KEGG   Cricetulus griseus (Chinese hamster): 100770957
Entry
100770957         CDS       T02813                                 
Symbol
Plcb4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
cge  Cricetulus griseus (Chinese hamster)
Pathway
cge00562  Inositol phosphate metabolism
cge01100  Metabolic pathways
cge04015  Rap1 signaling pathway
cge04020  Calcium signaling pathway
cge04022  cGMP-PKG signaling pathway
cge04062  Chemokine signaling pathway
cge04070  Phosphatidylinositol signaling system
cge04071  Sphingolipid signaling pathway
cge04072  Phospholipase D signaling pathway
cge04261  Adrenergic signaling in cardiomyocytes
cge04270  Vascular smooth muscle contraction
cge04310  Wnt signaling pathway
cge04371  Apelin signaling pathway
cge04540  Gap junction
cge04611  Platelet activation
cge04613  Neutrophil extracellular trap formation
cge04621  NOD-like receptor signaling pathway
cge04713  Circadian entrainment
cge04720  Long-term potentiation
cge04723  Retrograde endocannabinoid signaling
cge04724  Glutamatergic synapse
cge04725  Cholinergic synapse
cge04726  Serotonergic synapse
cge04728  Dopaminergic synapse
cge04730  Long-term depression
cge04742  Taste transduction
cge04750  Inflammatory mediator regulation of TRP channels
cge04911  Insulin secretion
cge04912  GnRH signaling pathway
cge04915  Estrogen signaling pathway
cge04916  Melanogenesis
cge04918  Thyroid hormone synthesis
cge04919  Thyroid hormone signaling pathway
cge04921  Oxytocin signaling pathway
cge04922  Glucagon signaling pathway
cge04924  Renin secretion
cge04925  Aldosterone synthesis and secretion
cge04926  Relaxin signaling pathway
cge04927  Cortisol synthesis and secretion
cge04928  Parathyroid hormone synthesis, secretion and action
cge04929  GnRH secretion
cge04933  AGE-RAGE signaling pathway in diabetic complications
cge04934  Cushing syndrome
cge04935  Growth hormone synthesis, secretion and action
cge04961  Endocrine and other factor-regulated calcium reabsorption
cge04970  Salivary secretion
cge04971  Gastric acid secretion
cge04972  Pancreatic secretion
cge04973  Carbohydrate digestion and absorption
cge05010  Alzheimer disease
cge05016  Huntington disease
cge05017  Spinocerebellar ataxia
cge05022  Pathways of neurodegeneration - multiple diseases
cge05142  Chagas disease
cge05143  African trypanosomiasis
cge05146  Amoebiasis
cge05163  Human cytomegalovirus infection
cge05200  Pathways in cancer
cge05415  Diabetic cardiomyopathy
cge05417  Lipid and atherosclerosis
Module
cge_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cge00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100770957 (Plcb4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100770957 (Plcb4)
   04310 Wnt signaling pathway
    100770957 (Plcb4)
   04371 Apelin signaling pathway
    100770957 (Plcb4)
   04020 Calcium signaling pathway
    100770957 (Plcb4)
   04070 Phosphatidylinositol signaling system
    100770957 (Plcb4)
   04072 Phospholipase D signaling pathway
    100770957 (Plcb4)
   04071 Sphingolipid signaling pathway
    100770957 (Plcb4)
   04022 cGMP-PKG signaling pathway
    100770957 (Plcb4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100770957 (Plcb4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100770957 (Plcb4)
   04613 Neutrophil extracellular trap formation
    100770957 (Plcb4)
   04621 NOD-like receptor signaling pathway
    100770957 (Plcb4)
   04062 Chemokine signaling pathway
    100770957 (Plcb4)
  09152 Endocrine system
   04911 Insulin secretion
    100770957 (Plcb4)
   04922 Glucagon signaling pathway
    100770957 (Plcb4)
   04929 GnRH secretion
    100770957 (Plcb4)
   04912 GnRH signaling pathway
    100770957 (Plcb4)
   04915 Estrogen signaling pathway
    100770957 (Plcb4)
   04921 Oxytocin signaling pathway
    100770957 (Plcb4)
   04926 Relaxin signaling pathway
    100770957 (Plcb4)
   04935 Growth hormone synthesis, secretion and action
