KEGG   REACTION: R08569
Entry
R08569                      Reaction                               
Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
Definition
2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid + H2O + NAD+ <=> 3-Dehydroquinate + Ammonia + NADH + H+
Equation
C16850 + C00001 + C00003 <=> C00944 + C00014 + C00004 + C00080
Comment
two-step reaction (oxidative deamination, cyclization)
possibly intermediate (3,7-dideoxy-D-threo-hept-2,6-diulosonic acid)
Reaction class
RC00001  C00003_C00004
RC02302  C00944_C16850
Enzyme
1.4.1.24
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.24
     R08569  2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid + H2O + NAD+ <=> 3-Dehydroquinate + Ammonia + NADH + H+
Orthology
K11646  3-dehydroquinate synthase II [EC:1.4.1.24]
Reference
1  [PMID:15182204]
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
Other DBs
RHEA: 25959

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Ontology (1)   
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   KEGG PATHWAY (6)   
Chemical substance (7)   
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Chemical reaction (3)   
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Gene (353)   
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   KEGG GENES (352)   
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