KEGG   ENZYME: 1.11.1.17Help
Entry
EC 1.11.1.17                Enzyme                                 

Name
glutathione amide-dependent peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
glutathione amide:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O [RN:R09563]
Reaction(KEGG)
Substrate
glutathione amide [CPD:C19689];
H2O2 [CPD:C00027]
Product
glutathione amide disulfide [CPD:C19690];
H2O [CPD:C00001]
Comment
This enzyme, which has been characterized from the proteobacterium Marichromatium gracile, is a chimeric protein, containing a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus. The enzyme has peroxidase activity towards hydrogen peroxide and several small alkyl hydroperoxides, and is thought to represent an early adaptation for fighting oxidative stress [1]. The glutathione amide disulfide produced by this enzyme can be restored to glutathione amide by EC 1.8.1.16 (glutathione amide reductase).
History
EC 1.11.1.17 created 2010
Reference
1  [PMID:11399772]
  Authors
Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ
  Title
Characterization of clutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide  redox cycling.
  Journal
J. Biol. Chem. 276 (2001) 20890-7.
  Organism
Marichromatium gracile
  Sequence
[up:B3EWI1]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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