KEGG   ENZYME: 1.1.1.132Help
Entry
EC 1.1.1.132                Enzyme                                 

Name
GDP-mannose 6-dehydrogenase;
guanosine diphosphomannose dehydrogenase;
GDP-mannose dehydrogenase;
guanosine diphosphomannose dehydrogenase;
guanosine diphospho-D-mannose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
GDP-D-mannose:NAD+ 6-oxidoreductase
Reaction(IUBMB)
GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+ [RN:R00880]
Reaction(KEGG)
Substrate
GDP-D-mannose [CPD:C00096];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
GDP-D-mannuronate [CPD:C00976];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on the corresponding deoxynucleoside diphosphate derivative as a substrate.
History
EC 1.1.1.132 created 1972
Pathway
Fructose and mannose metabolism
Amino sugar and nucleotide sugar metabolism
Orthology
K00066  
GDP-mannose 6-dehydrogenase
Genes
PAE: 
PA3540(algD)
PAEV: 
N297_3663(algD)
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
M802_3660(algD)
PPU: 
PP_1288(algD)
PPF: 
PPG: 
PPW: 
PPT: 
PPB: 
PPI: 
PPX: 
T1E_3168(algD)
PPUH: 
PPUT: 
PPUN: 
PP4_08000(algD)
PPUU: 
PST: 
PSB: 
PSYR: 
PSP: 
PCI: 
PFL: 
PFL_1024(algD)
PPRC: 
PFO: 
PFS: 
PFLU0990(algD)
PFE: 
PFC: 
PPZ: 
PEN: 
PSEEN3453(algD-2) PSEEN4535(algD)
PMY: 
PMK: 
PBA: 
PFV: 
PDR: 
PRE: 
PSV: 
PSK: 
PMON: 
PMOT: 
PKC: 
PKB_0968(algD)
AVN: 
AVL: 
AVD: 
ABO: 
ABO_0384(algD)
TAU: 
RFR: 
EBA: 
ebA4268(algD)
AZO: 
azo3269(algD)
APP: 
NIS: 
DSA: 
BMX: 
DTO: 
RHL: 
BJA: 
BRA: 
BRS: 
MNO: 
BID: 
DSH: 
Dshi_1896(algD)
NAR: 
CSC: 
MSM: 
MSG: 
MVA: 
MSP: 
MNE: 
ROP: 
ROP_57960(algD)
SCO: 
SCO0382(SCF62.08)
SCB: 
SVL: 
SBH: 
SHY: 
SHO: 
SVE: 
SRC: 
SALU: 
ACH: 
SRO: 
BSD: 
AMD: 
AMED_0547(algD)
AMN: 
AMM: 
AMES_0545(algD)
AMZ: 
B737_0546(algD)
AOI: 
AORI_0554(algD)
PDX: 
ABA: 
TRS: 
SUS: 
HAO: 
TER: 
NPU: 
CTHE: 
NKO: 
CMR: 
ZGA: 
STI: 
TAM: 
 » show all
Taxonomy
Reference
1  [PMID:14245351]
  Authors
PREISS J.
  Title
SUGAR NUCLEOTIDE REACTIONS IN ARTHROBACTER. II. BIOSYNTHESIS OF GUANOSINE DIPHOSPHOMANNURONATE.
  Journal
J. Biol. Chem. 239 (1964) 3127-32.
  Organism
Arthrobacter sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-63-8

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