KEGG   Bos taurus (cow): 281854
Entry
281854            CDS       T01008                                 
Symbol
IKBKB
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
bta  Bos taurus (cow)
Pathway
bta01523  Antifolate resistance
bta04010  MAPK signaling pathway
bta04014  Ras signaling pathway
bta04062  Chemokine signaling pathway
bta04064  NF-kappa B signaling pathway
bta04068  FoxO signaling pathway
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04210  Apoptosis
bta04380  Osteoclast differentiation
bta04620  Toll-like receptor signaling pathway
bta04621  NOD-like receptor signaling pathway
bta04622  RIG-I-like receptor signaling pathway
bta04623  Cytosolic DNA-sensing pathway
bta04625  C-type lectin receptor signaling pathway
bta04657  IL-17 signaling pathway
bta04658  Th1 and Th2 cell differentiation
bta04659  Th17 cell differentiation
bta04660  T cell receptor signaling pathway
bta04662  B cell receptor signaling pathway
bta04668  TNF signaling pathway
bta04722  Neurotrophin signaling pathway
bta04910  Insulin signaling pathway
bta04920  Adipocytokine signaling pathway
bta04930  Type II diabetes mellitus
bta04931  Insulin resistance
bta04932  Non-alcoholic fatty liver disease
bta04936  Alcoholic liver disease
bta05010  Alzheimer disease
bta05132  Salmonella infection
bta05135  Yersinia infection
bta05142  Chagas disease
bta05145  Toxoplasmosis
bta05160  Hepatitis C
bta05161  Hepatitis B
bta05162  Measles
bta05163  Human cytomegalovirus infection
bta05164  Influenza A
bta05165  Human papillomavirus infection
bta05166  Human T-cell leukemia virus 1 infection
bta05167  Kaposi sarcoma-associated herpesvirus infection
bta05168  Herpes simplex virus 1 infection
bta05169  Epstein-Barr virus infection
bta05170  Human immunodeficiency virus 1 infection
bta05171  Coronavirus disease - COVID-19
bta05200  Pathways in cancer
bta05206  MicroRNAs in cancer
bta05208  Chemical carcinogenesis - reactive oxygen species
bta05212  Pancreatic cancer
bta05215  Prostate cancer
bta05220  Chronic myeloid leukemia
bta05221  Acute myeloid leukemia
bta05222  Small cell lung cancer
bta05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bta05417  Lipid and atherosclerosis
bta05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    281854 (IKBKB)
   04014 Ras signaling pathway
    281854 (IKBKB)
   04064 NF-kappa B signaling pathway
    281854 (IKBKB)
   04668 TNF signaling pathway
    281854 (IKBKB)
   04068 FoxO signaling pathway
    281854 (IKBKB)
   04151 PI3K-Akt signaling pathway
    281854 (IKBKB)
   04150 mTOR signaling pathway
    281854 (IKBKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    281854 (IKBKB)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    281854 (IKBKB)
   04621 NOD-like receptor signaling pathway
    281854 (IKBKB)
   04622 RIG-I-like receptor signaling pathway
    281854 (IKBKB)
   04623 Cytosolic DNA-sensing pathway
    281854 (IKBKB)
   04625 C-type lectin receptor signaling pathway
    281854 (IKBKB)
   04660 T cell receptor signaling pathway
    281854 (IKBKB)
   04658 Th1 and Th2 cell differentiation
    281854 (IKBKB)
   04659 Th17 cell differentiation
    281854 (IKBKB)
   04657 IL-17 signaling pathway
    281854 (IKBKB)
   04662 B cell receptor signaling pathway
    281854 (IKBKB)
   04062 Chemokine signaling pathway
    281854 (IKBKB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    281854 (IKBKB)
   04920 Adipocytokine signaling pathway
    281854 (IKBKB)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    281854 (IKBKB)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    281854 (IKBKB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    281854 (IKBKB)
   05206 MicroRNAs in cancer
    281854 (IKBKB)
   05208 Chemical carcinogenesis - reactive oxygen species
    281854 (IKBKB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    281854 (IKBKB)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    281854 (IKBKB)
   05221 Acute myeloid leukemia
    281854 (IKBKB)
   05220 Chronic myeloid leukemia
    281854 (IKBKB)
   05215 Prostate cancer
    281854 (IKBKB)
   05222 Small cell lung cancer
    281854 (IKBKB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    281854 (IKBKB)
   05170 Human immunodeficiency virus 1 infection
    281854 (IKBKB)
   05161 Hepatitis B
    281854 (IKBKB)
   05160 Hepatitis C
    281854 (IKBKB)
   05171 Coronavirus disease - COVID-19
    281854 (IKBKB)
   05164 Influenza A
    281854 (IKBKB)
   05162 Measles
    281854 (IKBKB)
   05168 Herpes simplex virus 1 infection
    281854 (IKBKB)
   05163 Human cytomegalovirus infection
    281854 (IKBKB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    281854 (IKBKB)
