KEGG   Bos taurus (cow): 100137872
Entry
100137872         CDS       T01008                                 
Symbol
AKT3
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
bta  Bos taurus (cow)
Pathway
bta01521  EGFR tyrosine kinase inhibitor resistance
bta01522  Endocrine resistance
bta01524  Platinum drug resistance
bta04010  MAPK signaling pathway
bta04012  ErbB signaling pathway
bta04014  Ras signaling pathway
bta04015  Rap1 signaling pathway
bta04022  cGMP-PKG signaling pathway
bta04024  cAMP signaling pathway
bta04062  Chemokine signaling pathway
bta04066  HIF-1 signaling pathway
bta04068  FoxO signaling pathway
bta04071  Sphingolipid signaling pathway
bta04072  Phospholipase D signaling pathway
bta04140  Autophagy - animal
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04152  AMPK signaling pathway
bta04210  Apoptosis
bta04211  Longevity regulating pathway
bta04213  Longevity regulating pathway - multiple species
bta04218  Cellular senescence
bta04261  Adrenergic signaling in cardiomyocytes
bta04370  VEGF signaling pathway
bta04371  Apelin signaling pathway
bta04380  Osteoclast differentiation
bta04510  Focal adhesion
bta04550  Signaling pathways regulating pluripotency of stem cells
bta04611  Platelet activation
bta04613  Neutrophil extracellular trap formation
bta04620  Toll-like receptor signaling pathway
bta04625  C-type lectin receptor signaling pathway
bta04630  JAK-STAT signaling pathway
bta04660  T cell receptor signaling pathway
bta04662  B cell receptor signaling pathway
bta04664  Fc epsilon RI signaling pathway
bta04666  Fc gamma R-mediated phagocytosis
bta04668  TNF signaling pathway
bta04722  Neurotrophin signaling pathway
bta04725  Cholinergic synapse
bta04728  Dopaminergic synapse
bta04810  Regulation of actin cytoskeleton
bta04910  Insulin signaling pathway
bta04914  Progesterone-mediated oocyte maturation
bta04915  Estrogen signaling pathway
bta04917  Prolactin signaling pathway
bta04919  Thyroid hormone signaling pathway
bta04920  Adipocytokine signaling pathway
bta04922  Glucagon signaling pathway
bta04923  Regulation of lipolysis in adipocytes
bta04926  Relaxin signaling pathway
bta04929  GnRH secretion
bta04931  Insulin resistance
bta04932  Non-alcoholic fatty liver disease
bta04933  AGE-RAGE signaling pathway in diabetic complications
bta04935  Growth hormone synthesis, secretion and action
bta04936  Alcoholic liver disease
bta04973  Carbohydrate digestion and absorption
bta05010  Alzheimer disease
bta05017  Spinocerebellar ataxia
bta05132  Salmonella infection
bta05135  Yersinia infection
bta05142  Chagas disease
bta05145  Toxoplasmosis
bta05152  Tuberculosis
bta05160  Hepatitis C
bta05161  Hepatitis B
bta05162  Measles
bta05163  Human cytomegalovirus infection
bta05164  Influenza A
bta05165  Human papillomavirus infection
bta05166  Human T-cell leukemia virus 1 infection
bta05167  Kaposi sarcoma-associated herpesvirus infection
bta05168  Herpes simplex virus 1 infection
bta05169  Epstein-Barr virus infection
bta05170  Human immunodeficiency virus 1 infection
bta05200  Pathways in cancer
bta05205  Proteoglycans in cancer
bta05207  Chemical carcinogenesis - receptor activation
bta05208  Chemical carcinogenesis - reactive oxygen species
bta05210  Colorectal cancer
bta05211  Renal cell carcinoma
bta05212  Pancreatic cancer
bta05213  Endometrial cancer
bta05214  Glioma
bta05215  Prostate cancer
bta05218  Melanoma
bta05220  Chronic myeloid leukemia
bta05221  Acute myeloid leukemia
bta05222  Small cell lung cancer
bta05223  Non-small cell lung cancer
bta05224  Breast cancer
bta05225  Hepatocellular carcinoma
bta05226  Gastric cancer
bta05230  Central carbon metabolism in cancer
bta05231  Choline metabolism in cancer
bta05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bta05415  Diabetic cardiomyopathy
bta05417  Lipid and atherosclerosis
bta05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100137872 (AKT3)
   04012 ErbB signaling pathway
    100137872 (AKT3)
   04014 Ras signaling pathway
    100137872 (AKT3)
   04015 Rap1 signaling pathway
