KEGG   Canis familiaris (dog): 611939Help
Entry
611939            CDS       T01007                                 

Gene name
MAP2K2
Definition
mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
Orthology
K04369  
mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
cfa  Canis familiaris (dog)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
VEGF signaling pathway
Gap junction
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    611939 (MAP2K2)
   04015 Rap1 signaling pathway
    611939 (MAP2K2)
   04010 MAPK signaling pathway
    611939 (MAP2K2)
   04012 ErbB signaling pathway
    611939 (MAP2K2)
   04370 VEGF signaling pathway
    611939 (MAP2K2)
   04066 HIF-1 signaling pathway
    611939 (MAP2K2)
   04068 FoxO signaling pathway
    611939 (MAP2K2)
   04024 cAMP signaling pathway
    611939 (MAP2K2)
   04022 cGMP - PKG signaling pathway
    611939 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    611939 (MAP2K2)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    611939 (MAP2K2)
  Cell communication
   04540 Gap junction
    611939 (MAP2K2)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    611939 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    611939 (MAP2K2)
   04660 T cell receptor signaling pathway
    611939 (MAP2K2)
   04662 B cell receptor signaling pathway
    611939 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    611939 (MAP2K2)
  Endocrine system
   04910 Insulin signaling pathway
    611939 (MAP2K2)
   04912 GnRH signaling pathway
    611939 (MAP2K2)
   04915 Estrogen signaling pathway
    611939 (MAP2K2)
   04917 Prolactin signaling pathway
    611939 (MAP2K2)
   04921 Oxytocin signaling pathway
    611939 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    611939 (MAP2K2)
   04916 Melanogenesis
    611939 (MAP2K2)
  Circulatory system
   04270 Vascular smooth muscle contraction
    611939 (MAP2K2)
  Nervous system
   04720 Long-term potentiation
    611939 (MAP2K2)
   04730 Long-term depression
    611939 (MAP2K2)
   04722 Neurotrophin signaling pathway
    611939 (MAP2K2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    611939 (MAP2K2)
   05206 MicroRNAs in cancer
    611939 (MAP2K2)
   05205 Proteoglycans in cancer
    611939 (MAP2K2)
   05214 Glioma
    611939 (MAP2K2)
   05216 Thyroid cancer
    611939 (MAP2K2)
   05221 Acute myeloid leukemia
    611939 (MAP2K2)
   05220 Chronic myeloid leukemia
    611939 (MAP2K2)
   05218 Melanoma
    611939 (MAP2K2)
   05211 Renal cell carcinoma
    611939 (MAP2K2)
   05219 Bladder cancer
    611939 (MAP2K2)
   05215 Prostate cancer
    611939 (MAP2K2)
   05213 Endometrial cancer
    611939 (MAP2K2)
   05223 Non-small cell lung cancer
    611939 (MAP2K2)
  Neurodegenerative diseases
   05020 Prion diseases
    611939 (MAP2K2)
  Infectious diseases
   05164 Influenza A
    611939 (MAP2K2)
   05161 Hepatitis B
    611939 (MAP2K2)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     611939 (MAP2K2)
Protein kinases [BR:cfa01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   611939 (MAP2K2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
20
AA seq 400 aa AA seqDB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGIEGEPHSISPRPRP
PGRPISGHGTDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMSHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq 1203 nt NT seq  +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcactatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagcagagctagaacttgatgagcagcagaagaagcgactggaagccttcctcacccag
aaggccaaggtcggggaactcaaggatgatgacttcgaacggatctcagagctgggagcc
gggaacggcggggtggtcaccaaggtccagcacagaccttctggcctcatcatggcgaga
aagctgatccacctggaaatcaagccggccatccggaaccagatcatccgcgagctgcag
gtgctgcacgagtgtaactccccgtacatcgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcatatggatggcggctctctggaccaggtgttgaag
gaagccaagagaatccctgaggagatcctggggaaggtcagcattgcggttctccggggt
ttggcgtatctccgggagaagcaccagatcatgcaccgagacgtgaaaccatccaacatc
ctcgtcaactcccgaggggagattaagctgtgtgattttggggtgagcggccagctcatc
gactccatggccaactccttcgtgggaactcggtcctacatgtctccagagcggttgcag
ggcactcattactcagtgcagtcggacatctggagcatgggcctgtccctggtggagctg
tccattggaaggtaccccatcccgccaccagatgccaaggagctagaggccatcttcggc
cggcccatggttgacgggatagaaggagagcctcacagcatctcaccacggccgagaccc
cctggacgccccatcagcggtcatgggacggacagccggccagctatggccatctttgag
ctgctggactatattgtgaacgagccgcctcccaagctgcccaatggtgtcttcacccag
gacttccaggagtttgtaaataaatgcctaataaagaacccagcagagcgagcagatctg
aagatgctcatgagccacacgttcatcaagcggtccgaggtggaagaggtggattttgcc
ggctggttgtgtaaaacgctgcggctgaatcagcccagtacgcccacgcgcaccgccgtg
tga

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