KEGG   Drosophila melanogaster (fruit fly): Dmel_CG4067
Entry
Dmel_CG4067       CDS       T00030                                 
Symbol
pug
Name
(RefSeq) pugilist, isoform D
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
dme  Drosophila melanogaster (fruit fly)
Pathway
dme00670  One carbon pool by folate
dme01100  Metabolic pathways
dme01240  Biosynthesis of cofactors
Module
dme_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:dme00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    Dmel_CG4067 (pug)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:dme04147]
    Dmel_CG4067 (pug)
Enzymes [BR:dme01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     Dmel_CG4067 (pug)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     Dmel_CG4067 (pug)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     Dmel_CG4067 (pug)
Exosome [BR:dme04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   Dmel_CG4067 (pug)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH AcetDehyd-dimer Peptidase_C39
Other DBs
NCBI-GeneID: 41279
NCBI-ProteinID: NP_001014614
FlyBase: FBgn0020385
UniProt: O96553 E8NH74
Position
3R
AA seq 968 aa
MSAQYQRFLKVLEKWPAEKSKVGSGEWTAEPAIKMSGAKIISGTAVAKSIREELRNEVTA
MSKQLADFVPGLRIVQVGGREDSNVYIRMKIKAATEIGIDAAHVQLPRSITEVELLDKIN
DLNEDPRVHGIIVQMPLDCDTPIDSHRITDAVSPEKDVDGLHTVNEGRLAIGDLGGFLPC
TPWGCLELIRRSGVEIAGARAVVLGRSKIVGTPAAELLKWANATVTVCHSKTRNLEEITR
SADILVVGIGVAEMVKGSWIKPGAVVIDCGINVKPDASKASGSKLVGDVDYAEALQVAGH
LTPVPGGVGPMTVAMLMKNTVRSAARFLERLAKSQWALQTLPLKPQRPVPSDIVIARAQK
PKDIAVLAKEIGLEAREVSLYGNKKAKISLSVLERLKDKEVGHYVVVAGMTPTPLGEGKT
TTLMGLVQALGAHKLRNTMAALRQPSQGPTFGIKGGAAGGGYAQVIPMEEFNLHLTGDIH
AVSAANNLLAAQLDTRIFHENTQKDKALYDRLVPAIKGQRKFSPIQLRRLQKLGITKTDP
DTLTADEYGPFARLDIDPDTIMWERVVDINDRYLRTITVGQSPTEKGISRETRFSISVAS
EIMAVLALSRSLEDMKQRLADMVVAFDKRGKPVTADDLGVTGALAVLLKDALEPNLMQSL
EGTPVLVHAGPFANIAHGCNSIIADEVGLKLVGKNGFVCTEAGFGSDIGMEKFCNIKCRT
SGRKPNAMVLVATVRAIKMHGGGAPVTPGAPLNKQYTEENLELVQKGLPNLLQHIENGKA
FGMPVVVSLNAHSADTPAEHELVKKAALEAGAFAAVVSTHWADGGAGAVQLADAVIKACE
QGNQFRLLYDLELPLVDKMNKIATTMYGAGKVVLSPAAEEKVKRLTDAGFGNLPICMSKV
SGSFTGDAKIKGAPKGFTLDVEDVYVSAGAGFVVAMCGEVTKMPGLPTRPAIYDIDLNTE
TGEIEGLF
NT seq 2907 nt   +upstreamnt  +downstreamnt
atgtcggcgcaatatcaaagattcctgaaagtactagaaaagtggccagcggagaaatca
aaagtcggcagcggagagtggacagcagagccggctatcaagatgagtggggccaagatc
atatcgggcacggcggtggccaaatccattcgcgaagagctgcgtaacgaggtgacggct
atgagcaagcaattggcggattttgtgcccggcttaaggattgtccaggttggtggacgt
gaggactccaacgtttacatccgcatgaagatcaaggcggctacggagatcggtatcgat
gccgcccacgtccagctgccccgatccatcaccgaggtggaattgctcgataagataaac
gatctgaacgaggacccccgggtgcacggcatcatagtgcaaatgcccctggattgtgac
acacccatcgattcgcaccgaattacggacgccgtttccccggagaaggatgttgacggc
ttgcacacggttaacgaaggtcgcctggccatcggtgaccttggtggtttcctgccctgc
