPK15) 101812547 101814783(MAPK11) 101817298(NLK) 101817339(MAPK8) 101817434(MAPK13) 101817836(MAPK4) 101819306(MAPK9) 101819980(MAPK14)
PHI: 
102099139(MAPK6) 102099159(MAPK10) 102104312(MAPK15) 102106744(MAPK9) 102108455(NLK) 102109820(MAPK11) 102110009(MAPK12) 102110807(MAPK13) 102111004(MAPK14) 102111242(MAPK7) 102114247(MAPK4) 102114724(MAPK8)
CCW: 
104684015(MAPK6) 104684206(MAPK15) 104686785(MAPK4) 104686831(MAPK11) 104686906(MAPK12) 104689594(MAPK9) 104691151(NLK) 104692399(MAPK14) 104692401(MAPK13) 104696634(MAPK8) 104697227(MAPK10)
FPG: 
101912679 101915038(MAPK15) 101915315(NLK) 101917138(MAPK10) 101918008(MAPK4) 101919216(MAPK6) 101920170(MAPK12) 101920353(MAPK11) 101921076(MAPK9) 101921635(MAPK14) 101922433(MAPK13) 101924129(MAPK8)
FCH: 
102047380(MAPK8) 102051874(MAPK12) 102052038(MAPK11) 102053335(MAPK6) 102053931(NLK) 102054176(MAPK10) 102054359(MAPK13) 102055655(MAPK15) 102055660(MAPK9) 102057908(MAPK4) 102059377(MAPK14)
CLV: 
102084319(MAPK15) 102085027(MAPK9) 102085840(MAPK10) 102086843(NLK) 102087983(MAPK8) 102089248 102089738(MAPK14) 102089782 102089969(MAPK6) 102090037(MAPK13) 102090861(MAPK12) 102094655(MAPK4) 102097012
AAM: 
106482075(MAPK15) 106482177 106487858(MAPK13) 106487877(MAPK14) 106493457(MAPK9) 106493544 106494874 106495922(MAPK12) 106495935(MAPK11) 106496528(MAPK6) 106496655(MAPK10) 106497812(MAPK8) 106498756(NLK)
ASN: 
102374196(MAPK12) 102374345(MAPK4) 102374542(MAPK10) 102375835(MAPK11) 102375954(MAPK13) 102376040(MAPK9) 102376154(MAPK8) 102376541(MAPK14) 102376659(NLK) 102378924 102381114(MAPK6) 102385946(MAPK15) 102386241(MAPK7)
AMJ: 
102559907(MAPK15) 102563128(MAPK6) 102565670(MAPK14) 102566087(MAPK10) 102570366(MAPK8) 102570628(MAPK9) 102571177(MAPK11) 102571419(MAPK12) 102575019(NLK) 102575816(MAPK4) 102577139(MAPK7) 106736779(MAPK13)
PSS: 
102445212(NLK) 102445557(MAPK6) 102448785(MAPK14) 102450501 102452788(MAPK4) 102453224(MAPK9) 102455939(MAPK13) 102459702(MAPK8) 102460734(MAPK10) 102460982(MAPK15) 102462429(MAPK11) 102462672(MAPK12) 102463278(MAPK7)
CMY: 
102932835(MAPK10) 102934812(MAPK9) 102934859(MAPK14) 102935187(MAPK8) 102935899(MAPK15) 102938087(MAPK11) 102938366 102939637(MAPK6) 102940215(MAPK12) 102941338(MAPK13) 102944975(MAPK4) 102946225(NLK)
ACS: 
100553469(mapk4) 100553854(mapk7) 100555877(mapk1) 100558211(mapk10) 100560802(nlk) 100561204(mapk6) 100561907(mapk8) 100562588(mapk15) 100563538(mapk12) 100563731(mapk11) 100565814(mapk9) 100566699(mapk3) 100567479(mapk13) 100567618 100567676(mapk14)
PBI: 
GJA: 
XLA: 
100329215(p38-beta) 379876(mapk8) 379992(mapk14) 397785(mapk1-b) 398295(nlk.2) 398592(mapk12) 398985(mapk1-a) 414522(nlk) 446599(mapk7) 494669(mapk11) 734485(mapk15) 735153
XTR: 
100101766(mapk11) 100144638(nlk) 100144684(nlk.2) 100144715(mapk13) 100145045(mapk12) 100145558(mapk15) 100170194(mapk8) 100494114(mapk6) 100498202(mapk4) 448296(mapk14) 549834(mapk12) 549881(mapk1) 779515(mapk10) 779785(mapk7)
DRE: 
100002318(mapk13) 100149273(mapk9) 266756(mapk14b) 30681(mapk12a) 360144(mapk1) 399480(mapk3) 405892(nlk1) 406782(mapk4) 415185(mapk11) 541323(mapk7) 553780(mapk15) 557810(mapk12b) 562552(fc89f08) 562720(mapk8a) 563460(nlk2) 565830(mapk6) 569698(mapk10) 65236(mapk8b) 65237(mapk14a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102345149(MAPK6) 102346493(MAPK4) 102347709 102349570(MAPK15) 102351693(MAPK9) 102351958(MAPK10) 102352356(NLK) 102353948 102354316(MAPK11) 102354774(MAPK12) 102357573(MAPK8) 102358042(MAPK14) 102358481 102358623(MAPK7) 102359592
