KEGG   Caenorhabditis elegans (nematode): CELE_D2085.1
Entry
CELE_D2085.1      CDS       T00019                                 
Symbol
pyr-1
Name
(RefSeq) Glutamine-dependent carbamoyl-phosphate synthase
  KO
K11540  carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
Organism
cel  Caenorhabditis elegans (nematode)
Pathway
cel00240  Pyrimidine metabolism
cel00250  Alanine, aspartate and glutamate metabolism
cel01100  Metabolic pathways
cel01240  Biosynthesis of cofactors
Module
cel_M00051  De novo pyrimidine biosynthesis, glutamine (+ PRPP) => UMP
Brite
KEGG Orthology (KO) [BR:cel00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    CELE_D2085.1 (pyr-1)
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    CELE_D2085.1 (pyr-1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:cel01002]
    CELE_D2085.1 (pyr-1)
Enzymes [BR:cel01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.2  aspartate carbamoyltransferase
     CELE_D2085.1 (pyr-1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.3  dihydroorotase
     CELE_D2085.1 (pyr-1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5  carbamoyl-phosphate synthase (glutamine-hydrolysing)
     CELE_D2085.1 (pyr-1)
Peptidases and inhibitors [BR:cel01002]
 Cysteine peptidases
  Family C26: gamma-glutamyl hydrolase family
   CELE_D2085.1 (pyr-1)
 Metallo peptidases
  Family M38: beta-aspartyl dipeptidase family
   CELE_D2085.1 (pyr-1)
SSDB
Motif
Pfam: CPSase_L_D2 GATase OTCace_N CPSase_sm_chain OTCace CPSase_L_D3 MGS ATP-grasp Dala_Dala_lig_C ATPgrasp_Ter Amidohydro_1 ATP-grasp_3 Peptidase_C26 DJ-1_PfpI GSH-S_ATP ATP-grasp_5
Other DBs
NCBI-GeneID: 174385
NCBI-ProteinID: NP_495838
WormBase: WBGene00004259
Ensembl: WBGene00004259
UniProt: Q18990
Position
II:8651109..8658726
AA seq 2198 aa
MRATLHLEDGSTFVGSIYGATKSVVGEIVFQTGMVGYVESLTDPSYAKQLLTLTYPLIGN
YGVPSAEILDQFKLPAEFESDRIWPAALIVEKICVDGEHSHWQAVQSLSEWLRKADVPCL
SGIDVRQLVKKIRETGTMKAKLVIESDNAQNFDYVDVNAENLVDFVSRKEPVVYGSGDQT
ILAVDCGLKNNQIRCLAKRGFRVKVVPWNHPIDTESDYDGLFLSNGPGDPEICAPLVDRL
AKVIARGDKPIFGICLGHQILSRAIGAKTYKLKYGNRGHNQPCTHYATGRCYITSQNHGY
AVDPDSLPADWKALFTNENDKTNEGIVHSSKPFFSVQFHPEHTAGPTDCEFLFDVFADSV
RQAKSGTFMNVDQELTRLMTFTPIYHAKEQRKVLVLGSGGLTIGQAGEFDYSGAQALKAL
REEGIRTVLINPNIATVQTSKGFADFTYFLPITKEYVTDVIKKERPTGILCTFGGQTALN
CAIDLYKDGIFEQYDVQVLGTQINTIMKTEDRDLFNQEISAIGEKVAPSKAATTMEGAIE
AAEELGYPVLVRAAYALGGLGSGFADNREELIAIAQQALAHSNQVLVDKSLKGWKEVEYE
VVRDAYDNCITVCNMENVDPLGIHTGESVVVAPSQTLSDREYNALRTCAIKVIRHLGIIG
ECNIQYALDPYSLTYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGQHLPVIRNSVT
GTTTACFEPSLDYCVVKIPRWDLGKFARVSTQIGSSMKSVGEVMGIGRCFEEALQKALRM
VSDHADGFSPYTFSRPTTADDLSKPTDKRMFALARGMYYGDFDVEKAHELTRIDRWFLFR
MQNIVDIYHRLEKTDVNTVSAELLLEAKQAGFSDRQIAKKIGSNEYTVREARFVKGITPC
VKQIDTVAGEWPAQTNYLYTTFNGIENDVSFNMKNAVMVLGSGVYRIGSSVEFDSSCVGC
