KEGG   Canis lupus familiaris (dog): 482970
Entry
482970            CDS       T01007                                 
Symbol
ROCK2
Name
(RefSeq) rho-associated protein kinase 2 isoform X1
  KO
K17388  Rho-associated protein kinase 2 [EC:2.7.11.1]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa04022  cGMP-PKG signaling pathway
cfa04024  cAMP signaling pathway
cfa04062  Chemokine signaling pathway
cfa04071  Sphingolipid signaling pathway
cfa04270  Vascular smooth muscle contraction
cfa04310  Wnt signaling pathway
cfa04360  Axon guidance
cfa04510  Focal adhesion
cfa04520  Adherens junction
cfa04530  Tight junction
cfa04611  Platelet activation
cfa04670  Leukocyte transendothelial migration
cfa04810  Regulation of actin cytoskeleton
cfa04921  Oxytocin signaling pathway
cfa05132  Salmonella infection
cfa05135  Yersinia infection
cfa05163  Human cytomegalovirus infection
cfa05200  Pathways in cancer
cfa05205  Proteoglycans in cancer
cfa05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    482970 (ROCK2)
   04071 Sphingolipid signaling pathway
    482970 (ROCK2)
   04024 cAMP signaling pathway
    482970 (ROCK2)
   04022 cGMP-PKG signaling pathway
    482970 (ROCK2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    482970 (ROCK2)
   04520 Adherens junction
    482970 (ROCK2)
   04530 Tight junction
    482970 (ROCK2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    482970 (ROCK2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    482970 (ROCK2)
   04670 Leukocyte transendothelial migration
    482970 (ROCK2)
   04062 Chemokine signaling pathway
    482970 (ROCK2)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    482970 (ROCK2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    482970 (ROCK2)
  09158 Development and regeneration
   04360 Axon guidance
    482970 (ROCK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    482970 (ROCK2)
   05205 Proteoglycans in cancer
    482970 (ROCK2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    482970 (ROCK2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    482970 (ROCK2)
   05135 Yersinia infection
    482970 (ROCK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    482970 (ROCK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    482970 (ROCK2)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:cfa03036]
    482970 (ROCK2)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     482970 (ROCK2)
Protein kinases [BR:cfa01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   482970 (ROCK2)
Chromosome and associated proteins [BR:cfa03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    482970 (ROCK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Rho_Binding PH C1_1 Pkinase_C APH Irp3-like_C
Other DBs
NCBI-GeneID: 482970
NCBI-ProteinID: XP_038309430
Ensembl: ENSCAFG00000003549
VGNC: 49640
Position
17:complement(7863769..8005135)
AA seq 1500 aa
MSRAPATGKMPGAPEAAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVVHLYMQAVFQV
APFSPPLAQSDDTLGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTD
REVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVE
