KEGG   ENZYME: 1.1.1.27Help
Entry
EC 1.1.1.27                 Enzyme                                 
Name L-lactate dehydrogenase;
lactic acid dehydrogenase;
L(+)-nLDH;
L-(+)-lactate dehydrogenase;
L-lactic dehydrogenase;
L-lactic acid dehydrogenase;
lactate dehydrogenase;
lactate dehydrogenase NAD+-dependent;
lactic dehydrogenase;
NAD+-lactate dehydrogenase
Class Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname (S)-lactate:NAD+ oxidoreductase
Reaction(IUBMB) (S)-lactate + NAD+ = pyruvate + NADH + H+ [RN:R00703]
Reaction(KEGG) R00703;
(other) R01000 R03104
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Substrate (S)-lactate [CPD:C00186];
NAD+ [CPD:C00003]
Product pyruvate [CPD:C00022];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also
acts, more slowly, with the animal, but not the bacterial, enzyme.
Pathway ec00010  Glycolysis / Gluconeogenesis
ec00270  Cysteine and methionine metabolism
ec00620  Pyruvate metabolism
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology K00016  L-lactate dehydrogenase
Genes HSA: 160287(LDHAL6A) 3939(LDHA) 3945(LDHB) 3948(LDHC) 92483(LDHAL6B)
PTR: 451063(LDHA) 451064(LDHC) 464999 465337(LDHB) 466460(LDHAL6A)
     747141(LDHAL6B)
MCC: 693731(LDHC) 693802(LDHB) 693907 694309(LDHA) 696854(LDHA)
     696935(LDHB) 702403 706110(LDHB) 716800(LDHB) 718082(LDHB)
MMU: 106557(Ldhal6b) 16828(Ldha) 16832(Ldhb) 16833(Ldhc)
     433229(Gm5514)
RNO: 24533(Ldha) 24534(Ldhb) 29634(Ldhc) 369018(Ldhal6b)
     500965(RGD1562690)
CFA: 475101 476213 476882(LDHA) 476883(LDHC) 477675(LDHB) 477883
     479371 481004 482405 484048(LDHAL6B) 485449 490690 609013
     610330 611702
BTA: 281274(LDHA) 281275(LDHB) 509519(LDHAL6B) 784938(LDHA)
SSC: 100153697 407245(LDHA) 407246(LDHB)
ECB: 100033997(LDHB) 100057016(LDHA) 100057054 100059970
MDO: 100012604 100016009 100023295 100028279 100028290 503513(LDHA)
     554182(LDHB)
OAA: 100086588 791112(LDHA)
GGA: 373997(LDHB) 396221(LDHA)
TGU: 100190454 100223914
XLA: 380394(ldha) 380546(ldhb) 394355(ldha) 398121(ldhab)
XTR: 394477(ldhb) 394758(ldha)
DRE: 30496(ldha) 30497(ldhba) 436747(ldhbb)
CIN: 100174998
SPU: 586683
DME: Dmel_CG10160(ImpL3) Dmel_CG13334
DPO: Dpse_GA10121 Dpse_GA24202
DAN: Dana_GF10902 Dana_GF13705
DER: Dere_GG14061 Dere_GG20393
DPE: Dper_GL17466
DSE: Dsec_GM13843 Dsec_GM21480
DSI: Dsim_GD10977 Dsim_GD13128
DWI: Dwil_GK15970 Dwil_GK17340
DYA: Dyak_GE12554 Dyak_GE20486
DGR: Dgri_GH16279
DMO: Dmoj_GI13222
DVI: Dvir_GJ11996 Dvir_GJ17738
AGA: AgaP_AGAP004880
AAG: AaeL_AAEL012014
CQU: CpipJ_CPIJ014454 CpipJ_CPIJ016131
AME: 411188(GB13882)
NVI: 100118743(NV16814)
