KEGG   REACTION: R10052
Entry
R10052                      Reaction                               
Name
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Definition
(2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+
Equation
C04411 + C00003 <=> C00233 + C00011 + C00004 + C00080
Comment
two-step reaction (see R04426+R01652)
Reaction class
RC00001  C00003_C00004
RC03036  C00233_C04411
Enzyme
1.1.1.85
Pathway
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.85
     R10052  (2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+
Orthology
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
Other DBs
RHEA: 32274

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
Gene (8193)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (8191)   
All databases (8207)   

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