KEGG   ENZYME: 1.13.11.25Help
Entry
EC 1.13.11.25               Enzyme                                 

Name
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase;
steroid 4,5-dioxygenase;
3-alkylcatechol 2,3-dioxygenase;
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (ring-opening)
Reaction(IUBMB)
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate [RN:R04597]
Reaction(KEGG)
Substrate
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione [CPD:C04793];
O2 [CPD:C00007]
Product
3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate [CPD:C04844]
Comment
Requires Fe2+. Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.
History
EC 1.13.11.25 created 1972
Pathway
Steroid degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K16049  
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
Genes
PPUT: 
PPUN: 
PPUU: 
PRE: 
PKC: 
PKB_4267(hsaC)
PFZ: 
PPSY: 
SPL: 
SHL: 
PHA: 
PSHAa0900(tesB)
PTN: 
GPB: 
REU: 
REH: 
H16_B0654(bphC)
CNC: 
CTI: 
CBW: 
BUR: 
BCJ: 
BCEN: 
DM39_6216(hsaC)
BCEO: 
BCT: 
BCED: 
DM42_6321(hsaC)
BPYR: 
BCON: 
BFN: 
PVE: 
CTT: 
CTES: 
THU: 
NAR: 
NPP: 
SWI: 
SPHM: 
SSAN: 
SCH: 
MTU: 
Rv3568c(hsaC)
MTV: 
MTC: 
MRA: 
MRA_3607(bphC)
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
CFBS_3785(bphC)
MTL: 
MTO: 
MTD: 
UDA_3568c(bphC)
MTN: 
MTJ: 
MTUB: 
MTUC: 
MTUE: 
MTX: 
MTUL: 
MTUT: 
MTUU: 
MTQ: 
MBO: 
Mb3599c(bphC)
MBB: 
BCG_3633c(bphC)
MBT: 
JTY_3634(bphC)
MBM: 
MBK: 
MBX: 
MBZ: 
MAF: 
MAF_35810(bphC)
MCE: 
MCQ: 
MCV: 
MCX: 
MCZ: 
MPA: 
MAO: 
MAVI: 
MAVU: 
MAV: 
MAVD: 
MAVR: 
MAVA: 
MIT: 
MIR: 
MIA: 
MIE: 
MID: 
MYO: 
MSM: 
MSG: 
MSB: 
MSN: 
MSH: 
MSA: 
MUL: 
MUL_4139(bphC)
MVA: 
MGI: 
MSP: 
MAB: 
MABB: 
MMV: 
MAY: 
MABO: 
MABL: 
MAZ: 
MAK: 
MYS: 
MYC: 
MMC: 
MKM: 
MJL: 
MJD: 
MMI: 
MMAR_5063(bphC)
MRH: 
MMM: 
MCB: 
MLI: 
MKN: 
MKS: 
MKI: 
MNE: 
MYV: 
MYE: 
MGO: 
MFT: 
MHAD: 
ASD: 
NFA: 
NCY: 
NBR: 
NNO: 
RHA: 
RER: 
REY: 
REB: 
ROP: 
ROA: 
REQ: 
RPY: 
RAV: 
GBR: 
GPO: 
GOR: 
KTR9_0821(hsaC)
GOQ: 
TPR: 
SALU: 
SALL: 
SVT: 
PSIM: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AORI_2486(bphC)
AJA: 
AMQ: 
ALU: 
KAL: 
KPHY: 
STP: 
SAQ: 
AMS: 
AYM: 
 » show all
Taxonomy
Reference
1  [PMID:5908121]
  Authors
Gibson DT, Wang KC, Sih CJ, Whitlock H Jr.
  Title
Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms.
  Journal
J. Biol. Chem. 241 (1966) 551-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
37256-63-6

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