KEGG ORTHOLOGY: K00552

ORTHOLOGY: K00552

Entry

K00552                      KO

Symbol

GNMT

Name

glycine N-methyltransferase [EC:2.1.1.20]

Pathway

map00260

Glycine, serine and threonine metabolism

map00270

Cysteine and methionine metabolism

map01100

Metabolic pathways

Module

M00035

Methionine degradation

Reaction

R00367

S-adenosyl-L-methionine:glycine N-methyltransferase

Disease

H00184

Hypermethioninemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K00552  GNMT; glycine N-methyltransferase
   00270 Cysteine and methionine metabolism
    K00552  GNMT; glycine N-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.20  glycine N-methyltransferase
     K00552  GNMT; glycine N-methyltransferase

Other DBs

GO:

0017174

Genes

HSA:	27232(GNMT)

PTR:	462703(GNMT)

PPS:	100993237(GNMT)

GGO:	101143848(GNMT)

PON:	100432507(GNMT)

NLE:	100603199(GNMT)

HMH:	116460460(GNMT)

MCC:	697722(GNMT)

MCF:	102133929(GNMT)

MTHB:

126952406

MNI:	105489583(GNMT)

CSAB:

103221484(GNMT)

CATY:

105591544(GNMT)

PANU:

101008718(GNMT)

TGE:	112622332(GNMT)

MLEU:

105544315(GNMT)

RRO:	104667328(GNMT)

RBB:	108533480(GNMT)

TFN:	117087242(GNMT)

PTEH:

111543055(GNMT)

CANG:

105524930(GNMT)

CJC:	100413047(GNMT)

SBQ:	101053276(GNMT)

CIMI:

108317109(GNMT)

CSYR:

103268550(GNMT)

MMUR:

105875835(GNMT)

LCAT:

123631892(GNMT)

PCOQ:

105807466(GNMT)

OGA:	100950716(GNMT)

MMU:	14711(Gnmt)

MCAL:

110284012

MPAH:

110335591

RNO:	25134(Gnmt)

MCOC:

116075524(Gnmt)

ANU:

117722363

MUN:	110550343(Gnmt)

CGE:

100769585

MAUA:

101825665(Gnmt)

PROB:

127236611(Gnmt)

PLEU:

114705340(Gnmt)

MORG:

121450802(Gnmt)

MFOT:

126488896

AAMP:

119823462(Gnmt)

NGI:	103730804(Gnmt)

HGL:	101697457(Gnmt)

CPOC:

100717389

CCAN:

109682081(Gnmt)

DSP:

122101636

PLOP:

125352575(Gnmt)

NCAR:

124988152

MMMA:

107143924(Gnmt)

OCU:

100009512

OPI:	101517330(GNMT)

TUP:	102501380(GNMT)

GVR:	103585755(GNMT)

CFA:	474905(GNMT)

CLUD:

112641604(GNMT)

VVP:	112913997(GNMT)

VLG:	121490377(GNMT)

NPO:	129512905(GNMT)

AML:	100477196(GNMT)

UMR:	103664079(GNMT)

UAH:	113261284(GNMT)

UAR:	123794585(GNMT)

ELK:	111147599 111147995

LLV:

125102116

MPUF:

101680816(GNMT)

MNP:	132018050(GNMT)

MLK:	131833992(GNMT)

NVS:	122908333(GNMT)

ORO:	101377523(GNMT)

EJU:	114204495(GNMT)

ZCA:	113926507(GNMT)

MLX:	118000555(GNMT)

NSU:	110582195(GNMT)

LWW:	102741887(GNMT)

FCA:	101083006(GNMT)

PYU:	121029468(GNMT)

PCOO:

112862016(GNMT)

PBG:	122489532(GNMT)

PVIV:

125165691(GNMT)

LRUF:

124528630

PTG:	102965502(GNMT)

PPAD:

109271639(GNMT)

PUC:

125938222

AJU:

106973967

HHV:	120231230(GNMT)

