KEGG   ENZYME: 1.13.11.15Help
Entry
EC 1.13.11.15               Enzyme                                 

Name
3,4-dihydroxyphenylacetate 2,3-dioxygenase;
3,4-dihydroxyphenylacetic acid 2,3-dioxygenase;
HPC dioxygenase;
homoprotocatechuate 2,3-dioxygenase;
3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (ring-opening)
Reaction(IUBMB)
3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde [RN:R03303]
Reaction(KEGG)
Substrate
3,4-dihydroxyphenylacetate [CPD:C01161];
O2 [CPD:C00007]
Product
2-hydroxy-5-carboxymethylmuconate semialdehyde [CPD:C04642]
Comment
An iron protein.
History
EC 1.13.11.15 created 1972
Pathway
ec00350  Tyrosine metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K00455  3,4-dihydroxyphenylacetate 2,3-dioxygenase
Genes
EOJ: ECO26_5555(hpaD)
EOI: ECO111_5212(hpaD)
EOH: ECO103_5134(hpaD)
ECX: EcHS_A4582(hpaD)
ECY: ECSE_4627
ECR: ECIAI1_4573(hpaD)
EUM: ECUMN_4973(hpaD)
ECL: EcolC_3704
EBR: ECB_04228(hpaD)
EBD: ECBD_3668
EKF: KO11_23395(hpaD)
ELW: ECW_m4711(hpaD)
ELL: WFL_22950(hpaD)
EBL: ECD_04228(hpaD)
EBE: B21_04194(ybl226)
EFE: EFER_3064(hpaD)
STY: STY1137(hpcB)
STT: t1816(hpcB)
STM: STM1103(hpaD)
SEO: STM14_1252(hpaD)
SEY: SL1344_1042(hpaD)
SEJ: STMUK_1072(hpaD)
SEB: STM474_1095(hpaD)
SEF: UMN798_1145(hpcB)
SENR: STMDT2_10391(hpcB)
SEND: DT104_10851(hpcB)
SENI: CY43_05635
SPT: SPA1747(hpcB)
SEK: SSPA1624
SEI: SPC_2647(hpcB)
SEC: SCH_1053(hpaD)
SEH: SeHA_C1213(hpaD)
SHB: SU5_01734
SEE: SNSL254_A1198(hpaD)
SEW: SeSA_A1167(hpaD)
SEA: SeAg_B1062(hpaD)
SENS: Q786_04930
SED: SeD_A1178(hpaD)
SEG: SG0992(hpaD)
SEL: SPUL_1954(hpaD)
SEGA: SPUCDC_1940(hpaD)
SET: SEN0967(hpaD)
SENA: AU38_04990
SENO: AU37_04980
SENV: AU39_04980
SENQ: AU40_05595
SENL: IY59_05080
SEEP: I137_08880
SENB: BN855_10580(hpaD)
SENE: IA1_05430
SBG: SBG_0949(hpcB)
SBZ: A464_1043
SFL: SF4382(hpaD)
SFX: S4652(hpaD)
SFV: SFV_4382(hpaD)
SFE: SFxv_4776
SFN: SFy_6289
SFS: SFyv_6360
SFT: NCTC1_04758(hpaD)
SSN: SSON_4497(hpaD)
SBO: SBO_4410(hpaD)
SBC: SbBS512_E4888(hpaD)
ENC: ECL_00756
ECLO: ENC_44700
EEC: EcWSU1_00555(hpcB)
ECLX: LI66_03050
ECLY: LI62_03520
ECLZ: LI64_03025
KPN: KPN_04786(hpaD)
KPU: KP1_0740(hpaD)
KPP: A79E_4366
KPT: VK055_2653(hpaD)
KPE: KPK_4834(hpaD)
KPR: KPR_0865(hpaD)
KPJ: N559_4510
KPX: PMK1_02245(hpcB)
KPNU: LI86_23180
KPNK: BN49_4408(hpaD)
KVA: Kvar_4466
KOX: KOX_10045
KOE: A225_0711
EAE: EAE_10345
EAR: CCG31926
KQV: B8P98_24210(hpaD)
EBT: EBL_c33980(hpcB)
KGO: CEW81_19510(hpaD)