    100137872 (AKT3)
   04370 VEGF signaling pathway
    100137872 (AKT3)
   04371 Apelin signaling pathway
    100137872 (AKT3)
   04630 JAK-STAT signaling pathway
    100137872 (AKT3)
   04668 TNF signaling pathway
    100137872 (AKT3)
   04066 HIF-1 signaling pathway
    100137872 (AKT3)
   04068 FoxO signaling pathway
    100137872 (AKT3)
   04072 Phospholipase D signaling pathway
    100137872 (AKT3)
   04071 Sphingolipid signaling pathway
    100137872 (AKT3)
   04024 cAMP signaling pathway
    100137872 (AKT3)
   04022 cGMP-PKG signaling pathway
    100137872 (AKT3)
   04151 PI3K-Akt signaling pathway
    100137872 (AKT3)
   04152 AMPK signaling pathway
    100137872 (AKT3)
   04150 mTOR signaling pathway
    100137872 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100137872 (AKT3)
  09143 Cell growth and death
   04210 Apoptosis
    100137872 (AKT3)
   04218 Cellular senescence
    100137872 (AKT3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100137872 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    100137872 (AKT3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100137872 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100137872 (AKT3)
   04613 Neutrophil extracellular trap formation
    100137872 (AKT3)
   04620 Toll-like receptor signaling pathway
    100137872 (AKT3)
   04625 C-type lectin receptor signaling pathway
    100137872 (AKT3)
   04660 T cell receptor signaling pathway
    100137872 (AKT3)
   04662 B cell receptor signaling pathway
    100137872 (AKT3)
   04664 Fc epsilon RI signaling pathway
    100137872 (AKT3)
   04666 Fc gamma R-mediated phagocytosis
    100137872 (AKT3)
   04062 Chemokine signaling pathway
    100137872 (AKT3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100137872 (AKT3)
   04922 Glucagon signaling pathway
    100137872 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    100137872 (AKT3)
   04920 Adipocytokine signaling pathway
    100137872 (AKT3)
   04929 GnRH secretion
    100137872 (AKT3)
   04915 Estrogen signaling pathway
    100137872 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    100137872 (AKT3)
   04917 Prolactin signaling pathway
    100137872 (AKT3)
   04926 Relaxin signaling pathway
    100137872 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    100137872 (AKT3)
   04919 Thyroid hormone signaling pathway
    100137872 (AKT3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100137872 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100137872 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    100137872 (AKT3)
   04728 Dopaminergic synapse
    100137872 (AKT3)
   04722 Neurotrophin signaling pathway
    100137872 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100137872 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    100137872 (AKT3)
   04213 Longevity regulating pathway - multiple species
    100137872 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100137872 (AKT3)
   05205 Proteoglycans in cancer
    100137872 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    100137872 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    100137872 (AKT3)
   05230 Central carbon metabolism in cancer
    100137872 (AKT3)
   05231 Choline metabolism in cancer
    100137872 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100137872 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100137872 (AKT3)
   05212 Pancreatic cancer
    100137872 (AKT3)
   05225 Hepatocellular carcinoma
    100137872 (AKT3)
   05226 Gastric cancer
    100137872 (AKT3)
   05214 Glioma
    100137872 (AKT3)
   05221 Acute myeloid leukemia
    100137872 (AKT3)
   05220 Chronic myeloid leukemia
    100137872 (AKT3)
   05218 Melanoma
    100137872 (AKT3)
   05211 Renal cell carcinoma
    100137872 (AKT3)
   05215 Prostate cancer
    100137872 (AKT3)
   05213 Endometrial cancer
    100137872 (AKT3)
   05224 Breast cancer
    100137872 (AKT3)
   05222 Small cell lung cancer
    100137872 (AKT3)
   05223 Non-small cell lung cancer
