KEGG   ENZYME: 1.1.99.6Help
Entry
EC 1.1.99.6                 Enzyme                                 

Name
D-lactate dehydrogenase (acceptor);
D-2-hydroxy acid dehydrogenase;
D-2-hydroxy-acid dehydrogenase;
(R)-2-hydroxy-acid:acceptor 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other acceptors
BRITE hierarchy
Sysname
(R)-lactate:acceptor 2-oxidoreductase
Reaction(IUBMB)
(R)-lactate + acceptor = pyruvate + reduced acceptor [RN:R00297]
Reaction(KEGG)
Substrate
(R)-lactate [CPD:C00256];
acceptor [CPD:C00028]
Product
pyruvate [CPD:C00022];
reduced acceptor [CPD:C00030]
Comment
The zinc flavoprotein (FAD) from the archaeon Archaeoglobus fulgidus cannot utilize NAD+, cytochrome c, methylene blue or dimethylnaphthoquinone as acceptors. In vitro it is active with artificial electron acceptors such as 2,6-dichlorophenolindophenol, but the physiological acceptor is not yet known.
History
EC 1.1.99.6 created 1965, modified 2013
Reference
1  [PMID:10601217]
  Authors
Reed DW, Hartzell PL
  Title
The Archaeoglobus fulgidus D-lactate dehydrogenase is a Zn(2+) flavoprotein.
  Journal
J. Bacteriol. 181 (1999) 7580-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-83-5

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