KEGG   Canis lupus familiaris (dog): 611939
Entry
611939            CDS       T01007                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa04010  MAPK signaling pathway
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04024  cAMP signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04068  FoxO signaling pathway
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04140  Autophagy - animal
cfa04148  Efferocytosis
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04210  Apoptosis
cfa04218  Cellular senescence
cfa04270  Vascular smooth muscle contraction
cfa04370  VEGF signaling pathway
cfa04371  Apelin signaling pathway
cfa04540  Gap junction
cfa04550  Signaling pathways regulating pluripotency of stem cells
cfa04613  Neutrophil extracellular trap formation
cfa04620  Toll-like receptor signaling pathway
cfa04650  Natural killer cell mediated cytotoxicity
cfa04660  T cell receptor signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04720  Long-term potentiation
cfa04722  Neurotrophin signaling pathway
cfa04730  Long-term depression
cfa04810  Regulation of actin cytoskeleton
cfa04910  Insulin signaling pathway
cfa04912  GnRH signaling pathway
cfa04915  Estrogen signaling pathway
cfa04916  Melanogenesis
cfa04917  Prolactin signaling pathway
cfa04919  Thyroid hormone signaling pathway
cfa04921  Oxytocin signaling pathway
cfa04926  Relaxin signaling pathway
cfa04929  GnRH secretion
cfa04934  Cushing syndrome
cfa04935  Growth hormone synthesis, secretion and action
cfa05010  Alzheimer disease
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05132  Salmonella infection
cfa05135  Yersinia infection
cfa05160  Hepatitis C
cfa05161  Hepatitis B
cfa05163  Human cytomegalovirus infection
cfa05164  Influenza A
cfa05165  Human papillomavirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05200  Pathways in cancer
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05210  Colorectal cancer
cfa05211  Renal cell carcinoma
cfa05213  Endometrial cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05216  Thyroid cancer
cfa05218  Melanoma
cfa05219  Bladder cancer
cfa05220  Chronic myeloid leukemia
cfa05221  Acute myeloid leukemia
cfa05223  Non-small cell lung cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
cfa05230  Central carbon metabolism in cancer
cfa05231  Choline metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    611939 (MAP2K2)
   04012 ErbB signaling pathway
    611939 (MAP2K2)
   04014 Ras signaling pathway
    611939 (MAP2K2)
   04015 Rap1 signaling pathway
    611939 (MAP2K2)
   04370 VEGF signaling pathway
    611939 (MAP2K2)
   04371 Apelin signaling pathway
    611939 (MAP2K2)
   04066 HIF-1 signaling pathway
    611939 (MAP2K2)
   04068 FoxO signaling pathway
    611939 (MAP2K2)
   04072 Phospholipase D signaling pathway
    611939 (MAP2K2)
   04071 Sphingolipid signaling pathway
    611939 (MAP2K2)
   04024 cAMP signaling pathway
    611939 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    611939 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    611939 (MAP2K2)
   04150 mTOR signaling pathway
    611939 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    611939 (MAP2K2)
   04148 Efferocytosis
    611939 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    611939 (MAP2K2)
   04218 Cellular senescence
    611939 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    611939 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    611939 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    611939 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    611939 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    611939 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    611939 (MAP2K2)
   04660 T cell receptor signaling pathway
    611939 (MAP2K2)
   04662 B cell receptor signaling pathway
    611939 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    611939 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    611939 (MAP2K2)
   04929 GnRH secretion
    611939 (MAP2K2)
   04912 GnRH signaling pathway
    611939 (MAP2K2)
   04915 Estrogen signaling pathway
    611939 (MAP2K2)
   04917 Prolactin signaling pathway
    611939 (MAP2K2)
   04921 Oxytocin signaling pathway
    611939 (MAP2K2)
   04926 Relaxin signaling pathway
    611939 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    611939 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    611939 (MAP2K2)