TFPIPKAFVGNQLPFIGFTYYRENLLLSESSSCRENDSLQSRKNEESQEIQKKLYTLEEH
LSTEIQAKEELEQKCKSVNTRLEKVAKELEEEITLRKNVESALRQLEREKALLQHKNAEY
QRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTES
DTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFMNLQSVLESERRDRT
HGSEIINDLQGRISGLEEDLKNGKILLAKAEVEKRQLQERLTDLEKEKNNMEIDMTYQLK
VIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLSEERTLKQKVENLLL
EAEKRCSLFDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQ
QVNTLKMSEKQLKQENNHLMEMKMSLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTL
YKTQVRELKEECEEKTKLCKELQQKKQELQEERDSLAAQLEITLTKADSEQLARSIAEEQ
YSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNK
LKDAQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGSDTD
VRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSD
IEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPVHITQSRTMESMSFTYQRSSTSLNIA
TKPSSSHMLLDSDSDSEEESLPYLPISSEPNGTESRLEGWLSLPLRNNTKKFGWTKKYVI
VSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKDIPRIFQILYANEG
ESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRC
HIKCHKDHMDKKEEIIAPCKVYCDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPD
PFARSSPRTSMKIQQNQSIRRPSRQLAPNKPRLLDLAFKDWDWSFDDVDGGDDDDDVFDF
NT seq 4503 nt   +upstreamnt  +downstreamnt
atgagccgggccccggcgaccgggaaaatgcccggcgcccccgaggccgcgccgggggac
ggggcgggcgccagccgccagaggaagctggaggcgctgatccgggacccccgctcgccc
atcaacgtggagagcttgctggatggcttaaattccttggtccttgatttggattttcct
gctttgaggaaaaacaagaatatagataattttttaaatagatatgagaaaattgtgaaa
aaaatcagaggtctacagatgaaggcagaagactatgatgttgtaaaagttattggaaga
ggtgcttttggtgaggtgcagctggttcgtcataaagcatcacagaaggtgtatgctatg
aagcttcttagtaagtttgaaatgataaaaagatcagattctgcttttttctgggaagag
agagatattatggcctttgccaacagtccctgggtggttcagctcttttgtgcttttcaa
gatgataagtatctgtacatggtaatggagtacatgcctggtggagatcttgtaaacctt
atgagtaactatgacgtgcctgaaaaatgggccaaattctatactgctgaagttgttctt
gctctggatgccatacactccatgggcttaattcacagagatgtaaagcctgacaacatg
ctcttggataaacatggacatctaaagttagcagattttggcacatgtatgaagatggat
gaaacaggcatggtgcattgtgatacagcagttggaacacctgattatatttcacctgag
gttctcaaatcacaagggggtgatggttactatgggcgagaatgtgattggtggtcggtg
ggtgttttcctttttgagatgctggtggtgcatctctatatgcaggctgtgttccaggta
gctccattctccccgcctctggcccaatctgatgatacattaggggatactccattttat
gcagattcacttgtaggaacttatagcaaaattatggatcataaaaactcactgtgtttc
cctgaagatgcagaaatttctaaacatgcgaagaatctcatttgcgccttcttaacagat
agggaggtacgacttgggagaaatggggtagaagaaatcaaacagcatcctttctttaag
aatgatcaatggaattgggataacataagagagacggcagctcctgtagtaccagaactc
agcagtgacatagacagcagcaattttgatgacatcgaagatgataaaggagatgtagaa
acttttccaattcctaaagcttttgtgggaaatcagctgccttttataggatttacctac
tatagagaaaatctgttattaagtgagtcttcatcttgtagagaaaatgattcattacaa
tcaaggaaaaatgaagaaagtcaagagattcagaaaaaattatatacattagaagaacac
ctcagcactgagatacaagccaaagaagaactagagcaaaagtgcaaatctgttaatact
cgacttgaaaaagtagcaaaggaattagaagaagagattactttaaggaaaaatgtggaa
tcagcattaagacaattagaaagagaaaaggcacttcttcagcacaaaaatgcagaatat
cagcggaaagctgatcacgaagcagacaagaagcggaatttggaaaatgatgttaacagt
ttaaaggatcaacttgaagatttgaaaaaaagaaatcagaactctcaaatatccaccgag
aaagtgaatcagctccagagacaactggatgaaaccaatgctttactgagaacagaatct
