KEGG   Danio rerio (zebrafish): 561737Help
Entry
561737            CDS       T01004                                 

Gene name
pik3ca
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  KO
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
dre  Danio rerio (zebrafish)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Focal adhesion
Toll-like receptor signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
AGE-RAGE signaling pathway in diabetic complications
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:dre00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    561737 (pik3ca)
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    561737 (pik3ca)
   04370 VEGF signaling pathway
    561737 (pik3ca)
   04068 FoxO signaling pathway
    561737 (pik3ca)
   04070 Phosphatidylinositol signaling system
    561737 (pik3ca)
   04150 mTOR signaling pathway
    561737 (pik3ca)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    561737 (pik3ca)
  Cell growth and death
   04210 Apoptosis
    561737 (pik3ca)
  Cellular commiunity
   04510 Focal adhesion
    561737 (pik3ca)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    561737 (pik3ca)
  Endocrine system
   04910 Insulin signaling pathway
    561737 (pik3ca)
   04914 Progesterone-mediated oocyte maturation
    561737 (pik3ca)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    561737 (pik3ca)
 Human Diseases
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    561737 (pik3ca)
Enzymes [BR:dre01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     561737 (pik3ca)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
ZFIN: 
Ensembl: 
Vega: 
UniProt: 
Position
11
AA seq 1069 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVDCLLPNGMILTLECLREATLITIKHELFKEARKYPLHH
LLQEETSYIFVSVTQEAEREEFYDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDLVKDPEVQDFRRNILNVCKDSVELRDASGAHSRALYVYPPNVESSPELPKH
IYGKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSAEQLK
MCVQEYQGKYILKVCGCDEYLLEKYPISQYKYVRSCIMLGRLPNLMLMSKDSLYSQLPMD
NFTMPSYSRRISTATPYMNGEASTKSLWTINSTLRIRVLCATYVNVNIRDIDKIYVRTGI
YHGGEQLCDNVNTQRVPCSNPRWNEWLTYDMYIPDIPRAARLCLSICSVKGRKGAKEEHC
PLAWGNVNLFDYTHTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDYF
SSPVKFPDMATIEDHANWIISREMGYNYCQSGQSSRVARDHAMTEADIEQLRQLGNRDPL
SEITEQEKDFLWRHRQYCVNIPEILPKILLAVKWNSRDEVAQMYCLLKDWPAIKPEQAME
LLDCNYPDPMIRDFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNPLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDYMDALQNFTSPLNPAHQLGNLRLEDCRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRSSHTIMQIQCKGGLKGALQFNSTTLHQWLKDKNKGEMYDMAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGGTQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDI
AYIRKTLALDKTEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIRHHAQN
NT seq 3210 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccctcttcgggagagttatggggcatccatttgatgccccccaggatt
ttggtggactgtctgctgcccaatggcatgatcctgacactagagtgcctccgggaggct
acgctcataacaatcaaacatgaactgtttaaggaggctaggaaataccccctacaccat
ctgctgcaggaggagacctcttatattttcgtcagtgtaacgcaagaggcagagcgagag
