KEGG   ENZYME: 1.13.11.34Help
Entry
EC 1.13.11.34               Enzyme                                 
Name
arachidonate 5-lipoxygenase;
leukotriene-A4 synthase;
Delta5-lipoxygenase;
5Delta-lipoxygenase;
arachidonic 5-lipoxygenase;
arachidonic acid 5-lipoxygenase;
C-5-lipoxygenase;
LTA synthase;
leukotriene A4 synthase
Class
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2;
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
arachidonate:oxygen 5-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = leukotriene A4 + H2O (overall reaction) [RN:R08527];
(1a) arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate [RN:R01595];
(1b) (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = leukotriene A4 + H2O [RN:R03058]
Reaction(KEGG)
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007];
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate [CPD:C05356]
Product
leukotriene A4 [CPD:C00909];
H2O [CPD:C00001];
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate [CPD:C05356]
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K00461  
arachidonate 5-lipoxygenase
Genes
HSA: 
240(ALOX5)
PTR: 
450428(ALOX5)
PPS: 
100979027(ALOX5)
GGO: 
101135686(ALOX5)
PON: 
100460538(ALOX5)
MCC: 
707926(ALOX5)
MMU: 
11689(Alox5)
RNO: 
25290(Alox5)
CFA: 
477753(ALOX5)
AML: 
100476416(ALOX5)
FCA: 
101097422(ALOX5)
BTA: 
404074(ALOX5)
SSC: 
100156205(ALOX5)
ECB: 
100062042(ALOX5)
MDO: 
100013954(ALOX5)
SHR: 
100932471(ALOX5)
OAA: 
100077066
GGA: 
423769(ALOX5)
MGP: 
100542129(ALOX5)
TGU: 
100231888
ACS: 
100556313(alox5)
XTR: 
100036609(alox5)
DRE: 
567204(alox5)
TRU: 
101077167
OLA: 
101160835
CIN: 
100179479
SPU: 
584481
NVE: 
NEMVE_v1g145353 NEMVE_v1g229180
HMG: 
100215649
TAD: 
TRIADDRAFT_50085
AQU: 
100635761
CCX: 
COCOR_02733(loxA)
 » show all
Taxonomy
Reference
1  [PMID:2829172]
  Authors
Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B.
  Title
Molecular cloning and amino acid sequence of human 5-lipoxygenase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 26-30.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:3038871]
  Authors
Ohishi N, Izumi T, Minami M, Kitamura S, Seyama Y, Ohkawa S, Terao S, Yotsumoto H, Takaku F, Shimizu T.
  Title
Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers.
  Journal
J. Biol. Chem. 262 (1987) 10200-5.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:3012557]
  Authors
Shimizu T, Izumi T, Seyama Y, Tadokoro K, Radmark O, Samuelsson B.
  Title
Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 4175-9.
  Organism
Mus musculus [GN:mmu]
Reference
4  [PMID:6322165]
  Authors
Shimizu T, Radmark O, Samuelsson B.
  Title
Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 81 (1984) 689-93.
  Organism
Solanum tuberosum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
80619-02-9
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