KEGG ORTHOLOGY: K11519

ORTHOLOGY: K11519

Entry

K11519                      KO

Symbol

DERL1

Name

Derlin-1

Pathway

map04141

Protein processing in endoplasmic reticulum

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K11519  DERL1; Derlin-1
09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K11519  DERL1; Derlin-1
   05022 Pathways of neurodegeneration - multiple diseases
    K11519  DERL1; Derlin-1

Other DBs

TC:

3.A.16.1

Genes

HSA:	79139(DERL1)

PTR:	464364(DERL1)

PPS:	100986783(DERL1)

GGO:	101146086(DERL1)

PON:	100172781(DERL1)

NLE:	100605156(DERL1)

HMH:	116813560(DERL1)

MCC:	703803(DERL1)

MCF:	101926663(DERL1)

MTHB:

126961317

MNI:	105468497(DERL1)

CSAB:

103237376(DERL1)

CATY:

105598661(DERL1)

PANU:

101011564(DERL1)

TGE:	112629835(DERL1)

MLEU:

105534306(DERL1)

RRO:	104662779(DERL1)

RBB:	108517777(DERL1)

TFN:	117079439(DERL1)

PTEH:

111550883(DERL1)

CANG:

105516938(DERL1)

CJC:	100392139(DERL1)

SBQ:	101047272(DERL1)

CIMI:

108305954(DERL1)

CSYR:

103249803(DERL1)

MMUR:

105859496(DERL1)

LCAT:

123644457(DERL1)

PCOQ:

105823593(DERL1)

OGA:	100964192(DERL1)

MMU:	67819(Derl1)

MCAL:

110310509(Derl1)

MPAH:

110334616(Derl1)

RNO:	120094610 362912(Derl1)

MCOC:

116081723(Derl1)

ANU:	117718575(Derl1)

MUN:	110553359(Derl1)

CGE:

103161457

MAUA:

101824732(Derl1)

PROB:

127235207(Derl1)

PLEU:

114694827(Derl1)

MORG:

121461204(Derl1)

MFOT:

126503517

AAMP:

119822534(Derl1)

NGI:	103738157(Derl1) 103743862

HGL:	101722706(Derl1)

CPOC:

100727484(Derl1)

CCAN:

109681659(Derl1)

DORD:

105997693(Derl1)

DSP:	122102322(Derl1)

PLOP:

125360977(Derl1)

NCAR:

124995293

MMMA:

107142897(Derl1)

OCU:

100355027

OPI:	101517959(DERL1) 118758554

TUP:	102493714(DERL1)

GVR:	103596037(DERL1)

CFA:	475086(DERL1)

CLUD:

112662039(DERL1)

VVP:	112915958(DERL1)

VLG:	121498861(DERL1)

NPO:	129502523(DERL1)

AML:	100482281(DERL1)

UMR:	103661606(DERL1)

UAH:	113252761(DERL1)

UAR:	123797739(DERL1)

ELK:

111146592

LLV:

125096914

MPUF:

101673904(DERL1)

MNP:	132014269(DERL1)

MLK:	131826445(DERL1)

NVS:	122904329(DERL1)

ORO:	101379258(DERL1)

EJU:	114211145(DERL1)

ZCA:	113929601(DERL1)

MLX:	118015172(DERL1)

NSU:	110579230(DERL1)

LWW:	102726663(DERL1)

FCA:	101100445(DERL1)

PYU:	121042927(DERL1)

PCOO:

112859784(DERL1)

PBG:	122495770(DERL1)

PVIV:

125156486(DERL1)

LRUF:

124507777

PTG:	102966997(DERL1)

PPAD:

109273199(DERL1)

PUC:

125924429

AJU:

106978174

HHV:	120231755(DERL1)

BTA:	404121(DERL1)

BOM:	102276819(DERL1)

BIU:	109568202(DERL1)

BBUB:

102397988(DERL1)

BBIS:

104987846(DERL1)

CHX:	102169311(DERL1)

OAS:	100037686(DERL1)

BTAX:

128059160(DERL1)

ODA:	120878945(DERL1)

CCAD:

122451380(DERL1)

MBEZ:

129559894(DERL1)

SSC:	100626802(DERL1)

CFR:	102522634(DERL1)

CBAI:

105082908(DERL1)

CDK:	105098327(DERL1)

