KEGG   Bos taurus (cow): 281124
Entry
281124            CDS       T01008                                 
Symbol
DPYD
Name
(RefSeq) dihydropyrimidine dehydrogenase [NADP(+)]
  KO
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Organism
bta  Bos taurus (cow)
Pathway
bta00240  Pyrimidine metabolism
bta00410  beta-Alanine metabolism
bta00770  Pantothenate and CoA biosynthesis
bta00983  Drug metabolism - other enzymes
bta01100  Metabolic pathways
Module
bta_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Brite
KEGG Orthology (KO) [BR:bta00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    281124 (DPYD)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    281124 (DPYD)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    281124 (DPYD)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    281124 (DPYD)
Enzymes [BR:bta01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2  dihydropyrimidine dehydrogenase (NADP+)
     281124 (DPYD)
SSDB
Motif
Pfam: DHO_dh Fer4_20 Fer4_21 Pyr_redox_2 NAD_binding_8 Fer4_10 Fer4_7 Dus Pyr_redox_3 Pyr_redox Fer4_6 Fer4_2 Fer4_9 Fer4 FAD_oxidored
Other DBs
NCBI-GeneID: 281124
NCBI-ProteinID: NP_776466
BGD-bta: BT14767
Ensembl: ENSBTAG00000031358
VGNC: 28193
UniProt: Q28007
Position
3:45408337..46330781
AA seq 1025 aa
MAPVLSKDVADIESILALNPRTQSRATLRSTLAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSISNKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQYATEVFKAMNIPQIRNPSLPPPE
KMPEAYSAKIALLGAGPASISCASFLARLGYNDITIFEKQEYVGGISTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNDITLSTLKEEGYKAAFIGIGLPEPKKDHIFQGLTQD
QGFYTSKDFLPLVAKSSKAGMCACHSPLLSIRGTVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEVELAREEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDGDQIACLKADVVISAFGSVLSDPKVKEALSPIKFNRWDLPEVDPETMQTSEPWVFAGG
DVVGIANTTVEAVNDGKQASWYIHRYIQSQYGASVSAKPELPLFYTPIDLVDISVEMAAL
KFTNPFGLASATPTTSSSMIRRAFEAGWAFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNRNDWMELSRKAEAS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKADGTPWPAVGREKRTTYGGVSGTAIRPIALRAVTT
IARALPEFPILATGGIDSAESGLQFLHGGASVLQVCSAIQNQDFTIIQDYCTGLKALLYL
KSIEELQDWDGQSPATKSHQKGKPVPCIAELVGKKLPSFGPYLEKCKKIIAEEKLRLKKE
NVTVLPLERNHFIPKKPIPSVKDVIGKALQYLGTYGELNNTEQVVAVIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTVTDTCTGCTLCLSVCPIIDCIKMVSRTTPYEPKRGLPLA
VNPVS
NT seq 3078 nt   +upstreamnt  +downstreamnt
atggcccctgtgctaagcaaggacgtggcggatatcgagagtatcctggctttaaatcct
cgaacacagtctcgtgcaactctgcgttccactttggccaagaaattagacaagaaacat
tggaaaagaaatcctgataagaactgctttaattgcgagaagctggagaataattttgat
gacatcaagcacacgactcttggtgagcgaggagctctccgagaagcaatgagatgcctg
aaatgtgcagatgccccctgtcagaagagctgtccaacaaatctagatatcaaatcgttc
atcacaagtatctcaaacaagaactattatggagctgctaagatgatattttctgacaac
ccacttggtctgacctgtggaatggtatgccccacctctgatctttgtgtaggtggatgt
aatttgtatgccactgaagagggaccaattaatattggtggattgcagcaatatgctact
gaggtattcaaagcaatgaatatcccacaaatcaggaatccttctctgcctcccccagaa
