| Entry |
|
|---|
| Name |
catechol oxidase;
diphenol oxidase;
o-diphenolase;
polyphenol oxidase;
pyrocatechol oxidase;
dopa oxidase;
catecholase;
o-diphenol:oxygen oxidoreductase;
o-diphenol oxidoreductase
|
|---|
| Class |
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
 |
|---|
| Sysname |
1,2-benzenediol:oxygen oxidoreductase
|
|---|
| Reaction(IUBMB) |
2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O [RN: R00058]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
A type 3 copper protein that catalyses exclusively the oxidation of catechol (i.e., o-diphenol) to the corresponding o-quinone. The enzyme also acts on a variety of substituted catechols.
It is different from tyrosinase, EC 1.14.18.1, which can catalyse both the monooxygenation of monophenols and the oxidation of catechols.
|
|---|
| Pathway |
| Tyrosine metabolism | | Isoquinoline alkaloid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
|
|---|
| Genes |
 |
|---|
| Reference |
1 |
|---|
| Authors |
Brown, F.C. and Ward, D.N. |
|---|
| Title |
Preparation of a soluble mammalian tyrosinase. |
|---|
| Journal |
J. Am. Chem. Soc. 79 (1957) 2647-2648. |
|---|
| Reference |
2 |
|---|
| Authors |
Dawson, C.R. and Tarpley, W.B. |
|---|
| Title |
The copper oxidases. |
|---|
| Journal |
In: Sumner, J.B. and Myrback, K. (Eds.), The Enzymes, 1st ed., vol. 2, Academic Press, New York, 1951, p. 454-498. |
|---|
| Reference |
3 |
|---|
| Authors |
Gregory, R.P.F. and Bendall, D.S. |
|---|
| Title |
The purification and some properties of the polyphenol oxidse from tea (Camellia sinensis L.). |
|---|
| Journal |
Biochem. J. 101 (1966) 569-581. |
|---|
| Reference |
|
|---|
| Authors |
MASON HS. |
|---|
| Title |
Structures and functions of the phenolase complex. |
|---|
| Journal |
Nature. 177 (1956) 79-81. |
|---|
| Reference |
5 |
|---|
| Authors |
Mayer, A.M. and Harel, E. |
|---|
| Title |
Polyphenol oxidases in plants. |
|---|
| Journal |
Phytochemistry 18 (1979) 193-215. |
|---|
| Reference |
|
|---|
| Authors |
Patil SS, Zucker M. |
|---|
| Title |
Potato phenolases. Purification and properties. |
|---|
| Journal |
J. Biol. Chem. 240 (1965) 3938-43. |
|---|
| Organism |
Solanum tuberosum |
|---|
| Reference |
|
|---|
| Authors |
Pomerantz SH, Warner MC. |
|---|
| Title |
3,4-dihydroxy-L-phenylalanine as the tyrosinase cofactor. Occurrence in melanoma and binding constant. |
|---|
| Journal |
J. Biol. Chem. 242 (1967) 5308-14. |
|---|
| Organism |
hamster |
|---|
| Reference |
8 |
|---|
| Authors |
Robb, D.A. |
|---|
| Title |
`Tyrosinase. |
|---|
| Journal |
In: Lontie, R. (Ed.), Copper Proteins and Copper Enzymes, vol. 2, CRC Press, Boca Raton, FL, 1984, p. 207-240. |
|---|
| Reference |
|
|---|
| Authors |
Gerdemann C, Eicken C, Krebs B |
|---|
| Title |
The crystal structure of catechol oxidase: new insight into the function of type-3 copper proteins. |
|---|
| Journal |
Acc. Chem. Res. 35 (2002) 183-91. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9002-10-2 |
|---|
