KEGG   ORTHOLOGY: K00026Help
Entry
K00026                      KO                                     
Name
MDH2
Definition
malate dehydrogenase [EC:1.1.1.37]
Pathway
Citrate cycle (TCA cycle)
Pyruvate metabolism
Glyoxylate and dicarboxylate metabolism
Carbon fixation in photosynthetic organisms
Module
M00009  
Citrate cycle (TCA cycle, Krebs cycle)
M00011  
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00012  
Glyoxylate cycle
M00168  
CAM (Crassulacean acid metabolism), dark
M00171  
C4-dicarboxylic acid cycle, NAD+ -malic enzyme type
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00026  MDH2; malate dehydrogenase
   00620 Pyruvate metabolism
    K00026  MDH2; malate dehydrogenase
   00630 Glyoxylate and dicarboxylate metabolism
    K00026  MDH2; malate dehydrogenase
  Energy metabolism
   00710 Carbon fixation in photosynthetic organisms
    K00026  MDH2; malate dehydrogenase
KEGG pathway modules [BR:ko00002]
 Pathway module
  Energy metabolism
   Carbon fixation
    M00168  CAM (Crassulacean acid metabolism), dark
     K00026  MDH2; malate dehydrogenase
    M00171  C4-dicarboxylic acid cycle, NAD+ -malic enzyme type
     K00026  MDH2; malate dehydrogenase
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00009  Citrate cycle (TCA cycle, Krebs cycle)
     K00026  MDH2; malate dehydrogenase
    M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
     K00026  MDH2; malate dehydrogenase
   Other carbohydrate metabolism
    M00012  Glyoxylate cycle
     K00026  MDH2; malate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.37  malate dehydrogenase
     K00026  MDH2; malate dehydrogenase
BRITE hierarchy
Other DBs
RN: 
GO: 
Genes
HSA: 
4191(MDH2)
PTR: 
463484(MDH2)
PPS: 
100991112(MDH2)
GGO: 
101137732(MDH2)
PON: 
100174759(MDH2)
MCC: 
MMU: 
17448(Mdh2)
RNO: 
81829(Mdh2)
CFA: 
482945(MDH2)
AML: 
FCA: 
101084845(MDH2)
BTA: 
281306(MDH2)
SSC: 
397039(MDH2)
ECB: 
100061046(MDH2)
MDO: 
100018146(MDH2)
SHR: 
100927693(MDH2)
OAA: 
100082520
GGA: 
417517(MDH2)
MGP: 
100544516
TGU: 
100190484
ACS: 
100563761
XLA: 
443751(mdh2-b) 446263(mdh2-a)
XTR: 
496892(mdh2)
DRE: 
406405(mdh2)
TRU: 
101064979
OLA: 
101166000
BFO: 
BRAFLDRAFT_114460
CIN: 
100178529
SPU: 
587163
DME: 
Dmel_CG10748 Dmel_CG10749 Dmel_CG7998(Mdh2)
DPO: 
Dpse_GA10540 Dpse_GA10541 Dpse_GA20754
DAN: 
Dana_GF10673 Dana_GF23071 Dana_GF23749
DER: 
Dere_GG13791 Dere_GG15612 Dere_GG22759
DPE: 
Dper_GL12005 Dper_GL24873 Dper_GL25264
DSE: 
Dsec_GM15290 Dsec_GM24618 Dsec_GM25384
DSI: 
Dsim_GD12684 Dsim_GD14416 Dsim_GD19217
DWI: 
Dwil_GK22135 Dwil_GK22161 Dwil_GK22386
DYA: 
Dyak_GE20084 Dyak_GE21938 Dyak_GE25523
DGR: 
Dgri_GH18558 Dgri_GH21421 Dgri_GH21422
DMO: 
Dmoj_GI18598 Dmoj_GI24757
DVI: 
Dvir_GJ20394 Dvir_GJ22544
AGA: 
AgaP_AGAP001903
AAG: 
AaeL_AAEL008166
CQU: 
CpipJ_CPIJ008366
AME: 
408950 726838
NVI: 
100114033(NV17544) 100118243(NV15023)
TCA: 
662339
API: 
100145825
PHU: 
Phum_PHUM590780
ISC: 
IscW_ISCW003528
