KEGG   Caenorhabditis elegans (nematode): CELE_B0348.4
Entry
CELE_B0348.4      CDS       T00019                                 
Symbol
egl-8
Name
(RefSeq) Phosphoinositide phospholipase C
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cel  Caenorhabditis elegans (nematode)
Pathway
cel00562  Inositol phosphate metabolism
cel01100  Metabolic pathways
cel04020  Calcium signaling pathway
cel04070  Phosphatidylinositol signaling system
cel04310  Wnt signaling pathway
cel04361  Axon regeneration
Module
cel_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cel00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    CELE_B0348.4 (egl-8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    CELE_B0348.4 (egl-8)
   04020 Calcium signaling pathway
    CELE_B0348.4 (egl-8)
   04070 Phosphatidylinositol signaling system
    CELE_B0348.4 (egl-8)
 09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    CELE_B0348.4 (egl-8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cel04131]
    CELE_B0348.4 (egl-8)
Enzymes [BR:cel01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     CELE_B0348.4 (egl-8)
Membrane trafficking [BR:cel04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    CELE_B0348.4 (egl-8)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    CELE_B0348.4 (egl-8)
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y PH_14 DUF1154 EF-hand_like C2
Other DBs
NCBI-GeneID: 178537
NCBI-ProteinID: NP_001300014
WormBase: WBGene00001177
Ensembl: WBGene00001177
UniProt: A0A0K3AXH8
Position
V:<20818..>43704
AA seq 1512 aa
MAKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVL
DMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVEL
AKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKM
VQKCLNDLGLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRL
YNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLK
KHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLT
GRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQI
RDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPN
RLRKKILIKNKRLKTDIERHQLDQFLREGKLDEEDELNETPEVVGEDSVSPRSGGSGGTG
APEEVDDDTSDDDDDPSVQTSLNVMRTIPTVNTTSNNGSNRSARSSLDTPSPSGGSLMVP
DRATSTATSIKNAVLARSPNFSSLRQKLSFKRRQSPLAGDQRAHPEVEQPVSSSSPATPS
ISGPPPCATSSGSTSSITITTTGCSTSSSGPSKHILGGEMPAKENDEAHPELKQNFIAKN
LKGFGFSKKQPDSSTSLLTASPTPSSSSMAMSNANNPFSSSTLNSPQPMERSRSEKRSFR
QKKGGVFGDELHSDSAALIDFMRTASSRKKKPVLTKEEEERIFAEYHYTGATTNIHPLLS
SLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKG
ARVDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRT
FDPFSESPVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGN
GLNPVYNEDPFVFRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTN
QSFILSPVLFVQIVIKTYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDV
PNTRNMALRHVKQPPRQNGSSADLLANNGQTGSARGDQTSSMASSTIRSPNEQPQPVAVD
KFKVDPIEVDDLRRDKAFAKLLKRFQKELDDLRKKHQKQRDSIQKQQPARRRNSSIAWIQ
TNVDKLITNNRRSTKKEKGSRRSLTASVSSGCGSASGTVTVSVCSPSGASCSGYSTGGPS
TPVACNSDGTGSPATIGSPVPQDLVNNDRVRSLVNTQTGEWSAMVRRHDEEEFELKKVQL
KEQFDLLRKLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAER
DRRVKELNEKNLKMFVEERKRLAMKAQKHEEQLTKRHLDQLEQLDKDFHKALDAEVGNYK
EEQLAAQPTSVV
NT seq 4539 nt   +upstreamnt  +downstreamnt
atggcaaaggagttccagttcaattggaagcccactattatccctgaacttcttcatgga
tcggttttcgatcgatatgatgatgaaagtacgtgtctggaactaaatgctcaagttcga
attgacgagaacggtttctttctccggtggctgatcgaaggaaaagatgctgtcgtactc
gatatgggccaaatatgggaagctcgcacgggcggcctacccaaagacggccgaattatg
ttcgaattggagcagcgcggagccagcgaaacgatagctgaacgcacgatatggatcacg
catggccaggatttagtcaatgttcagtcgttttttcttgtcgccgaaagtgtcgagttg
gcaaaaacgtgtagagcgggcattaatgatattctaaagtcgtccagaatacgacacgtg
tgtccaactacccaattgatgaaataccatacatggctcaccatgaatgtcaacgaacga
cgaaaaatcccgatcaagttgataatcaaaacattttcgtctggaaaacctgaaaaaatg
gttcaaaagtgtctaaatgacttgggtcttggaggcgataagtacacgccggcacgggtc
atcaatcgatcgatgggcaagaagtttcggaatttctacaagtgcagtcggggacgaaaa
cgaaaggagcgcgaagaacttgacgtcgacatcctcacctttgaaaaattccagaggctc
tataacaagatttgtccgagaaccgaagttcaagagctgtttgttaaattatccggacag
aaagagtacctaaccaaagagcgactcatcaattttctgaatgaagaacaacgtgatcca
cgactcaacgagatcctcttcccattttttgattctcagcgtatcgttgcgcttctcaaa
aaacacgaaaacgacataaaatatcaagaagatggaaaaatgtccggtgacgggtttctc
cgattcctgatgtcagacgagaacccgccagtgtttctagaccgaattgaaatgtttatg
gatatggatcaaccgctgtgtcactactacatcaatagttcccataacacgtatcttacc
ggacggcagtatggtggaaaatcgtcttctgagatttatcgacaagttttgctcagcgga
tgtaggtgtattgagcttgattgttgggatggtactggtgaaaataaaggagaacccatt
atcactcacggaaaggccatgtgcacagacgtgttcttcaaggacgtcctggtacaaatt
cgagacaccgcatttgcccggtcggattttccagtggtcctttccttcgaaaaccattgc
tcaaaatcaaatcagctgaaaatggccaaatattgtatggacatttttggagatatgctg
ctgtccaaaccgtttgaagatgcgcctcttgaccccggagtctccctaccttctccaaac
cgcctgcgaaagaagatccttatcaaaaataagcgattaaaaaccgacatcgaacgtcac
caacttgaccaatttctgcgggaaggcaaactggacgaggaggacgagctgaatgagacg
cccgaagttgtcggagaggactccgtatcacctcgaagcggcgggagcggtggcaccgga
gccccggaagaagtggatgatgacacgtccgacgacgacgatgacccgtcggttcagaca
tcgctgaacgtgatgcgcaccatcccgaccgtgaacaccacatcgaacaacggatcgaat
cgatcggcaagaagttcactggacaccccatccccatccggtgggagcctgatggttcca
gatagggcaacatcgacagcgacgtcgatcaagaacgccgtgctcgcgaggtctccgaac
ttctcctcgttgagacaaaagttgtcgttcaagcggagacaatcaccactagcaggcgat
cagcgtgctcatccggaagtcgagcaacccgtgagctcatcctctccagccacaccgtcc
atcagcggacccccgccgtgtgccacgtcatcaggttcaacgtcatcaatcactattacc
acaacgggatgctccacgtcatcgtcgggaccctcaaaacatattctagggggtgaaatg
cccgccaaggaaaacgacgaagcacatccggagctaaagcagaatttcattgctaaaaat
ttgaaaggattcgggttttcgaaaaaacaacctgattcatccacttcattgctaaccgca
tcaccaacaccgtcctcttcatcgatggccatgtcaaatgcgaataatccgttctcctcc