    100137872 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100137872 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    100137872 (AKT3)
   05161 Hepatitis B
    100137872 (AKT3)
   05160 Hepatitis C
    100137872 (AKT3)
   05164 Influenza A
    100137872 (AKT3)
   05162 Measles
    100137872 (AKT3)
   05168 Herpes simplex virus 1 infection
    100137872 (AKT3)
   05163 Human cytomegalovirus infection
    100137872 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100137872 (AKT3)
   05169 Epstein-Barr virus infection
    100137872 (AKT3)
   05165 Human papillomavirus infection
    100137872 (AKT3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100137872 (AKT3)
   05135 Yersinia infection
    100137872 (AKT3)
   05152 Tuberculosis
    100137872 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100137872 (AKT3)
   05142 Chagas disease
    100137872 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100137872 (AKT3)
   05017 Spinocerebellar ataxia
    100137872 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100137872 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    100137872 (AKT3)
   05415 Diabetic cardiomyopathy
    100137872 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100137872 (AKT3)
   04932 Non-alcoholic fatty liver disease
    100137872 (AKT3)
   04931 Insulin resistance
    100137872 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100137872 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100137872 (AKT3)
   01524 Platinum drug resistance
    100137872 (AKT3)
   01522 Endocrine resistance
    100137872 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bta01001]
    100137872 (AKT3)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100137872 (AKT3)
Protein kinases [BR:bta01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   100137872 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 FTA2 ABC1 PH_11
Other DBs
NCBI-GeneID: 100137872
NCBI-ProteinID: NP_001178238
BGD-bta: BT10900
Ensembl: ENSBTAG00000017788
VGNC: 25800
UniProt: F1MYJ4
Position
16:33357625..33638939
AA seq 479 aa
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
NT seq 1440 nt   +upstreamnt  +downstreamnt
atgagcgatgttaccattgtgaaagaaggttgggttcagaagaggggagaatatataaaa
aactggaggccaagatatttccttttgaagacagatggctcattcataggatataaagag
aaaccccaagatgtggatttaccttatcccctcaacaacttttcagtagcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttattatcagatgtctccagtggacc
actgttatagagagaacatttcacgtagatactccagaggaaagggaagaatggacagaa
gctatccaggctgtagcagacagactccagaggcaagaagaagagagaatgaattgtagt
ccaacttcacaaattgataatataggagaggaagagatggatgcttctacaacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacttttggg
aaagttattttggttcgagagaaggcaagtggaaaatattatgctatgaagattctgaag
aaagaagttattattgccaaggatgaagtggcgcacactttaactgaaagcagagtatta
aagaacactagacatccctttttaacatccctgaaatattccttccagacaaaagaccgt
ttatgttttgtgatggaatatgttaatgggggagagctgtttttccatttgtcgagagag
cgggtgttctccgaggaccgcacacgtttctatggtgcagaaattgtctctgccttggac
tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatttgatgctggat
aaagatggccacataaaaatcacagattttggactttgcaaagaagggatcactgatgca
gccaccatgaagactttctgtggtacaccagagtatctggcaccagaggtgttagaagat
aatgactatggccgagctgtggattggtggggccttggggttgtcatgtatgaaatgatg
tgcgggagattacctttctataaccaggatcatgagaaactttttgaactaattctaatg
gaagatattaaatttcctcgaacactctcttcagatgcaaaatcattgctttcaggcctc
ttgataaaggatccaaataaacgccttggtggaggaccagatgatgcaaaagaaattatg
agacacagtttcttttctggagtaaactggcaagatgtgtatgataaaaagcttgtacct
ccttttaagcctcaagtaacatctgagacagacaccagatattttgatgaagaatttaca
gctcagactattacaataacaccacctgaaaaatatgatgaggacggtatggactgcatg
gacaatgagaggcggccgcacttccctcagttttcctactctgcaagtggacgagaataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (100)   
   KEGG PATHWAY (100)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   BGD-BTA (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (7)   
   UniProt (1)   
   RefSeq(pep) (6)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
Protein domain (9)   
   Pfam (9)   
All databases (142)   

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