BTA:	112443696 538212(GNMT)

BOM:	102287446(GNMT)

BIU:	109577223(GNMT)

BBUB:

102395585(GNMT)

BBIS:

105005232(GNMT)

CHX:

102170645

OAS:	101111134(GNMT)

BTAX:

128055977(GNMT)

ODA:	120870113(GNMT)

CCAD:

122429153(GNMT)

MBEZ:

129543209(GNMT)

SSC:	397444(GNMT)

CFR:	102506340(GNMT)

CBAI:

105083787(GNMT)

CDK:	105088648(GNMT)

VPC:	102544214(GNMT)

BACU:

103001201(GNMT)

BMUS:

118903492

LVE:	103077097(GNMT)

OOR:	101270773(GNMT)

DLE:	111178834(GNMT)

PCAD:

102994709(GNMT)

PSIU:

116761635(GNMT)

NASI:

112414009(GNMT)

ECB:	100067145(GNMT)

EPZ:	103548169(GNMT)

EAI:	106828715(GNMT)

MYB:	102250180(GNMT)

MYD:	102760706(GNMT)

MMYO:

118660030(GNMT)

MLF:	102442398(GNMT)

PKL:	118705248(GNMT)

EFUS:

103296654(GNMT)

MNA:	107536922(GNMT)

DRO:	112302127(GNMT)

SHON:

118991685(GNMT)

AJM:	119041338 119056163(GNMT)

PDIC:

114494172(GNMT)

PHAS:

123821630(GNMT)

MMF:	118621513(GNMT)

PPAM:

129067461(GNMT)

HAI:

109382878

RFQ:	117020130(GNMT)

PALE:

102898977(GNMT)

PGIG:

120596148(GNMT)

PVP:	105288454(GNMT)

RAY:	107501992(GNMT)

MJV:	108395057(GNMT)

TOD:	119252477(GNMT)

SARA:

101543105(GNMT)

SETR:

125995981(GNMT)

LAV:	100660725(GNMT)

TMU:

101355018

ETF:	101641334(GNMT)

DNM:	101434952(GNMT)

MDO:	100010632(GNMT)

GAS:	123245665(GNMT)

SHR:

100925098

AFZ:

127561759

PCW:	110201291(GNMT)

OAA:	100092827(GNMT)

GGA:	769542(GNMT)

PCOC:

116231565(GNMT)

MGP:	100540940(GNMT)

CJO:	107310908(GNMT)

TPAI:

128077306(GNMT)

LMUT:

125689496(GNMT)

NMEL:

110395296(GNMT)

APLA:

113842961(GNMT) 119716560

ACYG:

125184663(GNMT)

CATA:

118253563(GNMT)

AFUL:

116488118(GNMT)

TGU:	100231507(GNMT)

LSR:	110472810(GNMT)

SCAN:

103821310

PMOA:

120500924(GNMT)

OTC:	121346383(GNMT)

PRUF:

121353917(GNMT)

FAB:	101818171(GNMT)

OMA:	130251190(GNMT)

PHI:	102109993(GNMT)

PMAJ:

107202337(GNMT)

CCAE:

111922583

CCW:	120411694(GNMT)

CBRC:

103617483

ETL:	114066770(GNMT)

ZAB:	102074891(GNMT)

ACHL:

103799528(GNMT)

SVG:	106862738(GNMT)

MMEA:

130581316(GNMT)

HRT:	120751305(GNMT)

FCH:

102046712

CLV:

102096572

EGZ:	104128772(GNMT)

NNI:	104015806(GNMT)

PLET:

104617980(GNMT)

TALA:

116962039(GNMT)

AFOR:

103893486

ACHC:

115349946(GNMT)

HLE:	104838232(GNMT)

AGEN:

126052632

GCL:

127014806

CCRI:

104169554(GNMT)

CSTI:

104553735(GNMT)

FGA:	104073594(GNMT)

LDI:	104349264(GNMT)

MNB:	103773754(GNMT)