IRELKALGYSTITVNCNPETVSTDYDICDRLYFEEISFETVLDVYHLEKPKGVILAFGGQ
APNNIAMSLSRAQVKIFGTSPNDIDNAEDRFKFSRKLESLKISQPQWKKSENMEDAKNFC
AQVGYPCLIRPSYVLSGAAMNVAHNAEDLEVFLKQAAVVAKEHPVVVSKFINEAKELDVD
AVALDGKLVVMAVSEHIENAGVHSGDATLVTPAQDMNKLTLDRIKDITFRIAEAFNVNGP
FNMQLIAKNNELKVIECNLRVSRSFPFVSKTLDYDFVALATRAMMASDSPAIRATIKPTA
TLLKGKGRVGVKVPQFSFSRLAGADVMLGVEMASTGEVACFGTSRCDAYLKALLSTGFVV
PKQNIFISIGGYHAKAEMLKSVEALLKLGYELYGSKGTADYFQSNKINVKPVDWPFEEGS
SDEKTASGTRSVVEFLENKEFHLVINLPIRGSGAYRVSAFRTHGYKTRRMAIDNGIPLIT
DIKCAKTFIQALEMVGKRPTMNSLVDCVTSKSLKRLPGMVDIHVHVREPGATHKEDWATC
SKAALAGGVTTILAMPNTSPVLVDTDSFYQTEQLASAKSVVDYALYIGATPNNSKFAAEF
ADKAAGLKMYLNETFSTLKMDNISDWAKHLSAFPANRPIVCHAEKQTLAAILCMAQMANR
AVHIAHVATADEINLVKEAKQRGWNVTCEVCPHHLFLIEEDLPDGIREVRPRLVKPEDRQ
ALWDNMEYIDCFATDHAPHTWAEKTGKDGKIPPGFPGVEYMLPLLLTAVHDGKLTMKELT
DRMSTNPRRIFNLPPQDDTYIEVDLNEEWTIPENGGQSKAGWTPFAGRKVFGKVHNVIIR
GEEAVIDGRIVAIPGFGKNVRLYPHSGTAHRGDSDFDQILEPIPQQMIESSSDEQSPLHT
PPRAHTPIAFPGELLAKNCISVKHLDKGQINRIFELADRYKHDVEKGHPLTHILNGKVLV
NLFYEVSTRTSCSFSAAMQRLGGSVISVDSQSSSVQKGETLEDTVQVLGSYGDILVLRSN
ENGAADRAARVCDQPVINGGDGTGEHPTQALLDVYTIRQEMGTVNGLTIALVGDLKNGRT
VHSLAKLLCLYKDITLHYVAPSTELEMPQEVLDYVSSKSNFVQKKFTSLAEGINHVDVVY
VTRIQKERFSSPDEYNKVKGSYVINAKLLNEAARDVEEPSSLLVPARSLPIVMHPLPRVD
EIAVELDHDERAAYFRQAKNGVFVRMSILSLLLGRGHL
NT seq 6597 nt   +upstreamnt  +downstreamnt
atgagagcgactttgcatctcgaggacgggtccacttttgtgggctccatttatggagca
accaaaagtgtagttggagaaattgtttttcaaaccggaatggttggttatgtggaatct
cttaccgatccatcatacgccaagcagcttctcacacttacatatccacttattggaaat
tacggagttccatctgcagagattctggatcagttcaagctaccagctgaatttgagtct
gacaggatctggccagcagctctcattgttgagaaaatttgtgtcgatggagaacacagt
cattggcaagcagttcagtcgttatcagaatggctcagaaaagctgatgttccatgtctt
tccggaattgatgttcgccaattggtgaagaaaatcagagagactggaacaatgaaggcg
aagcttgtgatcgaatcagacaatgcacaaaacttcgactacgttgacgtcaatgctgaa
aatttggttgacttcgtgtcgagaaaagagccagttgtctatggatccggtgatcaaacc
attctcgcagttgattgtggtctcaagaataatcaaattagatgtctcgcaaaacgagga
tttcgtgtcaaagtggttccttggaatcatccaattgatactgaaagtgattatgatgga
cttttcctttccaacggaccaggagatccagaaatttgtgcaccactggtcgatcgatta
gccaaagttattgcaagaggagacaaaccaatttttggaatttgtctcggacaccaaatt
ttgtctagagctatcggagcgaaaacctacaaattgaaatacggtaaccgtggtcacaat
cagccatgcactcattatgctactggccgttgctacatcacttctcaaaatcatggatac
gcagttgatccagattcacttccagctgattggaaggcacttttcacgaatgagaatgac
aagaccaacgaaggaattgtgcactcgtctaaaccatttttcagtgttcaattccatcca
gaacacactgccgggccaactgattgcgagtttttgttcgatgtttttgctgattctgtg
agacaagcaaagagtggcacattcatgaatgtcgatcaagagctcactcgtcttatgact
ttcactcccatctatcatgccaaagaacagagaaaagttctcgttctcggatcaggcggt
ctcactattggtcaagctggagagtttgattattctggggctcaagctctgaaggcattg
agagaagaaggaattcgaacagttctcatcaacccaaacattgctacagttcaaacctcc
aaaggctttgctgatttcacttacttccttccaatcactaaagaatacgttaccgatgtg
atcaagaaggagcgaccaactggaatcttgtgtacctttggaggtcaaactgctctcaac
