KEGG   ENZYME: 1.13.11.33Help
Entry
EC 1.13.11.33               Enzyme                                 

Name
arachidonate 15-lipoxygenase;
15-lipoxygenase;
linoleic acid omega6-lipoxygenase;
omega6 lipoxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
arachidonate:oxygen 15-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate [RN:R01593]
Reaction(KEGG)
R01593;
(other) R03626
Show
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007]
Product
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate [CPD:C05966]
Comment
The product is rapidly reduced to the corresponding 15S-hydroxy compound.
History
EC 1.13.11.33 created 1984
Pathway
Arachidonic acid metabolism
Linoleic acid metabolism
Metabolic pathways
Orthology
K00460  
arachidonate 15-lipoxygenase
K08022  
arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type)
Genes
HSA: 
246(ALOX15) 247(ALOX15B)
PTR: 
455104(ALOX15B) 748294(ALOX15)
PPS: 
GGO: 
101130490(ALOX15) 101141127(ALOX15B)
PON: 
100174413(ALOX15) 100443582(ALOX15B)
MCC: 
709212(ALOX15) 716764(ALOX15B)
MCF: 
102114788(ALOX15B) 102124513(ALOX15)
MMU: 
11687(Alox15) 11688(Alox8)
RNO: 
266604(Alox15b) 81639(Alox15)
CGE: 
TUP: 
CFA: 
489458(ALOX15) 489485(ALOX15B)
AML: 
FCA: 
101101264(ALOX15B)
BTA: 
282139(ALOX15) 286820(ALOX15B)
BOM: 
102275513(ALOX15B) 102285661(ALOX15)
PHD: 
102340463(ALOX15) 102340759(ALOX15B)
CHX: 
SSC: 
100525835(ALOX15B) 396971(ALOX12)
CFR: 
102517336(ALOX15B) 102522465(ALOX15)
ECB: 
100072900(ALOX15) 100073039(ALOX15B)
MYB: 
MDO: 
SHR: 
100921165(ALOX15B)
OAA: 
GGA: 
425997(ALOXE3)
XMA: 
 » show all
Taxonomy
Reference
1  [PMID:6804460]
  Authors
Bryant RW, Bailey JM, Schewe T, Rapoport SM.
  Title
Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.
  Journal
J. Biol. Chem. 257 (1982) 6050-5.
  Organism
Glycine max [GN:gmx]
Reference
2  [PMID:6813644]
  Authors
Narumiya S, Salmon JA.
  Title
Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes.
  Journal
Methods. Enzymol. 86 (1982) 45-8.
  Organism
Oryctolagus cuniculus
Reference
3  [PMID:2496760]
  Authors
Oliw EH, Sprecher H.
  Title
Metabolism of polyunsaturated fatty acids by an (n - 6)-lipoxygenase associated with human ejaculates.
  Journal
Biochim. Biophys. Acta. 1002 (1989) 283-91.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:3112136]
  Authors
Shibata D, Steczko J, Dixon JE, Hermodson M, Yazdanparast R, Axelrod B.
  Title
Primary structure of soybean lipoxygenase-1.
  Journal
J. Biol. Chem. 262 (1987) 10080-5.
  Organism
Glycine max [GN:gmx]
  Sequence
[up:P08170]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
82249-77-2

DBGET integrated database retrieval system