VPC:	102543153(DERL1)

BACU:

103005670(DERL1)

BMUS:

118883584(DERL1)

LVE:	103082043(DERL1)

OOR:	101281053(DERL1)

DLE:	111164373(DERL1)

PCAD:

102996926(DERL1)

PSIU:

116742393(DERL1)

NASI:

112397034(DERL1)

ECB:	100057344(DERL1)

EPZ:	103564496(DERL1)

EAI:	106829117(DERL1)

MYB:	102252826(DERL1)

MYD:	102759314(DERL1)

MMYO:

118670813(DERL1)

MLF:	102421949(DERL1)

PKL:	118718255(DERL1)

EFUS:

103287640(DERL1)

MNA:	107533169(DERL1)

DRO:	112315454(DERL1)

SHON:

118988640(DERL1)

AJM:	119064848(DERL1)

PDIC:

114514702(DERL1)

PHAS:

123833151(DERL1)

MMF:	118631556(DERL1)

PPAM:

129084304(DERL1)

HAI:	109374816(DERL1)

RFQ:	117033787(DERL1)

PALE:

102878671(DERL1)

PGIG:

120595544(DERL1)

PVP:	105292532(DERL1)

RAY:	107503228(DERL1)

MJV:	108390493(DERL1)

TOD:	119238437(DERL1)

SARA:

101559225(DERL1)

SETR:

125997349(DERL1)

LAV:	100662094(DERL1)

TMU:

101344363

ETF:	101657557(DERL1)

DNM:	101432299(DERL1)

MDO:	100025904(DERL1)

GAS:	123241252(DERL1)

SHR:	100914619(DERL1)

AFZ:	127544417 127554765

PCW:	110193287(DERL1)

OAA:	100080383(DERL1)

GGA:	420350(DERL1)

PCOC:

116227718(DERL1)

MGP:	100546399(DERL1)

CJO:	107310497(DERL1)

TPAI:

128091068(DERL1)

LMUT:

125690663(DERL1)

NMEL:

110393450(DERL1)

APLA:

101795626(DERL1)

ACYG:

106038482(DERL1)

CATA:

118252690(DERL1)

AFUL:

116486059(DERL1)

TGU:	100226428(DERL1)

LSR:	110479272(DERL1)

SCAN:

103814361(DERL1)

PMOA:

120505174(DERL1)

OTC:	121337418(DERL1)

PRUF:

121355355(DERL1)

GFR:	102045398(DERL1)

FAB:	101818443(DERL1)

OMA:	130250333(DERL1)

PHI:	102112529(DERL1)

PMAJ:

107199790(DERL1)

CCAE:

111925100(DERL1)

CCW:	104692664(DERL1)

CBRC:

103623548(DERL1)

ETL:	114061313(DERL1)

ZAB:	102067694(DERL1)

ACHL:

103806023(DERL1)

SVG:	106849495(DERL1)

MMEA:

130574754(DERL1)

HRT:	120761094(DERL1)

FPG:	101918230(DERL1)

FCH:	102052942(DERL1)

CLV:	102092906(DERL1)

EGZ:	104123684(DERL1)

NNI:	104018013(DERL1)

PCRI:

104031056(DERL1)

PLET:

104623999(DERL1)

EHS:	104511914(DERL1)

PCAO:

104045659(DERL1)

ACUN:

113476733(DERL1)

TALA:

104367649(DERL1)

PADL:

103916391(DERL1)

AFOR:

103897270(DERL1)

ACHC:

115340327(DERL1)

HALD:

104312320(DERL1)

HLE:	104837680(DERL1)

AGEN:

126050015

GCL:

127029877

CCRI:

104169360(DERL1)

CSTI:

104551584(DERL1)

CMAC:

104487260(DERL1)

MUI:	104548004(DERL1)

BREG:

104633442(DERL1)

FGA:	104074532(DERL1)

LDI:	104349784(DERL1)

MNB:	103768965(DERL1)

OHA:	104330512(DERL1)

NNT:	104412696(DERL1)

SHAB:

115605562(DERL1)

DPUB:

104304972(DERL1)

PGUU:

104459060(DERL1)

ACAR:

104528485(DERL1)

CPEA:

104388716(DERL1)

AVIT:

104270946(DERL1)

CVF:	104282906(DERL1)

RTD:	128904887(DERL1)

CUCA:

