KEGG   Canis familiaris (dog): 476034Help
Entry
476034            CDS       T01007                                 

Gene name
PLCB3
Definition
(RefSeq) phospholipase C, beta 3 (phosphatidylinositol-specific)
  KO
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Aldosterone synthesis and secretion
AGE-RAGE signaling pathway in diabetic complications
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    476034 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    476034 (PLCB3)
   04310 Wnt signaling pathway
    476034 (PLCB3)
   04020 Calcium signaling pathway
    476034 (PLCB3)
   04070 Phosphatidylinositol signaling system
    476034 (PLCB3)
   04072 Phospholipase D signaling pathway
    476034 (PLCB3)
   04071 Sphingolipid signaling pathway
    476034 (PLCB3)
   04022 cGMP - PKG signaling pathway
    476034 (PLCB3)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    476034 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    476034 (PLCB3)
   04062 Chemokine signaling pathway
    476034 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    476034 (PLCB3)
   04922 Glucagon signaling pathway
    476034 (PLCB3)
   04912 GnRH signaling pathway
    476034 (PLCB3)
   04915 Estrogen signaling pathway
    476034 (PLCB3)
   04921 Oxytocin signaling pathway
    476034 (PLCB3)
   04918 Thyroid hormone synthesis
    476034 (PLCB3)
   04919 Thyroid hormone signaling pathway
    476034 (PLCB3)
   04916 Melanogenesis
    476034 (PLCB3)
   04924 Renin secretion
    476034 (PLCB3)
   04925 Aldosterone synthesis and secretion
    476034 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    476034 (PLCB3)
   04270 Vascular smooth muscle contraction
    476034 (PLCB3)
  Digestive system
   04970 Salivary secretion
    476034 (PLCB3)
   04971 Gastric acid secretion
    476034 (PLCB3)
   04972 Pancreatic secretion
    476034 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    476034 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    476034 (PLCB3)
   04725 Cholinergic synapse
    476034 (PLCB3)
   04728 Dopaminergic synapse
    476034 (PLCB3)
   04726 Serotonergic synapse
    476034 (PLCB3)
   04720 Long-term potentiation
    476034 (PLCB3)
   04730 Long-term depression
    476034 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    476034 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    476034 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    476034 (PLCB3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    476034 (PLCB3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    476034 (PLCB3)
   05016 Huntington's disease
    476034 (PLCB3)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    476034 (PLCB3)
  Infectious diseases
   05146 Amoebiasis
    476034 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    476034 (PLCB3)
   05143 African trypanosomiasis
    476034 (PLCB3)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     476034 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
18
AA seq 1230 aa AA seqDB search
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYSRLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWAEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHQPSTGVPNS
SVRKRPLEQSNSALSESSATTDPSSPQLGSPSSESCPGLSNGEEVGLEKPSLEPQKSLGE
DGLPRGPNTLGSADREDEEEEEEEEEQADPKKPTSDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASPETCQETPSQQP
GSQLTPNPTPSPLDTPPRRPPGPATAPTSPSLSSPGQRDDLIASLLSEVAPIPLEELRGH
KALVKLQNRQERELRELHKKHQRKAVALTRRLLEGLAQARAESRCRHRPGVLGGENEKEE
GEEVKRYQEFQKRQVQSLLELREAQVDTEAERRLEHLRQAQQRLREVVLDAHTTQFKKLK
EINEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRQERLVAGQQQVLQQLAEEEPKLLAQLAQECQEHRARLPQEIRQSLLGETPEGLGDRHL
VACASNGHAPGSSGHLSGADSESQEENTKL
