KEGG   ENZYME: 1.1.1.282Help
Entry
EC 1.1.1.282                Enzyme                                 

Name
quinate/shikimate dehydrogenase;
YdiB
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-quinate:NAD(P)+ 3-oxidoreductase
Reaction(IUBMB)
(1) L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+ [RN:R01872 R06846];
(2) shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+ [RN:R02413 R06847]
Reaction(KEGG)
Substrate
L-quinate [CPD:C00296];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
shikimate [CPD:C00493]
Product
3-dehydroquinate [CPD:C00944];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
3-dehydroshikimate [CPD:C02637]
Comment
This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, shikimate dehydrogenase, in that it can use both quinate and shikimate as substrate and either NAD+ or NADP+ as acceptor.
History
EC 1.1.1.282 created 2004
Pathway
Phenylalanine, tyrosine and tryptophan biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K05887  
quinate/shikimate dehydrogenase
Genes
ECO: 
b1692(ydiB)
ECJ: 
JW1682(ydiB)
ECD: 
EBW: 
BWG_1506(ydiB)
ECOK: 
ECE: 
Z2720(ydiB)
ECS: 
ECs2399(aroE)
ECF: 
ETW: 
ECSP_2259(ydiB)
ELX: 
EOJ: 
EOI: 
EOH: 
ECG: 
EOK: 
ELR: 
ECC: 
c2087(ydiB)
ECP: 
ECI: 
ECV: 
ECX: 
ECW: 
ECM: 
ECY: 
ECR: 
ECQ: 
ECK: 
ECT: 
EOC: 
CE10_1966(ydiB)
EUM: 
ECZ: 
ELO: 
ELN: 
ELH: 
ESE: 
ESO: 
ESM: 
ESL: 
ECL: 
EBR: 
ECB_01661(ydiB)
EBD: 
EKO: 
EKF: 
EAB: 
EDH: 
EDJ: 
EIH: 
ENA: 
ELU: 
EUN: 
ELW: 
ECW_m1861(ydiB)
ELL: 
WFL_09110(ydiB)
ELC: 
i14_1909(aroE)
ELD: 
i02_1909(aroE)
ELP: 
EBL: 
ECD_01661(ydiB)
EBE: 
B21_01650(ydiB)
ELF: 
LF82_2870(ydiB)
ECOA: 
ECOL: 
ECOI: 
ECOJ: 
ECOO: 
ECOH: 
EAL: 
STM: 
STM1359(aroE)
SEO: 
STM14_1650(aroE_1)
SEV: 
SEY: 
SEM: 
SEJ: 
SEB: 
SEF: 
SETU: 
SETC: 
SENR: 
SEND: 
SENI: 
SEEN: 
SPQ: 
SEI: 
SPC_2371(aroE)
SEC: 
SCH_1378(ydiB)
SEH: 
SHB: 
SENH: 
SEEH: 
SEE: 
SENN: 
SEW: 
SEA: 
SENS: 
SED: 
SEG: 
SG1757(ydiB)
SEL: 
SPUL_1177(ydiB)
SEGA: 
SET: 
SEN1685(ydiB)
SENA: 
SENO: 
SENV: 
SENQ: 
SENL: 
SENJ: 
SEEC: 
SEEB: 
SEEP: 
SENB: 
SENE: 
SENC: 
YAK: 
SFL: 
SF1722(aroE)
SFX: 
S1854(ydiB)
SFV: 
SFV_1718(ydiB)
SFE: 
SFxv_1929(ydiB)
SFN: 
SFS: 
SFT: 
SSN: 
SSON_1462(ydiB)
SSJ: 
SBC: 
SDY: 
SDY_1475(ydiB)
SDZ: 
CFD: 
CAMA: 
SERR: 
SFW: 
DDA: 
DDC: 
DZC: 
 » show all
Taxonomy
Reference
1  [PMID:12637497]
  Authors
Michel G, Roszak AW, Sauve V, Maclean J, Matte A, Coggins JR, Cygler M, Lapthorn AJ.
  Title
Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities.
  Journal
J. Biol. Chem. 278 (2003) 19463-72.
  Sequence
[eco:b1692]
Reference
2  [PMID:12624088]
  Authors
Benach J, Lee I, Edstrom W, Kuzin AP, Chiang Y, Acton TB, Montelione GT, Hunt JF.
  Title
The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase.
  Journal
J. Biol. Chem. 278 (2003) 19176-82.
  Sequence
[eco:b1692]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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