CEL: 
CELE_F20H11.3(mdh-2)
CBR: 
CBG15213(Cbr-mdh-1)
BMY: 
Bm1_46465
SMM: 
Smp_047370
NVE: 
NEMVE_v1g248519
HMG: 
100210170
AQU: 
100641593
ATH: 
AT1G53240(mMDH1) AT2G22780(PMDH1) AT3G15020(mMDH2) AT3G47520(MDH) AT5G09660(PMDH2)
ALY: 
ARALYDRAFT_474449 ARALYDRAFT_478929 ARALYDRAFT_481139(PMDH1) ARALYDRAFT_487785(PMDH2) ARALYDRAFT_905979
GMX: 
100170735 100777296 100783173 100799793 100814078 732641
MTR: 
MTR_4g092690 MTR_5g014710
CSV: 
101207078 101219252 101225691 101227781 101228632 101232093
RCU: 
RCOM_0339260 RCOM_1014110 RCOM_1381350 RCOM_1471880 RCOM_1520380
POP: 
POPTR_583880 POPTR_649749 POPTR_707785 POPTR_758803 POPTR_785828 POPTR_798097 POPTR_820117 POPTR_822907 POPTR_837445
VVI: 
100232859(MDH) 100232924(MDHG) 100247511 100253724 100260994 100265585
OSA: 
4326249 4327423 4334274 4339682 4343993 4345657 4352871
DOSA: 
Os01t0649100-01(Os01g0649100) Os01t0829800-01(Os01g0829800) Os03t0773800-01(Os03g0773800) Os05t0574400-01(Os05g0574400) Os07t0630800-01(Os07g0630800) Os08t0434300-01(Os08g0434300) Os12t0632700-01(Os12g0632700)
BDI: 
100831548 100832550 100832576 100838923 100841882
SBI: 
SORBI_02g040190(SORBIDRAFT_02g040190) SORBI_03g029570(SORBIDRAFT_03g029570) SORBI_08g022770(SORBIDRAFT_08g022770) SORBI_09g029240(SORBIDRAFT_09g029240)
ZMA: 
100193491(pco104294) 100193663 100193743(pco143139c) 100272900 100273428 100274264 100282134
SMO: 
SELMODRAFT_131967 SELMODRAFT_133026 SELMODRAFT_450868(MDH1-1) SELMODRAFT_90290
PPP: 
PHYPADRAFT_118897 PHYPADRAFT_129976 PHYPADRAFT_131843 PHYPADRAFT_135701 PHYPADRAFT_143364 PHYPADRAFT_162162 PHYPADRAFT_207351
CRE: 
CHLREDRAFT_126023(MDH2) CHLREDRAFT_137163(MDH1) CHLREDRAFT_60444(MDH4)
VCN: 
VOLCADRAFT_75816(mdh3) VOLCADRAFT_77493(mdh1) VOLCADRAFT_82979(mdh2)
OLU: 
OSTLU_12282 OSTLU_24671 OSTLU_32875
OTA: 
Ot03g00170
SCE: 
YDL078C(MDH3) YKL085W(MDH1) YOL126C(MDH2)
AGO: 
AGOS_ADL164C AGOS_ADR152C AGOS_ADR252W
ERC: 
Ecym_2046 Ecym_3407
KLA: 
KLLA0E07525g KLLA0F17050g KLLA0F25960g
LTH: 
KLTH0C01188g KLTH0E09614g KLTH0F18854g
PPA: 
PAS_chr2-1_0238 PAS_chr4_0815
VPO: 
Kpol_1020p28 Kpol_1041p28 Kpol_1073p7
ZRO: 
ZYRO0A08470g ZYRO0C02684g ZYRO0E00880g
CGR: 
CAGL0E01705g CAGL0L05236g CAGL0L06798g
NCS: 
NCAS_0A04020(NCAS0A04020) NCAS_0C04560(NCAS0C04560) NCAS_0H03320(NCAS0H03320)
NDI: 
NDAI_0C00340(NDAI0C00340) NDAI_0E01670(NDAI0E01670) NDAI_0G03940(NDAI0G03940)
TPF: 
TPHA_0A00460(TPHA0A00460) TPHA_0G02100(TPHA0G02100) TPHA_0L01990(TPHA0L01990)
TBL: 
TBLA_0A07800(TBLA0A07800) TBLA_0B09220(TBLA0B09220) TBLA_0C00860(TBLA0C00860)
TDL: 
TDEL_0B07350(TDEL0B07350) TDEL_0E00560(TDEL0E00560) TDEL_0G03230(TDEL0G03230)
KAF: 
KAFR_0C01710(KAFR0C01710) KAFR_0C03960(KAFR0C03960) KAFR_0F02690(KAFR0F02690)
DHA: 
DEHA2B02596g DEHA2B03058g DEHA2F09020g
PIC: 
PICST_40132(MDHM) PICST_66451(MDH1) PICST_78343(MDH2)
PGU: 
PGUG_01503 PGUG_02540 PGUG_02579
LEL: 
LELG_00466 LELG_02620 LELG_04196
CAL: 
CaO19.12072(MDH1) CaO19.12783(MDH3) CaO19.4602(MDH1) CaO19.5323(MDH3) CaO19.7481(MDH2)