104058501(DERL1)

TEO:	104375685(DERL1)

BRHI:

104488857(DERL1)

AAM:	106496228(DERL1)

AROW:

112970360(DERL1)

NPD:	112947408(DERL1)

TGT:	104574348(DERL1)

DNE:	112989152(DERL1)

SCAM:

104149392(DERL1)

ASN:	102382742(DERL1)

AMJ:	102569476(DERL1)

CPOO:

109321682(DERL1)

GGN:	109305169(DERL1)

PSS:	102444031(DERL1)

CMY:	102939736(DERL1)

CCAY:

125632806(DERL1)

DCC:	119851600(DERL1)

CPIC:

101933127(DERL1)

TST:	117870235(DERL1)

CABI:

116838361(DERL1)

MRV:	120397819(DERL1)

ACS:	100567026(derl1)

ASAO:

132775089(DERL1)

PVT:	110080541(DERL1)

SUND:

121929541(DERL1)

PBI:	103057755(DERL1)

PMUR:

107295160(DERL1)

CTIG:

120315453(DERL1)

TSR:	106543888(DERL1)

PGUT:

117668391(DERL1)

APRI:

131194698(DERL1)

PTEX:

113438290(DERL1)

NSS:	113419613(DERL1)

VKO:	123019029(DERL1)

PMUA:

114600281(DERL1)

PRAF:

128417104(DERL1)

ZVI:	118089732(DERL1)

HCG:	128323876(DERL1)

GJA:	107110297(DERL1)

STOW:

125438989(DERL1)

EMC:	129333175(DERL1)

XLA:	443827 444811(derl1.L)

XTR:	549477(derl1)

NPR:	108796379(DERL1)

RTEM:

120941488(DERL1)

BBUF:

121001297(DERL1)

BGAR:

122938999(DERL1)

MUO:	115480171(DERL1)

GSH:	117355184(DERL1)

DRE:	406753(derl1)

SRX:	107714924 107736822

SANH:

107657695 107699495

SGH:	107593655 107595682

CCAR:

109104783(derl1) 109105957

CAUA:

113059092 113116674

CGIB:

127975387 128030673

PTET:

122360274(derl1)

LROH:

127178794(derl1)

OMC:	131522440(derl1)

PPRM:

120484546(derl1)

RKG:	130101879(derl1)

MAMB:

125243371(derl1)

CIDE:

127497370

MASI:

127452883 127453822

TROS:

130557596(derl1)

TDW:	130432571(derl1)

MANU:

129448032(derl1)

IPU:	100528714(derl1)

IFU:	128606081(derl1)

PHYP:

113526542(derl1)

SMEO:

124385297(derl1)

TFD:	113647484(derl1)

TVC:	132846271(derl1)

AMEX:

103028975(derl1)

CMAO:

118823169(derl1)

EEE:	113575620(derl1)

CHAR:

122129483(derl1)

TRU:	101061860(derl1)

TFS:	130532656(derl1)

TNG:	GSTEN00035321G001

LCO:	104928084(derl1)

NCC:	104944812(derl1)

TBEN:

117480183(derl1)

CGOB:

115021862(derl1)

PGEO:

117460301(derl1)

GACU:

117540795(derl1)

EMAC:

134861638(derl1)

ELY:	117265726(derl1)

EFO:	125893454(derl1) 125893455

PLEP:

121946193(derl1)

SLUC:

116035234(derl1)

ECRA:

117945963(derl1)

ESP:	116690588(derl1)

PFLV:

114556758(derl1)

GAT:	120810277(derl1)

PPUG:

119197123(derl1)

AFB:	129110280(derl1)

CLUM:

117728212(derl1)

PSWI:

130212807(derl1)

MSAM:

119897977(derl1)

SCHU:

122881034(derl1)

CUD:	121514326(derl1)

ALAT:

119006063(derl1)

MZE:	101467839(derl1)

ONL:	100694674(derl1)

OAU:	116314967(derl1)

OLA:	101174652(derl1)

OML:	112138265 112140530(derl1)

CSAI:

133425884(derl1)

XMA:	102236484(derl1)

XCO:	114144132(derl1)

XHE:	116716054(derl1)

PRET:

103478286(derl1)

PFOR:

103142137(derl1)

PLAI:

106953056(derl1)

PMEI:

106928708(derl1)

