KEGG   Bos taurus (cow): 281739
Entry
281739            CDS       T01008                                 
Symbol
CYP17A1
Name
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase precursor
  KO
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Organism
bta  Bos taurus (cow)
Pathway
bta00140  Steroid hormone biosynthesis
bta01100  Metabolic pathways
bta04913  Ovarian steroidogenesis
bta04917  Prolactin signaling pathway
bta04927  Cortisol synthesis and secretion
bta04934  Cushing syndrome
Module
bta_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
bta_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
bta_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
bta_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:bta00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    281739 (CYP17A1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    281739 (CYP17A1)
   04917 Prolactin signaling pathway
    281739 (CYP17A1)
   04927 Cortisol synthesis and secretion
    281739 (CYP17A1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    281739 (CYP17A1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:bta00199]
    281739 (CYP17A1)
Enzymes [BR:bta01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     281739 (CYP17A1)
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     281739 (CYP17A1)
Cytochrome P450 [BR:bta00199]
 Cytochrome P450, animal type
  CYP17 family
   281739 (CYP17A1)
SSDB
Motif
Pfam: p450 ZSWIM4-8_C HEPN_MAE_28990
Other DBs
NCBI-GeneID: 281739
NCBI-ProteinID: NP_776729
BGD-bta: BT30209
Ensembl: ENSBTAG00000049558
VGNC: 110230
UniProt: P05185
Position
26:complement(23450460..23456663)
AA seq 509 aa
MWLLLAVFLLTLAYLFWPKTKHSGAKYPRSLPSLPLVGSLPFLPRRGQQHKNFFKLQEKY
GPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHGAH
WQLHRKLALNAFALFKDGNLKLEKIINQEANVLCDFLATQHGEAIDLSEPLSLAVTNIIS
FICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDIFPVLKIFPSKAMEKMKGCVQTRN
ELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNAGPDQDSKLLSNRHMLATIGDIF
GAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISDRNRLVLLEATIREV
LRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEWQHPDLFMPERFLDP
TGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDDGKLPSLEGHA
SLVLQIKPFKVKIEVRQAWKEAQAEGSTP
NT seq 1530 nt   +upstreamnt  +downstreamnt
atgtggctgctcctggctgtctttctgctcaccctcgcctatttattttggcccaagacc
aagcactctggtgccaagtaccccaggagcctcccatccctgcccctggtgggcagcctg
ccgttcctccccagacgtggccagcagcacaagaacttcttcaagctgcaggaaaaatat
ggccccatctattcctttcgtttgggttccaagacgactgtgatgattggacaccaccag
ttggccagggaggtgcttctcaagaagggcaaggaattctctgggcgtcccaaagtggcc
actctagacatcctgtcagacaaccaaaagggcattgcctttgccgaccatggtgcccac
tggcagctgcatcggaagctggcactgaatgcctttgccctgttcaaggatggcaacctg
aagttagagaagatcattaatcaggaagccaatgtgctctgtgatttcctggccacccag
catggagaggccatagatctgtccgagcctctctctctggcggtgaccaacataatcagc
tttatctgcttcaacttctccttcaagaatgaggatcctgccctgaaggccatacaaaat
gtcaatgatggcatcctggaggttctgagcaaggaagttctgttagacatattccctgtg
ctgaagattttccccagcaaagccatggaaaagatgaagggttgtgttcaaacgcgaaat
gaattgctgaatgaaatccttgaaaaatgtcaggagaacttcagcagtgattccatcact
aacttgctgcacatactgatccaagccaaggtgaatgcagacaataacaatgctggccca
gaccaggattcaaagctgctttcaaatagacacatgctcgctactataggggacatcttc
ggggctggtgtggagaccaccacgtctgtgataaagtggatcgtggcctacctgctacac
catccttcgttgaagaagaggatccaggatgacattgaccagattataggtttcaatcgc
accccaaccatcagtgaccggaaccgccttgtcctgctggaggcgaccatcagagaagtg
ctccgaatccggcctgtggcccctacgctgatcccccacaaggctgtcattgactccagc
attggcgaccttaccattgacaaaggcacagacgttgtggtcaacctgtgggcactgcat
cacagtgagaaggagtggcagcatcccgacctgttcatgcccgagcgcttcttggacccc
acggggacgcaactcatctcgccatcattaagctacttgccctttggagcaggaccccgc
tcctgcgtaggtgagatgctagcccgccaggagctcttcctcttcatgtcccggctgctg
cagaggttcaacctggagatcccggatgatgggaagctaccttctctggagggccatgcc
agtctcgtcttgcagatcaaacctttcaaggtgaagatcgaggtgcgccaggcctggaag
gaagcccaggctgagggtagcaccccatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (6)   
   KEGG MODULE (4)   
Chemical substance (20)   
   KEGG COMPOUND (20)   
Chemical reaction (11)   
   KEGG ENZYME (2)   
   KEGG REACTION (9)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   BGD-BTA (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (3)   
   Pfam (3)   
All databases (66)   

Download RDF
DBGET integrated database retrieval system