TCA: 656589
PHU: Phum_PHUM581610
CEL: F13D12.2(ldh-1)
CBR: CBG03136(Cbr-ldh-1)
BMY: Bm1_43730
SMM: Smp_038950 Smp_038960
ATH: AT4G17260
POP: POPTR_554197
RCU: RCOM_0540790
VVI: 100250615
OSA: 4328012(Os02g0105400) 4339856(Os06g0104900)
SBI: SORBI_04g000580
ZMA: 100193279 100282503(cl2158_1)
PPP: PHYPADRAFT_146489 PHYPADRAFT_195311 PHYPADRAFT_55784
CME: CMA145C CMC188C CMI306C CMJ002C CMK006C
LTH: KLTH0D00440g KLTH0G19558g
SPO: SPAC186.08c
NCR: NCU00720
PAN: PODANSg09793 PODANSg866
MGR: MGG_10453(MG10453.4)
FGR: FG10444.1
ANI: AN5842.2
AFM: AFUA_5G14800
ANG: An04g08220
ACT: ACLA_004370
PNO: SNOG_10492
MBR: MONBRDRAFT_32392
PFA: PF13_0141
ECG: E2348C_4376
ECC: c5039
ECI: UTI89_C4637
ECP: ECP_4280
ECV: APECO1_2404
ECZ: ECS88_4540
ELF: LF82_p646
EFE: EFER_4154
ENT: Ent638_2002
ESA: ESA_01812
CTU: Ctu_21690(ldh2)
KPN: KPN_01632
KPE: KPK_2747
KPU: KP1_2672
KVA: Kvar_2702
CKO: CKO_01547 CKO_03848
VVU: VV2_1457
VVY: VVA0276
VPA: VPA0147
VEX: VEA_000852
TTU: TERTU_0352
TGR: Tgr7_1919
TAU: Tola_1750
REH: H16_A0666(ldh)
RME: Rmet_0559
BGL: bglu_2g19240
BGE: BC1002_3504
BPE: BP0379(ldh)
BPA: BPP4051(ldh)
BBR: BB4524(ldh) BB4684
BAV: BAV3171(ldh)
VEI: Veis_4538
CJE: Cj1167(ldh)
CJR: CJE1301(ldh)
CJJ: CJJ81176_1182(ldh)
CJU: C8J_1111(ldh)
CJD: JJD26997_0565
ANT: Arnit_1568
SDL: Sdel_0325
GEO: Geob_0424
DVU: DVU0600(ldh)
DVL: Dvul_2352
SCL: sce5245(ldh)
AVI: Avi_4103(mdh)
RLE: pRL120231
RCP: RCAP_rcc00817(ldh)
RCE: RC1_3506
AZL: AZL_026880(ldh)
BSU: BSU03050(ldh)
BHA: BH3937(lctE)
BAN: BA_1923(ldh) BA_5125(ldh) BA_5240(ldh)
BAR: GBAA_1923(ldh) GBAA_5125(ldh) GBAA_5240(ldh)
BAA: BA_0106 BA_2427
BAT: BAS1784(ldh) BAS4762(ldh) BAS4869(ldh)
BAH: BAMEG_2667(ldh) BAMEG_5157(ldh) BAMEG_5294(ldh)
BAI: BAA_1993(ldh) BAA_5136(ldh) BAA_5272(ldh)
BCE: BC1924(ldh) BC4870(ldh) BC4996(ldh)
BCA: BCE_2007(ldh) BCE_5032(ldh) BCE_5135(ldh)
BCZ: BCZK1741(ldh) BCZK4624(ldh) BCZK4723(ldh)
BCR: BCAH187_A2028(ldh) BCAH187_A5012(ldh) BCAH187_A5142(ldh)
BCB: BCB4264_A1927(ldh) BCB4264_A5002(ldh) BCB4264_A5140(ldh)
BCU: BCAH820_1959(ldh) BCAH820_4981(ldh) BCAH820_5106(ldh)
BCG: BCG9842_B0100(ldh) BCG9842_B0236(ldh) BCG9842_B3415(ldh)
BCQ: BCQ_4689(ldh) BCQ_4814(ldh)
BCX: BCA_1989(ldh) BCA_5005(ldh) BCA_5136(ldh)
BCY: Bcer98_1484(ldh) Bcer98_3505(ldh) Bcer98_3591(ldh)
BTK: BT9727_1763(ldh) BT9727_4600(ldh) BT9727_4708(ldh)
BTL: BALH_1702(ldh) BALH_4435(ldh) BALH_4532(ldh)
BTB: BMB171_C1712(ldh) BMB171_C4509(ldh) BMB171_C4605(ldh)
BWE: BcerKBAB4_1798(ldh) BcerKBAB4_4713(ldh) BcerKBAB4_4826(ldh)
BLI: BL01703(ldh)
BLD: BLi00366(ldh)
BCL: ABC2872(ldh)
BAY: RBAM_003290(ldh)