NT seq 3693 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagcaagttcatcaaatgggacgaggagacctccagtcggaacctg
gtaaccctgcgtgtggattccaatggcttctttctatactggactggacccaacatggag
gtggacacactggacattagttccatcagggacacgcgaacaggtcgttactcccgcctg
ccaaaggaccccaagatccgggaggtgctgggctttgggggccctgatacccgactagag
gagaagttgatgacggtggtggccgggccagacccggtgaatacaacattcttgaacttc
atggctgtgcaggatgacacagccaaggtctgggccgaggagctgttcaagctggctatg
aacatcctggcccagaacgcctccaggaataccttcctgcggaaagcatacaccaagctg
aagctgcaggtgaaccaggatggacggatcccggttaagaatatcctgaagatgttttca
gcagataaaaagcgagtggagaccgcactagaatcctgtggcctcaatttcaaccggagt
gaatccatccggcccgatgagttttccttggaaatctttgagcggttcctgaataagttg
tgtctgcggccggacattgacaagatcctgctagagataggtgctaagggcaagccatac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccgaggctcaac
gaagtgctgtacccacccctgcggccctcccaggctcggctgctcattgagaagtatgag
cccaaccagcagttcctggagcgagatcagatgtccatggagggcttcagccgctacctg
ggaggtgaagagaatgggatcctgcccctggaggccctggatctgagcgctgacatgacc
cagccactcagtgcctatttcatcaactcctcacacaacacctatctcacagcggggcag
ctggctgggacctcgtcggtggagatgtaccggcaggcgctgctgtggggctgccgctgt
gtggagctggatgtgtggaaagggcggccgccggaggaggagcccttcatcacccacggc
ttcaccatgaccactgaggtgccgctgagagacgtgctcgaggccattgcagaaaccgcc
ttcaagacctcaccctatccagtcatcctctccttcgagaatcacgtggactcagcgaag
cagcaggccaagatggccgagtactgccgttccatctttggggacgcgctgctcatcgac
ccactggacaagtacccgctggccccaggtgtccccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcgacaccagcccagcactggtgtccccaacagc
tctgtgcgcaagcggccgctggagcagagcaactcggccctgagcgagagctctgccacc
actgacccctcctcacctcagcttgggtcccccagctctgagagctgcccaggcctgagc
aatggggaagaggtgggcctggagaagcctagcctggagcctcagaagtctctaggcgag
gatgggctcccacggggccccaacactcttggatctgctgaccgtgaggatgaggaagaa
gaggaggaagaggaggaacaggcagatcctaaaaagccaacctcagatgagggcactgcc
agcagtgaggtcaatgccactgaggaaatgtcaacactcgtcaactacattgagcctgtc
aagttcaagtcctttgaggctgctcgaaaaaggaacaaatgctttgagatgtcatccttc
gtcgaaaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaat
aaacagcagctcagccgcatctaccctaagggtacccgcgtggactcatccaactacatg
ccccagctcttttggaacgtgggctgccagcttgttgcactcaacttccagaccctggat
gtggcaatgcagctcaacgcaggcgtgttcgagtacaatgggcgcagtggctatctgctc
aaacctgagtttatgcggcggccagacaagtccttcgatcctttcaccgaagtcattgtg
gatggcattgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctatgtggaggtggacatgtttggcctccccgttgacacgcggcgc
aagtaccgtactcggacctctcaagggaactcattcaaccctgtgtgggatgaggaacct
tttgacttccccaaggtggtgctacccacgctggcttcgctgcgcatcgcggcctttgag
gaaggcggcaagtttgtggggcatcggattctgcccgtctctgccatccgctcagggtac
cactacatctgtctgcggaacgaggccaaccagccactttgcctgccagccctgctcatc
tacactgaagcctccgactatattcctgatgaccaccaggactacgcagaggccctgatc
aaccccatcaagcatgtcagcctgatggaccagagggccaagcagttggccgccctcatt
ggggagagtgaggctcaggccagcccagagacatgccaggagactccgtctcagcagccg
gggtcccagctgaccccaaaccctacacctagccccctggacacacccccgcgccggccc
ccaggccctgccacagcccctaccagcccctccctcagcagcccagggcagcgggatgac
ctcatcgccagcctcctctcagaggtggccccaatcccgctggaggagctccgaggccat
aaggcgctggtgaagctccagaaccggcaagaacgagagctgcgggagctacataagaag
caccagcggaaggccgtcgccctcacccgccggctgcttgagggcctggctcaggcccgg
gcggagagcaggtgccggcatcggccaggtgtcctaggcggggagaacgagaaggaagag
ggagaagaggtaaagcggtatcaggagttccagaagagacaggtgcagagtctgttggag
ctacgggaggctcaggtggacacagaggccgagcggaggctggagcacctgagacaggct
cagcagcggctcagggaagttgtcctggatgctcacacaactcagttcaagaagctgaag
gagataaatgagagggagaagaaggaattgcagaagattttagacaggaagcgccacaac
agtatctcagaggccaagactagggagaaacataagaaggaggcggaactgacagagatt
aaccgtcggcacatcactgagtcggtcaactccatccgtcggctggaggaggcccagaag
cagcggcaggaacgcctggtggctgggcagcagcaggtcctacagcagctggctgaagag
gagcccaagctgctggcccagctggcccaggagtgtcaggaacatcgagcaaggctgccc
caggagatccgccagagcctgctgggcgagacaccggaggggctgggggacaggcacctg
gtggcctgtgccagcaacggtcacgcacctgggagcagcgggcacctgtctggcgctgac
tcagagagccaagaggagaatacgaagctctga

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