KEGG   Drosophila melanogaster (fruit fly): Dmel_CG4792
Entry
Dmel_CG4792       CDS       T00030                                 
Symbol
Dcr-1
Name
(RefSeq) Dicer-1
  KO
K11592  endoribonuclease Dicer [EC:3.1.26.-]
Organism
dme  Drosophila melanogaster (fruit fly)
Brite
KEGG Orthology (KO) [BR:dme00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:dme03036]
    Dmel_CG4792 (Dcr-1)
Chromosome and associated proteins [BR:dme03036]
 Eukaryotic type
  Gene silencing
   RISC (RNA-induced silencing complex)
    Dmel_CG4792 (Dcr-1)
   microRNA pathway
    RISC loading complex
     Dmel_CG4792 (Dcr-1)
SSDB
Motif
Pfam: Ribonuclease_3 Dicer_platform Dicer_dsRBD Ribonucleas_3_3 Dicer_dimer PAZ Helicase_C Dicer_PBD
Other DBs
NCBI-GeneID: 42693
NCBI-ProteinID: NP_524453
FlyBase: FBgn0039016
UniProt: Q9VCU9 A0A515MFY5
Structure
Position
3R
AA seq 2249 aa
MAFHWCDNNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRARR
HGRVSVYLSCEVGTSTEPCSIYTMLTHLTDLRVWQEQPDMQIPFDHCWTDYHVSILRPEG
FLYLLETRELLLSSVELIVLEDCHDSAVYQRIRPLFENHIMPAPPADRPRILGLAGPLHS
AGCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLAD
VLNTHKSFLLDHRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQR
AAHHFYQCNEKLKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERY
SSPKVRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADFNRLSHTLESKCRMVDQMDQPP
TETRALVATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTR
RHHRDHNDGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTE
PKEAELEHRRQEEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCK
GRARAAPAYHVILVAPSYKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGS
DPYTFGTARGTVKILNPEVFSKQPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNT
SPSESSTEQKSRRFQCELSSLTEPEDTSDTTAEIDTAHSLASTTKDLVHQMAQYREIEQM
LLSKCANTEPPEQEQSEAERFSACLAAYRPKPHLLTGASVDLGSAIALVNKYCARLPSDT
FTKLTALWRCTRNERAGVTLFQYTLRLPINSPLKHDIVGLPMPTQTLARRLAALQACVEL
HRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQLSDEPRPGTTKRRQYYYKRIA
SEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIYPPEDAQQGFGILTTKRIPKLS
AFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTFTNVLRLQKFLMLFDPDSTEN
CVFIVPTVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQAQPFDPQRFQDAVVMPWY
RNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQNTSQPLLDVDHTSAR
LNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWRTAVCLPC
ILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQKES
LKDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGT
WSNDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGESGFKGPK
SSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVADDI
DAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQK
EPATIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVN
EDVLAKKLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQL
KLQYERIEIEPPTSTKAITSAILPAGFSFDRQPDLVGHPGPSPSIILQALTMSNANDGIN
LERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIA
TKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLADLLDIKNLSSVQICEMVREKADA
LGLEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGP
RGALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGAWPTPRSPLLHFAP
NATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCYQRLEFLGDAVLD
YLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFV
RIQQENGHCISEEYYLLSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVY
SNMMSPEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGI
GRNYRIAKCTAAKCALRQLKKQGLIAKKD
NT seq 6750 nt   +upstreamnt  +downstreamnt
atggcgttccactggtgcgacaacaatctgcacaccaccgtgttcacgccgcgcgacttt
caggtggagctactggccaccgcctacgagcggaacacgattatttgcctgggccatcga
