KEGG   ENZYME: 1.1.3.41Help
Entry
EC 1.1.3.41                 Enzyme                                 

Name
alditol oxidase;
xylitol oxidase;
xylitol:oxygen oxidoreductase;
AldO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
alditol:oxygen oxidoreductase
Reaction(IUBMB)
an alditol + O2 = an aldose + H2O2 [RN:R07152]
Reaction(KEGG)
Substrate
alditol [CPD:C00717];
O2 [CPD:C00007]
Product
aldose [CPD:C01370];
H2O2 [CPD:C00027]
Comment
The enzyme from Streptomyces sp. IKD472 and from Streptomyces coelicolor is a monomeric oxidase containing one molecule of FAD per molecule of protein [1,2]. While xylitol (five carbons) and sorbitol (6 carbons) are the preferred substrates, other alditols, including L-threitol (four carbons), D-arabitol (five carbons), D-galactitol (six carbons) and D-mannitol (six carbons) can also act as substrates, but more slowly [1,2]. Belongs in the vanillyl-alcohol-oxidase family of enzymes [2].
History
EC 1.1.3.41 created 2002, modified 2008
Orthology
K00594  
xylitol oxidase
Genes
SCO: 
SCO6147(aldo)
SMA: 
CMI: 
ART: 
AAU: 
BCV: 
ACE: 
KRA: 
AMI: 
Taxonomy
Reference
1  [PMID:16232758]
  Authors
Yamashita M, Omura H, Okamoto E, Furuya Y, Yabuuchi M, Fukahi K, Murooka Y.
  Title
Isolation, characterization, and molecular cloning of a thermostable xylitol oxidase from Streptomyces sp. IKD472.
  Journal
J. Biosci. Bioeng. 89 (2000) 350-60.
  Organism
Streptomyces sp.
  Sequence
[up:Q9KX73]
Reference
2  [PMID:17517896]
  Authors
Heuts DP, van Hellemond EW, Janssen DB, Fraaije MW
  Title
Discovery, characterization, and kinetic analysis of an alditol oxidase from Streptomyces coelicolor.
  Journal
J. Biol. Chem. 282 (2007) 20283-91.
Reference
3  [PMID:18154360]
  Authors
Forneris F, Heuts DP, Delvecchio M, Rovida S, Fraaije MW, Mattevi A
  Title
Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase.
  Journal
Biochemistry. 47 (2008) 978-85.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
177322-52-0

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