   04916 Melanogenesis
    611939 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    611939 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    611939 (MAP2K2)
   04730 Long-term depression
    611939 (MAP2K2)
   04722 Neurotrophin signaling pathway
    611939 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    611939 (MAP2K2)
   05206 MicroRNAs in cancer
    611939 (MAP2K2)
   05205 Proteoglycans in cancer
    611939 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    611939 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    611939 (MAP2K2)
   05230 Central carbon metabolism in cancer
    611939 (MAP2K2)
   05231 Choline metabolism in cancer
    611939 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    611939 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    611939 (MAP2K2)
   05225 Hepatocellular carcinoma
    611939 (MAP2K2)
   05226 Gastric cancer
    611939 (MAP2K2)
   05214 Glioma
    611939 (MAP2K2)
   05216 Thyroid cancer
    611939 (MAP2K2)
   05221 Acute myeloid leukemia
    611939 (MAP2K2)
   05220 Chronic myeloid leukemia
    611939 (MAP2K2)
   05218 Melanoma
    611939 (MAP2K2)
   05211 Renal cell carcinoma
    611939 (MAP2K2)
   05219 Bladder cancer
    611939 (MAP2K2)
   05215 Prostate cancer
    611939 (MAP2K2)
   05213 Endometrial cancer
    611939 (MAP2K2)
   05224 Breast cancer
    611939 (MAP2K2)
   05223 Non-small cell lung cancer
    611939 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    611939 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    611939 (MAP2K2)
   05161 Hepatitis B
    611939 (MAP2K2)
   05160 Hepatitis C
    611939 (MAP2K2)
   05164 Influenza A
    611939 (MAP2K2)
   05163 Human cytomegalovirus infection
    611939 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    611939 (MAP2K2)
   05165 Human papillomavirus infection
    611939 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    611939 (MAP2K2)
   05135 Yersinia infection
    611939 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    611939 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    611939 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    611939 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    611939 (MAP2K2)
   01522 Endocrine resistance
    611939 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    611939 (MAP2K2)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     611939 (MAP2K2)
Protein kinases [BR:cfa01001]
 Serine/threonine kinases: STE group
  STE7 family
   611939 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 Kdo APH
Other DBs
NCBI-GeneID: 611939
NCBI-ProteinID: NP_001041601
Ensembl: ENSCAFG00000019138
UniProt: Q1HG70
Position
20:55191875..55213954
AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGIEGEPHSISPRPRP
PGRPISGHGTDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMSHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcactatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagcagagctagaacttgatgagcagcagaagaagcgactggaagccttcctcacccag
aaggccaaggtcggggaactcaaggatgacgacttcgaacggatctcagagctgggagcc
gggaacggcggggtggtcaccaaggtccagcacagaccttctggcctcatcatggcgaga
aagctgatccacctggaaatcaagccggccatccggaaccagatcatccgcgagctgcag
gtgctgcacgagtgtaactccccatacatcgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcatatggatggcggctctctggaccaggtgttgaag
gaagccaagagaatccctgaggagatcctggggaaggtcagcattgcggttctccggggt
ttggcgtatctccgggagaagcaccagatcatgcaccgagacgtgaaaccatccaacatc
ctcgtcaactcccgaggggagattaagctgtgtgattttggggtgagcggccagctcatc
gactccatggccaactccttcgtgggaactcggtcctacatgtctccagagcggttgcag
ggcactcattactcagtgcagtcggacatctggagcatgggcctgtccctggtggagctg
tccattggaaggtaccccatcccgccaccagatgccaaggagctagaggccatcttcggc
cggcccatggttgacgggatagaaggagagcctcacagcatctcaccacggccgagaccc
cctggacgccccatcagcggtcatgggacggacagccggccagctatggccatctttgag
ctgctggactatattgtgaacgagccgcctcccaagctgcccaatggtgtcttcacccag
gacttccaggagtttgtaaataaatgcctaataaagaacccagcagagcgagcagatctg
aagatgctcatgagccacacgttcatcaagcggtccgaggtggaagaggtggattttgcc
ggctggttgtgtaaaacgctgcggctgaatcagcccagcacgcccacgcgcaccgccgtg
tga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (78)   
   KEGG PATHWAY (78)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
Protein domain (9)   
   Pfam (9)   
All databases (109)   

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