BPU: BPUM_0277(ldh)
BPF: BpOF4_04835
BMQ: BMQ_0521(ldh)
BMD: BMD_0524(ldh)
BSE: Bsel_2311
OIH: OB3279
GKA: GK0475(ldh)
GTN: GTNG_0487(ldh)
GWC: GWCH70_0489(ldh)
GYM: GYMC10_3602
GYC: GYMC61_1361(ldh)
GCT: GC56T3_2991
AFL: Aflv_0889(ldh)
SAU: SA0232(lctE) SA2395
SAV: SAV0241(lctE) SAV2602
SAW: SAHV_0240(lctE) SAHV_2586
SAH: SaurJH1_0231 SaurJH1_2678
SAJ: SaurJH9_0225 SaurJH9_2624
SAM: MW0217(lctE) MW2521
SAS: SAS0217 SAS2487
SAR: SAR0234(ldh1) SAR2680(ldh2)
SAC: SACOL0222(ldh1) SACOL2618(ldh2)
SAX: USA300HOU_0251(ldh)
SAA: SAUSA300_0235 SAUSA300_2537
SAO: SAOUHSC_00206 SAOUHSC_02922
SAE: NWMN_0176(ldh1) NWMN_2499(ldh)
SAD: SAAV_0206(ldh1) SAAV_2668(ldh2)
SAB: SAB0180 SAB2475c(ldh)
SEP: SE2145
SER: SERP2156(ldh)
SHA: SH0525
SSP: SSP0249 SSP1001
SCA: Sca_0343(ldh) Sca_1369(ldh)
SLG: SLGD_00048 SLGD_00459
LMO: lmo0210(ldh) lmo1534 lmo1667
LMF: LMOf2365_0221(ldh) LMOf2365_1553(ldh-2) LMOf2365_1691
LMH: LMHCC_0899 LMHCC_1035 LMHCC_2433(ldh)
LMC: Lm4b_00208(ldh) Lm4b_01544 Lm4b_01680
LMN: LM5578_1814 LM5578_2808(ldh)
LMY: LM5923_1766 LM5923_2757(ldh)
LIN: lin0242(ldh) lin1569 lin1775
LWE: lwe0172(ldh) lwe1034 lwe1547(ldhB) lwe1685
LSG: lse_0196(ldh-1) lse_1449(ldh-2) lse_1635
ESI: Exig_0870
EAT: EAT1b_0554
MCL: MCCL_0163(lctD) MCCL_0255
PJD: Pjdr2_5353
AAC: Aaci_0520
LLA: L0017(ldh) L0018(ldhB) L142159(ldhX)
LLK: LLKF_0427(ldhB) LLKF_0494 LLKF_1154(ldhX) LLKF_1422(ldhL)
LLC: LACR_0421 LACR_1239 LACR_1455(ldh)
LLM: llmg_0392(ldhB) llmg_1120(ldh) llmg_1429(ldhX)
SPY: SPy_1151(ldh)
SPZ: M5005_Spy_0873(ldh)
SPM: spyM18_1111(ldh)
SPG: SpyM3_0809(ldh)
SPS: SPs1008(ldh)
SPH: MGAS10270_Spy0987(ldh)
SPI: MGAS10750_Spy1022(ldh)
SPJ: MGAS2096_Spy0947(ldh)
SPK: MGAS9429_Spy0991(ldh)
SPF: SpyM50917(ldh)
SPA: M6_Spy0869(ldh)
SPB: M28_Spy0847(ldh)
SOZ: Spy49_0904c(ldh)
SPN: SP_1220(ldh)
SPD: SPD_1078(ldh)
SPR: spr1100(ldh)
SPW: SPCG_1081(ldh)
SPX: SPG_1112(ldh)
SNE: SPN23F_11170(ldh)
SPV: SPH_1335(ldh)
SNM: SP70585_1267(ldh)
SJJ: SPJ_1135(ldh)
SPP: SPP_1258(ldh)
SNT: SPT_1008(ldh)
SNC: HMPREF0837_11282(ldh)
SAG: SAG0128 SAG0959(ldh)
SAN: gbs0126 gbs0947(ldh)
SAK: SAK_0179 SAK_1054(ldh)
SMU: SMU.1115(ldh)
SMC: SmuNN2025_0926(ldh)
STC: str0644(hdhL) str1280(ldh)
STL: stu0644(hdhL) stu1280(ldh)
STE: STER_0694 STER_1257(ldh)
SSA: SSA_1221(ldh)
SSU: SSU05_1076(ldh)
SSV: SSU98_1087(ldh)
SSB: SSUBM407_0854(ldh)
SSI: SSU0927(ldh)
SSS: SSUSC84_0970(ldh)
SGO: SGO_1232(ldh) SGO_1369
SEQ: SZO_09420(ldh)
SEZ: Sez_1022(ldh)
SEU: SEQ_1169(ldh)
SUB: SUB0879(ldh)
SDS: SDEG_0911(ldh)
SGA: GALLO_1350
SMB: smi_1006(ldh)
LPL: lp_0537(ldhL1) lp_1101(ldh) lp_1245(hicD2) lp_2349(hicD3)