tcaacccttaactcaccccaaccaatggagaggtctcgaagcgaaaagcgatcgtttcga
cagaaaaagggcggcgttttcggtgacgaactccactcggactcggccgcacttatcgat
tttatgcggacggcgtcgagccgtaagaagaagccggtactgacaaaagaagaagaggag
cggattttcgccgagtatcattataccggggcaactacgaatatacatccgttactctct
tcactggtcaattatacacatcctgtcaagttttctggatttgacgttgcggaagccaac
aacctgcacttccacatgtcctcattttctgagtcaaccggtctcggctacctaaaacaa
tcggcgccggaatttgtgaactacaacaaacgacaatcgagtagaatttatccgaaagga
gccagagttgattcttccaattttttgccgcaaattttctggaacgccggatgtcaaatg
gtgtcgctcaactttcaaactcccgatgtctacatgcaattgaacatgggaaaattcgag
tacaacggtggctcggggtatctgctaaaaccagatttcctccgaagacccgacagaaca
ttcgacccattttccgagagcccggtggacggagtgattgcagcacattgtagtgttcgt
gtcatctcgggtcaattcctatcggatcgcaaaatcgggacatacgttgaggtggaaatg
tacggactacctactgacactattcgtaaggagcacaagacgaaggtaatacccgggaac
ggactgaatccagtttacaacgaggatccgtttgtcttccgaaaagttgtgctccccgag
ctcgccgtgctccggttcgccgtctacgatgagaacggcaagcagctgggtcagcggatt
cttccgctggatgggcttcaggcaggatatcggcatatttcgctgaggtctgacacgaat
cagagcttcattctgtcacctgtgctctttgtgcaaattgtgatcaagacttatgtgccg
gatgagctcagtggcctcgtcgatgctctcgccgacccacgagcattcctctcggagcag
aaaaaaaggcaggaagccctggctcacatgggtgttgacgatagtgatattcctgatgtg
cccaacaccaggaatatggctctccgacacgtgaaacaacctccaaggcagaacggatcg
tcagctgatctgctggcaaacaacggccaaactgggtcggctaggggtgatcagaccagc
tcgatggcttcaagtactattcggtcacccaacgaacaaccgcagccagtggctgtggat
aaatttaaggttgacccaatcgaagttgacgatttacgacgagacaaagcttttgcaaaa
ttgctcaagagatttcaaaaagagttggatgatctcaggaagaaacatcagaagcagagg
gatagcattcaaaaacagcagccggctcgccgccgtaattcgtccatagcgtggatccaa
accaacgtcgacaagctcatcacaaataaccgacgttccacgaaaaaagaaaaaggctca
aggagatccctgacggcttcagtatcatctggatgtggaagtgcatctggaactgtgact
gtcagtgtttgcagtccttctggcgcgagttgcagtgggtactccactgggggtccttcg
acaccggtggcatgtaactctgatggtaccgggtctccagcgactattggaagtccagtg
ccacaagatttggtcaataatgatagggtccgatctctcgtgaacactcaaaccggagaa
tggtccgctatggtccgtagacatgacgaggaagagtttgagctgaaaaaagtacagctc
aaagagcaattcgatctgctaagaaaactcatgagtgaagctcaaaagaaccaaatgttg
gctctgaagctccggttagaagccgaagggaaagatctaaagcagacgcagacgaaaaaa
agcatggaagatgcgaaagttattcaattggacaaaggtattaagaccaaggcagaacgt
gatcgtcgtgtcaaggaactcaacgagaagaacctgaaaatgtttgtggaggagaggaag
agattagccatgaaagcccaaaagcacgaagagcaactcacaaaacgacatctcgaccag
ctcgagcaactagacaaggatttccataaggccttggatgcggaggtcggcaactacaaa
gaagagcaactggctgctcaaccgacttctgtcgtttga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (50)   
   KEGG ORTHOLOGY (1)   
   RefGene (44)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   WORMBASE (1)   
Protein sequence (26)   
   UniProt (1)   
   RefSeq(pep) (25)   
DNA sequence (25)   
   RefSeq(nuc) (25)   
Protein domain (6)   
   Pfam (6)   
All databases (130)   

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