KEGG   Callithrix jacchus (white-tufted-ear marmoset): 100391655
Entry
100391655         CDS       T03264                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
cjc  Callithrix jacchus (white-tufted-ear marmoset)
Pathway
cjc00562  Inositol phosphate metabolism
cjc01100  Metabolic pathways
cjc01521  EGFR tyrosine kinase inhibitor resistance
cjc01522  Endocrine resistance
cjc01524  Platinum drug resistance
cjc04012  ErbB signaling pathway
cjc04014  Ras signaling pathway
cjc04015  Rap1 signaling pathway
cjc04024  cAMP signaling pathway
cjc04062  Chemokine signaling pathway
cjc04066  HIF-1 signaling pathway
cjc04068  FoxO signaling pathway
cjc04070  Phosphatidylinositol signaling system
cjc04071  Sphingolipid signaling pathway
cjc04072  Phospholipase D signaling pathway
cjc04140  Autophagy - animal
cjc04150  mTOR signaling pathway
cjc04151  PI3K-Akt signaling pathway
cjc04152  AMPK signaling pathway
cjc04210  Apoptosis
cjc04211  Longevity regulating pathway
cjc04213  Longevity regulating pathway - multiple species
cjc04218  Cellular senescence
cjc04360  Axon guidance
cjc04370  VEGF signaling pathway
cjc04380  Osteoclast differentiation
cjc04510  Focal adhesion
cjc04550  Signaling pathways regulating pluripotency of stem cells
cjc04611  Platelet activation
cjc04613  Neutrophil extracellular trap formation
cjc04620  Toll-like receptor signaling pathway
cjc04625  C-type lectin receptor signaling pathway
cjc04630  JAK-STAT signaling pathway
cjc04650  Natural killer cell mediated cytotoxicity
cjc04660  T cell receptor signaling pathway
cjc04662  B cell receptor signaling pathway
cjc04664  Fc epsilon RI signaling pathway
cjc04666  Fc gamma R-mediated phagocytosis
cjc04668  TNF signaling pathway
cjc04670  Leukocyte transendothelial migration
cjc04722  Neurotrophin signaling pathway
cjc04725  Cholinergic synapse
cjc04750  Inflammatory mediator regulation of TRP channels
cjc04810  Regulation of actin cytoskeleton
cjc04910  Insulin signaling pathway
cjc04914  Progesterone-mediated oocyte maturation
cjc04915  Estrogen signaling pathway
cjc04917  Prolactin signaling pathway
cjc04919  Thyroid hormone signaling pathway
cjc04923  Regulation of lipolysis in adipocytes
cjc04926  Relaxin signaling pathway
cjc04929  GnRH secretion
cjc04930  Type II diabetes mellitus
cjc04931  Insulin resistance
cjc04932  Non-alcoholic fatty liver disease
cjc04933  AGE-RAGE signaling pathway in diabetic complications
cjc04935  Growth hormone synthesis, secretion and action
cjc04960  Aldosterone-regulated sodium reabsorption
cjc04973  Carbohydrate digestion and absorption
cjc05010  Alzheimer disease
cjc05017  Spinocerebellar ataxia
cjc05020  Prion disease
cjc05100  Bacterial invasion of epithelial cells
cjc05132  Salmonella infection
cjc05135  Yersinia infection
cjc05142  Chagas disease
cjc05146  Amoebiasis
cjc05160  Hepatitis C
cjc05161  Hepatitis B
cjc05162  Measles
cjc05163  Human cytomegalovirus infection
cjc05164  Influenza A
cjc05165  Human papillomavirus infection
cjc05166  Human T-cell leukemia virus 1 infection
cjc05167  Kaposi sarcoma-associated herpesvirus infection
cjc05168  Herpes simplex virus 1 infection
cjc05169  Epstein-Barr virus infection
cjc05170  Human immunodeficiency virus 1 infection
cjc05171  Coronavirus disease - COVID-19
cjc05200  Pathways in cancer
cjc05203  Viral carcinogenesis
cjc05205  Proteoglycans in cancer
cjc05206  MicroRNAs in cancer
cjc05207  Chemical carcinogenesis - receptor activation
cjc05208  Chemical carcinogenesis - reactive oxygen species
cjc05210  Colorectal cancer
cjc05211  Renal cell carcinoma
cjc05212  Pancreatic cancer
cjc05213  Endometrial cancer
cjc05214  Glioma
cjc05215  Prostate cancer
cjc05218  Melanoma
cjc05220  Chronic myeloid leukemia
cjc05221  Acute myeloid leukemia
cjc05222  Small cell lung cancer
cjc05223  Non-small cell lung cancer
cjc05224  Breast cancer
cjc05225  Hepatocellular carcinoma
cjc05226  Gastric cancer
cjc05230  Central carbon metabolism in cancer
cjc05231  Choline metabolism in cancer
cjc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cjc05415  Diabetic cardiomyopathy
cjc05417  Lipid and atherosclerosis
cjc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cjc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100391655 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100391655 (PIK3CB)
   04014 Ras signaling pathway
    100391655 (PIK3CB)
   04015 Rap1 signaling pathway
    100391655 (PIK3CB)
   04370 VEGF signaling pathway
    100391655 (PIK3CB)
   04630 JAK-STAT signaling pathway
    100391655 (PIK3CB)
   04668 TNF signaling pathway
    100391655 (PIK3CB)
   04066 HIF-1 signaling pathway
    100391655 (PIK3CB)
