KEGG   ENZYME: 1.1.1.184Help
Entry
EC 1.1.1.184                Enzyme                                 
Name
carbonyl reductase (NADPH);
aldehyde reductase 1;
prostaglandin 9-ketoreductase;
xenobiotic ketone reductase;
NADPH-dependent carbonyl reductase;
ALR3;
carbonyl reductase;
nonspecific NADPH-dependent carbonyl reductase;
carbonyl reductase (NADPH2)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
secondary-alcohol:NADP+ oxidoreductase
Reaction(IUBMB)
R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+ [RN:R03557]
Reaction(KEGG)
Substrate
R-CHOH-R' [CPD:C01612];
NADP+ [CPD:C00006]
Product
R-CO-R' [CPD:C01450];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin and prostaglandins E and F, reducing them to the corresponding alcohol. B-specific with respect to NADPH [cf. EC 1.1.1.2 alcohol dehydrogenase (NADP+)].
Pathway
Arachidonic acid metabolism
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Orthology
K00079  
carbonyl reductase 1
K00081  
carbonyl reductase 2
K00084  
carbonyl reductase 3
Genes
HSA: 
873(CBR1) 874(CBR3)
PTR: 
458533(CBR3) 473983(CBR1)
PPS: 
100982905(CBR3) 100984486(CBR1)
GGO: 
101128365(CBR1) 101128728(CBR3)
PON: 
100172097(CBR1) 100452311(CBR3)
MCC: 
695769(CBR3) 699655(CBR1)
MMU: 
109857(Cbr3) 12408(Cbr1) 12409(Cbr2)
RNO: 
29224(Cbr1) 304078(Cbr3) 688320
CFA: 
AML: 
FCA: 
101082844(CBR3) 101083875 101084134 101091418 101091614
BTA: 
515946(CBR1) 516036(CBR3) 782391(DCXR)
SSC: 
100512990(CBR3) 100622246 396780(CBR2) 397143(CBR1)
ECB: 
100061454 100061690 100061787
MDO: 
100015103 100015187 100015233 100025250
SHR: 
100918643 100920969(CBR1)
OAA: 
100081857
GGA: 
418512(CBR1)
MGP: 
100550018
TGU: 
100222525(CBR1)
ACS: 
100567688 100568150
XLA: 
443787(cbr3) 734804(cbr1)
XTR: 
100145008(cbr3) 496612(cbr1)
DRE: 
337696(cbr1l) 373866(cbr1)
TRU: 
101070504
OLA: 
100125494(hsd20b)
BFO: 
BRAFLDRAFT_118601 BRAFLDRAFT_261426 BRAFLDRAFT_274685
CIN: 
100182286
SPU: 
590243
TCA: 
661972
API: 
100573373 100573774
ISC: 
IscW_ISCW014791
SMM: 
Smp_033540
NVE: 
NEMVE_v1g238099
HMG: 
100200320
AQU: 
100637791
ALY: 
ARALYDRAFT_495168 ARALYDRAFT_919433
GMX: 
100790340 100793649 100801160
MTR: 
MTR_3g098470
CSV: 
101205654
RCU: 
RCOM_0723560
POP: 
POPTR_570377 POPTR_929217
BDI: 
100836851
SBI: 
SORBI_03g044750(SORBIDRAFT_03g044750)
ZMA: 
100216741
PPP: 
PHYPADRAFT_131272
CRE: 
CHLREDRAFT_159999
ZTR: 
MYCGRDRAFT_36990
TGO: 
TGME49_090890
 » show all
Taxonomy
Reference
1  [PMID:31888]
  Authors
Ahmed NK, Felsted RL, Bachur NR.
  Title
Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers.
  Journal
Biochem. Pharmacol. 27 (1978) 2713-9.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu], Rattus norvegicus [GN:rno], Oryctolagus cuniculus
Reference
2  [PMID:666816]
  Authors
Lin YM, Jarabak J.
  Title
Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition.
  Journal
Biochem. Biophys. Res. Commun. 81 (1978) 1227-34.
  Organism
Oryctolagus cuniculus
Reference
3  [PMID:7005231]
  Authors
Wermuth B.
  Title
Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase.
  Journal
J. Biol. Chem. 256 (1981) 1206-13.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
89700-36-7
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