KEGG   Bos taurus (cow): 404181
Entry
404181            CDS       T01008                                 
Symbol
RPS6KB1
Name
(RefSeq) ribosomal protein S6 kinase beta-1
  KO
K04688  ribosomal protein S6 kinase beta [EC:2.7.11.1]
Organism
bta  Bos taurus (cow)
Pathway
bta01521  EGFR tyrosine kinase inhibitor resistance
bta01522  Endocrine resistance
bta04012  ErbB signaling pathway
bta04066  HIF-1 signaling pathway
bta04140  Autophagy - animal
bta04150  mTOR signaling pathway
bta04151  PI3K-Akt signaling pathway
bta04152  AMPK signaling pathway
bta04211  Longevity regulating pathway
bta04213  Longevity regulating pathway - multiple species
bta04350  TGF-beta signaling pathway
bta04371  Apelin signaling pathway
bta04666  Fc gamma R-mediated phagocytosis
bta04714  Thermogenesis
bta04910  Insulin signaling pathway
bta04931  Insulin resistance
bta05163  Human cytomegalovirus infection
bta05165  Human papillomavirus infection
bta05170  Human immunodeficiency virus 1 infection
bta05200  Pathways in cancer
bta05205  Proteoglycans in cancer
bta05207  Chemical carcinogenesis - receptor activation
bta05210  Colorectal cancer
bta05212  Pancreatic cancer
bta05221  Acute myeloid leukemia
bta05224  Breast cancer
bta05225  Hepatocellular carcinoma
bta05226  Gastric cancer
bta05231  Choline metabolism in cancer
bta05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    404181 (RPS6KB1)
   04350 TGF-beta signaling pathway
    404181 (RPS6KB1)
   04371 Apelin signaling pathway
    404181 (RPS6KB1)
   04066 HIF-1 signaling pathway
    404181 (RPS6KB1)
   04151 PI3K-Akt signaling pathway
    404181 (RPS6KB1)
   04152 AMPK signaling pathway
    404181 (RPS6KB1)
   04150 mTOR signaling pathway
    404181 (RPS6KB1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    404181 (RPS6KB1)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    404181 (RPS6KB1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    404181 (RPS6KB1)
  09149 Aging
   04211 Longevity regulating pathway
    404181 (RPS6KB1)
   04213 Longevity regulating pathway - multiple species
    404181 (RPS6KB1)
  09159 Environmental adaptation
   04714 Thermogenesis
    404181 (RPS6KB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    404181 (RPS6KB1)
   05205 Proteoglycans in cancer
    404181 (RPS6KB1)
   05207 Chemical carcinogenesis - receptor activation
    404181 (RPS6KB1)
   05231 Choline metabolism in cancer
    404181 (RPS6KB1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    404181 (RPS6KB1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    404181 (RPS6KB1)
   05212 Pancreatic cancer
    404181 (RPS6KB1)
   05225 Hepatocellular carcinoma
    404181 (RPS6KB1)
   05226 Gastric cancer
    404181 (RPS6KB1)
   05221 Acute myeloid leukemia
    404181 (RPS6KB1)
   05224 Breast cancer
    404181 (RPS6KB1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    404181 (RPS6KB1)
   05163 Human cytomegalovirus infection
    404181 (RPS6KB1)
   05165 Human papillomavirus infection
    404181 (RPS6KB1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    404181 (RPS6KB1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    404181 (RPS6KB1)
   01522 Endocrine resistance
    404181 (RPS6KB1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bta01001]
    404181 (RPS6KB1)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     404181 (RPS6KB1)
Protein kinases [BR:bta01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   404181 (RPS6KB1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like Pkinase_fungal ABC1 DUF1015
Other DBs
NCBI-GeneID: 404181
NCBI-ProteinID: NP_991385
BGD-bta: BT27438
Ensembl: ENSBTAG00000016851
VGNC: 34146
UniProt: Q6TJY3
Position
19:10841303..10877730
AA seq 527 aa
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSALSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNLEL
NT seq 1584 nt   +upstreamnt  +downstreamnt
atgaggcgacgaaggaggcgggacggtttctacccagcgccggacttccgagacagggaa
gctgaggacatggcaggggtgtttgacatagacctggaccagccagaggacgcgggctct
gaggatgagctggaggaggggggtcagttaaatgaaagcatggaccatgggggggttgga
ccatatgaacttggcatggaacattgtgagaagtttgaaatctcagaaactagtgtgaac
agagggccagaaaaaatcagaccagaatgttttgagctccttcgagtacttggtaaaggg
ggctatggaaaggtttttcaagtacgaaaagtaacaggagcaaataccgggaaaatattt
gccatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaagatacagctcataca
aaagcagaacggaatattctggaggaagtaaagcatcctttcattgtggatttaatttat
gcctttcagaccggtggaaaactctacctcatccttgagtatctcagtggaggagaatta
tttatgcagttagaaagagaaggaatatttatggaagacacagcctgcttttacttggca
gaaatctccatggctttggggcatttacatcaaaaggggatcatctacagagacctgaag
ccggagaatatcatgcttaatcaccaaggtcacgtcaaactaacagattttggactatgc
aaagaatctattcatgacggaacagtcacacacaccttttgtggaacaatagaatacatg
gcccctgagatcttgatgagaagtggccacaatcgtgctgtggattggtggagtttggga
gcattaatgtatgacatgctgactggagcacccccgttcactggggagaatagaaagaaa
acaattgacaaaatcctcaaatgtaaactcaatttgcctccctacctcacgcaagaagcc
agagatctgcttaaaaagctgctgaaaagaaatgctgcttctcgtcttggagctggtcct
ggggatgctggagaagttcaagctcatccattcttcagacatattaactgggaagaactg
ctggctcggaaggtggagccccccttcaaacctcttttgcaatcagaagaggatgtgagt
cagtttgattccaagtttacacgtcagacacctgttgacagcccagatgactcagctctc
agtgaaagtgccaaccaggtctttctgggttttacatatgtggctccatctgtacttgaa
agcgtgaaagaaaagttttcctttgaaccaaaaatccgatcccctcgaagatttattggc
agcccacgaacacctgtcagcccagtcaaattttctcctggggatttctggggaagaggt
gcttcagccagcacggcaaatccgcagacgcctgtggaataccccatggagacaagtggg
atagagcagatggacgtgacgatgagcggggaggcttcagcaccgcttccaatacgacag
ccaaactccggaccgtacaaaaaacaagcttttcccatgatctccaaacgaccagagcac
ctgcgtatgaatctagagctctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (30)   
   KEGG PATHWAY (30)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   BGD-BTA (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
Protein domain (7)   
   Pfam (7)   
All databases (59)   

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