   05169 Epstein-Barr virus infection
    281854 (IKBKB)
   05165 Human papillomavirus infection
    281854 (IKBKB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    281854 (IKBKB)
   05135 Yersinia infection
    281854 (IKBKB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    281854 (IKBKB)
   05142 Chagas disease
    281854 (IKBKB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    281854 (IKBKB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    281854 (IKBKB)
   05418 Fluid shear stress and atherosclerosis
    281854 (IKBKB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    281854 (IKBKB)
   04936 Alcoholic liver disease
    281854 (IKBKB)
   04932 Non-alcoholic fatty liver disease
    281854 (IKBKB)
   04931 Insulin resistance
    281854 (IKBKB)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    281854 (IKBKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bta01001]
    281854 (IKBKB)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     281854 (IKBKB)
Protein kinases [BR:bta01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   281854 (IKBKB)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo ubiquitin YrbL-PhoP_reg APH Glyco_hydro_65m
Other DBs
NCBI-GeneID: 281854
NCBI-ProteinID: NP_776778
Ensembl: ENSBTAG00000007599
VGNC: 106778
UniProt: Q95KV0
Position
27:37127753..37180365
AA seq 756 aa
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLNHPNVVAARDVPEGMQSLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
MDIVVSEDLNGAVKFSSSLPHPNNLNSVLAQRLEKWLQLMLMWHPRQRGTDPVYGPNGCF
KALDDILNLKLLHVLNMVTGTLHTYPVTEDESLQSLKARIRQDTGILEEDQELLQEAGLA
LIPDKPAAQCLSDGKLNEGRTLDMDLVFLFDNSRVTYESQVSPQPQPESVSCILQEPKRN
LPFFQLRKVWGQVWHSIQALKEDCSRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQG
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMSEDEKMVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSHPCQLMSQPCTAPDSLPEAAEKSEDLVAEAHTLCTQLE
NALQDTMKEQDQSLRSLDWSWLQSEEEEQQSLERAS
NT seq 2271 nt   +upstreamnt  +downstreamnt
atgagctggtcaccttccctgccaacccagacatgtggggcctgggaaatgaaagagcgt
cttgggacagggggatttgggaacgtcatccgatggcacaatcaggagacgggcgagcag
atcgccatcaagcagtgccggcaagagctcagtccccggaaccgcgagcgctggtgcctg
gagatccagatcatgaggaggctgaaccaccccaatgtggtggccgcccgggacgtccct
gaaggcatgcagagcctggctcccaacgacctgcccctgctggccatggagtactgccag
ggcggggacctgcgcaagtacctgaaccagtttgagaactgctgcggcctgcgggaagga
gccatcctcaccttgctgagcgacattgcctctgcacttcgataccttcatgagaacaga
atcatccatcgggatctgaagccagaaaacattgtcctgcagcaaggggaacagagatta
atacacaaaattattgacctgggatacgccaaggagctggaccagggcagcctctgcacg
tccttcgtggggaccctgcagtacctggcccccgagctgctggagcagcagaagtacacg
gtgaccgtggactactggagcttcggcaccttggccttcgagtgcatcaccggcttccgg
cctttcctgcccaactggcagcccgtgcagtggcactccaaagtccggcagaagagcgag
atggacattgtggtgagcgaggacctgaacggggccgtgaagttctccagctcgctgccg
caccccaacaacctcaacagcgtcctggcccagcggctggagaagtggctgcagctgatg
ctgatgtggcacccgcgccagaggggcaccgaccctgtctacgggcccaacggctgcttc
aaggccctggacgacatcttgaacttgaagctgcttcatgtcctgaacatggtcacgggc
accctgcacacctaccccgtgaccgaggacgagagcctgcagagcctgaaggcccgcatc
cgccaggacacaggcatcctcgaggaggaccaggagctgctgcaggaggcagggctggcc
ctgatccccgacaagcctgccgcccagtgcctctcggacggcaagctgaacgagggccgc
acgctggacatggacctcgttttcctctttgacaacagcagggtcacctatgaaagccag
gtctccccacagccccagcctgaaagcgtcagctgcatcttgcaagagcccaagaggaac
ctcccgttcttccagctgcggaaggtgtggggccaagtctggcacagcatccaggccctg
aaggaagactgcagccgcctgcagcagggccagcgcgcggccatgatgaatctgctgcgg
aacaacagctgtctgtccaagatgaagaactccatggcctccatgtctcagcagctcaag
gccaagctggacttctttaagactagtatccagattgacctggagaagtacagggagcag
acggagtttgggatcacgtcggacaagctgctgctagcctggagggagatggagcaggcc
gtggagctctgcggacgggagaacgaggtgaagcacttggtggagcggatgatggccctg
cagacggacatcgtggacctgcagcgcagccccatgggccggaagcagggcgggacgctg
gatgatctggaagagcaggcgcgggagctttaccgcaggctgagggagaagcccagagac
cagcggactgatggtgacagtcaggaaatggtgcggctgctcctccaggcaatccaaggc
tttgagaagaaagtgcgagtgatttatacgcagctcagtaagaccgtggtctgcaagcag
aaggccctggaactgctgcccaaggtggaggaggtggtcagcctgatgagcgaggacgag
aagatggtggtgcggctgcaggagaagcggcagaaggagctctggaacctcctgaagatt
gcgtgtagcaaggtccggggtcccgtcagcggaagcccggacagtatgaacgcctcccgc
ctgagtcacccctgccagctgatgtcacagccctgcacggctcccgacagcttgcccgag
gccgccgagaagagtgaggacctggtggctgaagctcacaccctgtgcacccagctggag
aacgccctgcaggacaccatgaaggagcaggaccagagtttgaggtctctagactggagc
tggttgcagtcggaggaggaggaacagcagagcctggagcgggcctcgtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (56)   
   KEGG PATHWAY (56)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (9)   
   RefSeq(nuc) (3)   
   GenBank (3)   
   EMBL (3)   
Protein domain (10)   
   Pfam (10)   
All databases (92)   

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