KEGG   Canis familiaris (dog): 476034Help
Entry
476034            CDS       T01007                                 

Gene name
PLCB3
Definition
phospholipase C, beta 3 (phosphatidylinositol-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cfa  Canis familiaris (dog)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    476034 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    476034 (PLCB3)
   04310 Wnt signaling pathway
    476034 (PLCB3)
   04020 Calcium signaling pathway
    476034 (PLCB3)
   04070 Phosphatidylinositol signaling system
    476034 (PLCB3)
   04022 cGMP - PKG signaling pathway
    476034 (PLCB3)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    476034 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    476034 (PLCB3)
   04062 Chemokine signaling pathway
    476034 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    476034 (PLCB3)
   04912 GnRH signaling pathway
    476034 (PLCB3)
   04915 Estrogen signaling pathway
    476034 (PLCB3)
   04921 Oxytocin signaling pathway
    476034 (PLCB3)
   04918 Thyroid hormone synthesis
    476034 (PLCB3)
   04919 Thyroid hormone signaling pathway
    476034 (PLCB3)
   04916 Melanogenesis
    476034 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    476034 (PLCB3)
   04270 Vascular smooth muscle contraction
    476034 (PLCB3)
  Digestive system
   04970 Salivary secretion
    476034 (PLCB3)
   04971 Gastric acid secretion
    476034 (PLCB3)
   04972 Pancreatic secretion
    476034 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    476034 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    476034 (PLCB3)
   04725 Cholinergic synapse
    476034 (PLCB3)
   04728 Dopaminergic synapse
    476034 (PLCB3)
   04726 Serotonergic synapse
    476034 (PLCB3)
   04720 Long-term potentiation
    476034 (PLCB3)
   04730 Long-term depression
    476034 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    476034 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    476034 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    476034 (PLCB3)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    476034 (PLCB3)
   05016 Huntington's disease
    476034 (PLCB3)
  Infectious diseases
   05146 Amoebiasis
    476034 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    476034 (PLCB3)
   05143 African trypanosomiasis
    476034 (PLCB3)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     476034 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
18
AA seq 1163 aa AA seqDB search
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEKLMTVVAGPDPVNTTFLNFMAVQDDT
AKVWAEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVE
TALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLM
DFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGI
LPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWK
GRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAE
YCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHQPSTGVPNSSVRKRPL
EQSNSALSESSATTDPSSPQLGSPSSESCPGLSNGEEVGLEKPSLEPQKSLGEDGLPRGP
NTLGSADREDEEEEEEEEEQADPKKPTSDEGTASSEVNATEEMSTLVNYIEPVKFKSFEA
ARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNV
GCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANA
LRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVV
LPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLIYTEASDY
IPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASPETCQETPSQQPGSQLTPN
PTPSPLDTPPRRPPGPATAPTSPSLSSPGQRDDLIASLLSEVAPIPLEELRGHKALVKLQ
NRQERELRELHKKHQRKAVALTRRLLEGLAQARAESRCRHRPGVLGGENEKEEGEEVKRY
QEFQKRQVQSLLELREAQVDTEAERRLEHLRQAQQRLREVVLDAHTTQFKKLKEINEREK
KELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQKQRQERLV
