KEGG   Bos taurus (cow): 517948Help
Entry
517948            CDS       T01008                                 

Gene name
PIK3CB, PI3K, PI3Kbeta
Definition
phosphoinositide-3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
bta  Bos taurus (cow)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:bta00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    517948 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    517948 (PIK3CB)
   04015 Rap1 signaling pathway
    517948 (PIK3CB)
   04012 ErbB signaling pathway
    517948 (PIK3CB)
   04370 VEGF signaling pathway
    517948 (PIK3CB)
   04630 Jak-STAT signaling pathway
    517948 (PIK3CB)
   04668 TNF signaling pathway
    517948 (PIK3CB)
   04066 HIF-1 signaling pathway
    517948 (PIK3CB)
   04068 FoxO signaling pathway
    517948 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    517948 (PIK3CB)
   04024 cAMP signaling pathway
    517948 (PIK3CB)
   04022 cGMP - PKG signaling pathway
    517948 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    517948 (PIK3CB)
   04152 AMPK signaling pathway
    517948 (PIK3CB)
   04150 mTOR signaling pathway
    517948 (PIK3CB)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    517948 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    517948 (PIK3CB)
  Cellular commiunity
   04510 Focal adhesion
    517948 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    517948 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    517948 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    517948 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    517948 (PIK3CB)
   04660 T cell receptor signaling pathway
    517948 (PIK3CB)
   04662 B cell receptor signaling pathway
    517948 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    517948 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    517948 (PIK3CB)
   04670 Leukocyte transendothelial migration
    517948 (PIK3CB)
   04062 Chemokine signaling pathway
    517948 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    517948 (PIK3CB)
   04915 Estrogen signaling pathway
    517948 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    517948 (PIK3CB)
   04917 Prolactin signaling pathway
    517948 (PIK3CB)
   04921 Oxytocin signaling pathway
    517948 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    517948 (PIK3CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    517948 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    517948 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    517948 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    517948 (PIK3CB)
   04722 Neurotrophin signaling pathway
    517948 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    517948 (PIK3CB)
  Development
   04380 Osteoclast differentiation
    517948 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    517948 (PIK3CB)
   05230 Central carbon metabolism in cancer
    517948 (PIK3CB)
   05231 Choline metabolism in cancer
    517948 (PIK3CB)
   05205 Proteoglycans in cancer
    517948 (PIK3CB)
   05203 Viral carcinogenesis
    517948 (PIK3CB)
   05210 Colorectal cancer
    517948 (PIK3CB)
   05212 Pancreatic cancer
    517948 (PIK3CB)
   05214 Glioma
    517948 (PIK3CB)
   05221 Acute myeloid leukemia
    517948 (PIK3CB)
   05220 Chronic myeloid leukemia
    517948 (PIK3CB)
   05218 Melanoma
    517948 (PIK3CB)
   05211 Renal cell carcinoma
    517948 (PIK3CB)
   05215 Prostate cancer
    517948 (PIK3CB)
   05213 Endometrial cancer
    517948 (PIK3CB)
   05222 Small cell lung cancer
    517948 (PIK3CB)
   05223 Non-small cell lung cancer
    517948 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    517948 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    517948 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    517948 (PIK3CB)
   05166 HTLV-I infection
    517948 (PIK3CB)
   05162 Measles
    517948 (PIK3CB)
   05164 Influenza A
    517948 (PIK3CB)
   05161 Hepatitis B
    517948 (PIK3CB)
   05160 Hepatitis C
    517948 (PIK3CB)
   05169 Epstein-Barr virus infection
    517948 (PIK3CB)
   05146 Amoebiasis
