KEGG   ENZYME: 1.13.11.12Help
Entry
EC 1.13.11.12               Enzyme                                 

Name
linoleate 13S-lipoxygenase;
13-lipoxidase;
carotene oxidase;
13-lipoperoxidase;
fat oxidase;
13-lipoxydase;
lionoleate:O2 13-oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
linoleate:oxygen 13-oxidoreductase
Reaction(IUBMB)
(1) linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate [RN:R03626];
(2) alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
Reaction(KEGG)
R03626;
(other) R07864 R07869
Show
Substrate
linoleate [CPD:C01595];
O2 [CPD:C00007];
alpha-linolenate [CPD:C06427]
Product
(9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate;
(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate
Comment
Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C-13 position with (S)-configuration. This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. EC 1.13.11.58, linoleate 9S-lipoxygenase, catalyses a similar reaction at the second available position of these fatty acids.
History
EC 1.13.11.12 created 1961 as EC 1.99.2.1, transferred 1965 to EC 1.13.1.13, transferred 1972 to EC 1.13.11.12, modified 2011, modified 2012
Pathway
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Orthology
K00454  
lipoxygenase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0001s05310g(POPTRDRAFT_1065943) POPTR_0001s05320g(POPTRDRAFT_750772) POPTR_0001s16780g POPTR_0003s06560g(POPTRDRAFT_756717) POPTR_0008s17810g(POPTRDRAFT_1085564) POPTR_0009s02750g(POPTRDRAFT_204011) POPTR_0010s06720g(POPTRDRAFT_833438) POPTR_0014s01850g(POPTRDRAFT_1097920) POPTR_0014s17550g(POPTRDRAFT_732623) POPTR_0328s00200g POPTR_828417
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0194700-01(Os02g0194700) Os03t0179900-01(Os03g0179900) Os04t0447100-01(Os04g0447100) Os05t0304600-01(Os05g0304600) Os08t0508800-01(Os08g0508800) Os08t0509100-01(Os08g0509100) Os12t0559200-01(Os12g0559200)
BDI: 
SBI: 
SORBI_01g045240(SORBIDRAFT_01g045240) SORBI_06g018040(SORBIDRAFT_06g018040) SORBI_07g027760(SORBIDRAFT_07g027760) SORBI_08g023120(SORBIDRAFT_08g023120)
ZMA: 
100037806(lox9) 100037807(lox7) 100037808(ts1) 100037809(lox10) 100037810(lox11) 100037829(LOX12)
SITA: 
SMO: 
PPP: 
VCN: 
CSL: 
CVR: 
 » show all
Taxonomy
Reference
1  [PMID:5461103]
  Authors
Christopher J, Pistorius E, Axelrod B
  Title
Isolation of an isozyme of soybean lipoxygenase.
  Journal
Biochim. Biophys. Acta. 198 (1970) 12-9.
Reference
2  [PMID:18907700]
  Authors
THEORELL H, HOLMAN RT, AKESON A
  Title
Crystalline lipoxidase.
  Journal
Acta. Chem. Scand. 1 (1947) 571-6.
Reference
3  [PMID:5447012]
  Authors
Zimmerman DC, Vick BA.
  Title
Specificity of flaxseed lipoxidase.
  Journal
Lipids. 5 (1970) 392-7.
  Organism
Glycine max [GN:gmx], Linum usitatissimum
Reference
4  [PMID:8702864]
  Authors
Royo J, Vancanneyt G, Perez AG, Sanz C, Stormann K, Rosahl S, Sanchez-Serrano JJ
  Title
Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns.
  Journal
J. Biol. Chem. 271 (1996) 21012-9.
  Organism
Solanum tuberosum
  Sequence
Reference
5  [PMID:12452441]
  Authors
Bachmann A, Hause B, Maucher H, Garbe E, Voros K, Weichert H, Wasternack C, Feussner I
  Title
Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts.
  Journal
Biol. Chem. 383 (2002) 1645-57.
  Organism
Hordeum vulgare
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-60-1

DBGET integrated database retrieval system