| Entry |
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| Name |
L-iditol 2-dehydrogenase;
polyol dehydrogenase;
sorbitol dehydrogenase;
L-iditol:NAD+ 5-oxidoreductase;
L-iditol (sorbitol) dehydrogenase;
glucitol dehydrogenase;
L-iditol:NAD+ oxidoreductase;
NAD+-dependent sorbitol dehydrogenase;
NAD+-sorbitol dehydrogenase
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
L-iditol:NAD+ 2-oxidoreductase
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| Reaction(IUBMB) |
L-iditol + NAD+ = L-sorbose + NADH + H+ [RN: R07145]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD+ and can not use NADP+.
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| Pathway |
| Fructose and mannose metabolism | | Metabolic pathways |
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | TCA: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | NVE: | | AQU: | | ATH: | | ALY: | | GMX: | | MTR: | | RCU: | | POP: | | VVI: | | OSA: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | CME: | | SCE: | | AGO: | | KLA: | | VPO: | | DHA: | | PIC: | | PGU: | | YLI: | | NCR: | | PAN: | | MGR: | | FGR: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CPW: | | URE: | | TVE: | | PNO: | | TML: | | SPO: | | CNE: | | CNB: | | LBC: | | CCI: | | SCM: | | UMA: | | ECF: | | ECI: | | ECT: | | SEA: | | SED: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPS: | | YPI: | | YPY: | | YPB: | | KOX: | | PFS: | | HCH: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPZ: | | BPQ: | | BTE: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BPH: | | BPY: | | BUG: | | BGE: | | BGF: | | BYI: | | BPX: | | POL: | | DAC: | | DEL: | | VAP: | | VPE: | | BMX: | | MLO: | | MES: | | ATU: | | RET: | | RLE: | | BJA: | | RDE: | | BSU: | | BSR: | | BSS: | | BST: | | BSN: | | BSQ: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAZ: | | BQL: | | BXH: | | BQY: | | BAE: | | BHA: | | BCZ: | | BCL: | | BPU: | | BMQ: | | BMD: | | BAG: | | BJS: | | OIH: | | GMC: | | SAU: | | SAV: | | SAW: | | SAH: | | SAJ: | | SAM: | | SAS: | | SAR: | | SAC: | | SAX: | | SAA: | | SAO: | | SAE: | | SAD: | | SAB: | | SHA: | | SSP: | | SLG: | | SLN: | | LMO: | | LMF: | | LMH: | | LMC: | | LMN: | | LMY: | | LMT: | | LMS: | | LMQ: | | LML: | | LMON: | | LMOC: | | LIN: | | LWE: | | LSG: | | GYM: | | PMS: | | PMQ: | | PMW: | | AAC: | | AAD: | | LPL: | | LPJ: | | THL: | | CPF: | | CTH: | | CBO: | | CBA: | | CBH: | | CBY: | | CBL: | | CBK: | | CBB: | | CBI: | | CBT: | | CBF: | | CBE: | | CCE: | | CLB: | | CDF: | | CDC: | | CDL: | | CST: | | AMT: | | DRU: | | PTH: | | DOR: | | DMI: | | TMR: | | CHY: | | TEP: | | COB: | | COW: | | CKN: | | TOC: | | TTM: | | MAS: | | SSG: | | MSM: | | MSG: | | MVA: | | MSP: | | MMC: | | MKM: | | MJL: | | MRH: | | MCB: | | ASD: | | RHA: | | RER: | | ROP: | | GPO: | | AAU: | | ACH: | | APN: | | RSA: | | BCV: | | BFA: | | PAC: | | PAK: | | MPH: | | NDA: | | FRE: | | NML: | | GOB: | | KRA: | | CWO: | | CGO: | | TDE: | | ABA: | | ACA: | | ACM: | | TSA: | | SUS: | | CTM: | | CPI: | | CMR: | | STR: | | RBA: | | TEL: | | CYN: | | AMR: | | GVI: | | ANA: | | NPU: | | AVA: | | NAZ: | | DET: | | DEH: | | DGE: | | DDR: | | DMR: | | TRA: | | DTH: | | DTU: | | TYE: | | TTR: | | HMA: | | HHI: | | HUT: | | HME: | | HJE: | | SSO: | | STO: | | SAI: | | SIS: | | SIA: | | SIM: | | SID: | | SIY: | | SIN: | | SII: | | MSE: | | NMR: | | CSY: | |
» show all
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| Reference |
1 |
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| Authors |
Bailey, J.P., Renz, C. and McGuinness, E.T. |
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| Title |
Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties. |
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| Journal |
Comp. Biochem. Physiol. 69B (1981) 909-914. |
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| Reference |
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| Authors |
Burnell JN, Holmes RS. |
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| Title |
Purification and properties of sorbitol dehydrogenase from mouse liver. |
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| Journal |
Int. J. Biochem. 15 (1983) 507-11. |
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| Organism |
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| Reference |
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| Authors |
Leissing N, McGuinness ET. |
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| Title |
Rapid affinity purification and properties of rat liver sorbitol dehydrogenase. |
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| Journal |
Biochim. Biophys. Acta. 524 (1978) 254-61. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Negm FB, Loescher WH. |
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| Title |
Detection and Characterization of Sorbitol Dehydrogenase from Apple Callus Tissue. |
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| Journal |
Plant. Physiol. 64 (1979) 69-73. |
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| Organism |
Malus domestica |
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| Reference |
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| Authors |
O'Brien MM, Schofield PJ, Edwards MR. |
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| Title |
Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase. |
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| Journal |
Biochem. J. 211 (1983) 81-90. |
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| Organism |
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| Reference |
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| Authors |
Ng K, Ye R, Wu XC, Wong SL |
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| Title |
Sorbitol dehydrogenase from Bacillus subtilis. Purification, characterization, and gene cloning. |
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| Journal |
J. Biol. Chem. 267 (1992) 24989-94. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9028-21-1 |
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