KEGG   ORTHOLOGY: K01327
Entry
K01327                      KO                                     
Symbol
ELANE
Name
leukocyte elastase [EC:3.4.21.37]
Pathway
map04613  Neutrophil extracellular trap formation
map05202  Transcriptional misregulation in cancer
map05322  Systemic lupus erythematosus
Disease
H00100  Neutropenic disorders
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K01327  ELANE; leukocyte elastase
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K01327  ELANE; leukocyte elastase
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K01327  ELANE; leukocyte elastase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01327  ELANE; leukocyte elastase
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K01327  ELANE; leukocyte elastase
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01327  ELANE; leukocyte elastase
   00536 Glycosaminoglycan binding proteins
    K01327  ELANE; leukocyte elastase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.37  leukocyte elastase
     K01327  ELANE; leukocyte elastase
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K01327  ELANE; leukocyte elastase
Chaperones and folding catalysts [BR:ko03110]
 Intramolecular chaperones
  Other peptidases
   K01327  ELANE; leukocyte elastase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01327  ELANE; leukocyte elastase
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Enzymes
   K01327  ELANE; leukocyte elastase
Genes
HSA: 1991(ELANE)
PPS: 100969272(ELANE)
PON: 100452808(ELANE)
NLE: 100595921(ELANE)
HMH: 116482905(ELANE)
MCC: 106992354(ELANE)
MCF: 102135637(ELANE)
MTHB: 126942977
MNI: 105486435(ELANE)
CSAB: 103233572(ELANE)
CATY: 105591688(ELANE)
TGE: 112612320(ELANE)
MLEU: 105532878(ELANE)
RRO: 104671432(ELANE)
RBB: 108537896(ELANE)
TFN: 117074366(ELANE)
PTEH: 111534745(ELANE)
CANG: 105527607(ELANE)
CJC: 100389262(ELANE)
SBQ: 101030517(ELANE)
CIMI: 108293190(ELANE)
MMUR: 105860756(ELANE)
LCAT: 123632351(ELANE)
PCOQ: 105811217(ELANE)
OGA: 100965078(ELANE)
MMU: 50701(Elane)
MCAL: 110304016(Elane)
MPAH: 110326943(Elane)
RNO: 299606(Elane)
MCOC: 116076175
ANU: 117696369
MUN: 110551370(Elane)
CGE: 100752732(Elane)
MAUA: 106022252(Elane)
PROB: 127216810
PLEU: 114684136(Elane)
MORG: 121459202(Elane)
MFOT: 126489243
AAMP: 119815440
NGI: 103737354
HGL: 101705441 101715199(Elane)
CPOC: 100724414
CCAN: 109693670
DSP: 122122820
PLOP: 125348533
MMMA: 107157229
OCU: 127490148
OPI: 101525948
TUP: 102488298(ELANE)
GVR: 103607669(ELANE)
CFA: 442980(ELANE)
CLUD: 112666918
VVP: 112935508
VLG: 121496213
NPO: 129521404
AML: 105234312
UMR: 103681765
UAH: 113242651(ELANE)
UAR: 123794053
LLV: 125087398
MPUF: 101684702
MNP: 132009634
MLK: 131825709
NVS: 122910277
ORO: 101375336
EJU: 114226239
ZCA: 113916132
MLX: 118005404
NSU: 110594100
LWW: 102729363
FCA: 100301482(ELANE)
PYU: 121021310(ELANE)
PBG: 122486349
PVIV: 125159748
LRUF: 124527663
PTG: 102951727(ELANE)
PPAD: 109257711
PUC: 125928787
AJU: 113597259
HHV: 120242411
BTA: 100126050(ELANE)
BOM: 102274925(ELANE)
BBUB: 102411920(ELANE)
BBIS: 104991906(ELANE)
CHX: 102173292(ELANE)
OAS: 101110841(ELANE)
BTAX: 128051781(ELANE)
ODA: 120864495(ELANE)
MBEZ: 129558743(ELANE)
SSC: 100522182(ELANE)
CFR: 102507529
CBAI: 105078346
CDK: 105106576(ELANE)
VPC: 102529857(ELANE)
BACU: 103003856(ELANE)
BMUS: 118892699(ELANE)
LVE: 103074519(ELANE)
OOR: 101272927(ELANE)
DLE: 111170497(ELANE)
PCAD: 102995281(ELANE)
PSIU: 116750552(ELANE)
NASI: 112396312
ECB: 111774155(ELANE)
EPZ: 103544822(ELANE)
EAI: 106834239(ELANE)
MYB: 106723590(ELANE)
MYD: 102756029(ELANE)
MMYO: 118658984(ELANE)
MLF: 102437746(ELANE)
PKL: 118711780(ELANE)
EFUS: 103294436(ELANE)
MNA: 107538546(ELANE)
DRO: 112312421(ELANE)
SHON: 118984390(ELANE)
AJM: 119044598
PDIC: 114503126
MMF: 118616311(ELANE)
PPAM: 129080092(ELANE)
HAI: 109390590(ELANE)
RFQ: 117038398(ELANE)
PALE: 102888696(ELANE)
PGIG: 120583673(ELANE)
RAY: 107500956
MJV: 108395534
TOD: 119240359
SETR: 126030031(ELANE) 126030032
LAV: 100672001(ELANE)
TMU: 101350466
ETF: 101653944
DNM: 101412103
MDO: 100030465(ELANE)
GAS: 123232212
AFZ: 127545084
PCW: 110196241(ELANE)
OAA: 791113
XTR: 448597(prtn3)
AGIF: 122856252
 » show all
Reference
PMID:21079042
  Authors
Korkmaz B, Horwitz MS, Jenne DE, Gauthier F
  Title
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.
  Journal
Pharmacol Rev 62:726-59 (2010)
DOI:10.1124/pr.110.002733
Reference
PMID:2322278
  Authors
Okano K, Aoki Y, Shimizu H, Naruto M
  Title
Functional expression of human leukocyte elastase (HLE)/medullasin in eukaryotic cells.
  Journal
Biochem Biophys Res Commun 167:1326-32 (1990)
DOI:10.1016/0006-291x(90)90668-d
  Sequence
[hsa:1991]

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