CMK: 
103176608 103177012(mapk11) 103177013(mapk12) 103179134(mapk14) 103179136 103179665(mapk15) 103180867(mapk10) 103183358(nlk) 103183732(mapk9) 103185857(mapk8) 103186853(mapk6) 103187338(mapk4)
BFO: 
CIN: 
100184138 778596(erk1/2) 778597(erk5) 778660(jnk) 778685(nemo-like) 778927(p38) 778965(erk3/4)
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD14046(Dsim_GD14046) Dsimw501_GD16072(Dsim_GD16072) Dsimw501_GD18318(Dsim_GD18318) Dsimw501_GD18319(Dsim_GD18319) Dsimw501_GD22289(Dsim_GD22289) Dsimw501_GD23919(Dsim_GD23919)
DWI: 
DYA: 
Dyak_GE10824(dyak_GLEANR_10716) Dyak_GE10825(dyak_GLEANR_10717) Dyak_GE11327(dyak_GLEANR_11578) Dyak_GE15459(dyak_GLEANR_16972) Dyak_GE18678(dyak_GLEANR_2463) Dyak_GE21651(dyak_GLEANR_5396) Dyak_GE26274(dyak_GLEANR_983)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
408917(erk7) 409286(bsk) 409523(rl) 410956(nmo) 411915(p38b)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
CEL: 
CELE_B0218.3(pmk-1) CELE_B0478.1(jnk-1) CELE_C04G6.1(mpk-2) CELE_C05D10.2(C05D10.2) CELE_F42G8.3(pmk-2) CELE_F42G8.4(pmk-3) CELE_F43C1.2(mpk-1) CELE_W06F12.1(lit-1)
CBR: 
CBG01553(Cbr-pmk-3) CBG01554(Cbr-pmk-2) CBG01555(Cbr-pmk-1) CBG02327(Cbr-mpk-2) CBG05733(Cbr-jnk-1) CBG18286(Cbr-lit-1) CBG21144 CBG21247(Cbr-mpk-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G01560(MPK11) AT1G07880(ATMPK13) AT1G10210(MPK1) AT1G18150(ATMPK8) AT1G59580(MPK2) AT2G18170(MPK7) AT2G43790(MPK6) AT2G46070(MPK12) AT3G45640(MPK3) AT3G59790(MPK10) AT4G01370(MPK4) AT4G11330(MPK5) AT4G36450(MPK14)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0001s27860g(POPTRDRAFT_797776) POPTR_0002s03340g(POPTRDRAFT_643073) POPTR_0002s16400g(POPTRDRAFT_816604) POPTR_0005s12140g POPTR_0005s25270g(POPTRDRAFT_801509) POPTR_0007s13370g(POPTRDRAFT_655357) POPTR_0009s07050g(POPTRDRAFT_833180) POPTR_0010s12240g(POPTRDRAFT_726880) POPTR_0012s04590g(POPTRDRAFT_806337)
VVI: 
SLY: 
100736510(MAPK8) 100736512(MPK9) 100736539(MAPK16) 543792(mpka1;1) 543879(MPK2) 543880(MPK3)
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4328297(MAP3) 4332475(BIMK1) 4340170(MAPK6) 4341956(MAP2) 4344698(MPK2) 4349225(MPK6)
DOSA: 
Os02t0135200-00(Os02g0135200) Os02t0148100-01(Os02g0148100) Os03t0285800-01(Os03g0285800) Os06t0154500-01(Os06g0154500) Os06t0699400-01(Os06g0699400) Os08t0157000-00(Os08g0157000)
OBR: 
BDI: 
100834779(MPK6) 100837420(MPK3) 100839224(MPK11) 100839537(MPK14) 100841616(MPK7-1)
SBI: 
SORBI_01g030680(SORBIDRAFT_01g030680) SORBI_04g003480(SORBIDRAFT_04g003480) SORBI_07g003810(SORBIDRAFT_07g003810) SORBI_10g003810(SORBIDRAFT_10g003810) SORBI_10g028780(SORBIDRAFT_10g028780) SORBI_10g029400(SORBIDRAFT_10g029400)
ZMA: 
100272353(gpm443) 100283121(pco133201) 100285952(cl9707_1a) 100286386(MPK7) 100381337(GRMZM2G062914) 103639280(gpm355) 542144(simk1)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
CCP: 
SCE: 