    100770957 (Plcb4)
   04918 Thyroid hormone synthesis
    100770957 (Plcb4)
   04919 Thyroid hormone signaling pathway
    100770957 (Plcb4)
   04928 Parathyroid hormone synthesis, secretion and action
    100770957 (Plcb4)
   04916 Melanogenesis
    100770957 (Plcb4)
   04924 Renin secretion
    100770957 (Plcb4)
   04925 Aldosterone synthesis and secretion
    100770957 (Plcb4)
   04927 Cortisol synthesis and secretion
    100770957 (Plcb4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100770957 (Plcb4)
   04270 Vascular smooth muscle contraction
    100770957 (Plcb4)
  09154 Digestive system
   04970 Salivary secretion
    100770957 (Plcb4)
   04971 Gastric acid secretion
    100770957 (Plcb4)
   04972 Pancreatic secretion
    100770957 (Plcb4)
   04973 Carbohydrate digestion and absorption
    100770957 (Plcb4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100770957 (Plcb4)
  09156 Nervous system
   04724 Glutamatergic synapse
    100770957 (Plcb4)
   04725 Cholinergic synapse
    100770957 (Plcb4)
   04728 Dopaminergic synapse
    100770957 (Plcb4)
   04726 Serotonergic synapse
    100770957 (Plcb4)
   04720 Long-term potentiation
    100770957 (Plcb4)
   04730 Long-term depression
    100770957 (Plcb4)
   04723 Retrograde endocannabinoid signaling
    100770957 (Plcb4)
  09157 Sensory system
   04742 Taste transduction
    100770957 (Plcb4)
   04750 Inflammatory mediator regulation of TRP channels
    100770957 (Plcb4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100770957 (Plcb4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100770957 (Plcb4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100770957 (Plcb4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100770957 (Plcb4)
   05142 Chagas disease
    100770957 (Plcb4)
   05143 African trypanosomiasis
    100770957 (Plcb4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100770957 (Plcb4)
   05016 Huntington disease
    100770957 (Plcb4)
   05017 Spinocerebellar ataxia
    100770957 (Plcb4)
   05022 Pathways of neurodegeneration - multiple diseases
    100770957 (Plcb4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100770957 (Plcb4)
   05415 Diabetic cardiomyopathy
    100770957 (Plcb4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100770957 (Plcb4)
   04934 Cushing syndrome
    100770957 (Plcb4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cge04131]
    100770957 (Plcb4)
Enzymes [BR:cge01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100770957 (Plcb4)
Membrane trafficking [BR:cge04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100770957 (Plcb4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100770957 (Plcb4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y DUF1154 EF-hand_like C2 EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 100770957
NCBI-ProteinID: XP_035302602
UniProt: A0A9J7H217
Position
6:complement(42622253..42926981)
AA seq 1194 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPSCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRLAAIPKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTTGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMRIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPANILEDDNEEEIENADQEEEAHPEYKFGSELSADDFSHKEAVANSVKKGLV
TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNVHYNMSSFNESVG
LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL
NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT
YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK
LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK
FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANPAKANVTPQSSSELRPTTTAA
LGSGQEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELSSLKKKHAKEHSTMQKLHCTQ
VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH
TKEWSEMINTHSAEEQEIRDLHLNQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAHQ
AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ
LEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQSAN
NT seq 3585 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagtgccatctttcttgcaagaaggg
gcagtttttgacagatatgaagaggaatcttttgtgtttgagcccagctgcctcttcaaa
gtggacgaatttggcttcttcctgacctggaagagtgaaggcaaggaaggccaagtgcta
gaatgttccctcatcaacagtattcgactggcagccataccaaaggatcccaaaatcctg
gctgctcttgaagctgttggaaaatctgaaaatgatctggaagggcggatattgtgtgtc
tgcagtggcacagatctggtgaacattggctttacttacatggtggccgaaaacccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcattcacaacttcagggccaacaat
gtcagtcccatgacatgcctcaagaaacactggatgaaactggcgtttctgaccaacaca
actggtaaaattccagtgagaagtattactagaacctttgcgtcggggaagacagaaaag
gtgatctttcaagccctcaaggaattaggtctgcccagtggaaagaatgatgaaattgag
cctgctgcgtttacttatgaaaagttctacgaactgacacaaaagatttgtcctcggaca
gatatagaagacctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaacgaacatcaacgagatcctcggctgaatgagattttattc
ccattttatgatgctaaaagagcaatgcggatcattgagatgtatgaacctgatgaagat
ttgaagaagaaaggcctcatatcaagtgatgggttttgcagatatctcatgtcagatgaa
aacgccccagtcttcctagatcgcttagaactttaccaggagatggatcaccccctggct
cactacttcatcagttcttcccacaacacctatctcaccgggcggcagtttggcggaaag
tcttcagtggaaatgtacagacaagttctcctggctggttgcaggtgtgttgaacttgac
tgttgggatggaaaaggtgaagatcaggaaccgataataactcatggaaaagcaatgtgt
acagacatcctttttaaggatgtaatccaagccatcaaggaaacagcatttgtcacatcg
gagtaccctgtaattctctcctttgaaaaccactgcagcaaatatcaacagtacaagatg
tccaagtattgtgaagatctatttggggatctcctgttgaaacaagcactggagtcacat
ccacttgaaccaggcaggcctttgccatcccccaatgacctcaaaagaaaaatacttatc
aaaaataaaaggctgaaacctgaagttgaaaaaaagcagcttgaagctttgaaaagcatg
atggaagccggagaatcagctgccccagctaacatcttagaagatgacaatgaagaggag
atagaaaatgctgatcaagaagaagaagcccaccctgagtacaaatttggaagtgaacta
tctgctgatgacttcagtcacaaggaagcagttgcaaacagcgtcaagaagggcctggtc
actgtagaagatgagcaggcttggatggcatcttataaatatgtaggtgctactacgaac
atccatccgtacttgtccacaatgatcaactacgcccagcctgtgaagtttcaaggtttc
catgtggctgaagagcgcaatgttcattataacatgtcttcttttaatgagtcagttggc
ctgggctacttgaagacacacgcgattgaatttgtaaattacaataagcgacaaatgagc
cgcatttaccccaagggaggccgagttgattccagtaattacatgcctcagattttctgg
aacgctggttgccagatggtttcactgaactatcaaaccccagatttagcgatgcaattg
aatcagggaaaatttgagtataatggatcctgcgggtatcttctcaagccagattttatg
aggcggcctgaccggacgtttgatcctttctctgaaaccccagtggatggggttattgca
gccacatgctcagtgcaggttatatcagggcaattcctatcagataagaagatcggcaca
tacgtggaagtagacatgtacgggttgcccaccgataccatacggaaggagttccggact
cgcatggttatgaacaatggcctcaacccagtttacaatgaagaatcatttgtgtttcgg
aaggtgattctgcctgatcttgctgtcctgagaattgcagtgtatgatgacaacaacaag
ctgattggccagagaatccttcctttggatggcctccaagcaggctaccgacacatctcc
ctaagaaatgagggaaacaaaccattatcactgccaacgattttctgcaacattgttctt
aaaacatatgtgcctgatggatttggagatattgtggatgctttatccgatccaaagaaa
tttctttcaatcacagaaaagagagcagaccaaatgagagctatgggcattgaaactagt
gacatagcagatgtgcccagtgacacttccaaaaatgacaagaaaggcaaagccaaccca
gccaaagcaaatgtgacccctcagagcagctctgagctcagacccaccactacagccgct
ctgggctctggccaggaagccaagaaaggtattgagcttatcccacaagtgagaatagaa
gatttaaagcaaatgaaggcttacttgaagcacttaaagaaacaacagaaagagttaagc
tctttaaagaagaaacacgcaaaggaacacagtaccatgcagaagttacactgcacacaa
gttgacaaaatcgtggcccagtacgacaaagagaagtcaactcatgagaaaatcctggag
aaggcaatgaagaagaaagggggaagtaattgtcttgaaatgaaaaaagaaacagaaatt
aaaattcagaccctgacatcagatcacaaatctaaggtcaaagagattgtggcacagcac
acaaaggagtggtcagaaatgatcaacactcatagtgccgaggagcaagagatccgggat
ctgcacttgaaccagcagtgtgagctgctgagaaagctgctcatcaacgctcatgaacag
cagacccagcagctgaagctctctcatgacagggaaagcaaggagatgcgagcccatcag
gctaagatttctatggaaaatagtaaagccatcagtcaagataaatctatcaagaataag
gcagaacgggaaaggcgagtcagggagttgaacagcagcaacactaaaaagtttctagaa
gaaagaaagagactggcgatgaaacagtcaaaagaaatggatcaattgaaaaaagtccag
ctcgagcacctagaattcctagagaaacagaatgagcagcttttgaaatcctgtcatgca
gtgtcccaaacacaaggcgaaggagatgcagcagatggtgaaattggaagccgagatgga
ccgcagaccagcaacagtagtatgaagcttcagagtgcaaactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (61)   
   KEGG PATHWAY (60)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (8)   
   Pfam (8)   
All databases (109)   

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