gatactgcggcccggttaagaaaaacccaggcagaaagttcaaaacagattcagcagctg
gaatctaacaatagagatctccaagataaaaattgcctgctagagactgccaagttaaaa
cttgaaaaggaatttatgaatcttcagtcagttctagaatctgaaaggagggaccgaacc
cacggatccgagataattaatgacttacaaggtagaatatctggcctagaagaagactta
aagaatggaaaaatcttattagcaaaagcagaggtggagaagagacaactgcaggagaga
cttactgatttggaaaaggaaaagaacaacatggaaatagatatgacgtaccaactaaaa
gttatacagcagagcttagaacaagaagaagctgagcataaggccacaaaagcacggctg
gcagataaaaataagatttatgagtccattgaagaagcaaaatcagaagccatgaaagaa
atggagaagaagctctcagaggaaaggacgttaaaacagaaggtggagaatctattgctg
gaagctgagaaaagatgctctttatttgactgtgacctcaagcagtcacagcagaaaata
aatgaactccttaaacagaaagatgtgctaaatgaggatgttagaaacttgacattaaaa
atagagcaggaaactcagaagcgctgccttacacaaaatgacttgaagatgcaaacacag
caagttaacacactaaaaatgtcagaaaaacagttaaaacaagagaataatcatctcatg
gaaatgaaaatgagcttggaaaagcagaatgctgaacttcggaaagaacgtcaagatgca
gatgggcaaatgaaagaacttcaggatcagcttgaagcggagcagtatttctcaaccctc
tataaaacacaggtgagggaacttaaagaagaatgtgaagaaaaaaccaaactttgtaaa
gaattacagcagaagaaacaggaattacaggaagaaagggattccttggctgctcaactg
gagatcaccttgaccaaagcagattctgagcagctggctcgttcaattgctgaagagcag
tattctgatttggaaaaagagaaaattatgaaggagcttgagatcaaagagatgatggct
agacacaaacaggaactcactgaaaaagatgctacaattgcatctcttgaagaaacgaat
agaacactaactagtgatgttgccaatcttgcaaatgagaaagaagaattaaataacaaa
ttgaaagatgcacaagaacagctgtcacggctgaaggatgaggagatcagtgcagctgct
attaaagcacagtttgagaagcagctgctcacagagagaacactgaaaactcaagctgtg
aataagttggctgagatcatgaatcgaaaagaacctgtcaagcgtggtagtgacactgat
gtgcggagaaaagagaaagaaaatcggaagctacatatggagcttaaatctgaacgtgaa
aaactgacccagcagatgatcaagtaccagaaagaactgaatgaaatgcaggctcaaata
gctgaagagagccagattcgaattgaactgcagatgacactggacagtaaagatagtgac
attgagcagctgcggtcacagctccaggctttgcatattggtctggatagttccagtata
ggcagtggaccgggggacgctgaggcagatgatgggtttccagttcatatcactcaatca
cgcactatggaatccatgtcattcacctaccagcgttcctctacttctctcaatattgcc
actaagccttccagttctcatatgcttcttgactctgattctgactcagaagaagaatct
ttgccttacttacctatttcatcggaacctaatggtacagaatcaagactagaaggatgg
ctttcattgcctttacgaaacaacactaagaaatttggatggactaaaaagtatgtgatt
gtaagcagtaagaagattcttttctatgacagcgaacaagataaagaacaatctaatcct
tacatggttttagatatagacaaattatttcatgtccgaccagttacacagacagatgta
tatagagcagatgctaaagatattccaaggatatttcagattctgtacgccaatgaagga
gaaagtaagaaggaacaagaatttccagtggagccagtaggagaaaaatcaaattatatt
tgccataaaggacatgaatttattcctactctgtatcatttcccaaccaactgtgaggct
tgtatgaagccattgtggcatatgtttaaacctcctcctgctttagaatgccggcgctgc
catattaaatgtcataaagatcacatggacaaaaaggaggagattatagcaccttgcaag
gtttattgtgatatttcgacggcaaagaatctattgttgttagcaaattctacagaagag
cagcagaagtgggttagtcggttggtgaaaaagattcctaaaaagcctccagctccagac
ccttttgcacggtcatcacctagaacttcaatgaagatacaacaaaaccagtctattaga
cggccaagtcgacagcttgccccaaacaaaccaagattgcttgatttggcatttaaagac
tgggattggtcatttgatgatgttgatggtggtgatgatgatgacgatgtttttgatttc
tga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (51)   
   KEGG ORTHOLOGY (1)   
   RefGene (45)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (40)   
   RefSeq(pep) (40)   
DNA sequence (77)   
   RefSeq(nuc) (75)   
   GenBank (1)   
   EMBL (1)   
Protein domain (8)   
   Pfam (8)   
All databases (202)   

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