KEGG   ENZYME: 1.1.1.189Help
Entry
EC 1.1.1.189                Enzyme                                 

Name
prostaglandin-E2 9-reductase;
PGE2-9-OR;
reductase, 15-hydroxy-9-oxoprostaglandin;
9-keto-prostaglandin E2 reductase;
9-ketoprostaglandin reductase;
PGE-9-ketoreductase;
PGE2 9-oxoreductase;
PGE2-9-ketoreductase;
prostaglandin 9-ketoreductase;
prostaglandin E 9-ketoreductase;
prostaglandin E2-9-oxoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ [RN:R02581]
Reaction(KEGG)
Substrate
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate [CPD:C00639];
NADP+ [CPD:C00006]
Product
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate [CPD:C00584];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces prostaglandin E2 to prostaglandin F2alpha. A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. May be identical with EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+).
History
EC 1.1.1.189 created 1984, modified 1989
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K00079  
carbonyl reductase 1
Genes
HSA: 
873(CBR1)
PTR: 
473983(CBR1)
PPS: 
100984486(CBR1)
GGO: 
101128365(CBR1)
PON: 
100172097(CBR1)
NLE: 
100595150(CBR1)
MCC: 
699655(CBR1)
MCF: 
102141127(CBR1)
CSAB: 
103218526(CBR1)
RRO: 
104680046(CBR1)
CJC: 
100385429(CBR1)
SBQ: 
101053953(CBR1)
MMU: 
12408(Cbr1)
RNO: 
CGE: 
NGI: 
103736428(Cbr1)
HGL: 
OCU: 
TUP: 
102493488(CBR1)
CFA: 
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
515946(CBR1)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
100622246(CBR3) 397143(CBR1)
CFR: 
102513911(CBR1)
BACU: 
LVE: 
103084663(CBR1)
ECB: 
MYB: 
MYD: 
102773942(CBR1)
PALE: 
102891228(CBR1)
LAV: 
MDO: 
SHR: 
100920969(CBR1)
OAA: 
100081857(CBR1)
GGA: 
418512(CBR1)
MGP: 
100550018(CBR1)
CJO: 
APLA: 
101794661(CBR1)
TGU: 
100222525(CBR1)
GFR: 
102043656(CBR1)
FAB: 
PHI: 
102114609(CBR1)
CCW: 
FPG: 
101915985(CBR1)
FCH: 
102057061(CBR1)
CLV: 
102094554(CBR1)
AAM: 
ASN: 
102386516(CBR1)
AMJ: 
102575087(CBR1)
PSS: 
102454231(CBR1)
CMY: 
ACS: 
PBI: 
103066276(CBR1)
GJA: 
XLA: 
443787(cbr3) 496039 734804(cbr1)
XTR: 
100145008(cbr3) 496612(cbr1)
DRE: 
337696(cbr1l) 373866(cbr1)
TRU: 
101070504(cbr1)
TNG: 
MZE: 
OLA: 
100125494(cbr1)
XMA: 
SASA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
SKO: 
AME: 
551072(GB16229)
BIM: 
SOC: 
AEC: 
HST: 
CFO: 
TCA: 
BMOR: 
PXY: 
API: 
DPX: 
ISC: 
BMY: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
ADF: 
HMG: 
AQU: 
THJ: 
GMX: 
PVU: 
AIP: 
FVE: 
PPER: 
PMUM: 
SLY: 
SPEN: 
SOT: 
SIND: 
BDI: 
PPP: 
CRE: 
CSL: 
GSL: 
TTT: 
VAL: 
VDA: 
PTE: 
BZE: 
BSC: 
BOR: 
PFJ: 
BCOM: 
SHS: 
ADL: 
GTR: 
MRR: 
SCM: 
PFP: 
SRE: 
ACAN: 
TGO: 
SMIN: 
v1.2.012697.t1(symbB.v1.2.012697.t1) v1.2.027692.t1(symbB.v1.2.027692.t1)
AAF: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:166995]
  Authors
Lee SC, Levine L.
  Title
Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase.
  Journal
J. Biol. Chem. 250 (1975) 4549-55.
Reference
2  [PMID:6586494]
  Authors
Schlegel W, Kruger S, Korte K.
  Title
Purification of prostaglandin E2-9-oxoreductase from human decidua vera.
  Journal
FEBS. Lett. 171 (1984) 141-4.
Reference
3  [PMID:7132747]
  Authors
Tai HH, Yuan B.
  Title
Purification and assay of 9-hydroxyprostaglandin dehydrogenase from rat kidney.
  Journal
Methods. Enzymol. 86 (1982) 113-7.
Reference
4  [PMID:3901124]
  Authors
Watkins JD, Jarabak J.
  Title
The effect of NaCl intake on 9-ketoprostaglandin reductase activity in the rabbit kidney.
  Journal
Prostaglandins. 30 (1985) 335-49.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
42613-35-4

DBGET integrated database retrieval system