Entry |
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Symbol |
DOT1L, DOT1
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Name |
[histone H3]-lysine79 N-trimethyltransferase [EC: 2.1.1.360]
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Pathway |
map05202 | Transcriptional misregulation in cancer |
|
Reaction |
R04866 | S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase |
R04867 | S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase |
|
Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
K11427 DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
K11427 DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins
K11427 DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
Enzymes [BR:ko01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
K11427 DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
K11427 DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
HMT complexes
Dot1-containing complex
K11427 DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase
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Other DBs |
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Genes |
» show all
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Reference |
|
Authors |
Barry ER, Corry GN, Rasmussen TP |
Title |
Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development. |
Journal |
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Reference |
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Authors |
San-Segundo PA, Roeder GS |
Title |
Role for the silencing protein Dot1 in meiotic checkpoint control. |
Journal |
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Sequence |
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