GAF:	122831536(derl1)

PPRL:

129367480(derl1)

CVG:	107086337(derl1)

CTUL:

119786284(derl1)

GMU:	124863910(derl1)

NFU:	107378948(derl1)

KMR:	108232250(derl1)

ALIM:

106526034(derl1)

NWH:	119410381(derl1)

AOCE:

111572962(derl1)

MCEP:

125015956(derl1)

CSEM:

103388784(derl1)

POV:	109632144(derl1)

SSEN:

122775204(derl1)

HHIP:

117777385(derl1)

HSP:	118113869(derl1)

SMAU:

118297122(derl1)

LCF:

108888047

SDU:	111227648(derl1)

SLAL:

111658071(derl1)

XGL:	120783894(derl1)

HCQ:	109529693(derl1)

SSCV:

125974763

SBIA:

133500512(derl1)

PEE:	133401201(derl1)

PTAO:

133479075(derl1)

BPEC:

110171615(derl1)

MALB:

109958557(derl1)

BSPL:

114842714(derl1)

SJO:	128365977(derl1)

SASA:

106592583(derl1) 106593653

STRU:

115181388 115181403

OTW:	112237140(derl1)

OMY:	110520878(derl1)

OGO:	124019773(derl1)

ONE:	115118432(derl1)

OKI:	109876952 116371889

OKE:	118380805(derl1)

SNH:	120030879 120030881

CCLU:

121542767 121586080

ELS:	105016537(derl1)

SFM:	108919303(derl1)

PKI:	111852229(derl1)

AANG:

118233200(derl1)

LOC:	102682446(derl1)

PSPA:

121313296 121314879

ARUT:

117394414 117400556 117970949

PSEX:

120516959(derl1)

LCM:	102358985(DERL1)

CMK:	103183205(derl1)

RTP:	109914629(derl1)

CPLA:

122549228(derl1)

HOC:	132813067(derl1)

LERI:

129696643(derl1)

PMRN:

116944225(DERL1)

LRJ:	133350922(DERL1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG10908(Der-1)

DER:

6543291

DSE:

6617428

DSI:	Dsimw501_GD23120(Dsim_GD23120)

DYA:	Dyak_GE17801

DAN:

6497413

DSR:	110181294 110181303

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17281

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108361235 108375768

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:	119601288 119601303

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ012528

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_213496

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110377631(Der-1)

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111064466 120353261

HVI:

124367941

MQU:	128994010 129004728

PHU:	Phum_PHUM549590

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:	110855804 110856325 110863265

DPX:	DAPPUDRAFT_299872

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

LSM:

TCF:

PPOI:

ISC:

DSV:	119461637 119462365 119462366

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F25D7.1(cup-2)

CBR:	CBG_02198(Cbr-cup-2)

CRQ:	GCK72_002360

NAI:	NECAME_00205

BMY:	BM_BM3572(Bma-cup-2)

LOA:	LOAG_03445

TSP:

Tsp_09512

HRO:	HELRODRAFT_67318

LGI:	LOTGIDRAFT_205920

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111099122 111138253

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106180419 106181715

OVI:	T265_09002

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_23843 TRIADDRAFT_51239

AQU:

100641463

GSL:	Gasu_21850

PTRC:

PtA15_8A549

PSTR:

Pst134EA_032866

MBR:	MONBRDRAFT_37095

SRE:	PTSG_01086

DFA:	DFA_11047(derl1)

PTI:	PHATRDRAFT_31697(sDer1-1)

TPS:	THAPSDRAFT_9466

» show all

Reference

PMID:15215856

Authors

Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA

Title

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.

Journal

Nature 429:841-7 (2004)
DOI:10.1038/nature02656

Sequence

[hsa:79139] [cel:CELE_F25D7.1]

Reference

PMID:16055502

Authors

Katiyar S, Joshi S, Lennarz WJ

Title

The retrotranslocation protein Derlin-1 binds peptide:N-glycanase to the endoplasmic reticulum.

Journal

Mol Biol Cell 16:4584-94 (2005)
DOI:10.1091/mbc.e05-04-0345

All links

Ontology (2)   
   KEGG BRITE (1)   
   TC (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Gene (2348)   
   KEGG GENES (686)   
   KEGG MGENES (249)   
   RefGene (1407)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (2358)   

Download RDF

DBGET integrated database retrieval system