KEGG   Danio rerio (zebrafish): 561737Help
Entry
561737            CDS       T01004                                 

Gene name
pik3ca
Definition
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
dre  Danio rerio (zebrafish)
Pathway
dre00562  Inositol phosphate metabolism
dre04012  ErbB signaling pathway
dre04068  FoxO signaling pathway
dre04070  Phosphatidylinositol signaling system
dre04140  Autophagy - animal
dre04150  mTOR signaling pathway
dre04210  Apoptosis
dre04218  Cellular senescence
dre04370  VEGF signaling pathway
dre04510  Focal adhesion
dre04620  Toll-like receptor signaling pathway
dre04625  C-type lectin receptor signaling pathway
dre04810  Regulation of actin cytoskeleton
dre04910  Insulin signaling pathway
dre04914  Progesterone-mediated oocyte maturation
dre04933  AGE-RAGE signaling pathway in diabetic complications
Module
dre_M00676  PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:dre00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    561737 (pik3ca)
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    561737 (pik3ca)
   04370 VEGF signaling pathway
    561737 (pik3ca)
   04068 FoxO signaling pathway
    561737 (pik3ca)
   04070 Phosphatidylinositol signaling system
    561737 (pik3ca)
   04150 mTOR signaling pathway
    561737 (pik3ca)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    561737 (pik3ca)
  Cell growth and death
   04210 Apoptosis
    561737 (pik3ca)
   04218 Cellular senescence
    561737 (pik3ca)
  Cellular community - eukaryotes
   04510 Focal adhesion
    561737 (pik3ca)
  Cell motility
   04810 Regulation of actin cytoskeleton
    561737 (pik3ca)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    561737 (pik3ca)
   04625 C-type lectin receptor signaling pathway
    561737 (pik3ca)
  Endocrine system
   04910 Insulin signaling pathway
    561737 (pik3ca)
   04914 Progesterone-mediated oocyte maturation
    561737 (pik3ca)
 Human Diseases
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    561737 (pik3ca)
Enzymes [BR:dre01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     561737 (pik3ca)
Membrane trafficking [BR:dre04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    561737 (pik3ca)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_rbd PI3K_C2 PI3K_p85B DUF2321 C2 Ribosomal_S15
Motif
Other DBs
NCBI-GeneID: 561737
NCBI-ProteinID: XP_009304451
ZFIN: ZDB-GENE-130409-1
Ensembl: ENSDARG00000075456
Vega: OTTDARG00000035776
UniProt: F1QAD7
Position
11
AA seq 1069 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVDCLLPNGMILTLECLREATLITIKHELFKEARKYPLHH
LLQEETSYIFVSVTQEAEREEFYDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDLVKDPEVQDFRRNILNVCKDSVELRDASGAHSRALYVYPPNVESSPELPKH
IYGKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSAEQLK
MCVQEYQGKYILKVCGCDEYLLEKYPISQYKYVRSCIMLGRLPNLMLMSKDSLYSQLPMD
NFTMPSYSRRISTATPYMNGEASTKSLWTINSTLRIRVLCATYVNVNIRDIDKIYVRTGI
YHGGEQLCDNVNTQRVPCSNPRWNEWLTYDMYIPDIPRAARLCLSICSVKGRKGAKEEHC
PLAWGNVNLFDYTHTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDYF
SSPVKFPDMATIEDHANWIISREMGYNYCQSGQSSRVARDHAMTEADIEQLRQLGNRDPL
SEITEQEKDFLWRHRQYCVNIPEILPKILLAVKWNSRDEVAQMYCLLKDWPAIKPEQAME
LLDCNYPDPMIRDFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNPLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDYMDALQNFTSPLNPAHQLGNLRLEDCRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRSSHTIMQIQCKGGLKGALQFNSTTLHQWLKDKNKGEMYDMAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGGTQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDI
