KEGG   ENZYME: 1.13.11.31Help
Entry
EC 1.13.11.31               Enzyme                                 
Name
arachidonate 12-lipoxygenase;
Delta12-lipoxygenase;
12-lipoxygenase;
12Delta-lipoxygenase;
C-12 lipoxygenase;
12S-lipoxygenase;
leukotriene A4 synthase;
LTA4 synthase
Class
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2;
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
arachidonate:oxygen 12-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [RN:R01596]
Reaction(KEGG)
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007]
Product
(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate [CPD:C05965]
Comment
The product is rapidly reduced to the corresponding 12S-hydroxy compound.
Pathway
Arachidonic acid metabolism
Orthology
K00458  
arachidonate 12-lipoxygenase
Genes
HSA: 
239(ALOX12)
PTR: 
455242(ALOX12) 455243
PPS: 
GGO: 
PON: 
100448016(ALOX12)
MCC: 
713683 713748(ALOX12)
MMU: 
11684(Alox12) 11685(Alox12e)
RNO: 
287454(Alox12) 303252(Alox12e)
CFA: 
479476(ALOX12) 607567
AML: 
100471037(ALOX12)
FCA: 
101094304(ALOX12)
BTA: 
407169(ALOX12) 787450(ALOX12E)
SSC: 
100620614
ECB: 
100072906 100072916(ALOX12)
MDO: 
100015746(ALOX12) 100015831
SHR: 
100933073
DRE: 
322732(alox12)
 » show all
Taxonomy
Reference
1  [PMID:4215079]
  Authors
Hamberg M, Samuelsson B.
  Title
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 71 (1974) 3400-4.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:804329]
  Authors
Nugteren DH.
  Title
Arachidonate lipoxygenase in blood platelets.
  Journal
Biochim. Biophys. Acta. 380 (1975) 299-307.
  Organism
Bos taurus [GN:bta], Sus scofa [GN:ssc], Equus caballus [GN:ecb], Ovis aries
Reference
3  [PMID:6783111]
  Authors
Wallach DP, Brown VR.
  Title
A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases.
  Journal
Biochim. Biophys. Acta. 663 (1981) 361-72.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
82391-43-3
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