agttccaaggagtttatagccctcaagctgctccaggagctgtcgcgtcgagcacgccga
catggtcgtgtcagtgtctatctcagttgcgaggttggcaccagcacggaaccatgctcc
atctacacgatgctcacccacttgactgacctgcgggtgtggcaggagcagccggatatg
caaattccctttgatcattgctggacggactatcacgtttccatcctacggccagaggga
tttctttatctgctcgaaactcgcgagctgctgctgagcagcgtcgaactgatcgtgctg
gaagattgtcatgacagcgccgtttatcagaggataaggcctctgttcgagaatcacatt
atgccagcgccaccggcggacaggccacggattctcggactcgctggaccgctgcacagc
gccggatgtgagctgcagcaactgagcgccatgctggccaccctggagcagagtgtgctt
tgccagatcgagacggccagtgatattgtcaccgtgttgcgttactgttcccgaccgcac
gaatacatcgtacagtgcgcccccttcgagatggacgaactgtccctggtgcttgccgat
gtgctcaacacacacaagtcctttttattggaccaccgctacgatccctacgaaatctac
ggcacagaccagtttatggacgaactgaaagacatacccgatcccaaggtggaccccctg
aacgtcatcaactcactactggtcgtgctgcacgagatgggtccttggtgcacgcagcgg
gctgcacatcacttttaccaatgcaatgagaagttaaaggtgaagacgccgcacgaacgt
cactacttgctgtactgcctagtgagcacggcccttatccaactgtactccctctgcgaa
cacgcattccatcgacatttaggaagtggcagcgattcacgccagaccatcgaacgctat
tccagccccaaggtgcgacgtctgttgcagacactgaggtgcttcaagccggaagaggtg
cacacccaagcggacggactgcgcagaatgcggcatcaggtggatcaggcggacttcaat
cggttatctcatacgctggaaagcaagtgccgaatggtggatcaaatggaccaaccgccg
acggagacacgagccctggtggccactcttgagcagattctgcacacgacagaggacagg
cagacgaacagaagcgccgctcgggtgactcctactcctactcccgctcatgcgaagccg
aaacctagctctggtgccaacactgcacaaccacgaactcgtagacgtgtgtacaccagg
cgccaccaccgggatcacaatgatggcagcgacacgctctgcgcactgatttactgcaac
cagaaccacacggctcgcgtgctctttgagcttctagcggagattagcagacgtgatccc
gatctcaagttcctacgctgccagtacaccacggaccgggtggcagatcccaccacggag
cccaaagaggctgagttggagcaccggcggcaggaagaggtgctaaagcgcttccgcatg
catgactgcaatgtcctgatcggtacttcggtgctggaagagggcatcgatgtgcccaag
tgcaatttggttgtgcgctgggatccgccaaccacatatcgcagttacgttcagtgcaaa
ggtcgagcccgtgctgctccagcctatcatgtcattctcgtcgctccgagttataaaagc
ccaactgtggggtcagtgcagctgaccgatcggagtcatcggtatatttgcgcgactggt
gatactacagaggcggacagcgactctgatgattcagcgatgccaaactcgtccggctcg
gatccctatacttttggcacggcacgcggaaccgtgaagatcctcaaccccgaagtgttc
agtaaacaaccaccgacagcgtgcgacattaagctgcaggagatccaggacgaattgcca
gccgcagcgcagctggatacgagcaactccagcgacgaagccgtcagcatgagtaacacg
tctccaagcgagagcagtacagaacaaaaatccagacgcttccagtgcgagctgagctct
ttaacggagccagaagacacaagtgatactacagccgaaatcgatactgctcatagttta
gccagcaccacgaaggacttggtgcatcaaatggcacagtatcgcgaaatcgagcagatg
ctgctatccaagtgcgccaacacagagccgccggagcaggagcagagtgaggcggaacgt
tttagtgcctgcctggccgcataccgacccaagccgcacctgctaacaggcgcctccgtg
gatctgggttctgctatagctttggtcaacaagtactgcgcccgactgccaagcgacacg
ttcaccaagttgacggcgttgtggcgctgcacccgaaacgaaagggctggagtgaccctg
tttcagtacacactccgtctgcccatcaactcgccattgaagcatgacattgtgggtctt
ccgatgccaactcaaacattggcccgccgactggctgccttgcaggcttgcgtggaactg
cacaggatcggtgagttagacgatcagttgcagcctatcggcaaggagggatttcgtgcc
ctggagccggactgggagtgctttgaactggagccagaggacgaacagattgtgcagcta
agcgatgaaccacgtccgggaacaacgaagcgtcgtcagtactattacaaacgcattgca
tccgaattttgcgattgccgtcccgttgccggagcgccatgctatttgtactttatccaa
ctgacgctccaatgtccgattcccgaagagcaaaacacgcggggacgcaagatttatccg
cccgaagatgcgcagcagggattcggcattctaaccaccaaacggatacccaagctgagt
gctttctcgatattcacgcgttccggtgaggtgaaggtttccctggagttagctaaggaa
cgcgtgattctaactagcgaacaaatagtctgcatcaacggatttttaaactacacgttc
accaatgtactgcgtttgcaaaagtttctgatgctcttcgatccggactccacggaaaat
tgtgtattcattgtgcccaccgtgaaggcaccagctggcggcaagcacatcgactggcag
tttctggagctgatccaagcgaatggaaatacaatgccacgggcagtgcccgatgaggag
cgccaggcgcagccgtttgatccgcaacgcttccaggatgccgtcgttatgccgtggtat
cgcaaccaggatcaaccgcagtatttctatgtggcggagatatgtccacatctatcccca
ctcagctgcttccctggtgacaactaccgcacgttcaagcactactacctcgtcaagtat
ggtctgaccatacagaatacctcgcagccgctattggacgtggatcacaccagtgcgcgg
