KEGG   ENZYME: 1.10.3.1Help
Entry
EC 1.10.3.1                 Enzyme                                 

Name
catechol oxidase;
diphenol oxidase;
o-diphenolase;
polyphenol oxidase;
pyrocatechol oxidase;
dopa oxidase;
catecholase;
o-diphenol:oxygen oxidoreductase;
o-diphenol oxidoreductase
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
1,2-benzenediol:oxygen oxidoreductase
Reaction(IUBMB)
2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O [RN:R00058]
Reaction(KEGG)
Substrate
catechol [CPD:C00090];
O2 [CPD:C00007]
Product
1,2-benzoquinone [CPD:C02351];
H2O [CPD:C00001]
Comment
A type 3 copper protein that catalyses exclusively the oxidation of catechol (i.e., o-diphenol) to the corresponding o-quinone. The enzyme also acts on a variety of substituted catechols.
It is different from tyrosinase, EC 1.14.18.1, which can catalyse both the monooxygenation of monophenols and the oxidation of catechols.
History
EC 1.10.3.1 created 1961, deleted 1972, reinstated 1978
Pathway
Tyrosine metabolism
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00422  
polyphenol oxidase
Reference
1
  Authors
Brown, F.C. and Ward, D.N.
  Title
Preparation of a soluble mammalian tyrosinase.
  Journal
J. Am. Chem. Soc. 79 (1957) 2647-2648.
Reference
2
  Authors
Dawson, C.R. and Tarpley, W.B.
  Title
The copper oxidases.
  Journal
In: Sumner, J.B. and Myrback, K. (Eds.), The Enzymes, 1st ed., vol. 2, Academic Press, New York, 1951, p. 454-498.
Reference
3
  Authors
Gregory, R.P.F. and Bendall, D.S.
  Title
The purification and some properties of the polyphenol oxidse from tea (Camellia sinensis L.).
  Journal
Biochem. J. 101 (1966) 569-581.
Reference
4  [PMID:13288597]
  Authors
MASON HS.
  Title
Structures and functions of the phenolase complex.
  Journal
Nature. 177 (1956) 79-81.
Reference
5
  Authors
Mayer, A.M. and Harel, E.
  Title
Polyphenol oxidases in plants.
  Journal
Phytochemistry 18 (1979) 193-215.
Reference
6  [PMID:5842066]
  Authors
Patil SS, Zucker M.
  Title
Potato phenolases. Purification and properties.
  Journal
J. Biol. Chem. 240 (1965) 3938-43.
  Organism
Solanum tuberosum
Reference
7  [PMID:4965136]
  Authors
Pomerantz SH, Warner MC.
  Title
3,4-dihydroxy-L-phenylalanine as the tyrosinase cofactor. Occurrence in melanoma and binding constant.
  Journal
J. Biol. Chem. 242 (1967) 5308-14.
  Organism
hamster
Reference
8
  Authors
Robb, D.A.
  Title
`Tyrosinase.
  Journal
In: Lontie, R. (Ed.), Copper Proteins and Copper Enzymes, vol. 2, CRC Press, Boca Raton, FL, 1984, p. 207-240.
Reference
9  [PMID:11900522]
  Authors
Gerdemann C, Eicken C, Krebs B
  Title
The crystal structure of catechol oxidase: new insight into the function of type-3 copper proteins.
  Journal
Acc. Chem. Res. 35 (2002) 183-91.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9002-10-2

DBGET integrated database retrieval system