   04068 FoxO signaling pathway
    100391655 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    100391655 (PIK3CB)
   04072 Phospholipase D signaling pathway
    100391655 (PIK3CB)
   04071 Sphingolipid signaling pathway
    100391655 (PIK3CB)
   04024 cAMP signaling pathway
    100391655 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    100391655 (PIK3CB)
   04152 AMPK signaling pathway
    100391655 (PIK3CB)
   04150 mTOR signaling pathway
    100391655 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100391655 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    100391655 (PIK3CB)
   04218 Cellular senescence
    100391655 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100391655 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    100391655 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100391655 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100391655 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    100391655 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    100391655 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    100391655 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    100391655 (PIK3CB)
   04660 T cell receptor signaling pathway
    100391655 (PIK3CB)
   04662 B cell receptor signaling pathway
    100391655 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    100391655 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    100391655 (PIK3CB)
   04670 Leukocyte transendothelial migration
    100391655 (PIK3CB)
   04062 Chemokine signaling pathway
    100391655 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100391655 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    100391655 (PIK3CB)
   04929 GnRH secretion
    100391655 (PIK3CB)
   04915 Estrogen signaling pathway
    100391655 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    100391655 (PIK3CB)
   04917 Prolactin signaling pathway
    100391655 (PIK3CB)
   04926 Relaxin signaling pathway
    100391655 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    100391655 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    100391655 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100391655 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100391655 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    100391655 (PIK3CB)
   04722 Neurotrophin signaling pathway
    100391655 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100391655 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    100391655 (PIK3CB)
   04380 Osteoclast differentiation
    100391655 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    100391655 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    100391655 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100391655 (PIK3CB)
   05206 MicroRNAs in cancer
    100391655 (PIK3CB)
   05205 Proteoglycans in cancer
    100391655 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    100391655 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    100391655 (PIK3CB)
   05203 Viral carcinogenesis
    100391655 (PIK3CB)
   05230 Central carbon metabolism in cancer
    100391655 (PIK3CB)
   05231 Choline metabolism in cancer
    100391655 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100391655 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100391655 (PIK3CB)
   05212 Pancreatic cancer
    100391655 (PIK3CB)
   05225 Hepatocellular carcinoma
    100391655 (PIK3CB)
   05226 Gastric cancer
    100391655 (PIK3CB)
   05214 Glioma
    100391655 (PIK3CB)
   05221 Acute myeloid leukemia
    100391655 (PIK3CB)
   05220 Chronic myeloid leukemia
    100391655 (PIK3CB)
   05218 Melanoma
    100391655 (PIK3CB)
   05211 Renal cell carcinoma
    100391655 (PIK3CB)
   05215 Prostate cancer
    100391655 (PIK3CB)
   05213 Endometrial cancer
    100391655 (PIK3CB)
   05224 Breast cancer
    100391655 (PIK3CB)
   05222 Small cell lung cancer
    100391655 (PIK3CB)
   05223 Non-small cell lung cancer
    100391655 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100391655 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    100391655 (PIK3CB)
   05161 Hepatitis B
    100391655 (PIK3CB)
   05160 Hepatitis C
    100391655 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    100391655 (PIK3CB)
   05164 Influenza A
    100391655 (PIK3CB)
   05162 Measles
    100391655 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    100391655 (PIK3CB)
   05163 Human cytomegalovirus infection
    100391655 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100391655 (PIK3CB)
   05169 Epstein-Barr virus infection
    100391655 (PIK3CB)
   05165 Human papillomavirus infection