tgcgccatcgacttgtataaagatggaatttttgagcaatacgatgtgcaggttcttgga
actcaaatcaacacaattatgaaaacagaagatcgcgatttgttcaatcaagaaatttcg
gctattggagaaaaggttgcaccaagtaaagcagcgacgaccatggaaggtgccattgaa
gcagctgaagagttgggttatccagttcttgtcagagccgcatatgctcttggtggactt
ggatcaggattcgctgacaaccgggaagagctcattgcaattgctcaacaagctttagca
cactcaaatcaggttcttgttgataagagtttgaaaggatggaaggaagtggaatatgaa
gttgttcgggacgcttacgataattgtattaccgtttgcaacatggaaaatgtggatcca
cttggaattcatactggtgaaagtgttgttgttgcaccatctcaaactctttctgacaga
gaatacaatgctcttagaacatgtgcaatcaaagttattcggcacttgggaattattgga
gagtgtaatattcaatacgctctggatccgtattccttgacttattacattatcgaagtc
aatgcacgactttctcgttcttctgctcttgcctcaaaagccaccggatacccattggca
tatgttgctgcaaagttggcattgggacaacatctgccagtcatccgaaatagtgtcact
ggaaccacaactgcatgctttgagccaagtttggactattgtgttgtgaagattcctcgt
tgggatcttggaaaattcgctcgtgtcagcacacaaattggaagctctatgaaatcagtt
ggagaagtcatgggaatcgggagatgctttgaagaggctcttcagaaggcgttgagaatg
gtgtccgatcatgctgacggtttctctccatacacattcagtcgtcctacaacagctgat
gatctttcaaagcctacagataagagaatgtttgcattggcacgtggaatgtattatgga
gactttgatgttgaaaaagctcacgagctgacacgtattgatcgttggttcttgttcaga
atgcagaacatcgttgatatttaccatcgcctcgaaaagactgacgtcaatacagtatct
gctgaactgctcctggaggcgaaacaagcaggattctccgacagacaaatagcaaagaaa
atcggaagcaacgaatacacagttcgcgaagctcgtttcgtcaaaggaatcactccttgc
gtgaagcaaattgacacagttgctggagaatggcctgctcagacaaactacctctacaca
acattcaatggaatagagaatgatgtttcattcaatatgaagaacgctgtgatggttctc
ggatcaggagtataccgaatcggttcttcagttgaatttgattcttcttgcgttggatgc
atcagagagttgaaggctttgggatactctacaatcaccgtcaattgcaatcctgaaact
gtttctacggattatgatatttgtgatcgattgtattttgaagagatttcttttgaaacc
gttctcgacgtttatcatttggaaaaaccaaagggagtgattctggcatttggaggtcaa
gcaccgaataacattgcgatgagcttgagcagagctcaggtgaagatctttggaacttca
ccaaacgacattgataacgcagaagatagattcaagttctcaagaaaattggaatctttg
aaaatcagccagccacaatggaagaaaagcgaaaatatggaagatgctaagaacttctgt
gctcaagttggatatccatgcttgatccgtccttcatatgttttatctggtgcagcaatg
aatgtggctcacaacgctgaagacttggaagtctttctcaagcaagctgctgtggtcgcc
aaggagcatccagttgttgtgagcaaatttatcaatgaagcgaaggaattggatgtagat
gcagttgcccttgatggaaaactcgttgtaatggctgtcagtgaacatattgaaaatgca
ggtgttcattcgggagatgctactcttgtcactccagctcaggatatgaacaaactgaca
ttggatagaatcaaggatatcactttcagaatcgctgaagcatttaatgtcaacggacct
ttcaatatgcagctcattgctaaaaataacgaactcaaagttattgaatgcaacttgcga
gtatccagatcattcccgttcgtctcaaaaactctcgattacgattttgtggctttggct
actcgtgcaatgatggcttcagattcacctgcaattcgagctacaatcaaaccaacagcc
accttgctcaaaggaaagggaagagtcggagtgaaggttcctcaattctctttctcaaga
ctcgctggtgccgatgtgatgcttggtgtcgagatggcttcaactggagaagttgcttgc
ttcggaacttcaagatgcgatgcctacctcaaagctttactctccactggtttcgttgtt
ccaaaacaaaatattttcatttccattggaggatatcacgcgaaggctgagatgctcaag
tctgtagaagcattgctgaagttgggatacgaattgtatggatccaaaggaactgccgac
tatttccaatcgaataagatcaatgtgaagccagtcgattggccttttgaagaaggatcg
tccgatgagaaaactgcaagtggaacaagatctgtagttgaattcctcgagaacaaagaa