gagttctacgatgagaccagaagactctgcgaccttcggcttttccagccattcctaaaa
gttatcgaacctgtagggaacagagaggaaaagatcctcaacagagaaattggttttgcc
attggcatgccagtgtgtgagtttgatctagtgaaggatcctgaggtgcaggacttcagg
agaaatatccttaatgtctgcaaggactcagtagagttgcgggacgccagcggggcacac
agtcgagcactatacgtttatcctcctaacgtggagtcttcaccagagcttccaaagcat
atatatggcaaattagacaaaggtcaaatcattgtggtcatctgggtgatcgtctcgccc
aacaacgacaagcagaagtacacactaaagatcaatcacgactgcgtacctgagcaggtg
atcgccgaagccatcaggaagaaaaccagaagcatgctgctgtcagccgagcagctaaag
atgtgcgtgcaggaatatcagggcaaatacatcctgaaggtctgcggctgtgacgagtat
cttttggaaaagtaccccatcagtcagtacaagtatgtacggagttgcattatgctgggt
cgcttgccaaacctcatgcttatgtccaaggacagtctttactctcagctgccgatggac
aacttcaccatgccctcctattcccgccgcatctccaccgccacgccttacatgaacgga
gaggcctccaccaaatctctctggaccattaacagcacccttaggatacgggtcctctgc
gcaacatacgttaatgtgaacattcgggacattgataagatttatgtgcggacggggatc
taccatggtggagaacagttgtgtgataatgtcaacacgcagcgtgtcccgtgttcaaat
ccgaggtggaacgagtggctgacttatgacatgtacattcctgacatcccccgggcggct
cgtctctgtctctccatctgttctgtgaaaggaaggaagggggcaaaagaggagcactgt
ccactggcctggggaaacgtcaacctgttcgactacacacacactctggtctcaggaaag
atggcactgaatctgtggcctgtaccacacggcctagaagacctgcttaaccccatcggt
gtcacaggctccaaccctaacaaggaaaccccatgtttagagctggagtttgactatttc
agctcacctgttaagttccctgacatggctacaattgaggatcacgctaactggataata
tccagagagatgggatacaattactgccagtctggacagagcagtagagtggcacgagac
catgcaatgacagaggcagatatagagcaacttcggcagctgggaaacagggacccgctt
tctgagatcactgagcaggaaaaagacttcctatggaggcacaggcagtattgtgtaaat
ataccagaaatcctgcccaagattctgctggcggtgaagtggaattccagagatgaagtt
gcacagatgtattgccttctgaaagattggcctgcaataaagccggaacaagccatggag
ttgcttgactgtaactaccctgatccaatgatccgagactttgcggttcggtgccttgag
aagtatctaaccgatgacaaactctcgcagtacctcattcaattggttcaggttttgaag
tacgagcagtatcttgataacccactggtgcgatttctgctaaaaaaagctctcaccaac
cagaggattgggcacttcttcttttggcatttgaagtcagagatgcacaataaaactgtg
agtcagcggtttggcctactgctggagtcgtactgccgcgcgtgtggcatgtacctgaag
cacctgagcagacaagtggaggccatggagaagctcatcaacctcacagacattctcaaa
caggagaagaaggatgaaactcagaaggtgcaaatgaagtttctagtggagcagatgagg
cgaccagactacatggatgccctccaaaatttcacctctccactaaaccctgcccaccag
ctggggaacctacgacttgaagactgcagaatcatgtcctctgccaagagaccgctctgg
ctgaactgggaaaatcctgacatcatgtccgaacttctcttccaaaacaatgagatcatc
ttcaagaacggagatgatctgcggcaagacatgttgacgcttcagatcatcagaataatg
gagaacatttggcaaaatcagggtctggacctgagaatgctcccctatggctgcttgtct
attggagattgtgtgggtctcatcgaggtggtaagaagttctcacaccatcatgcagatt
caatgtaaaggaggcctgaagggtgcgctgcagtttaacagtacaacgctgcatcagtgg
ctaaaagacaagaacaagggtgaaatgtacgacatggctatagacttgtttacgcgatcc
tgtgctggctattgtgtggccactttcattctgggtattggtgacaggcacaacagtaac
atcatggtgaaggatgatgggcagctgtttcatatagattttggtcactttttggaccac
aagaagaagaagtttggctacaagcgagagcgagtgccgttcgtcttgactcaagacttc
ctaattgtgatcagcaaaggaggaacccaggagtgcactaaaaccagagagtttgagagg
tttcaagagatgtgctacaaggcatacctggccatccgacagcatgccaacctcttcatc
aacctcttctccatgatgctgggctcaggaatgccggagctgcagtccttcgacgacatc
gcttacatccgcaagactctggcattagacaaaaccgagcaggaagccctggactatttc
atgaagcagatgaatgacgctcaccatggcggatggaccaccaagatggactggatcttc
cacaccatccgtcaccatgcccaaaactga

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