    100391655 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100391655 (PIK3CB)
   05135 Yersinia infection
    100391655 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    100391655 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100391655 (PIK3CB)
   05142 Chagas disease
    100391655 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100391655 (PIK3CB)
   05017 Spinocerebellar ataxia
    100391655 (PIK3CB)
   05020 Prion disease
    100391655 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100391655 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    100391655 (PIK3CB)
   05415 Diabetic cardiomyopathy
    100391655 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100391655 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    100391655 (PIK3CB)
   04931 Insulin resistance
    100391655 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100391655 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100391655 (PIK3CB)
   01524 Platinum drug resistance
    100391655 (PIK3CB)
   01522 Endocrine resistance
    100391655 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cjc04131]
    100391655 (PIK3CB)
Enzymes [BR:cjc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100391655 (PIK3CB)
Membrane trafficking [BR:cjc04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100391655 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 100391655
NCBI-ProteinID: XP_002759595
Ensembl: ENSCJAG00000002252
UniProt: F7CM33
Position
17:38628648..38794627
AA seq 1070 aa
MCFSFIMPPAMADILDIWAVDSQIASDGTIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDGLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENSQDVFSFQVSPNMNPIKINELAIQKRLTIHGKEDE
ISPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIILVKGNKLNTEETVKVHVRAGLFHG
TELLCKTVVSSEVSGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKAKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagatagcatctgatggcaccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgatccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctccatgaatttgatggcttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagtgaggagaagatc
ctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccagagcat
gaaccatccatccctgaaaacttagaagataaactttatggaggaaagctcattgtagct
gttcattttgaaaactcccaggatgtgtttagctttcaagtatctcctaatatgaatcct
ataaaaataaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
attagcccctatgattatgtgctgcaagtcagcgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccggaactgtgtaatgaacaggaccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaggaaatgattgccata
gaggctgccataaatagaaattcatctaatcttcctcttccattaccaccaaagaaaaca
cgaattatttctcatgtttgggaaaataacaaccctttccaaattatcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgagctcctgtgtaaaacagtcgtaagctctgaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatatcaatacttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgcagttttggataaagcaaaaacaaagaaatcaacgaaaactatt
aatccctctaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcgtgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacac
agctggtcttcatttccagatgaacttgaagaaatgttgaatccaatgggaactgttcag
acaaatccatatactgaaaatgcaacagctttgcatattaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagaatttcccacagtcattgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgcgcagcttcaggcactgcttcagatttggcctaaa
ctgcccccccgggaggccctagagcttctggatttcaactatccagaccagtatgttcga
gaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttctcaatatctttta
caactggtgcaagttttaaagtatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttgctaatcggaggatagggcagtttctattttggcatcttaggtcg
gaagtgcacattcctgctgtctcagtacagtttggtgtcatccttgaagcatactgtcgg
ggaagtgtggggcacatgaaagtactttccaagcaggttgaagccctcaataagttaaaa
actttaaatagtttaataaaactgaatgcagtgaagttaaacagagccaaagggaaggag
gccatgcacacctgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcggaactctatgttgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctggtatacaataacaaagtatttggtgaggattcagtt
ggagtgattttcaaaaatggtgatgatttacgacaggatatgttgacactccaaatgttg
cgcttgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaattggcttaaagaatacaattctggggatgacctggaccgagccattgaggaa
tttactctgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttggc
cggttccgtcagtgttgtgaggatgcgtatctgattttacgacggcatgggaatctcttc
atcactctctttgcattgatgttaactgcagggctccctgaactcacatcagtcaaggat
atacagtatcttaaggactctcttgcattggggaagagtgaagaagaagcactcaaacag
tttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (105)   
   KEGG PATHWAY (105)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   RefSeq(pep) (13)   
DNA sequence (21)   
   RefSeq(nuc) (13)   
   GenBank (4)   
   EMBL (4)   
Protein domain (7)   
   Pfam (7)   
All databases (166)   

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