LEI: C2U54_08005(hpaD)
LEH: C3F35_08685(hpaD)
LNI: CWR52_09215(hpaD)
EBF: D782_3921
YPE: YPO1764(hpaD)
YPK: y2545(hpaD)
YPA: YPA_1136
YPN: YPN_2359
YPM: YP_1629(hpaD)
YPG: YpAngola_A1645(hpaD)
YPZ: YPZ3_1954(hpaD)
YPD: YPD4_1562(hpaD)
YPX: YPD8_1992(hpaD)
YPH: YPC_2518(hpaD)
YPW: CH59_3403(hpaD)
YPJ: CH55_914(hpaD)
YPV: BZ15_1785(hpaD)
YPL: CH46_3359(hpaD)
YPS: YPTB1640(hpaD)
YPO: BZ17_862(hpaD)
YPI: YpsIP31758_2362(hpaD)
YPY: YPK_2458
YPB: YPTS_1764
YPQ: DJ40_583(hpaD)
YPU: BZ21_990(hpaD)
YPR: BZ20_335(hpaD)
YPC: BZ23_1268(hpaD)
YPF: BZ19_1067(hpaD)
SPE: Spro_0628
SMAF: D781_0572
SERF: L085_01180
PLU: plu0987(hpcB)
PAY: PAU_00930(hpaD)
XBO: XBJ1_0869
XBV: XBW1_1476(hpcB)
XNE: XNC1_0820
XNM: XNC2_0805
XDO: XDD1_1023(hpaD)
PSI: S70_06440
PSX: DR96_1980(hpaD)
PRG: RB151_008110(hpcB)
PALA: CO695_00755(hpaD)
ETE: ETEE_3254(hpaD)
PMU: PM1531(hpaD)
PMV: PMCN06_1798(hpcB)
PMP: Pmu_17980(hpcB)
PMUL: DR93_380(hpaD)
VVY: VV1588
VNI: VIBNI_B1976(hpcB)
VMI: AL543_16455(hpaD)
PAE: PA4124(hpcB)
PAEV: N297_4256(hpaD)
PAEI: N296_4256(hpaD)
PAU: PA14_10620(hpcB)
PAP: PSPA7_0968(hpaD)
PAG: PLES_08471(hpcB)
PAF: PAM18_0815(hpcB)
PNC: NCGM2_5325(hpcB)
PAEB: NCGM1900_0836(hpcB)
PAEP: PA1S_04200
PAEM: U769_04225
PAEL: T223_04135
PAEU: BN889_04578(hpcB)
PAEG: AI22_29415
PAEC: M802_4254(hpaD)
PAEO: M801_4122(hpaD)
PRE: PCA10_16320(hpaD)
PCQ: PcP3B5_43410(hpcB)
PPUN: PP4_18970(hpaD)
PFL: PFL_3373(hpaD)
PPRC: PFLCHA0_c34030(hpcB)
PPRO: PPC_3397(hpaD)
PFS: PFLU_3272
PFC: PflA506_3397(hpaD)
PFW: PF1751_v1c34810(hpaD)
PFB: VO64_1098
PEN: PSEEN3095(hpaD)
PKC: PKB_2456(hpcB)
PSES: PSCI_3409(hpaD)
PSEM: TO66_17400
PSEC: CCOS191_2710(hpcB)
PSOS: POS17_3354(hpaD)
PANR: A7J50_3681
ABAZ: P795_8030
ABAU: IX87_20475
GAI: IMCC3135_16375(hpcB)
ADI: B5T_03294
AXE: P40_15430
RPI: Rpic_1957
RIN: ACS15_1522(hpaD)
BMA: BMAA1137(hpcB)
BML: BMA10229_0103(hpaD)
BMN: BMA10247_A1510(hpaD)
BMAL: DM55_4411(hpaD)
BMAE: DM78_3453(hpaD)
BMAQ: DM76_3361(hpaD)
BMAI: DM57_09690
BMAF: DM51_4806(hpaD)
BMAZ: BM44_4559(hpaD)
BMAB: BM45_3684(hpaD)
BPS: BPSS0695(hpcB)
BPM: BURPS1710b_A2267(hpaD)
BPL: BURPS1106A_A0941(hpaD)
BPD: BURPS668_A1026(hpaD)
BPSE: BDL_3926(hpaD)
BPSM: BBQ_5498(hpaD)
BPSU: BBN_4096(hpaD)
BPSD: BBX_5763(hpaD)
BPZ: BP1026B_II0768(hpcB)
BPK: BBK_3795(hpaD)
BPSH: DR55_4655(hpaD)
BPSA: BBU_5347(hpaD)
BPSO: X996_3878(hpaD)
BUT: X994_3921(hpaD)
BTE: BTH_II1732(hpaD)
BTQ: BTQ_5020(hpaD)
BTJ: BTJ_3647(hpaD)
BTZ: BTL_4494(hpaD)
BTD: BTI_5504(hpaD)
