KEGG   ENZYME: 1.1.1.21Help
Entry
EC 1.1.1.21                 Enzyme                                 

Name
aldehyde reductase;
aldose reductase;
polyol dehydrogenase (NADP+);
ALR2;
alditol:NADP+ oxidoreductase;
alditol:NADP+ 1-oxidoreductase;
NADPH-aldopentose reductase;
NADPH-aldose reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
alditol:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
alditol + NAD(P)+ = aldose + NAD(P)H + H+ [RN:R02819 R02820]
Reaction(KEGG)
Substrate
alditol [CPD:C00717];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
aldose [CPD:C01370];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Has wide specificity.
History
EC 1.1.1.21 created 1961 (EC 1.1.1.139 created 1972, incorporated 1978)
Pathway
Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
Orthology
K00011  
aldehyde reductase
Genes
HSA: 
231(AKR1B1) 57016(AKR1B10)
PTR: 
463867(AKR1B10) 737737(AKR1B1)
PPS: 
100967410(AKR1B15) 100975756(AKR1B10) 100996067(AKR1B1)
GGO: 
PON: 
100444840(AKR1B1) 100445201(AKR1B10)
NLE: 
100585224(AKR1B1) 100585571 100585902(AKR1B10)
MCC: 
705957(AKR1B1) 706187(AKR1B10) 706406 706528
MCF: 
CJC: 
100387030(AKR1B10) 100387387(AKR1B1)
MMU: 
11677(Akr1b3) 11997(Akr1b7) 14187(Akr1b8) 67861(Akr1b10)
RNO: 
116463(Akr1b7) 24192(Akr1b1) 286921(Akr1b8) 296972(Akr1b10)
CGE: 
NGI: 
HGL: 
101705915 101706493(Akr1b10) 101720124(Akr1b1)
OCU: 
100009122(AKR1B1) 100341518(AKR1B10)
TUP: 
CFA: 
607537(AKR1B1)
AML: 
UMR: 
103678252(AKR1B1)
FCA: 
101095406(AKR1B1)
PTG: 
102953851(AKR1B1)
BTA: 
317748(AKR1B1) 525193(AKR1B10)
BOM: 
102283791(AKR1B1) 102284069(AKR1B10) 102286471
PHD: 
102333142(AKR1B10) 102333495(AKR1B1)
CHX: 
102187190(AKR1B1) 102187646(AKR1B10)
OAS: 
101107697(AKR1B10) 101120824(AKR1B1)
SSC: 
396816(AKR1B1)
CFR: 
102513557(AKR1B1)
BACU: 
103005435(AKR1B10) 103010471(AKR1B1)
LVE: 
ECB: 
100065145(AKR1B1)
MYB: 
MYD: 
102753092(AKR1B1) 102772161(AKR1B10)
PALE: 
102887071(AKR1B1)
MDO: 
100021757(AKR1B1)
SHR: 
100923275(AKR1B1)
OAA: 
GGA: 
395338(AKR1B10) 418169 418171(AKR1B1L) 425137
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
398904(akr1b1)
XTR: 
496546(akr1b1)
DRE: 
553452(zgc:153855)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103191362(akr1b1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551968(GB18109)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_Y39G8B.1(Y39G8B.1)
CBR: 
BMY: 
LOA: 
TSP: 
LGI: 
SMM: 
AQU: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
DOSA: 
Os01t0847800-01(Os01g0847800)
OBR: 
BDI: 
PDA: 
ATR: 
s00012p00263360(AMTR_s00012p00263360)
EIN: 
EHE: 
NCE: 
DFA: 
EHI: 
EHI_029620(466.t00004)
EDI: 
BEQ: 
EHX: 
GTT: 
TVA: 
REH: 
H16_A3186(h16_A3186)
ABA: 
 » show all
Taxonomy
Reference
1  [PMID:4216364]
  Authors
Attwood MA, Doughty CC.
  Title
Purification and properties of calf liver aldose reductase.
  Journal
Biochim. Biophys. Acta. 370 (1974) 358-68.
Reference
2  [PMID:36151]
  Authors
Boghosian RA, McGuinness ET.
  Title
Affinity purification and properties of porcine brain aldose reductase.
  Journal
Biochim. Biophys. Acta. 567 (1979) 278-86.
Reference
3  [PMID:14401390]
  Authors
HERS HG.
  Title
[Aldose reductase.]
  Journal
Biochim. Biophys. Acta. 37 (1960) 120-6.
Reference
4  [PMID:4381350]
  Authors
Scher BM, Horecker BL.
  Title
Pentose metabolism in Candida. 3. The triphosphopyridine nucleotide-specific polyol dehydrogenase of Candida utilis.
  Journal
Arch. Biochem. Biophys. 116 (1966) 117-28.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-31-3

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