CTP: 
CTRG_00226 CTRG_01021 CTRG_02024
CDU: 
CD36_24490 CD36_25650 CD36_41790
COT: 
CORT_0C03740 CORT_0E00500
YLI: 
YALI0D16753g YALI0E14190g
CLU: 
CLUG_04330 CLUG_04354 CLUG_05128
NCR: 
NCU04899 NCU06211
SMP: 
SMAC_07106 SMAC_08400
PAN: 
PODANSg5466 PODANSg6062
TTT: 
THITE_2120059 THITE_66001
MTM: 
MYCTH_2305575 MYCTH_2315052
MGR: 
MGG_08835 MGG_09367
FGR: 
FG02461.1 FG02504.1
NHE: 
NECHADRAFT_62182 NECHADRAFT_70151
VAL: 
VDBG_08589 VDBG_08654
SSL: 
SS1G_08975 SS1G_13825
BFU: 
BC1G_07409 BC1G_10724
ANI: 
AN6499.2 AN6717.2
NFI: 
NFIA_026980 NFIA_051790
AFM: 
AFUA_6G05210 AFUA_7G05740
AOR: 
AOR_1_26114(AO090701000013) AOR_1_766174(AO090005000438)
ANG: 
ANI_1_12134(An15g00070) ANI_1_268064(An07g02160)
AFV: 
AFLA_054750 AFLA_076710
ACT: 
ACLA_007430 ACLA_095320
PCS: 
Pc12g04750 Pc20g01610
CIM: 
CIMG_02580 CIMG_05466
CPW: 
CPC735_037510 CPC735_066110
PBL: 
PAAG_00053 PAAG_08449
URE: 
UREG_03159 UREG_06260
ABE: 
ARB_00653 ARB_04281
TVE: 
TRV_00150 TRV_04780
AJE: 
HCAG_03969 HCAG_06901
PNO: 
SNOG_05974 SNOG_09027
PTE: 
PTT_04395 PTT_16268
ZTR: 
MYCGRDRAFT_105501(MDH2) MYCGRDRAFT_105971(mdh1)
TML: 
GSTUM_00001731001 GSTUM_00005180001
SPO: 
SPCC306.08c
CNE: 
CNG03100 CNG03490
CNB: 
CNBG1280 CNBG1650
CGI: 
CGB_G1590C CGB_G2280C
LBC: 
LACBIDRAFT_185536 LACBIDRAFT_326114
MPR: 
MPER_04599 MPER_07111
CCI: 
CC1G_06656 CC1G_09115
SCM: 
SCHCODRAFT_71301 SCHCODRAFT_85988
UMA: 
UM00403.1 UM04919.1
MGL: 
MGL_2703 MGL_3809
PGR: 
PGTG_04865 PGTG_17218
MBR: 
MONBRDRAFT_38523
EHI: 
EHI_067860(8.t00059)
TET: 
TTHERM_01029960
PTM: 
GSPATT00014396001
TBR: 
Tb10.61.0980 Tb10.70.5110 Tb10.70.5120
TCR: 
506195.110 506503.69 507883.100 507883.109 511293.69
LMA: 
LMJF_19_0710(gMDH) LMJF_34_0130 LMJF_34_0140 LMJF_34_0150 LMJF_34_0160(mMDH)
LIF: 
LINJ_19_0710 LINJ_34_0140 LINJ_34_0150 LINJ_34_0160 LINJ_34_0170(mMDH)
LDO: 
LDBPK_190710 LDBPK_340140 LDBPK_340150 LDBPK_340160 LDBPK_340170
LMI: 
LMXM_19_0710 LMXM_33_0130 LMXM_33_0140 LMXM_33_0150 LMXM_33_0160
LBZ: 
LBRM_19_1020 LBRM_20_0010(mMDH) LBRM_20_0020 LBRM_20_0030 LBRM_20_0040
PTI: 
PHATRDRAFT_51297(MDH)
TPS: 
THAPSDRAFT_20726(MDH1)
PIF: 
PITG_13614
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9639601 (M.thermoautotrophicum)
  Authors
Thompson H, Tersteegen A, Thauer RK, Hedderich R
  Title
Two malate dehydrogenases in Methanobacterium thermoautotrophicum.
  Journal
Arch Microbiol 170:38-42 (1998)
Reference
  Authors
Minarik P, Tomaskova N, Kollarova M, Antalik M
  Title
Malate dehydrogenases--structure and function.
  Journal
Gen Physiol Biophys 21:257-65 (2002)
Reference
PMID:7849603
  Authors
Goward CR, Nicholls DJ
  Title
Malate dehydrogenase: a model for structure, evolution, and catalysis.
  Journal
Protein Sci 3:1883-8 (1994)
Reference
  Authors
Madern D
  Title
Molecular evolution within the L-malate and L-lactate dehydrogenase super-family.
  Journal
J Mol Evol 54:825-40 (2002)
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