BTV: BTHA_5723(hpaD)
BTHE: BTN_4145(hpaD)
BTHM: BTRA_3948(hpaD)
BTHA: DR62_4180
BTHL: BG87_4476(hpaD)
BOK: DM82_4774(hpaD)
BOC: BG90_5819(hpaD)
BVE: AK36_4114(hpaD)
BCN: Bcen_4132
BCJ: BCAM1369(hpaD)
BCEN: DM39_3636(hpaD)
BCEW: DM40_4258(hpaD)
BCEO: I35_5221(hpaD)
BAM: Bamb_3656
BMU: Bmul_4371
BMK: DM80_3534(hpaD)
BMUL: NP80_4261(hpaD)
BCT: GEM_4386
BCED: DM42_3718(hpaD)
BDL: AK34_4139(hpaD)
BCON: NL30_05815
BUB: BW23_5046(hpaD)
BLAT: WK25_23655
BTEI: WS51_04535
BSEM: WJ12_26645
BPSL: WS57_07250
BMEC: WJ16_25235
BSTG: WT74_25605
BUK: MYA_4418
BUL: BW21_5185(hpaD)
BXE: Bxe_B2031
BXB: DR64_7333(hpaD)
BFN: OI25_4433(hpaD)
PARB: CJU94_20025(hpaD)
PHS: C2L64_36780(hpaD)
PTER: C2L65_32270(hpaD)
BPAR: BN117_0695(hpaD)
BBR: BB0737(hpaD)
BBM: BN115_0711(hpaD)
BBH: BN112_2698(hpaD)
BBX: BBS798_0715(hpaD)
AXY: AXYL_04171(hpaD)
AXX: ERS451415_03954(hpcB)
ASW: CVS48_22585(hpaD)
ACHR: C2U31_24560(hpaD)
AMIM: MIM_c17530(hpcB)
RTA: Rta_01790(hpcB)
LIM: L103DPR2_00427(hpcB)
LIH: L63ED372_02768(hpcB)
HYR: BSY239_4293(hpaD)
HYB: Q5W_21315
BRA: BRADO4665(hpcB)
BBT: BBta_3528(hpcB)
AOL: S58_30090
BRAD: BF49_2116
BRO: BRAD285_4460(hpcB)
RPA: RPA1663(hpaD)
RPB: RPB_3868
RPT: Rpal_1859
SIL: SPOA0026(hpcB)
PHP: PhaeoP97_03881(hpcB)
LABR: CHH27_13915(hpaD)
MAG: amb0804
BLI: BL03909
BLD: BLi03991
BGY: BGLY_4395
AAC: Aaci_1623
AAD: TC41_1519(hpaD)
SAY: TPY_0652(hpaD)
PUF: UFO1_3793
SRO: Sros_7520
SESP: BN6_34240(hpaD)
ALL: CRK57839
 » show all
Taxonomy
Reference
1  [PMID:14263147]
  Authors
ADACHI K, TAKEDA Y, SENOH S, KITA H.
  Title
METABOLISM OF P-HYDROXYPHENYLACETIC ACID IN PSEUDOMONAS OVALIS.
  Journal
Biochim. Biophys. Acta. 93 (1964) 483-93.
Reference
2  [PMID:6895079]
  Authors
Barbour MG, Bayly RC.
  Title
Control of meta-cleavage degradation of 4-hydroxyphenylacetate in Pseudomonas putida.
  Journal
J. Bacteriol. 147 (1981) 844-50.
Reference
3  [PMID:588248]
  Authors
Kutty RK, Devi NA, Veeraswamy M, Ramesh S, Rao PV.
  Title
Degradation of (+/-)-synephrine by Arthrobacter synephrinum. Oxidation of 3,4-dihydroxyphenylacetate to 2-hydroxy-5-carboxymethyl-muconate semialdehyde.
  Journal
Biochem. J. 167 (1977) 163-70.
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.15
IUBMB Enzyme Nomenclature: 1.13.11.15
ExPASy - ENZYME nomenclature database: 1.13.11.15
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.15
BRENDA, the Enzyme Database: 1.13.11.15
CAS: 37256-56-7

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