ttaaacttcctcacgccacgatacgttaatcgcaagggcgttgctctgcccactagttcg
gaggagacaaagcgggcaaagcgcgagaatctcgaacagaagcagatccttgtgccagag
ctctgcactgtgcatccattccccgcctccttgtggcgaactgccgtgtgcctgccctgc
atcctgtaccgcataaatggtcttctattggccgacgatattcggaaacaggtttctgcg
gatctggggctgggaaggcaacagatcgaagatgaggatttcgagtggcccatgctggac
tttgggtggagtctatcggaggtgctcaagaaatcgcgggagtccaaacaaaaggagtcc
cttaaggatgatactattaatggcaaagacttagctgatgttgaaaagaaaccgactagc
gaggagacccaactagataaggattcaaaagacgataaggttgagaaaagtgctattgaa
ctaatcattgagggagaggagaagctgcaagaggctgatgacttcattgagataggcact
tggtcaaacgatatggccgacgatatagctagttttaaccaagaagacgacgacgaggat
gacgccttccatctcccagttttaccggcaaacgttaagttctgtgatcagcaaacgcgc
tacggttcgcccacattttgggatgtgagcaatggcgaaagcggcttcaagggtccaaag
agcagtcagaataagcagggtggcaagggcaaagcaaagggtccggcaaagcccacattt
aactattatgactcggacaattcgctgggttccagctacgatgacgacgataacgcaggt
ccgctcaattacatgcatcacaactacagttcggatgacgacgatgtggcagatgatatc
gatgcgggacgcattgcgttcacctccaagaatgaagcggagactattgaaaccgcacag
gaagtggaaaagcgccagaagcagctgtccatcatccaggcgaccaatgctaacgagcgg
cagtatcagcagacaaagaacctgctcattggattcaattttaagcatgaggaccagaag
gaacctgccactataagatatgaagaatccatagctaagctcaaaacggaaatagaatcc
ggcggcatgttggtgccgcacgaccagcagttggttctaaaaagaagtgatgccgctgag
gctcaggttgcaaaggtatcgatgatggagctattgaagcagctgctgccgtatgtaaat
gaagatgtgctggccaaaaagctgggtgataggcgcgagcttctgctgtcggatttggta
gagctaaatgcagattgggtagcgcgacatgagcaggagacctacaatgtaatgggatgc
ggagatagttttgacaactataacgatcatcatcggctgaacttggatgaaaagcaactg
aaactgcaatacgaacgaattgaaattgagccacctacttccacgaaggccataacctca
gccatattaccagctggcttcagtttcgatcgacaaccggatctagtgggccatccagga
cccagtcccagcatcattttgcaagccctcacaatgtccaatgctaacgatggcatcaat
ctggagcgactggagacaattggagattcctttctaaagtatgccattaccacctacttg
tacatcacctacgagaatgtgcacgagggaaaactaagtcacctgcgctccaagcaggtt
gccaatctcaatctctatcgtctgggcagacgtaagagactgggtgaatatatgatagcc
actaaattcgagccgcacgacaattggctgccaccctgctactacgtgccaaaggagcta
gagaaggcgctcatcgaggcgaagatccccactcaccattggaagctggccgatctgcta
gacattaagaacctaagcagtgtgcaaatctgcgagatggttcgcgaaaaagccgatgcc
ctgggcttggagcagaatgggggtgcccaaaatggacaacttgacgactccaatgatagc
tgcaatgattttagctgttttattccctacaaccttgtttcgcaacacagcattccggat
aagtctattgccgattgcgtcgaagccctcattggagcctatctcattgagtgcggaccc
cgaggggctttactctttatggcctggctgggcgtgagagtgctccctatcacaaggcag
ttggacgggggtaaccaggagcaacgaatacccggtagcacaaaaccgaatgccgaaaat
gtggtcaccgtttacggtgcatggcccacgccgcgtagtccactgctgcactttgctcca
aatgctacggaggagctggaccagttactaagcggctttgaggagtttgaggagagtttg
ggatacaagttccgggatcggtcgtacctgttgcaagccatgacacatgccagttacacg
cccaatcgattgacggattgctatcagcgtctggagttcctgggcgatgctgttctagat
tacctcattacgcggcatttatacgaagatccccgccagcattctccaggcgcattaacg
gatttgcggtcagcactggtgaataatacaatattcgcctccctggctgttcgccatggc
ttccacaagttcttccggcacctctcgccgggccttaacgatgtgattgaccgttttgtg
cggatccagcaggagaatggacactgcatcagtgaggagtactacttattgtccgaggag
gagtgcgatgacgccgaggacgttgaggtgcccaaggcattgggcgacgttttcgagtcg
atcgcaggtgccatttttctcgactcaaacatgtcgctggacgtggtttggcacgtatat
agcaacatgatgagcccggagatcgagcagttcagcaactcagtgccaaaatcgcccatt
cgggagctcctcgagctggagccggaaaccgccaagttcggcaagcccgagaagctggcg
gatgggcgacgggtgcgcgttaccgtggatgtcttctgcaaaggaaccttccgtggcatc
ggacgcaactatcgcattgccaagtgcacggcggccaaatgcgcattgcgccaactcaaa
aagcagggcttgatagccaaaaaagactaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (153)   
   KEGG ORTHOLOGY (1)   
   RefGene (148)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   FLYBASE (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
3D Structure (6)   
   PDB (6)   
Protein domain (8)   
   Pfam (8)   
All databases (175)   

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