actccttggggttgcctggagttaattcgccgttctggagtagagatcgccggagccagg
gctgtggttctgggacgcagcaagatcgtgggcactcccgccgccgaactgctcaagtgg
gccaatgccacggtcacagtgtgccactcaaagacccgcaacctggaggagatcacccga
agtgcagacattctggtggtcggaattggagtggccgagatggttaagggatcgtggata
aagcccggagcagtggtcatcgattgcggcatcaatgtgaagccagacgccagcaaggcc
agtggcagcaagctggtcggggacgtggactacgcggaagctctccaagtggcaggacat
ttgacgccagtgcccggcggcgtgggacccatgacggtggccatgcttatgaaaaacacc
gtgcgatctgcggcccgattccttgagcgtcttgctaagagccagtgggcccttcaaacg
ctgcccctcaagccccagcgtcccgtgcccagcgatattgtgattgcccgtgcccaaaaa
ccgaaggacattgccgtgctggccaaggagattggtctggaagctcgtgaggtttccttg
tacggaaataagaaggccaagatttcactgtcagtgttggagcgtctgaaggacaaggag
gtgggtcactatgtggttgtagccggtatgacaccaacgcctttgggtgagggtaagacc
accacactaatgggcttggtccaggctctcggcgcgcacaagctgagaaacaccatggct
gctctgcgacagccctcccaaggtccaacctttggcatcaaaggaggagctgctggcggc
ggatacgcccaggtgattcccatggaggagttcaatctccatctgacaggagacattcat
gcggtatcggcagccaataacttgctggccgcccagctggacacccgcatcttccacgag
aatacccaaaaggacaaggccttgtatgacagattggtgcccgcgatcaagggtcagcgg
aaattcagccccattcagctacgccggctccagaaattgggaatcaccaaaaccgatccc
gatacccttaccgctgacgaatacggaccttttgcccggctggacatcgatccggacacg
attatgtgggagcgtgtggtggacatcaacgatcggtacctacgcaccattaccgttggg
caatcgcccactgaaaagggtatttcgagggagacccggttctccatctcggtggccagc
gagatcatggctgtgctagcactatcccgaagtctggaggacatgaagcagcggctggct
gacatggtggtggcattcgacaaacgaggcaagcccgtaaccgctgacgatttgggtgtc
accggtgccctggcagttcttttgaaggacgctctcgagccgaacctgatgcagtcgctc
gagggaactccagtgctggtgcacgctggtccctttgccaacatcgcccacggttgcaac
tcgatcatcgctgatgaagtcggcctaaagctggttggtaaaaatggatttgtctgcacg
gaggccgggttcggatcagatattggcatggaaaagttttgcaacattaagtgtcggaca
tccggtcgcaagccgaacgccatggtgctggtagccactgtgagggccatcaagatgcac
ggcggcggagctcccgtcactcccggagcccccttgaacaagcagtacaccgaggagaac
ttggagctcgtccagaagggtctgcccaatctgctgcagcacatcgagaacggaaaggcc
ttcggcatgccagtggtggtgagccttaatgctcattcagcagacaccccggcggagcat
gagttggtcaaaaaggctgctctggaggcaggtgcattcgccgccgtagtctccactcac
tgggcggacggaggagccggagccgttcagctggccgatgccgtgatcaaggcctgcgaa
cagggcaatcaattccgattgctctacgatctggagctgccgctggtggataagatgaac
aagatcgctacgacgatgtacggcgctggaaaggtggtgctctcgccggcggctgaggag
aaggtcaaacgcctgacggatgcgggttttggcaatctacctatctgcatgtccaaagtc
tccggctccttcaccggcgatgccaaaatcaaaggcgcccccaagggcttcaccctggac
gttgaggacgtatatgtttcagccggagccggctttgtggtcgccatgtgcggtgaggtc
accaaaatgccgggtcttcccacccgcccggcgatctacgatatcgatctgaatacggaa
accggagaaattgagggcctattttag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (6)   
   KEGG ENZYME (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   FLYBASE (1)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (5)   
   Pfam (5)   
All databases (70)   

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