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Entry
EC 1.1.3.46                 Enzyme                                 

Name
4-hydroxymandelate oxidase;
4HmO;
HmO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
(S)-4-hydroxymandelate:oxygen 1-oxidoreductase
Reaction(IUBMB)
(S)-4-hydroxymandelate + O2 = 2-(4-hydroxyphenyl)-2-oxoacetate + H2O2 [RN:R06633]
Reaction(KEGG)
Substrate
(S)-4-hydroxymandelate [CPD:C03198];
O2 [CPD:C00007]
Product
2-(4-hydroxyphenyl)-2-oxoacetate [CPD:C03590];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FMN). The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics.
History
EC 1.1.3.46 created 2014
Pathway
Monobactam biosynthesis
Biosynthesis of vancomycin group antibiotics
Biosynthesis of antibiotics
Orthology
K16422  
4-hydroxymandelate oxidase
Genes
EBI: 
PAO: 
KLN: 
PSUW: 
PMY: 
PRE: 
PPSE: 
BN5_0696(glcD3)
AVN: 
AVL: 
AVD: 
ACX: 
ATT: 
AEI: 
AJO: 
ZAL: 
LFA: 
LHA: 
MARS: 
GSN: 
CGD: 
CR3_3245(glcD)
BGU: 
BPLA: 
AFA: 
ACK: 
LIH: 
RGE: 
PKT: 
RBU: 
MEU: 
AGE: 
SCL: 
SCU: 
LLU: 
HOH: 
HOE: 
PLA: 
NWI: 
BOP: 
AZC: 
HNI: 
DEQ: 
RHZ: 
PDE: 
ALI: 
ABS: 
ABQ: 
ATI: 
NBR: 
REB: 
RHB: 
SCO: 
SCO3228(SCE63.05)
SGB: 
SVL: 
SBH: 
SHY: 
SHO: 
SALS: 
SRC: 
SALU: 
SALL: 
SLV: 
STRE: 
STRC: 
SAMB: 
SRW: 
TUE45_pSRc_0230(TUE45_pSRTUE45c_0230)
STRF: 
KSK: 
FRP: 
LMOI: 
CFL: 
KFL: 
AER: 
FRA: 
BSD: 
MMAR: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AORI_1496(glcD)
AJA: 
ALU: 
AMI: 
KAL: 
KPHY: 
STP: 
SAQ: 
MAU: 
MIL: 
VMA: 
ACTN: 
AFS: 
CAI: 
BTP: 
RXY: 
ABAI: 
CYJ: 
TER: 
MIC: 
CEP: 
ANA: 
NPU: 
NOS: 
NOP: 
NON: 
AVA: 
ANB: 
CSG: 
CALO: 
CALH: 
CTHE: 
PLP: 
HAU: 
DCH: 
DAB: 
DPU: 
OBT: 
ABAC: 
LuPra_01597(lldD_1) LuPra_02070(lldD_2)
GAU: 
GBA: 
 » show all
Taxonomy
Reference
1  [PMID:11137816]
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem. Biol. 7 (2000) 931-42.
  Sequence
Reference
2  [PMID:12240298]
  Authors
Li TL, Choroba OW, Charles EH, Sandercock AM, Williams DH, Spencer JB
  Title
Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics.
  Journal
Chem. Commun. (Camb).  (2001) 1752-3.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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