aaaatgcctgaagcctattctgcaaagattgctcttttgggtgctgggcctgcaagtata
agttgtgcttcgttcttggctcgattaggctacaatgacatcactatatttgaaaaacaa
gaatacgttggtggtataagtacttctgaaatccctcagttccggctgccatatgatgta
gtaaattttgagattgagcttatgaaggaccttggtgtaaagataatttgtggtaaaagc
ctttcagtgaatgacattactcttagtactttgaaagaagaagggtacaaagctgctttc
attgggataggtttgccagaacccaagaaggatcacatcttccaaggcctgacacaggac
caggggttttacacttccaaagactttctgcctcttgtagccaaaagcagtaaagcagga
atgtgcgcctgtcactctccattgctgtcgatacggggaaccgtgattgtactcggagct
ggagacacagctttcgactgtgcaacatccgctttacgttgtggagcccgccgagtgttc
atcgtcttcagaaaaggctttgttaatataagagctgtccctgaggaggtggagcttgct
agagaagaaaaatgtgaatttttgcctttcttgtctccacggaaggttatagtaaaaggt
gggagaattgttgccatgcaatttgttcggacagagcaagatgaaactggaaaatggaat
gaagatggagatcagatagcctgtctgaaagccgatgtggtcatcagtgcctttggctca
gttctgagtgatcctaaagtaaaagaagccttgagccctataaaatttaacagatgggat
ctcccagaagtagatccagaaactatgcaaaccagtgagccatgggtgtttgcaggtggt
gatgtggttggtatagccaacactacagtggaagccgtgaatgatggaaagcaagcctct
tggtacattcacagatatatacagtcacaatatggagcttcagtttctgctaagcccgaa
ctccccctgttttatactcccattgatctggtggacattagtgtggaaatggctgcattg
aagtttacaaatccttttggtcttgccagtgcaactccaactaccagttcgtcaatgatt
cgaagagcttttgaagctggatgggcctttgctctgaccaaaactttctctcttgataag
gatatagtgacaaatgtttcacccagaatcatccgggggaccacctctggccccatgtat
ggccctggacaaagctctttcctgaatattgagctcatcagtgaaaaaacggctgcatat
tggtgtcaaagtgtcactgaactaaaagccgactttccagacaatattgtgattgctagc
atcatgtgcagttacaacagaaatgactggatggaactctccagaaaggctgaggcttct
ggagcagacgccctggagttaaatttatcgtgtccgcatggcatgggagaaagaggaatg
ggtctggcttgtggacaggatccagagctggtgcggaacatctgtcgctgggttaggcaa
gctgttcggattcctttttttgccaagttgaccccaaatgtcactgatattgtaagcata
gccagagctgcaaaggaaggtggggcaaatggtgttacagctaccaacactgtctcaggt
ctcatgggattaaaagctgatggcacaccctggccagcagtgggccgtgagaagcggact
acatacggcggagtgtccggcacagccatcagacctattgctttgagagctgtgaccacc
attgctcgtgctttgcctgaatttcccattttggccactggtggaattgactcagctgaa
agtggtcttcagtttctccacggtggtgcttcggtgctccaggtatgcagtgctattcaa
aatcaggatttcactatcatccaagactactgcactggcctcaaagccttgctttatctg
aaaagcattgaagaactacaggactgggatgggcagagtccagccacgaagagtcaccag
aaagggaaaccagtcccttgtattgctgaacttgtgggaaagaaactgccaagctttgga
ccttatcttgagaagtgcaagaaaatcatagcagaggaaaagttgagactgaaaaaagaa
aatgtgaccgttctaccacttgaaagaaaccattttatcccaaaaaaacctattccttct
gttaaggatgtgattggaaaagctctgcagtaccttggaacatatggtgaactgaacaac
acagagcaggttgtggctgtgatcgatgaagagatgtgtatcaactgtggcaaatgctac
atgacctgtaatgactctggctaccaggctatccagtttgatcctgaaacccacctgccc
accgttactgacacttgtacaggctgtaccctgtgtctctccgtctgccctattatcgac
tgcatcaaaatggtttccaggacaacaccttatgaaccaaagagaggcttgcccttggct
gtgaatcctgtgtcttaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   BGD-BTA (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (7)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (2)   
Protein domain (15)   
   Pfam (15)   
All databases (69)   

Download RDF
DBGET integrated database retrieval system