ttccacttggtcatcaacctaccgattcgtggatcaggagcataccgagtctctgccttc
cgcactcatggttacaagacgagaaggatggcaattgacaatggaattcccttgataact
gatattaagtgtgctaagaccttcattcaagcccttgaaatggttggaaaacgtccaact
atgaattcattggtcgattgtgtgacttccaagagtttgaagcgtttgccaggaatggtt
gatattcatgtacatgttagagaaccaggagcaacacacaaagaagattgggcaacttgt
tcaaaggctgcactagctggaggtgttactacaattttggcaatgccaaacacttctcct
gttcttgtggatactgattccttctatcaaacggaacagttggcttctgcaaaatcggtc
gtcgactacgccctctacatcggagctactccaaacaattcgaagtttgcagcggagttt
gctgacaaagccgctggcttgaagatgtatctcaatgagacattcagtactctgaagatg
gataatatttcagactgggctaagcacctgagtgccttccctgctaatcgtccgatcgtc
tgtcacgccgagaagcaaacacttgccgccattctttgtatggctcagatggcgaataga
gcagttcacattgcccacgtcgctacggctgatgagattaatctcgtcaaggaagctaaa
caaagaggatggaatgttacctgtgaagtctgcccacatcatcttttcctcattgaagaa
gatcttcctgatggaattcgtgaagttcgtccacgtctcgtaaaaccagaagatcgtcag
gctctttgggacaacatggaatacattgattgttttgcaactgatcatgcacctcatacg
tgggctgagaagactggaaaagatgggaaaattccaccaggcttccctggagttgagtac
atgctcccacttcttcttacagctgtgcatgatggtaaattgaccatgaaggaactcact
gatcgtatgtccaccaatcctcgtcgaattttcaacttgcctccacaagatgatacctac
attgaggttgatttgaacgaagaatggacaattccagagaatggaggacagagcaaagct
ggatggactccatttgctggtagaaaagtgtttggaaaagtgcacaatgtgatcatcaga
ggagaagaagctgttattgatggaagaatcgttgcaattccaggattcggaaagaatgtc
cgtctttatccacactctggaactgctcatcgtggagattcagacttcgatcaaatcttg
gaaccaattcctcaacaaatgattgaaagttcttcagatgaacaaagtccacttcatact
ccacctagagctcatacgccgattgcattccctggagagcttcttgccaagaattgtatc
agtgtgaagcatcttgataagggccagatcaatcgtattttcgagttggcggaccgatac
aagcacgatgtcgaaaagggccacccattgacacatattctgaatggaaaagtattggtc
aatctattctacgaagtgtcaacaagaacatcttgctcgttctctgcagccatgcaacgt
cttggaggatctgtcatctctgttgatagtcaatcatcttcagttcaaaagggagaaact
ttggaagacacagtgcaggttttgggaagttacggagatattctggttctgagaagtaat
gagaatggagctgctgatagagctgctcgagtttgcgatcaaccggtcatcaatggaggt
gatggaactggtgaacatccaactcaagctcttctcgatgtgtacactattcgacaagaa
atgggaacagtcaatggacttaccatcgctttggttggagatttgaagaatggaagaacg
gttcactcattggctaaacttttatgtttgtataaggacatcacccttcactacgttgct
ccgagtaccgaacttgaaatgccacaggaagtcttggactacgtctcgtcgaagtcgaat
tttgttcagaagaagttcaccagtctggctgaaggaatcaatcatgtcgacgttgtctac
gtgacaagaattcaaaaagaacgattctcatctccagatgaatacaataaggtgaaagga
agctacgtaatcaatgcgaaacttctcaatgaggccgccagagatgtcgaggaaccatcg
agtctgttggttccagctcgttctcttccaatcgtcatgcatccattgcctcgtgtggat
gagattgctgttgaactggatcatgatgaaagagccgcctacttcagacaagcaaagaat
ggggtcttcgttcgtatgtctattctatcccttcttcttggaagagggcatctttaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (14)   
   KEGG COMPOUND (14)   
Chemical reaction (10)   
   KEGG ENZYME (3)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   WORMBASE (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (16)   
   Pfam (16)   
All databases (78)   

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