    517948 (PIK3CB)
   05145 Toxoplasmosis
    517948 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    517948 (PIK3CB)
Enzymes [BR:bta01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     517948 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
BGD-bta: 
Ensembl: 
Position
1
AA seq 1070 aa AA seqDB search
MCFYFMMPPAMADVLDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISCIKQMLW
KQVTNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGRGLHEFDALKDPEVNEFRIKMRRFSEEKIQSLVGLSWMDWLKHTYPPEL
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHSLIQFQYIRNCVMNRTLPHFILVECCKIKKLYEQEMVAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEPLEFDINTCDLPRMTRLCFAVYAVLDKVKTKKSTKTM
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPHALPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKALSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKTEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttctacttcatgatgcctcctgctatggcagacgtccttgacatctgggcagtg
gactcacagatagcgtctgatggctccatacccgtggattttcttttgcccactgggatt
tatatccagttggaggtgcctcgtgaagctaccatttcctgtattaagcagatgttatgg
aaacaagttaccaattacccaatgtttaacctccttatggaaatcgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggaactcgaagatgaaacaagaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaagaggtctgcatgaatttgatgccttg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcagattcagtgaggaaaagatt
cagtcgcttgtgggattatcttggatggattggctaaagcatacctatccacctgagctt
gaaccatccatccctgaaaatttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagttttcaggtatctcctaatatgaatcct
atcaaaataaatgaattggcaatccaaaaacgtctgactattcatgggaaagaagatgaa
gttagcccttatgactatgtgttgcaagtcagtgggagagtagaatatgtgtttggtgat
cactcactaattcagttccagtatatccggaactgtgtaatgaacagaacattgccccat
tttatacttgtggaatgttgcaagatcaagaagctgtatgaacaggagatggttgccata
gaggctgccataaatcgaaattcatctaaccttcctcttcctttaccaccaaagaaaact
cgaattatttctcatgtttgggaaaataacaatcctttccaaattgtcttggttaaagga
aataaacttaacacagaagaaactgtaaaagttcatgtcagggccggcctttttcatggt
accgaactcctgtgtaaaactgtcgtaagctcagagatatcagggaagaatgatcatatt
tggaatgaaccactggaatttgatatcaacacttgtgacctgccacgaatgactcgatta
tgttttgctgtttatgcagttttggataaagtgaaaactaagaaatcaactaaaaccatg
aatccctctaagtatcagaccatcaggaaatctggaaaagtgcattatcctgtagcctgg
gtaaatacgatggtttttgactttaaaggacagttgagatctggagatataatattacac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatacagaaaatgcaacagctttgcacataaaattcccagagaataaaaaa
caaccttattactatcctcccttcgataagattattgaaaaagcagctgagattgcaagc
agtgatagtgctaatgtatcaagtcgaggtggaaagaagtttcttgctgtactgaaagaa
atcttggacagggatcctttgtctcaactgtgtgagaatgaaatggatcttatttggact
ttgcgacaagactgcagagagaatttcccacacgcgttgccgaaattgctgctgtcgatc
aagtggaataaacttgaggatgttgctcagcttcaagcactgcttcagatttggcctaaa
ctgcccccccgggaggcccttgagcttctagatttcaactatccagatcagtatgtgcga
gaatatgctgtgggctgcctgcaacagatgagtgatgaagaactctctcaatatctttta
cagttggtgcaagttttaaaatatgagccttttcttgattgtgccttgtctagattccta
ctagaaagagcacttgctaatcggaggatagggcagtttttattttggcacctcagatct
gaagtacacattcctgctgtttcagtacaatttggtgttatccttgaagcgtactgccgg
ggaagcgtaggtcacatgaaggcgctttctaagcaggttgaagcactcaataaactaaaa
actttaaatagtttaatcaaactgaatgcaatgaagctaaatagagccaaagggaaagaa
gcaatgcacacttgtttaaaacagaatgcttaccgtgaagccctctctgacctgcagtca
cctctcaacccatgtgttatcctctcagaactctatgttgagaagtgtaaatacatggat
tccaaaatgaagcctttgtggcttgtgtacaacaacaaggtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacggcaggatatgttgacactccaaatgctg
cgcttgatggatttactctggaaagaagctggtctggaccttcggatgctaccttacggc
tgcttagcaacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgttgctgcagcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggag
tttaccctatcctgtgccggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgataacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggagcgagtgccttttattctt
acttatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaaatttggc
cggttccgccagtgttgtgaggatgcatatctgattttacgccggcatgggaatctcttc
atcacgctctttgcactgatgttgactgcagggcttcctgagctcacctcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagactgaagaagaagcactcaagcaa
ttcaagcaaaaatttgatgaggcactcagggaaagttggactactaaagtcaattggatg
gcccacacagttcgcaaagactacagatcttaa

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