KEGG   ENZYME: 1.12.98.1Help
Entry
EC 1.12.98.1                Enzyme                                 

Name
coenzyme F420 hydrogenase;
8-hydroxy-5-deazaflavin-reducing hydrogenase;
F420-reducing hydrogenase;
coenzyme F420-dependent hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
hydrogen:coenzyme F420 oxidoreductase
Reaction(IUBMB)
H2 + oxidized coenzyme F420 = reduced coenzyme F420 [RN:R03025]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
oxidized coenzyme F420 [CPD:C00876]
Product
reduced coenzyme F420 [CPD:C01080]
Comment
An iron-sulfur flavoprotein (FAD) containing nickel. The enzyme from some sources contains selenocysteine. The enzyme also reduces the riboflavin analogue of F420, flavins and methylviologen, but to a lesser extent. The hydrogen acceptor coenzyme F420 is a deazaflavin derivative.
History
EC 1.12.98.1 created 1989 as EC 1.12.99.1, transferred 2002 to EC 1.12.98.1
Pathway
Methane metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00440  
coenzyme F420 hydrogenase subunit alpha
K00441  
coenzyme F420 hydrogenase subunit beta
K00443  
coenzyme F420 hydrogenase subunit gamma
Genes
TPS: 
PBM: 
MICC: 
MAGA: 
TMB: 
HHA: 
HHC: 
EBS: 
PDQ: 
RAC: 
LIH: 
RGE: 
RBN: 
METR: 
MEU: 
BEB: 
DAF: 
DRT: 
DSF: 
DOL: 
DML: 
DAL: 
DAT: 
DTI: 
DBR: 
MLN: 
MAMO: 
AAK: 
RPA: 
RPB: 
RPC: 
RPD: 
RPE: 
RPT: 
RPX: 
RVA: 
BSB: 
BRL: 
JAN: 
RDE: 
RLI: 
DSH: 
THW: 
LVS: 
HBC: 
SSAN: 
CIJ: 
BLAS: 
ADO: 
PNS: 
RRU: 
RRF: 
RCE: 
RC1_0144(frhB)
RPM: 
PGM: 
PAEF: 
PAEQ: 
PRI: 
BPB: 
DKU: 
DGI: 
PTH: 
PTH_1492(FrhB)
AWO: 
CHY: 
PFT: 
FRO: 
MCHE: 
ROP: 
ROA: 
SALU: 
SALL: 
STRE: 
SNR: 
ACH: 
BRV: 
MPH: 
NML: 
ARD: 
ABAI: 
RXY: 
RRD: 
AYM: 
MPRO: 
DET: 
DEB: 
DMD: 
DMY: 
DUC: 
TTR: 
CTM: 
TAM: 
DTE: 
TID: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP0083 MMP0817(frcB) MMP0818(frcG) MMP0820(frcA) MMP1382(fruA) MMP1384(fruG) MMP1385(fruB)
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MBA: 
MBY: 
MBW: 
MBAR: 
MBAK: 
MMA: 
MMAZ: 
MMJ: 
MMAC: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MHAZ: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MCON_2320(frhB)
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MEMA: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MCP_2174(frhB-1) MCP_2409(frhA-1) MCP_2411(frhG-1) MCP_2412(frhB-2) MCP_2452(frhA-2) MCP_2453(frhG-2) MCP_2454(frhB-3)
MEZ: 
Mtc_0999(frhB-1) Mtc_1000(frhG-1) Mtc_1001(frhA-1) Mtc_1195(frhB-3) Mtc_2127(frhA-2) Mtc_2129(frhG-2) Mtc_2130(frhB-2)
RCI: 
RCIX1471(frhB-3) RCIX2136(frhB-2) RCIX2137(frhG-2) RCIX2138(frhA-2) RCIX2388(frhA-1) RCIX2390(frhG-1) RCIX2391(frhB-1) RCIX2759(frhB-4)
MTH: 
MMG: 
METC: 
MWO: 
MWSIV6_0607(frhB1) MWSIV6_0735(frhB3) MWSIV6_1686(frhB5) MWSIV6_1687(frhG) MWSIV6_1689(frhA)
MST: 
Msp_1302(frhA) Msp_1304(frhG) Msp_1305(frhB)
MSI: 
MRU: 
mru_2061(frhB1) mru_2062(frhG) mru_2064(frhA) mru_2081(frhB2)
MEB: 
Abm4_0826(frhB2) Abm4_1630(frhB1) Abm4_1632(frhG) Abm4_1634(frhA)
MMIL: 
sm9_0191(frhA) sm9_0193(frhG) sm9_0194(frhB1) sm9_1453(frhB2)
MEYE: 
MOL: 
MEL: 
MEW: 
METH: 
MFC: 
BRM9_0650(frhB2) BRM9_2249(frhB) BRM9_2250(frhG) BRM9_2252(frhA)
MFI: 
MCUB: 
MCBB_1652(frhB1) MCBB_2184(frhB3) MCBB_2185(frhG) MCBB_2187(frhA3)
MFV: 
MKA: 
APO: 
AVE: 
AST: 
HJE: 
NPH: 
HUT: 
HME: 
HBO: 
HTU: 
HDA: 
HXA: 
NAT: 
NPE: 
NOU: 
SALI: 
HLR: 
NAJ: 
PYA: 
PYC: 
TON: 
TGA: 
TGAM_0066(frhB) TGAM_0067(frhG) TGAM_0068(frhA)
THE: 
THM: 
THS: 
TNU: 
TEU: 
TGY: 
TPIE: 
FFO: 
CSU: 
BARC: 
LOKI: 
 » show all
Taxonomy
Reference
1  [PMID:6786341]
  Authors
Adams MW, Mortenson LE, Chen JS.
  Title
Hydrogenase.
  Journal
Biochim. Biophys. Acta. 594 (1980) 105-76.
Reference
2  [PMID:6211447]
  Authors
Yamazaki S.
  Title
A selenium-containing hydrogenase from Methanococcus vannielii. Identification of the selenium moiety as a selenocysteine residue.
  Journal
J. Biol. Chem. 257 (1982) 7926-9.
Reference
3  [PMID:3663585]
  Authors
Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT.
  Title
8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization.
  Journal
Biochemistry. 26 (1987) 4219-27.
  Sequence
Reference
4  [PMID:3121317]
  Authors
Muth E, Morschel E, Klein A.
  Title
Purification and characterization of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from the archaebacterium Methanococcus voltae.
  Journal
Eur. J. Biochem. 169 (1987) 571-7.
Reference
5  [PMID:2738024]
  Authors
Baron SF, Ferry JG.
  Title
Purification and properties of the membrane-associated coenzyme F420-reducing hydrogenase from Methanobacterium formicicum.
  Journal
J. Bacteriol. 171 (1989) 3846-53.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-05-8

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