LPJ: JDM1_0436(ldhL1) JDM1_0908(ldh) JDM1_1054(hicD2)
     JDM1_1964(hicD3)
LJO: LJ0274 LJ1403(ldh)
LJF: FI9785_1528(hicD) FI9785_337(ldh) FI9785_863(ldh)
LAC: LBA0271 LBA0910(ldh) LBA1516
LSA: LSA1606(ldh)
LSL: LSL_1362(ldh)
LDB: Ldb0120(ldh)
LBU: LBUL_0100(ldh)
LBR: LVIS_0514
LCA: LSEI_0634 LSEI_2549 LSEI_2607
LCB: LCABL_06930(ldh) LCABL_27160(ldh) LCABL_27730(hicD3)
LGA: LGAS_0269 LGAS_0849(ldh)
LRE: Lreu_0194 Lreu_0716 Lreu_0907 Lreu_1272
LRF: LAR_0185 LAR_0688 LAR_0853 LAR_1206
LHE: lhv_0289 lhv_0978(ldh) lhv_1578
LFE: LAF_0348 LAF_0806
LRH: LGG_00606(ldh) LGG_02523(ldh) LGG_02591(hicD)
LRL: LC705_00585(ldh) LC705_02527(ldh) LC705_02599(hicD)
LCR: LCRIS_00274(ldh1) LCRIS_00963(ldh2) LCRIS_01483(ldh3)
PPE: PEPE_1554
EFA: EF0255(ldh) EF0641(ldh-2)
LCI: LCK_01655
LKI: LKI_06135
LGS: LEGAS_1815
CAC: CA_C0267(ldh) CA_C3552
CPE: CPE0103(ldh)
CPF: CPF_0098(ldh)
CPR: CPR_0102(ldh)
CTC: CTC01998(ldh)
CNO: NT01CX_0236(ldh)
CTH: Cthe_1053(ldh)
CDF: CD2164(ldh)
CDC: CD196_2027(ldh)
CDL: CDR20291_2070(ldh)
CBO: CBO1519(ldh)
CBA: CLB_1540(ldh)
CBH: CLC_1552(ldh)
CBY: CLM_1754(ldh)
CBL: CLK_0997(ldh)
CBK: CLL_A2569 CLL_A3511
CBB: CLD_3035(ldh)
CBI: CLJ_B1617(ldh)
CBT: CLH_2335 CLH_3305
CBF: CLI_1599(ldh)
CBE: Cbei_1014 Cbei_2789 Cbei_4903
CKL: CKL_1381
CKR: CKR_1277
CPY: Cphy_1117 Cphy_1232
CCE: Ccel_2485(ldh)
VPR: Vpar_0498
AFN: Acfer_1037
ATE: Athe_1918
DRM: Dred_2797
PTH: PTH_0747(mdh)
DAU: Daud_1522
TJR: TherJR_0751
HMO: HM1_2756(ldh)
APR: Apre_1065
EEL: EUBELI_20026
ERE: EUBREC_2331
CLO: HMPREF0868_0218
TEX: Teth514_0216
TPD: Teth39_1997
TIT: Thit_0237
TMT: Tmath_0320
MTA: Moth_1826
ADG: Adeg_1582
CSC: Csac_1027
HOR: Hore_16140
MGE: MG_460(ldh)
MPN: MPN674(ldh)
MPU: MYPU_7590(ldh)
MPE: MYPE9640
MGA: MGA_0746(mdh)
MMY: MSC_0532(ldh)
MMO: MMOB0410(ldh)
MHY: mhp245(ictD) mhp469(ldh)
MHJ: MHJ_0133(ldh) MHJ_0468
MHP: MHP7448_0137(ldh) MHP7448_0471
MSY: MS53_0461(ldh)
MCP: MCAP_0439(ldh)
MAA: MAG_4900(ldh)
MAL: MAGa5370(ldh)
MAT: MARTH_orf109(ldh)
MCO: MCJ_001000 MCJ_006130(ldh)
MHO: MHO_3580(ldh)
ACL: ACL_1028(ldh)
MFL: Mfl596
MVA: Mvan_0439
MGI: Mflv_0307
MMC: Mmcs_0382
MKM: Mkms_0391
MJL: Mjls_0370
CGL: NCgl2810(ldh)
CGB: cg3219(ldh)
CGT: cgR_2812(ldh)
CEF: CE2753(ldh)
CDI: DIP0427 DIP2255(ldh)
CJK: jk0113(ldh)
CAR: cauri_2403(ldh)
CKP: ckrop_0111(ldh) ckrop_1700
RER: RER_42180(ldh)
GBR: Gbro_1116
SMA: SAV_339(ldhA)
ART: Arth_3978
KRH: KRH_05010(ldh)
MLU: Mlut_21510
BCV: Bcav_2434
JDE: Jden_1053
XCE: Xcel_1257
SKE: Sked_23050
CFL: Cfla_1564
PAC: PPA0012 PPA0887 PPA1952
PAK: HMPREF0675_3011 HMPREF0675_3945 HMPREF0675_5012
PFR: PFREUD_11570(ldh1) PFREUD_12840(ldh2)