AGQQQVLQQLAEEEPKLLAQLAQECQEHRARLPQEIRQSLLGETPEGLGDRHLVACASNG
HAPGSSGHLSGADSESQEENTKL
NT seq 3492 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagcaagttcatcaaatgggacgaggagaagttgatgacggtggtg
gccgggccagacccggtgaatacaacattcttgaacttcatggctgtgcaggatgacaca
gccaaggtctgggccgaggagctgttcaagctggctatgaacatcctggcccagaacgcc
tccaggaataccttcctgcggaaagcatacaccaagctgaagctgcaggtgaaccaggat
ggacggatcccggttaagaatatcctgaagatgttttcagcagataaaaagcgagtggag
accgcactagaatcctgtggcctcaatttcaaccggagtgaatccatccggcccgatgag
ttttccttggaaatctttgagcggttcctgaataagttgtgtctgcggccggacattgac
aagatcctgctagagataggtgctaagggcaagccatacctgacgctggagcagctcatg
gacttcatcaaccagaagcaacgggacccgaggctcaacgaagtgctgtacccacccctg
cggccctcccaggctcggctgctcattgagaagtatgagcccaaccagcagttcctggag
cgagatcagatgtccatggagggcttcagccgctacctgggaggtgaagagaatgggatc
ctgcccctggaggccctggatctgagcgctgacatgacccagccactcagtgcctatttc
atcaactcctcacacaacacctatctcacagcggggcagctggctgggacctcgtcggtg
gagatgtaccggcaggcgctgctgtggggctgccgctgtgtggagctggatgtgtggaaa
gggcggccgccggaggaggagcccttcatcacccacggcttcaccatgaccactgaggtg
ccgctgagagacgtgctcgaggccattgcagaaaccgccttcaagacctcaccctatcca
gtcatcctctccttcgagaatcacgtggactcagcgaagcagcaggccaagatggccgag
tactgccgttccatctttggggacgcgctgctcatcgacccactggacaagtacccgctg
gccccaggtgtccccctgcccagcccccaggacctgatgggccgcatcctggtgaagaac
aagaagcgacaccagcccagcactggtgtccccaacagctctgtgcgcaagcggccgctg
gagcagagcaactcggccctgagcgagagctctgccaccactgacccctcctcacctcag
cttgggtcccccagctctgagagctgcccaggcctgagcaatggggaagaggtgggcctg
gagaagcctagcctggagcctcagaagtctctaggcgaggatgggctcccacggggcccc
aacactcttggatctgctgaccgtgaggatgaggaagaagaggaggaagaggaggaacag
gcagatcctaaaaagccaacctcagatgagggcactgccagcagtgaggtcaatgccact
gaggaaatgtcaacactcgtcaactacattgagcctgtcaagttcaagtcctttgaggct
gctcgaaaaaggaacaaatgctttgagatgtcatccttcgtcgaaaccaaggccatggag
caactgaccaagagccccatggagtttgtggaatacaataaacagcagctcagccgcatc
taccctaagggtacccgcgtggactcatccaactacatgccccagctcttttggaacgtg
ggctgccagcttgttgcactcaacttccagaccctggatgtggcaatgcagctcaacgca
ggcgtgttcgagtacaatgggcgcagtggctatctgctcaaacctgagtttatgcggcgg
ccagacaagtccttcgatcctttcaccgaagtcattgtggatggcattgtggccaatgcc
ttgcgggtcaaggtgatctcggggcagttcctgtccgacaggaaggtgggcatctatgtg
gaggtggacatgtttggcctccccgttgacacgcggcgcaagtaccgtactcggacctct
caagggaactcattcaaccctgtgtgggatgaggaaccttttgacttccccaaggtggtg
ctacccacgctggcttcgctgcgcatcgcggcctttgaggaaggcggcaagtttgtgggg
catcggattctgcccgtctctgccatccgctcagggtaccactacatctgtctgcggaac
gaggccaaccagccactttgcctgccagccctgctcatctacactgaagcctccgactat
attcctgatgaccaccaggactacgcagaggccctgatcaaccccatcaagcatgtcagc
ctgatggaccagagggccaagcagttggccgccctcattggggagagtgaggctcaggcc
agcccagagacatgccaggagactccgtctcagcagccggggtcccagctgaccccaaac
cctacacctagccccctggacacacccccgcgccggcccccaggccctgccacagcccct
accagcccctccctcagcagcccagggcagcgggatgacctcatcgccagcctcctctca
gaggtggccccaatcccgctggaggagctccgaggccataaggcgctggtgaagctccag
aaccggcaagaacgagagctgcgggagctacataagaagcaccagcggaaggccgtcgcc
ctcacccgccggctgcttgagggcctggctcaggcccgggcggagagcaggtgccggcat
cggccaggtgtcctaggcggggagaacgagaaggaagagggagaagaggtaaagcggtat
caggagttccagaagagacaggtgcagagtctgttggagctacgggaggctcaggtggac
acagaggccgagcggaggctggagcacctgagacaggctcagcagcggctcagggaagtt
gtcctggatgctcacacaactcagttcaagaagctgaaggagataaatgagagggagaag
aaggaattgcagaagattttagacaggaagcgccacaacagtatctcagaggccaagact
agggagaaacataagaaggaggcggaactgacagagattaaccgtcggcacatcactgag
tcggtcaactccatccgtcggctggaggaggcccagaagcagcggcaggaacgcctggtg
gctgggcagcagcaggtcctacagcagctggctgaagaggagcccaagctgctggcccag
ctggcccaggagtgtcaggaacatcgagcaaggctgccccaggagatccgccagagcctg
ctgggcgagacaccggaggggctgggggacaggcacctggtggcctgtgccagcaacggt
cacgcacctgggagcagcgggcacctgtctggcgctgactcagagagccaagaggagaat
acgaagctctga

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