AYIRKTLALDKTEQEALDYFMKQMNDAHHGGWTTKMDWIFHTIRHHAQN
NT seq 3210 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccctcttcgggagagttatggggcatccatttgatgccccccaggatt
ttggtggactgtctgctgcccaatggcatgatcctgacactagagtgcctccgggaggct
acgctcataacaatcaaacatgaactgtttaaggaggctaggaaataccccctacaccat
ctgctgcaggaggagacctcttatattttcgtcagtgtaacgcaagaggcagagcgagag
gagttctacgatgagaccagaagactctgcgaccttcggcttttccagccattcctaaaa
gttatcgaacctgtagggaacagagaggaaaagatcctcaacagagaaattggttttgcc
attggcatgccagtgtgtgagtttgatctagtgaaggatcctgaggtgcaggacttcagg
agaaatatccttaatgtctgcaaggactcagtagagttgcgggacgccagcggggcacac
agtcgagcactatacgtttatcctcctaacgtggagtcttcaccagagcttccaaagcat
atatatggcaaattagacaaaggtcaaatcattgtggtcatctgggtgatcgtctcgccc
aacaacgacaagcagaagtacacactaaagatcaatcacgactgcgtacctgagcaggtg
atcgccgaagccatcaggaagaaaaccagaagcatgctgctgtcagccgagcagctaaag
atgtgcgtgcaggaatatcagggcaaatacatcctgaaggtctgcggctgtgacgagtat
cttttggaaaagtaccccatcagtcagtacaagtatgtacggagttgcattatgctgggt
cgcttgccaaacctcatgcttatgtccaaggacagtctttactctcagctgccgatggac
aacttcaccatgccctcctattcccgccgcatctccaccgccacgccttacatgaacgga
gaggcctccaccaaatctctctggaccattaacagcacccttaggatacgggtcctctgc
gcaacatacgttaatgtgaacattcgggacattgataagatttatgtgcggacggggatc
taccatggtggagaacagttgtgtgataatgtcaacacgcagcgtgtcccgtgttcaaat
ccgaggtggaacgagtggctgacttatgacatgtacattcctgacatcccccgggcggct
cgtctctgtctctccatctgttctgtgaaaggaaggaagggggcaaaagaggagcactgt
ccactggcctggggaaacgtcaacctgttcgactacacacacactctggtctcaggaaag
atggcactgaatctgtggcctgtaccacacggcctagaagacctgcttaaccccatcggt
gtcacaggctccaaccctaacaaggaaaccccatgtttagagctggagtttgactatttc
agctcacctgttaagttccctgacatggctacaattgaggatcacgctaactggataata
tccagagagatgggatacaattactgccagtctggacagagcagtagagtggcacgagac
catgcaatgacagaggcagatatagagcaacttcggcagctgggaaacagggacccgctt
tctgagatcactgagcaggaaaaagacttcctatggaggcacaggcagtattgtgtaaat
ataccagaaatcctgcccaagattctgctggcggtgaagtggaattccagagatgaagtt
gcacagatgtattgccttctgaaagattggcctgcaataaagccggaacaagccatggag
ttgcttgactgtaactaccctgatccaatgatccgagactttgcggttcggtgccttgag
aagtatctaaccgatgacaaactctcgcagtacctcattcaattggttcaggttttgaag
tacgagcagtatcttgataacccactggtgcgatttctgctaaaaaaagctctcaccaac
cagaggattgggcacttcttcttttggcatttgaagtcagagatgcacaataaaactgtg
agtcagcggtttggcctactgctggagtcgtactgccgcgcgtgtggcatgtacctgaag
cacctgagcagacaagtggaggccatggagaagctcatcaacctcacagacattctcaaa
caggagaagaaggatgaaactcagaaggtgcaaatgaagtttctagtggagcagatgagg
cgaccagactacatggatgccctccaaaatttcacctctccactaaaccctgcccaccag
ctggggaacctacgacttgaagactgcagaatcatgtcctctgccaagagaccgctctgg
ctgaactgggaaaatcctgacatcatgtccgaacttctcttccaaaacaatgagatcatc
ttcaagaacggagatgatctgcggcaagacatgttgacgcttcagatcatcagaataatg
gagaacatttggcaaaatcagggtctggacctgagaatgctcccctatggctgcttgtct
attggagattgtgtgggtctcatcgaggtggtaagaagttctcacaccatcatgcagatt
caatgtaaaggaggcctgaagggtgcgctgcagtttaacagtacaacgctgcatcagtgg
ctaaaagacaagaacaagggtgaaatgtacgacatggctatagacttgtttacgcgatcc
tgtgctggctattgtgtggccactttcattctgggtattggtgacaggcacaacagtaac
atcatggtgaaggatgatgggcagctgtttcatatagattttggtcactttttggaccac
aagaagaagaagtttggctacaagcgagagcgagtgccgttcgtcttgactcaagacttc
ctaattgtgatcagcaaaggaggaacccaggagtgcactaaaaccagagagtttgagagg
tttcaagagatgtgctacaaggcatacctggccatccgacagcatgccaacctcttcatc
aacctcttctccatgatgctgggctcaggaatgccggagctgcagtccttcgacgacatc
gcttacatccgcaagactctggcattagacaaaaccgagcaggaagccctggactatttc
atgaagcagatgaatgacgctcaccatggcggatggaccaccaagatggactggatcttc
cacaccatccgtcaccatgcccaaaactga

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