NML: Namu_0206
AHE: Arch_1453
BLO: BL0710(ldh1) BL1308(ldh2)
BLJ: BLD_0165(ldh) BLD_0435
BLN: Blon_0840 Blon_1090
BLL: BLJ_1065 BLJ_1311
BAD: BAD_1117(ldh2)
BLA: BLA_0305(ldh) BLA_0792
BLC: Balac_0321 Balac_1214
BLT: Balat_0321 Balat_1214
GVA: HMPREF0424_0663
APV: Apar_0054
ELE: Elen_2253
BBU: BB0087
BBZ: BbuZS7_0087
BGA: BG0088(ldh)
BAF: BAPKO_0088(ldh)
BTU: BT0087
BHR: BH0087
BDU: BDU_90(ldh)
BRE: BRE_89(ldh)
TDE: TDE0351(ldh)
LIL: LA_1488(lldD)
BHY: BHWA1_01750(ldh)
BRM: Bmur_1505
ABA: Acid345_1483
SRU: SRU_0681
SRM: SRM_00857(ldh)
RMR: Rmar_0132
FNU: FN1169
STR: Sterm_2675
SMF: Smon_0985
OTE: Oter_1299
RBA: RB2566(ldh) RB856(ldh)
PSL: Psta_3289
PLM: Plim_1203 Plim_1746
CYA: CYA_2670
CYB: CYB_2165
MAR: MAE_05340
CYT: cce_5187(ldh)
CYC: PCC7424_3778
GVI: gll3324
NPU: Npun_R1983
AMR: AM1_5026(ldh)
CTS: Ctha_2381
CAU: Caur_1675
CAG: Cagg_2397
CHL: Chy400_1816
DRA: DR_2364
DDR: Deide_22290(ldh)
TTH: TTC0748
TTJ: TTHA1113
TMA: TM1867
TPT: Tpet_0930
TLE: Tlet_1246
TRQ: TRQ2_0952
TNA: CTN_0802
TNP: Tnap_0624
TAF: THA_1478
FNO: Fnod_1175
PMO: Pmob_1893
KOL: Kole_0912
DTH: DICTH_0539
DTU: Dtur_0700
HUT: Huta_0463
HVO: HVO_0214
Taxonomy
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13815938]
DENNIS D, KAPLAN NO.
D- and L-lactic acid dehydrogenases in Lactobacillus plantarum.
J. Biol. Chem. 235 (1960) 810-8.
Lactobacillus plantarum [GN:lpl]
Reference
  Authors

  Title
  Journal
  Organism
 2  [PMID:4146647]
Adams MJ, Buehner M, Chandrasekhar K, Ford GC, Hackert ML, Liljas A,
Rossmann MG, Smiley IE, Allison WS, Everse J, Kaplan NO, Taylor SS.
Structure-function relationships in lactate dehydrogenase.
Proc. Natl. Acad. Sci. U. S. A. 70 (1973) 1968-72.
Squalus acanthius
Reference
  Authors
  Title
  Journal

 3
Holbrook, J.J., Liljas, A., Steindel, S.J. and Rossmann, M.G.
Lactate dehydrogenase.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 11, Academic
Press, New York, 1975, p. 191-292.
Reference
  Authors
  Title


  Journal
  Organism

 4  [PMID:114469]
Schar HP, Zuber H.
Structure and function of L-lactate dehydrogenases from thermophilic
and mesophilic bacteria. I) Isolation and characterization of
lactate dehydrogenases from thermophilic and mesophilic bacilli.
Hoppe. Seylers. Z. Physiol. Chem. 360 (1979) 795-807.
Bacillus subtilis [GN:bsu], Bacillus stearothermophilus, Bacillus
caldotenax
Other DBs ExplorEnz - The Enzyme Database: 1.1.1.27
IUBMB Enzyme Nomenclature: 1.1.1.27
ExPASy - ENZYME nomenclature database: 1.1.1.27
BRENDA, the Enzyme Database: 1.1.1.27
CAS: 9001-60-9
DBGET integrated database retrieval system