KEGG   Amycolatopsis mediterranei U32: AMED_8886
Entry
AMED_8886         CDS       T01269                                 
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
  KO
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Organism
amd  Amycolatopsis mediterranei U32
Pathway
amd00290  Valine, leucine and isoleucine biosynthesis
amd00620  Pyruvate metabolism
amd01100  Metabolic pathways
amd01110  Biosynthesis of secondary metabolites
amd01210  2-Oxocarboxylic acid metabolism
amd01230  Biosynthesis of amino acids
Module
amd_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:amd00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    AMED_8886 (leuA)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    AMED_8886 (leuA)
Enzymes [BR:amd01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     AMED_8886 (leuA)
SSDB
Motif
Pfam: HMGL-like LeuA_dimer PP_kinase_C
Other DBs
NCBI-ProteinID: ADJ50577
UniProt: A0A0H3DK36
Position
9738545..9740230
AA seq 561 aa
MPVHRYRPWYDVVENIDLPDRTWPEKRIDRAPLWCAVDLRDGNQALIDPMSPARKRKFFD
LLVRMGYKEIEVGFPAASQTDFDFVREIIEEHAIPDDVSIQVLTQCRPELIERTFKSLEG
APRAIVHIYNSTSILQRRVVFREEREGIKKIATQAAEMVVELAAKQPDTDFRFQYSPESY
TGTELSYALEVCNAVTEIWQPTPEKPVILNLPATVEMATPNVYADSIEWMSRNLDRRDSV
ILSLHPHNDRGTGIAAAELGYQAGADRIEGCLFGNGERTGNVDLVALGMNLYSQGIDPQI
DFSDMDEIKRTVEYCNQLPVGERSPWGGDLVFTAFSGSHQDAINKGLDALKDAADKAGVP
IDEYPWEVPYLPIDPKDVGRMYEAVIRVNSQSGKGGVAYIMKAEHQLDLPRRLQIEFSKV
IQRYTDTEGGEVDPATMYNAFSAEYLELKTPLELVRQHVRDNGDGEYDITATVKVEGDEH
EVTGRGNGPIAAFFDALSTVGFDLRLLDYNEHTLSPGDDARAASYIECAISDRVFWGIGI
DPSIVTASLRAVVSAVNRANR
NT seq 1686 nt   +upstreamnt  +downstreamnt
atgccggtccaccgctaccgcccctggtacgacgtggtcgagaacatcgacctgcccgac
cgcacctggcccgagaagcgcatcgaccgcgcgccgctgtggtgcgccgtcgacctgcgg
gacggcaaccaggccctgatcgacccgatgtcgcccgcgcgcaagcgcaagttcttcgac
ctgctggtccgcatggggtacaaggagatcgaggtcggcttcccggccgcgtcccagacc
gacttcgacttcgtccgcgagatcatcgaagagcacgccatcccggacgacgtcagcatc
caggtgctgacccagtgccgtcccgagctgatcgaacgcaccttcaagtcgctcgaaggc
gcgccgcgggcgatcgtccacatctacaactcgacgtcgatcctgcagcgccgcgtggtc
ttccgcgaggagcgcgagggcatcaagaagatcgcgacgcaggccgcggaaatggtcgtc
gagctggccgcgaagcagccggacaccgacttccgcttccagtactcgccggagtcctac
accggcaccgagctgtcctacgcgctcgaggtctgcaacgccgtcaccgagatctggcag
ccgacgccggagaagccggtgatcctgaacctgccggcgaccgtcgagatggcgacgccg
aacgtctacgccgactcgatcgagtggatgtcccggaacctggaccgccgcgactcggtg
atcctgtcgctgcacccgcacaacgaccgcggcaccggcatcgccgccgccgagctgggc
taccaggccggcgccgaccggatcgagggctgcctgttcggcaacggggagcgcaccggc
aacgtcgacctggtcgcgctgggcatgaacctctacagccagggcatcgacccgcagatc
gacttctccgacatggacgagatcaagcggacggtcgagtactgcaaccagctgccggtc
ggcgagcgctcgccgtggggcggcgacctggtgttcaccgcgttctcgggcagccaccag
gacgcgatcaacaagggcctcgacgcgctgaaggacgccgccgacaaggccggcgtcccg
atcgacgagtacccgtgggaggtcccgtacctgccgatcgacccgaaggacgtcggccgg
atgtacgaggccgtgatccgggtgaactcgcagtccggcaagggcggcgtcgcctacatc
atgaaggccgagcaccagctcgacctgccgcggcggctgcagatcgagttctcgaaggtc
atccagcgctacaccgacaccgagggcggcgaggtcgacccggccaccatgtacaacgcc
ttctcggccgagtacctggagctgaagacgccgctggagctggtccgccagcacgtgcgc
gacaacggcgacggcgagtacgacatcaccgcgaccgtgaaggtggagggtgacgagcac
gaggtcaccggccgcggcaacggcccgatcgcggcgttcttcgacgcgctgtcgacggtg
ggcttcgacctgcgcctgctggactacaacgaacacacgctctcgccgggcgacgacgcg
cgcgccgcgtcgtacatcgagtgcgcgatctcggaccgggtgttctggggcatcggcatc
gacccgtcgatcgtcacggcgtcactgcgcgcggtcgtctcggcggtgaaccgcgccaac
cgctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (3)   
   Pfam (3)   
All databases (27)   

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