NNT:	104405885(GNMT)

SHAB:

115613655(GNMT)

DPUB:

104300901(GNMT)

ACAR:

104519526

CPEA:

104395327(GNMT)

AVIT:

104279738(GNMT)

CVF:	104295130(GNMT)

RTD:	128906809(GNMT)

CUCA:

104060738(GNMT)

TEO:	104376891(GNMT)

AAM:	106494152(GNMT)

AROW:

112973557(GNMT)

NPD:

112949349

TGT:	104570050(GNMT)

DNE:	112985529(GNMT)

ASN:

102386281

AMJ:	102566047(GNMT)

CPOO:

109319031

GGN:

109304209

PSS:

102460961

CMY:	102938095(GNMT)

CCAY:

125633270(GNMT)

DCC:	119853338(GNMT)

CPIC:

101948133

TST:	117874136(GNMT)

CABI:

116824871(GNMT)

MRV:	120400901(GNMT)

ACS:	100552842(gnmt)

ASAO:

132761523(GNMT)

PVT:	110087012(GNMT)

SUND:

121919446(GNMT)

PBI:	103067312(GNMT)

PMUR:

107297201(GNMT)

CTIG:

120299559(GNMT)

TSR:	106538009(GNMT)

PGUT:

117671591(GNMT)

APRI:

131189179(GNMT)

PTEX:

113433360(GNMT)

NSS:	113422928(GNMT)

VKO:	123023227(GNMT)

PMUA:

114594784(GNMT)

PRAF:

128411262(GNMT)

ZVI:	118083074(GNMT)

HCG:	128352865(GNMT)

GJA:	107123075(GNMT)

STOW:

125424889(GNMT)

EMC:	129333114(GNMT)

XLA:	108716567 108717630

XTR:	116410885(gnmt)

NPR:

108803755

RTEM:

120921851(GNMT)

BBUF:

120984424

BGAR:

122923284

MUO:	115465289(GNMT)

GSH:	117357772(GNMT)

DRE:	403338(gnmt)

SRX:	107706413 107748599

SANH:

107697528(gnmt) 107703804

SGH:	107553737 107566124

CCAR:

CAUA:

CGIB:

PTET:

LROH:

127179542(gnmt)

OMC:	131523170(gnmt)

PPRM:

120494925(gnmt)

RKG:	130088929(gnmt)

MAMB:

125268364(gnmt)

CIDE:

127498492

MASI:

127410990

TROS:

130549548(gnmt)

TDW:	130437074(gnmt)

IPU:

108270118

IFU:	128612581(gnmt)

PHYP:

113545046(gnmt)

SMEO:

124390082(gnmt)

TFD:	113659593(gnmt)

TVC:	132852183(gnmt)

AMEX:

103028138

CMAO:

118823180(gnmt)

EEE:	113572147(gnmt)

CHAR:

105888545(gnmt)

TRU:	101067368 115246826

TFS:	130540187(gnmt)

TNG:	GSTEN00016922G001

LCO:	104932648(gnmt)

NCC:	104954782(gnmt)

TBEN:

117486745(gnmt)

CGOB:

115027654(gnmt)

PGEO:

117467818(gnmt)

GACU:

117558521(gnmt)

EMAC:

134881525(gnmt)

ELY:	117267179(gnmt)

EFO:	125900391(gnmt)

PLEP:

121953867(gnmt)

SLUC:

116042433(gnmt)

ECRA:

117935637(gnmt)

ESP:	116669936(gnmt)

PFLV:

114546486(gnmt)

GAT:	120832577(gnmt)

PPUG:

119228166(gnmt)

AFB:	129103685(gnmt)

CLUM:

117751385(gnmt)

PSWI:

130205839(gnmt)

MSAM:

119910871(gnmt)

SCHU:

122861874(gnmt)

CUD:	121526476(gnmt)

ALAT:

119005000(gnmt)

MZE:	101484870(gnmt)

