KEGG   ENZYME: 1.1.1.105Help
Entry
EC 1.1.1.105                Enzyme                                 

Name
all-trans-retinol dehydrogenase (NAD+);
retinol (vitamin A1) dehydrogenase;
MDR;
microsomal retinol dehydrogenase;
retinol dehydrogenase (misleading);
retinal reductase (ambiguous);
retinene reductase;
epidermal retinol dehydrogenase 2;
SDR16C5 (gene name);
RDH16 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
all-trans retinol:NAD+ oxidoreductase
Reaction(IUBMB)
all-trans-retinol---[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal---[cellular-retinol-binding-protein] + NADH + H+
Reaction(KEGG)
(other) R02124
Show
Substrate
all-trans-retinol---[cellular-retinol-binding-protein];
NAD+ [CPD:C00003]
Product
all-trans-retinal---[cellular-retinol-binding-protein];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD+/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form [2]. No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315, 11-cis retinol dehydrogenase). Also active with 3alpha-hydroxysteroids [2].
History
EC 1.1.1.105 created 1972, modified 2011
Pathway
Retinol metabolism
Metabolic pathways
Orthology
K13369  
17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K15734  
all-trans-retinol dehydrogenase (NAD+)
Genes
HSA: 
195814(SDR16C5) 8630(HSD17B6)
PTR: 
472773(SDR16C5)
PPS: 
100993740(SDR16C5) 100996145(HSD17B6)
GGO: 
101152181(SDR16C5) 101153072(HSD17B6)
PON: 
100450496(SDR16C5) 100458219(HSD17B6)
MCC: 
696397(SDR16C5) 713549(HSD17B6)
MCF: 
MMU: 
242285(Sdr16c5) 27400(Hsd17b6)
RNO: 
100362350 286964(Hsd17b6) 297805(Sdr16c5)
CGE: 
100760372(Sdr16c5) 100762147(Hsd17b6)
HGL: 
101699287(Hsd17b6) 101723971(Sdr16c5)
TUP: 
CFA: 
477888(SDR16C5) 481118(HSD17B6)
AML: 
FCA: 
101082207(SDR16C5) 101088341(HSD17B6)
PTG: 
102959434(SDR16C5) 102971783(HSD17B6)
BTA: 
526726(SDR16C5) 533086(HSD17B6)
BOM: 
102278015(SDR16C5) 102283510(HSD17B6)
PHD: 
102332625(HSD17B6) 102338064(SDR16C5)
CHX: 
102185066(HSD17B6) 102186703(SDR16C5)
SSC: 
100157319(SDR16C5) 100620470(HSD17B6)
CFR: 
BACU: 
103000587(SDR16C5) 103008169(HSD17B6)
LVE: 
103076064(HSD17B6) 103076578(SDR16C5)
ECB: 
100052840(HSD17B6) 100067801(SDR16C5)
MYB: 
102260999(SDR16C5)
MYD: 
102753241(SDR16C5)
PALE: 
102881754(SDR16C5) 102883634(HSD17B6)
MDO: 
100029976(SDR16C5)
SHR: 
OAA: 
100083362(SDR16C5)
GGA: 
421130(SDR16C5)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
102083489(SDR16C5)
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
398882(rdh16) 444148(sdr16c5)
XTR: 
100135184(rdh16) 448386(sdr16c5)
DRE: 
405814(sdr16c5a) 406799(sdr16c5b) 563950
TRU: 
MZE: 
OLA: 
XMA: 
CMK: 
103177053(sdr16c5)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409260(GB13292) 552689(GB17613)
NVI: 
TCA: 
BMOR: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG04146(Cbr-dhs-3) CBG23222(Cbr-dhs-19)
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
NCE: 
MBR: 
ACAN: 
TET: 
PTM: 
PIF: 
NGD: 
EHX: 
DAL: 
CVT: 
STQ: 
 » show all
Taxonomy
Reference
1  [PMID:5972368]
  Authors
Koen AL, Shaw CR.
  Title
Retinol and alcohol dehydrogenases in retina and liver.
  Journal
Biochim. Biophys. Acta. 128 (1966) 48-54.
  Organism
Rattus norvegicus
Reference
2  [PMID:9677409]
  Authors
Gough WH, VanOoteghem S, Sint T, Kedishvili NY
  Title
cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids.
  Journal
J. Biol. Chem. 273 (1998) 19778-85.
  Organism
Homo sapiens
Reference
3  [PMID:12372410]
  Authors
Matsuzaka Y, Okamoto K, Tsuji H, Mabuchi T, Ozawa A, Tamiya G, Inoko H
  Title
Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion.
  Journal
Biochem. Biophys. Res. Commun. 297 (2002) 1171-80.
  Organism
Homo sapiens
  Sequence
[hsa:195814]
Reference
4  [PMID:18926804]
  Authors
Lee SA, Belyaeva OV, Kedishvili NY
  Title
Biochemical characterization of human epidermal retinol dehydrogenase 2.
  Journal
Chem. Biol. Interact. 178 (2009) 182-7.
  Organism
Homo sapiens
  Sequence
[hsa:195814]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9033-53-8

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