YBL016W(FUS3) YGR040W(KSS1) YHR030C(SLT2) YLR113W(HOG1) YPR054W(SMK1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A06680(NCAS0A06680) NCAS_0A11020(NCAS0A11020) NCAS_0C03380(NCAS0C03380) NCAS_0F02410(NCAS0F02410)
NDI: 
NDAI_0A05280(NDAI0A05280) NDAI_0C03900(NDAI0C03900) NDAI_0D01620(NDAI0D01620) NDAI_0G02700(NDAI0G02700)
TPF: 
TPHA_0A01630(TPHA0A01630) TPHA_0B02440(TPHA0B02440) TPHA_0E02270(TPHA0E02270) TPHA_0M01500(TPHA0M01500)
TBL: 
TBLA_0A06670(TBLA0A06670) TBLA_0A10420(TBLA0A10420) TBLA_0C03140(TBLA0C03140) TBLA_0H01330(TBLA0H01330)
TDL: 
TDEL_0C04800(TDEL0C04800) TDEL_0E03520(TDEL0E03520) TDEL_0F04290(TDEL0F04290)
KAF: 
KAFR_0B02980(KAFR0B02980) KAFR_0E01580(KAFR0E01580) KAFR_0E01810(KAFR0E01810) KAFR_0H01040(KAFR0H01040)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.10404(ERK1) CaO19.2886(ERK1) CaO19.460(CEK2) CaO19.7208(CSK1) CaO19.7523(MKC1) CaO19.8091(CEK2) CaO19.8514(HOG1) CaO19.895(HOG1)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NCU02393(mak-2) NCU07024(os-2)
NTE: 
NEUTE1DRAFT121521(NEUTE1DRAFT_121521) NEUTE1DRAFT97364(NEUTE1DRAFT_97364)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1044194 AOR_1_332184(AO090009000199) AOR_1_692154(AO090003000402)
ANG: 
ANI_1_1286014(An01g09520) ANI_1_1432074(An08g10670) ANI_1_492064(An07g03980) ANI_1_826074(An08g05850)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT112477(AGABI1DRAFT_112477) AGABI1DRAFT22411(AGABI1DRAFT_22411)
ABV: 
AGABI2DRAFT192446(AGABI2DRAFT_192446) AGABI2DRAFT223047(AGABI2DRAFT_223047) AGABI2DRAFT41003(AGABI2DRAFT_41003)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
DFA_01227(erkA) DFA_08980(erkB)
EHI: 
EHI_073650(67.t00005) EHI_194420(46.t00053)
EDI: 
EIV: 
ACAN: 
PFA: 
PF11_0147(map-2) PF14_0294(PfMAP1)
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
TOT: 
BEQ: 
BBO: 
BBOV_IV005520(23.m06268) BBOV_IV010480(23.m06413)
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
AAF: 
NGD: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:2842341]
  Authors
Ray LB, Sturgill TW.
  Title
Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.
  Journal
J. Biol. Chem. 263 (1988) 12721-7.
Reference
2  [PMID:1657919]
  Authors
Rossomando AJ, Sanghera JS, Marsden LA, Weber MJ, Pelech SL, Sturgill TW.
  Title
Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations.
  Journal
J. Biol. Chem. 266 (1991) 20270-5.
Reference
3  [PMID:1321146]
  Authors
Seger R, Ahn NG, Posada J, Munar ES, Jensen AM, Cooper JA, Cobb MH, Krebs EG.
  Title
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
  Journal
J. Biol. Chem. 267 (1992) 14373-81.
Reference
4  [PMID:9235954]
  Authors
Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS.
  Title
p38-2, a novel mitogen-activated protein kinase with distinct properties.
  Journal
J. Biol. Chem. 272 (1997) 19509-17.
  Sequence
[hsa:5600]
Reference
5  [PMID:10715136]
  Authors
Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P.
  Title
Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.
  Journal
Biochemistry. 39 (2000) 3141-8.
  Sequence
[hsa:5602]
Reference
6  [PMID:15187187]
  Authors
Roux PP, Blenis J.
  Title
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.
  Journal
Microbiol. Mol. Biol. Rev. 68 (2004) 320-44.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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