ONL:	100706279(gnmt)

OAU:	116311098(gnmt)

OLA:	101154832(gnmt)

OML:	112144840(gnmt)

CSAI:

133462264(gnmt)

XMA:	102219353(gnmt)

XCO:	114134382(gnmt)

XHE:	116708699 116726160

PFOR:

103154189(gnmt)

PLAI:

106937322(gnmt)

PMEI:

106904043(gnmt)

GAF:	122845739(gnmt)

PPRL:

129374881(gnmt)

CVG:	107084845(gnmt)

CTUL:

119781787

GMU:	124855913(gnmt)

NFU:	107389170 107392578(gnmt)

KMR:	108246999(gnmt)

ALIM:

106521247(gnmt)

NWH:	119427916(gnmt)

AOCE:

111562587(gnmt)

MCEP:

125023941(gnmT)

CSEM:

103380842(gnmt)

POV:	109628164(gnmt)

SSEN:

122759962(gnmt)

HHIP:

117756209(gnmt)

HSP:	118116217(gnmt)

SMAU:

118285912(gnmt)

LCF:

108898000

SDU:	111226206(gnmt)

SLAL:

111668120(gnmt)

XGL:	120795580(gnmt)

HCQ:	109530231(gnmt)

SSCV:

125981326

SBIA:

133513460(gnmt)

PEE:	133413175(gnmt)

PTAO:

133487795(gnmt)

BPEC:

110155508(gnmt)

MALB:

109973687(gnmt)

BSPL:

114848273(gnmt)

SJO:	128375518(gnmt)

SASA:

106561891(gnmt)

STRU:

115202816(gnmt)

OTW:	112263437(gnmt)

OMY:	110506251(gnmt)

OGO:	124035938(gnmt)

ONE:	115113437(gnmt)

OKI:	109895585(gnmt)

OKE:	118402591(gnmt)

SALP:

111969168(gnmt)

SNH:	120025133(gnmt)

CCLU:

121539682(gnmt)

ELS:	105006939(gnmt)

SFM:	108923148(gnmt)

PKI:	111834432(gnmt)

AANG:

118215023(gnmt)

LOC:	102697278(gnmt)

PSPA:

121316224 121317350

ARUT:

117402945 117411412

PSEX:

120526399(gnmt)

LCM:	102360222(GNMT)

CMK:	103187634(gnmt)

CPLA:

122548511(gnmt)

HOC:	132836767(gnmt)

LERI:

129697634(gnmt)

PMRN:

116948385(GNMT)

LRJ:	133352627(GNMT)

BFO:	118403902 118421975

BBEL:

109464842 109487980

SPU:	105438157 105439109 575025 579000 579441 580044 589953 752758

LPIC:

129263263 129263534 129263541 129263666 129264872 129265454 129282198 129283305 129283548 129283549

APLC:

110974275 110981790

AJC:

117111684

SKO:

100378448

DME:	Dmel_CG6188(Gnmt)

DER:

6553637

DSE:

6606629

DSI:	Dsimw501_GD18854(Dsim_GD18854)

DYA:	Dyak_GE26214

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10501

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:	119659359 119660372 119660404 119660432

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ015956

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100121709 100122726

CSOL:

TPRE:

LHT:

LBD:

MDL:	103577735 103578163 103578164 103578165 103578166 103578167

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	662005 662371

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_204745

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113506686 113508201

SLIU:

OFU:

PXY:

PGW:

CFEL:

113384692 113384693 113385227

CCRN:

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_230833

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

LAK:

NVE:

EPA:

ATEN:

ADF:	107351994 107351995

AMIL:

PDAM:

SPIS:

DGT:

HMG:

HSY:

TAD:	TRIADDRAFT_59780

» show all

Reference

PMID:15340920

Authors

Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer ME

Title

Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes.

Journal

Proteins 57:331-7 (2004)
DOI:10.1002/prot.20209

Sequence

[hsa:27232] [mmu:14711]

DBGET integrated database retrieval system